EKS-ICT-00004
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ICT-00004
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Eph515.41.9E-155608867260
StatusUnreviewed
Ensembl ProteinENSSTOP00000013782
UniProt AccessionI3MPN2;
Protein Name
Protein Synonyms/Alias
Gene NameEPHB2
Gene Synonyms/Alias EPHB2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSSTOG00000015377ENSSTOP00000013782ENSSTOT00000015388
OrganismIctidomys tridecemlineatus
Functional Description
Protein Length973
Protein Sequence
(FASTA)
LLALPTETLM DSTTATAELG WMVHPPSGWE EVSGYDENMN TIRTYQVCNV FESSQNNWLR 60
TKFIRRRGAH RIHVEMKFSV RDCSSIPSVP GSCKETFNLY YYEADFDSAT KTFPNWMENP 120
WVKVDTIAAD ESFSQVDLGG RVMKINTEVR SFGPVARNGF YLAFQDYGGC MSLIAVRVFY 180
RKCPRVIQNG AIFQETLSGA ESTSLVAARG SCIANAEEVD VPIKLYCNGD GEWLVPIGRC 240
MCKAGFEAVE NGTVCRGCPS GTFKANQGDE ACTHCPINSR TTSEGATNCV CRNGYYRADL 300
DPLDMPCTTI PSAPQAVISS VNETSLMLEW TPPRDSGGRE DLVYNIICKS CGSGRGACTR 360
CGDNVQYAPR QLGLTEPRIY ISDLLAHTQY TFEIQAVNGV TDQSPFSPQF ASVNITTNQA 420
APSAVAIMHQ VSRTVDSITL SWSQPDQPNG VILDYELQYY EKELSEYNAT AIKSPTNTVT 480
VQGLKAGAIY VFQVRARTVA GYGRYSGKMY FQTMTEAEYQ TSIQEKLPLV IGSSAAGLVF 540
LIAVVVIAIV CNRRRGFERA DSEYTDKLQH YTSGHMTPGM KIYIDPFTYE DPNEAVREFA 600
KEIDISCVKI EQVIGAGEFG EVCSGHLKLP GKREIFVAIK TLKSGYTEKQ RRDFLSEASI 660
MGQFDHPNVI HLEGVVTKST PVMIITEFME NGSLDSFLRQ NDGQFTVIQL VGMLRGIAAG 720
MKYLADMNYV HRDLAARNIL VNSNLVCKVS DFGLSRFLED DTSDPTYTSA LGGKIPIRWT 780
APEAIQYRKF TSASDVWSYG IVMWEVMSYG ERPYWDMTNQ DVINAIEQDY RLPPPMDCPS 840
ALHQLMLDCW QKDRNHRPKF GQIVNTLDKM IRNPNSLKAM APLSSGVNLP LLDRTIPDYT 900
SFNTVDEWLE AIKMGQYKES FANAGFTSFD VVSQMMMEDI LRVGVTLAGH QKKILNSIQV 960
MRAQMNQIQS VEV 973
Nucleotide Sequence
(FASTA)
CTCCTTGCTC TCCCCACAGA AACGCTGATG GACTCCACTA CGGCGACGGC AGAGCTGGGC 60
TGGATGGTGC ATCCCCCATC AGGGTGGGAA GAGGTGAGCG GCTACGACGA GAACATGAAC 120
ACCATCCGGA CGTACCAGGT GTGCAACGTC TTTGAGTCCA GCCAGAACAA CTGGCTGCGG 180
ACCAAGTTCA TCCGGCGCCG CGGCGCCCAC CGCATCCACG TGGAGATGAA GTTCTCCGTG 240
CGCGACTGCA GCAGCATCCC CAGCGTGCCC GGCTCCTGCA AGGAGACCTT CAACCTCTAC 300
TACTACGAGG CCGACTTTGA CTCGGCCACC AAGACCTTCC CCAACTGGAT GGAGAATCCC 360
TGGGTGAAGG TGGATACCAT TGCCGCCGAC GAGAGCTTCT CCCAGGTGGA CCTGGGTGGC 420
CGGGTCATGA AGATCAACAC CGAGGTGCGC AGCTTCGGGC CCGTGGCCCG CAATGGCTTC 480
TACCTGGCCT TCCAGGACTA CGGCGGCTGC ATGTCCCTCA TTGCTGTGCG CGTCTTCTAC 540
CGCAAGTGCC CGCGCGTCAT CCAGAACGGC GCCATCTTCC AGGAGACCCT GTCAGGGGCT 600
GAGAGCACGT CGCTGGTGGC TGCCCGGGGC AGCTGCATTG CCAACGCGGA GGAGGTGGAC 660
GTGCCCATCA AGCTCTACTG CAACGGGGAC GGCGAGTGGC TGGTGCCCAT CGGCCGCTGC 720
ATGTGCAAAG CGGGCTTCGA GGCCGTGGAG AACGGCACCG TCTGCCGAGG TTGTCCCTCA 780
GGAACCTTCA AGGCCAACCA AGGGGACGAG GCCTGCACGC ACTGCCCCAT CAACAGCCGG 840
ACCACCTCGG AAGGGGCCAC CAACTGTGTC TGCCGCAATG GCTACTACAG AGCCGACCTG 900
GACCCCCTGG ACATGCCCTG CACAACCATC CCCTCCGCCC CCCAGGCTGT GATCTCCAGT 960
GTCAACGAGA CCTCCCTCAT GCTGGAGTGG ACCCCTCCGC GCGACTCCGG GGGCCGCGAG 1020
GATCTGGTCT ACAACATCAT CTGCAAGAGC TGCGGCTCCG GCCGGGGCGC CTGCACCCGC 1080
TGTGGGGACA ACGTGCAGTA CGCGCCCCGC CAGCTGGGCC TGACGGAGCC GCGCATCTAC 1140
ATCAGCGACC TGCTGGCCCA CACCCAGTAC ACCTTCGAGA TCCAGGCCGT GAATGGCGTC 1200
ACCGACCAGA GCCCCTTCTC GCCCCAGTTC GCCTCGGTGA ACATCACCAC CAACCAAGCA 1260
GCGCCGTCGG CCGTGGCCAT CATGCATCAG GTGAGCCGCA CCGTGGACAG CATCACCCTG 1320
