EKS-ICT-00375

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ICT-00375

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Axl	548.8	1.9E-165	477	742	266

Status

Unreviewed

Ensembl Protein

ENSSTOP00000013763

UniProt Accession

I3MPL7;

Protein Name

Protein Synonyms/Alias

Gene Name

TYRO3

Gene Synonyms/Alias

TYRO3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSTOG00000015360	ENSSTOP00000013763	ENSSTOT00000015367

Organism

Ictidomys tridecemlineatus

Functional Description

Protein Length

849

Protein Sequence
(FASTA)

GLKLVGAPVK LTVSQGQPVK LNCSVEGMEE PEIQWVKDGA VVQSLDQMYI SVSEQHWIGF 60

LSLKSVERSD AGRYWCQVED GEEIEISQPV WLTVEGVPFF TVEPKDLAVP PNAPFQLSCE 120

AVGPPEPVTI IWWRGGTKIG GPAPSPSVLN VTGVTQRTEF SCEAHNRKGL ASSRPAIVHL 180

QARPAAPFNI TVTKLSSSNA SVAWMPGADG RAVLQSCTVQ VTQAPGDWEV LAVVVPVPPF 240

TCLLRDLEPA TNYSLRVRCT NALGPSPYAD WVPFQTKGLA PSSAPQNLHA IRTDSGLILE 300

WEEVIPEGPL EGPLGPYKLF WIQDNGTQDE LTVEGTRTNL TGWDPQKDLI VRVCVSNAVG 360

CGPWSQPLVV SSHDHAGQEG PPHSRTSWVP VVLGVLTALV TAAALALILL RKRRKETRFG 420

QAFDSVMTRG EPAVHFRAAR SFNRERPERI EATLDSLGIS DELKDKLEDV LIPEQQFTLG 480

RMLGKGEFGS VREAQLKQED GSFVKVAVKM LKADIIASSD IEEFLREAAC MKEFDHPHVA 540

KLVGVSLRSR AKGRLPIPMV ILPFMKHGDL HAFLLASRIG ENPFNLPLQT LIRFMVDIAC 600

GMEYLSSRNF IHRDLAARNC MLAEDMTVCV ADFGLSRKIY SGDYYRQGCA SKLPVKWLAL 660

ESLADNLYTV HSDVWAFGVT MWEIMTRGQT PYAGIENAEI YNYLIGGNRL KQPPECMEDV 720

YDLMYQCWSA DPKQRPSFTC LRMELENILG HLSVLSASQD PLYINIERAE QPTEEGSLEL 780

PCRDQPSSRA GDISGMGAVG ATSSDYRYIL SPGGLAELPV QADQQPESPL NEAQRLLLLQ 840

QGLLPHSSC 849

Nucleotide Sequence
(FASTA)

