EKS-ICT-00267

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ICT-00267

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	408.5	1.4E-122	191	478	288

Status

Unreviewed

Ensembl Protein

ENSSTOP00000013315

UniProt Accession

I3MNP8;

Protein Name

Protein Synonyms/Alias

Gene Name

ACVR2B

Gene Synonyms/Alias

ACVR2B;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSTOG00000014862	ENSSTOP00000013315	ENSSTOT00000014864

Organism

Ictidomys tridecemlineatus

Functional Description

Protein Length

513

Protein Sequence
(FASTA)

WFGTVALWGM LSVSSLGTGS GRGEAETREC IYYNANWELE RTNQSGLERC EGEQDKRLHC 60

YASWRNSSGT IELVKKGCWL DDFNCYDRQE CVATEENPQV YFCCCEGNFC NERFTHLPEA 120

GGPEVTYEPP PTAPTLLTVL AYSLLPIGGL SLIVLLAFWM YRHRKPPYGH VDIHEDPGPP 180

PPSPLVGLKP LQLLEIKARG RFGCVWKAQL MNDFVAVKIF PLQDKQSWQS EREIFSTPGM 240

KHENLLQFIA AEKRGSNLEV ELWLITAFHD KGSLTDYLKG NIITWNELCH VAETMSRGLS 300

YLHEDVPWCR GEGHKPSIAH RDFKSKNVLL KSDLTAVLAD FGLAVRFEPG KPPGDTHGQV 360

GTRRYMAPEV LEGAINFQRD AFLRIDMYAM GLVLWELVSR CKAADGPVDE YMLPFEEEIG 420

QHPSLEELQE VVVHKKMRPT IKDHWLKHPG LAQLCVTIEE CWDHDAEARL SAGCVEERVS 480

LIRRSVNGTT SDCLVSLVTS VTNVDLPPKE SSI 513

Nucleotide Sequence
(FASTA)

