EKS-ICT-00468

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ICT-00468

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/RIPK	387.2	3.6E-116	19	287	269

Status

Unreviewed

Ensembl Protein

ENSSTOP00000013591

UniProt Accession

I3MPA0;

Protein Name

Protein Synonyms/Alias

Gene Name

RIPK2

Gene Synonyms/Alias

RIPK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSTOG00000015168	ENSSTOP00000013591	ENSSTOT00000015169

Organism

Ictidomys tridecemlineatus

Functional Description

Protein Length

538

Protein Sequence
(FASTA)

MNGDAICSAL PTIPYRKLAD LCYLSRGASG TVSSARHADW RVQVAVKHLH IHTPLLDSER 60

NDVLREAEIL HKARFSYILP ILGICNEPEF LGIVTEYMPN GSLNELLHRK IEYPDVPWPL 120

RFRILHEIAL GVNYLHNMNP PLLHHDLKTQ NILLDSEFHV KIADFGLSKW RMMSLSQSRS 180

NKSAPEGGTI IYMPPENYEP GQKSRASVKH DIYSYAVIMW EMLSRKQPFE DVINPLQIMY 240

SVSQGHRPDT TEESLPFDIP HRAVMTSLIE SGWAQNPDER PSFLKCLIEL EPVLRTYEEI 300

TFLEAVIQLK KTKLQSASST VHSCDKRKEV SLNIPVNHGP QEESCGSSQL HKSSSSPGTS 360

RSLSTPQEND FLSGKTPDYS SMNLHQSVNH SWDSTVAASQ KAIFCDHKTT PCSSTIINSF 420

LTERYSERLQ PGIAQQWIQS KREDIVNQMT EACLNQSLDA LLSRDLIMKE DYELISTKPT 480

RTSKVRQLLD TSDIQGEEFA KVIVQKLKDN KQMGLQPYPE ILVISRLPSS NFPQNKSL 538

Nucleotide Sequence
(FASTA)