GGCCTGAAGC TCGTAGGAGC CCCGGTGAAG CTGACAGTGT CTCAGGGGCA GCCTGTGAAG 60

CTCAACTGCA GCGTGGAGGG GATGGAGGAG CCTGAGATAC AGTGGGTGAA GGACGGGGCT 120

GTGGTCCAAA GTTTGGACCA GATGTACATC TCAGTCAGCG AGCAGCACTG GATTGGCTTC 180

CTCAGCCTGA AGTCAGTGGA GCGTTCTGAT GCAGGCCGGT ACTGGTGCCA AGTAGAGGAT 240

GGGGAAGAAA TTGAGATCTC ACAGCCAGTG TGGCTCACAG TAGAAGGTGT GCCATTTTTC 300

ACTGTAGAGC CAAAAGATCT GGCAGTGCCA CCCAATGCCC CTTTCCAACT GTCTTGTGAA 360

GCCGTGGGCC CCCCTGAACC TGTTACCATT ATCTGGTGGA GAGGAGGCAC CAAGATTGGA 420

GGTCCTGCTC CCTCTCCCTC CGTTTTAAAT GTAACAGGTG TGACCCAGAG AACAGAGTTT 480

TCCTGTGAAG CTCACAACAG AAAAGGCCTG GCCTCTTCAC GACCAGCTAT TGTTCACCTT 540

CAAGCAAGGC CTGCAGCCCC CTTTAACATC ACAGTGACAA AGCTCTCCAG CAGCAATGCT 600

AGCGTGGCCT GGATGCCAGG TGCTGATGGC CGAGCTGTGC TCCAATCCTG TACAGTCCAG 660

GTCACACAGG CCCCAGGGGA CTGGGAGGTC CTAGCTGTAG TGGTCCCTGT ACCACCCTTT 720

ACCTGCCTCC TCCGGGATCT GGAGCCTGCC ACCAACTACA GCCTCAGGGT GCGCTGTACC 780

AACGCCTTGG GGCCCTCTCC CTACGCTGAC TGGGTGCCCT TTCAGACAAA GGGTCTAGCC 840

CCATCTAGCG CTCCCCAGAA CCTCCACGCC ATCCGCACAG ATTCAGGCCT CATCCTGGAG 900

TGGGAAGAAG TGATCCCTGA GGGCCCTTTG GAAGGTCCCC TGGGCCCCTA TAAACTGTTT 960

TGGATTCAAG ACAATGGAAC CCAGGATGAG CTGACTGTGG AGGGGACCAG GACCAATCTG 1020

ACAGGCTGGG ATCCCCAGAA GGACCTGATC GTGCGTGTGT GCGTCTCCAA TGCAGTTGGC 1080

TGTGGGCCCT GGAGTCAGCC ATTGGTGGTC TCTTCTCACG ACCATGCAGG CCAGGAGGGC 1140

CCCCCTCACA GCCGCACATC CTGGGTGCCT GTGGTTCTGG GTGTGCTGAC AGCCCTGGTG 1200

ACAGCCGCTG CTCTGGCCCT CATCCTCCTT CGAAAGAGGC GGAAAGAGAC ACGGTTCGGG 1260

CAAGCCTTTG ACAGTGTCAT GACCCGAGGG GAGCCAGCTG TTCATTTTCG GGCAGCCCGG 1320

TCCTTCAATC GAGAAAGGCC TGAGCGCATT GAGGCCACAC TGGACAGCCT GGGCATCAGT 1380

GATGAACTGA AGGACAAACT GGAAGATGTG CTCATCCCAG AGCAGCAATT CACCCTGGGC 1440

CGGATGTTGG GCAAAGGAGA ATTTGGTTCA GTGCGAGAGG CCCAGCTGAA GCAGGAAGAT 1500

GGCTCCTTTG TAAAAGTGGC TGTAAAGATG CTAAAAGCTG ACATCATTGC CTCAAGTGAC 1560

ATTGAAGAGT TCCTCAGGGA AGCAGCTTGC ATGAAGGAGT TTGACCATCC TCATGTGGCC 1620

AAGCTTGTTG GGGTGAGCCT CCGGAGCAGG GCTAAAGGCC GTCTCCCCAT TCCCATGGTC 1680

ATCCTGCCCT TCATGAAACA TGGGGACCTG CATGCATTCC TGCTTGCCTC CCGGATTGGA 1740

GAGAACCCTT TTAACCTGCC CCTCCAGACC CTGATCCGGT TCATGGTGGA CATTGCCTGT 1800

GGCATGGAGT ACCTGAGCTC CCGGAACTTC ATCCACCGAG ACCTGGCTGC TCGAAATTGC 1860

ATGTTGGCAG AGGACATGAC AGTGTGTGTG GCTGACTTTG GACTTTCTCG AAAAATCTAT 1920

AGTGGGGACT ACTATCGTCA GGGCTGTGCC TCCAAATTGC CTGTCAAGTG GCTGGCCCTG 1980

GAGAGCTTGG CTGACAACCT GTATACTGTA CACAGTGATG TGTGGGCCTT TGGAGTGACC 2040

ATGTGGGAGA TCATGACTCG TGGGCAGACA CCATATGCTG GCATCGAAAA CGCTGAGATT 2100

TACAACTACC TCATCGGCGG GAACCGCCTG AAACAGCCTC CCGAGTGTAT GGAGGACGTG 2160

TATGATCTCA TGTACCAGTG CTGGAGTGCT GACCCAAAGC AGCGCCCAAG CTTCACATGT 2220