TGGTTTGGGA CAGTAGCCCT GTGGGGCATG CTCAGTGTCT CTTCTCTGGG CACAGGTTCA 60

GGGCGTGGGG AGGCTGAGAC ACGGGAGTGC ATTTACTACA ACGCCAACTG GGAGCTGGAA 120

CGCACCAATC AGAGTGGCTT GGAGCGCTGT GAGGGTGAGC AAGACAAGAG GCTGCACTGC 180

TACGCCTCCT GGCGCAACAG CTCAGGCACC ATCGAGCTCG TCAAGAAGGG CTGCTGGCTG 240

GATGATTTCA ACTGCTACGA CAGGCAGGAG TGTGTGGCCA CCGAGGAGAA CCCGCAGGTG 300

TACTTCTGCT GCTGCGAAGG CAACTTCTGC AACGAGCGCT TCACCCACTT GCCAGAGGCT 360

GGGGGCCCAG AAGTCACGTA CGAGCCACCC CCGACAGCCC CTACCCTGCT CACGGTGCTG 420

GCCTACTCGC TGCTGCCCAT TGGGGGCCTC TCCCTCATCG TCCTGCTGGC CTTCTGGATG 480

TATCGGCATC GTAAGCCTCC CTATGGCCAT GTGGACATCC ACGAGGACCC TGGGCCTCCA 540

CCCCCATCCC CCCTGGTGGG TCTGAAGCCA CTGCAGCTAT TAGAGATCAA GGCTCGTGGC 600

CGCTTTGGCT GTGTCTGGAA GGCCCAGCTC ATGAATGACT TTGTGGCTGT CAAGATCTTC 660

CCACTCCAGG ACAAGCAGTC GTGGCAGAGT GAAAGGGAGA TCTTCAGCAC GCCTGGCATG 720

AAGCATGAGA ACCTGCTGCA GTTCATTGCT GCTGAGAAAC GAGGCTCCAA CCTTGAGGTG 780

GAGCTGTGGC TCATCACGGC CTTCCATGAC AAGGGCTCCC TCACGGATTA CCTCAAGGGG 840

AACATCATCA CATGGAACGA ACTGTGTCAT GTGGCAGAAA CGATGTCACG AGGCCTTTCG 900

TACCTGCACG AGGATGTACC CTGGTGCCGT GGTGAGGGCC ACAAGCCGTC TATCGCCCAC 960

AGGGATTTTA AAAGCAAGAA TGTATTGCTG AAGAGTGACC TCACAGCTGT CCTGGCTGAC 1020

TTTGGCCTGG CTGTTCGGTT TGAGCCAGGG AAACCTCCAG GGGACACCCA TGGGCAGGTA 1080

GGCACCAGAC GGTACATGGC CCCTGAGGTG CTTGAGGGAG CCATCAACTT CCAGCGAGAC 1140

GCCTTCCTGC GCATTGACAT GTATGCTATG GGGCTGGTGC TGTGGGAGCT TGTGTCTCGC 1200

TGCAAGGCTG CGGATGGACC CGTGGATGAG TATATGCTGC CTTTTGAGGA GGAGATTGGC 1260

CAGCACCCTT CGCTGGAAGA GCTGCAGGAG GTGGTTGTTC ACAAGAAGAT GCGACCCACC 1320

ATTAAGGATC ACTGGCTAAA GCACCCGGGC CTGGCCCAGC TCTGTGTGAC CATTGAGGAG 1380

TGCTGGGACC ATGATGCAGA AGCTCGCCTA TCTGCAGGCT GCGTGGAGGA GCGAGTGTCC 1440

CTGATCCGGA GGTCGGTCAA CGGCACTACC TCGGACTGTC TTGTCTCCCT GGTGACCTCT 1500

GTCACCAATG TGGACCTGCC CCCTAAGGAG TCCAGCATCT AA 1542

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         l+lle+ ++Gr+g+Vwka+l+++ vAvKif+ +d++sw++E+ei++t+ ++hen+lqfia

Q: 191   LQLLEIKARGRFGCVWKAQLMNDFVAVKIFPLQDKQSWQSEREIFSTPGMKHENLLQFIA  250

         6899********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         a+k+ +++++el+l+t++h+kgsL+dyLk ++++++el+++a+++++Gl++LHe++++++

Q: 251   AEKRGSNLEVELWLITAFHDKGSLTDYLKGNIITWNELCHVAETMSRGLSYLHEDVPWCR  310

         ************************************************************

S: 121   g.kkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaP  179

         g  +Kp+iaHRD+kskN+l+k+dlt+++aD+GLa+++e  k   d  ++ qvGt+RYmaP

Q: 311   GeGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGD--THGQVGTRRYMAP  368

         *99***************************************888..79***********

S: 180   EvleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPslee  239

         Evle+a+n+++ +af r+D+Y++gLvlWE++sRc+++d+ v+ey+lpfee++g++Pslee

Q: 369   EVLEGAINFQR-DAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQHPSLEE  427

         **********9.9***********************************************

S: 240   mkevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkr  290

         ++evvv+kk+rP+i+++w k++ l++l+ ++eecWd+d+eaRl+a +v++r

Q: 428   LQEVVVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHDAEARLSAGCVEER  478

         ************************************************998

Domain Sequence
(FASTA)

LQLLEIKARG RFGCVWKAQL MNDFVAVKIF PLQDKQSWQS EREIFSTPGM KHENLLQFIA 60

AEKRGSNLEV ELWLITAFHD KGSLTDYLKG NIITWNELCH VAETMSRGLS YLHEDVPWCR 120

GEGHKPSIAH RDFKSKNVLL KSDLTAVLAD FGLAVRFEPG KPPGDTHGQV GTRRYMAPEV 180

LEGAINFQRD AFLRIDMYAM GLVLWELVSR CKAADGPVDE YMLPFEEEIG QHPSLEELQE 240

VVVHKKMRPT IKDHWLKHPG LAQLCVTIEE CWDHDAEARL SAGCVEER 288

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0017002	; F:activin-activated receptor activity
GO:0005524	; F:ATP binding
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0023014	; P:signal transduction by phosphorylation

KEGG

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR015768	; Activin_II_recpt.
IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.

SMARTs

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013