ATGAACGGAG ACGCCATCTG CAGCGCCCTG CCCACCATTC CCTACCGCAA GCTCGCCGAC 60

CTGTGCTACC TGAGCCGCGG CGCCTCTGGC ACCGTGTCGT CCGCCCGCCA CGCAGACTGG 120

CGCGTTCAGG TGGCTGTGAA GCACCTGCAC ATCCACACCC CGCTGCTCGA CAGTGAAAGA 180

AATGATGTCT TAAGAGAAGC TGAAATTTTG CACAAAGCAA GATTTAGTTA CATTCTTCCT 240

ATATTGGGAA TTTGCAATGA GCCAGAATTT TTGGGAATAG TTACTGAATA CATGCCAAAT 300

GGATCATTAA ATGAACTCCT ACATAGGAAA ATTGAATATC CTGATGTTCC TTGGCCATTA 360

AGATTCCGCA TCCTGCATGA AATCGCACTT GGTGTAAATT ACCTGCATAA TATGAATCCT 420

CCTCTACTTC ATCATGACTT GAAGACTCAG AATATCTTGT TAGACAGTGA ATTTCATGTT 480

AAGATTGCAG ATTTTGGTTT ATCAAAATGG CGTATGATGT CTCTCTCACA ATCACGAAGT 540

AACAAATCTG CTCCAGAAGG AGGGACAATT ATCTATATGC CACCTGAAAA CTATGAACCT 600

GGACAGAAAT CAAGGGCCAG TGTCAAACAT GATATATATA GCTATGCAGT TATCATGTGG 660

GAAATGTTAT CCAGAAAACA GCCTTTTGAA GACGTCATCA ATCCTTTGCA GATTATGTAC 720

AGTGTGTCTC AAGGACATCG ACCTGACACT ACTGAAGAAA GTTTGCCATT TGATATACCT 780

CATCGAGCAG TCATGACCTC TCTAATAGAA AGCGGATGGG CACAAAATCC AGATGAAAGA 840

CCTTCTTTCT TAAAGTGTTT AATAGAGCTT GAGCCAGTTC TGAGAACATA TGAAGAGATA 900

ACTTTTCTTG AAGCTGTTAT TCAGCTAAAG AAAACAAAGT TACAGAGTGC CTCGAGTACT 960

GTTCACTCAT GTGACAAGAG GAAGGAGGTG TCTCTGAACA TACCTGTAAA TCATGGTCCC 1020

CAGGAGGAAT CATGTGGATC CTCTCAGCTT CATAAAAGCA GTAGTTCTCC TGGAACCTCA 1080

AGGTCCCTAT CAACTCCCCA AGAAAACGAC TTTTTATCTG GAAAAACTCC AGACTACTCT 1140

TCTATGAATC TACATCAGTC AGTAAATCAC AGTTGGGATA GTACTGTTGC TGCATCTCAG 1200

AAGGCCATAT TCTGTGATCA CAAGACCACC CCTTGCTCTT CAACAATAAT AAATTCATTC 1260

TTAACTGAGA GGTATTCAGA GCGTCTACAA CCTGGTATAG CCCAACAGTG GATCCAGAGC 1320

AAAAGGGAAG ACATTGTGAA CCAAATGACT GAAGCCTGCC TTAACCAATC ACTAGATGCC 1380

CTCCTGTCCA GGGACTTGAT CATGAAGGAG GACTATGAAC TTATTAGTAC CAAACCTACA 1440

AGGACTTCAA AAGTTAGACA ATTATTGGAC ACCAGTGACA TCCAAGGAGA AGAATTTGCT 1500

AAAGTTATAG TACAAAAGTT GAAAGATAAC AAACAAATGG GTCTTCAACC CTACCCAGAA 1560

ATACTAGTGA TTTCCAGACT ACCATCTTCA AATTTCCCTC AAAATAAAAG TTTATAA 1617

Domain Profile

S: 2     eelelvgsGgfgkvfkarhrkwrvevavkslvlktdaldserkelleeakkmeklrfsyv  61

         ++l ++++G++g+v++arh++wrv+vavk+l+++t++ldser+++l+ea++++k+rfsy+

Q: 19    ADLCYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERNDVLREAEILHKARFSYI  78

         67889*******************************************************

S: 62    lkllGvikeeeklglvmeymenGsLeklLkseielp...wplkfRilkevvlgmnyLhsl  118

         l++lG+++e+e+lg+v+eym+nGsL++lL+++ie+p   wpl+fRil+e++lg+nyLh++

Q: 79    LPILGICNEPEFLGIVTEYMPNGSLNELLHRKIEYPdvpWPLRFRILHEIALGVNYLHNM  138

         *********************************988888*********************

S: 119   kPpllhkDLkpeniLlDnelhvkiaDfGlskf.meessqskevsssaegGtlaYlaPell  177

         +Ppllh+DLk++niLlD+e+hvkiaDfGlsk+ m++ sqs++ +s++egGt++Y++Pe++

Q: 139   NPPLLHHDLKTQNILLDSEFHVKIADFGLSKWrMMSLSQSRSNKSAPEGGTIIYMPPENY  198

         ************************************************************

S: 178   eevnk.kaseksDvYsfaiviWavlakkepyeeeknslqiiivvkkgnRPeleevseelP  236

         e+ +k +as k+D+Ys+a+++W++l++k+p+e+++n lqi+++v++g+RP+++e  e+lP

Q: 199   EPGQKsRASVKHDIYSYAVIMWEMLSRKQPFEDVINPLQIMYSVSQGHRPDTTE--ESLP  256

         ***9999***********************************************..****

S: 237   revpq...lieLmkrcWeadpeeRPsFleie  264

          ++p+   + +L++++W+++p+eRPsFl++

Q: 257   FDIPHravMTSLIESGWAQNPDERPSFLKCL  287

         ****************************986

Domain Sequence
(FASTA)

ADLCYLSRGA SGTVSSARHA DWRVQVAVKH LHIHTPLLDS ERNDVLREAE ILHKARFSYI 60

LPILGICNEP EFLGIVTEYM PNGSLNELLH RKIEYPDVPW PLRFRILHEI ALGVNYLHNM 120

NPPLLHHDLK TQNILLDSEF HVKIADFGLS KWRMMSLSQS RSNKSAPEGG TIIYMPPENY 180

EPGQKSRASV KHDIYSYAVI MWEMLSRKQP FEDVINPLQI MYSVSQGHRP DTTEESLPFD 240

IPHRAVMTSL IESGWAQNPD ERPSFLKCL 269

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0043065	; P:positive regulation of apoptotic process

KEGG

InterPros

IPR001315	; CARD.
IPR011029	; DEATH-like.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017322	; Rcpt-int_Ser/Thr_kinase-2.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00619	; CARD; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00114

; CARD; 1.

Prosites

PS50209	; CARD; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013