CTGCGAATGG AACTGGAAAA CATCCTAGGC CACCTATCTG TCCTGTCCGC CAGCCAGGAC 2280

CCCTTGTACA TCAACATTGA GAGAGCTGAG CAACCTACTG AGGAAGGCAG CCTGGAGCTG 2340

CCCTGTAGGG ATCAGCCCAG CAGCAGAGCT GGGGATATCA GTGGCATGGG GGCAGTGGGT 2400

GCCACCTCCA GTGACTATCG GTACATCCTC AGCCCTGGAG GACTGGCCGA GCTGCCTGTA 2460

CAGGCAGACC AGCAGCCAGA GAGCCCCCTC AATGAGGCCC AGAGGCTGCT GCTGCTGCAG 2520

CAAGGGCTAC TGCCCCACAG TAGCTGTTAG 2550

Domain Profile

S: 1     lvlgkvlgegefgsvmegqlkqedgsilkvavktlkldiiarseieeflseaacmkefdh  60

         ++lg++lg+gefgsv+e+qlkqedgs++kvavk+lk+diia+s+ieefl+eaacmkefdh

Q: 477   FTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFDH  536

         68**********************************************************

S: 61    pnvirlvgvslessekgrlpkpvvilpfmkygdlhafllysrlgenpvylplqtlvkfmv  120

         p+v++lvgvsl+s++kgrlp+p+vilpfmk+gdlhafll+sr+genp++lplqtl++fmv

Q: 537   PHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLIRFMV  596

         ************************************************************

S: 121   diasgmeylssrnfihrdlaarncmlaedmtvcvadfglskkiysgdyyrqgriaklpvk  180

         dia+gmeylssrnfihrdlaarncmlaedmtvcvadfgls+kiysgdyyrqg+++klpvk

Q: 597   DIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPVK  656

         ************************************************************

S: 181   wiaiesladrvytsksdvwafgvtmweiatrgqtpyagvenaeiydyllqgnrlkqpedc  240

         w+a+eslad++yt++sdvwafgvtmwei+trgqtpyag+enaeiy+yl++gnrlkqp++c

Q: 657   WLALESLADNLYTVHSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPEC  716

         ************************************************************

S: 241   ldelydlmyrcweadpkdrpsfsvlr  266

         ++++ydlmy+cw+adpk+rpsf+ lr

Q: 717   MEDVYDLMYQCWSADPKQRPSFTCLR  742

         ***********************998

Domain Sequence
(FASTA)

FTLGRMLGKG EFGSVREAQL KQEDGSFVKV AVKMLKADII ASSDIEEFLR EAACMKEFDH 60

PHVAKLVGVS LRSRAKGRLP IPMVILPFMK HGDLHAFLLA SRIGENPFNL PLQTLIRFMV 120

DIACGMEYLS SRNFIHRDLA ARNCMLAEDM TVCVADFGLS RKIYSGDYYR QGCASKLPVK 180

WLALESLADN LYTVHSDVWA FGVTMWEIMT RGQTPYAGIE NAEIYNYLIG GNRLKQPPEC 240

MEDVYDLMYQ CWSADPKQRP SFTCLR 266

Keyword

ATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR003961	; Fibronectin_type3.
IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003599	; Ig_sub.
IPR003598	; Ig_sub2.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF00041	; fn3; 2.
PF07679	; I-set; 1.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00060	; FN3; 2.
SM00409	; IG; 1.
SM00408	; IGc2; 1.
SM00219	; TyrKc; 1.

Prosites

PS50853	; FN3; 2.
PS50835	; IG_LIKE; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013