TCGTGGTCCC AGCCAGACCA GCCCAACGGC GTGATCCTGG ACTACGAGCT GCAGTACTAT 1380
GAGAAGGAGC TCAGTGAGTA CAACGCCACA GCCATAAAAA GTCCCACCAA CACAGTCACC 1440
GTGCAGGGCC TCAAAGCCGG CGCCATCTAT GTCTTCCAGG TGCGGGCACG CACCGTGGCC 1500
GGCTATGGGC GCTACAGTGG CAAGATGTAC TTCCAGACCA TGACAGAAGC CGAGTACCAG 1560
ACGAGCATCC AGGAGAAGCT GCCCCTGGTC ATCGGCTCCT CGGCCGCCGG CCTGGTCTTC 1620
CTCATCGCCG TGGTTGTCAT CGCCATCGTG TGCAACAGAA GACGGGGGTT TGAGCGCGCC 1680
GACTCCGAGT ACACGGACAA GCTGCAGCAC TACACCAGCG GCCACATGAC CCCAGGCATG 1740
AAGATCTACA TTGACCCTTT CACCTACGAG GACCCCAATG AGGCAGTGCG GGAGTTCGCC 1800
AAGGAAATCG ACATCTCCTG CGTCAAAATC GAGCAGGTGA TCGGAGCAGG GGAGTTTGGT 1860
GAGGTCTGCA GTGGCCACCT GAAGCTGCCG GGCAAGAGGG AGATCTTCGT GGCCATCAAG 1920
ACGCTCAAGT CGGGCTACAC GGAGAAGCAG CGGCGGGACT TCCTGAGCGA GGCCTCCATC 1980
ATGGGCCAGT TCGACCACCC CAACGTCATC CACCTGGAGG GCGTCGTCAC CAAGAGCACC 2040
CCTGTGATGA TCATCACCGA GTTCATGGAG AACGGCTCCC TGGACTCCTT CCTCAGGCAA 2100
AACGACGGGC AGTTCACTGT CATCCAGCTG GTGGGCATGC TGCGGGGCAT CGCCGCGGGC 2160
ATGAAGTACC TCGCAGACAT GAACTACGTC CACCGCGACC TGGCCGCCCG CAACATCCTG 2220
GTCAACAGCA ACCTGGTCTG CAAGGTGTCC GACTTCGGGC TCTCACGCTT CCTAGAGGAC 2280
GACACCTCAG ACCCCACCTA CACCAGCGCC TTGGGTGGAA AGATCCCCAT CCGTTGGACA 2340
GCTCCGGAAG CCATCCAGTA CCGGAAGTTT ACCTCAGCCA GCGACGTGTG GAGCTACGGA 2400
ATCGTCATGT GGGAGGTGAT GTCCTACGGG GAGCGGCCCT ACTGGGACAT GACCAACCAG 2460
GACGTCATCA ACGCCATCGA GCAGGACTAC CGGCTACCAC CGCCCATGGA CTGCCCGAGC 2520
GCCCTGCACC AGCTCATGCT GGACTGCTGG CAGAAGGACC GCAACCACAG GCCCAAATTC 2580
GGCCAGATCG TCAACACGCT GGACAAGATG ATCCGCAACC CCAACAGCCT CAAAGCCATG 2640
GCGCCCCTCT CCTCTGGCGT CAACCTGCCG CTGCTGGACC GCACGATCCC CGACTACACC 2700
AGCTTTAACA CGGTGGACGA GTGGCTGGAG GCCATCAAGA TGGGGCAGTA CAAGGAGAGC 2760
TTCGCCAACG CCGGCTTCAC CTCCTTCGAT GTTGTGTCTC AGATGATGAT GGAGGACATC 2820
CTCCGGGTTG GGGTCACCCT GGCTGGCCAC CAGAAAAAAA TCCTGAACAG TATCCAGGTG 2880
ATGCGGGCAC AGATGAACCA GATTCAGTCT GTGGAGGTGT GA 2922
Domain Profile
S: 1     vkiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhp  60
         vkie+viGaGefGevcsG+lklpgkrei vaiktlk+g+tekqrrdflseasi+Gqfdhp
Q: 608   VKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIMGQFDHP  667
         79**********************************************************
S: 61    niirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdm  120
         n+i+leGvvtks+pvmi+te+meng+ldsflr++dgqftviqlvgmlrGia+gmkyl+dm
Q: 668   NVIHLEGVVTKSTPVMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLADM  727
         ************************************************************
S: 121   gyvhrdlaarnilvnsnlvckvsdfGlsrvledds.eaaytts.ggkipirwtapeaiay  178
         +yvhrdlaarnilvnsnlvckvsdfGlsr+ledd+ +++yt++ ggkipirwtapeai+y
Q: 728   NYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTsDPTYTSAlGGKIPIRWTAPEAIQY  787
         **********************************99*****999****************
S: 179   rkftsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlml  238
         rkftsasdvwsyGiv+wev+syGerpywdm+nqdvi+aie++yrlpppmdcp+al+qlml
Q: 788   RKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIEQDYRLPPPMDCPSALHQLML  847
         ************************************************************
S: 239   dcwqkdraerpkfeqivsil  258
         dcwqkdr++rpkf qiv++l
Q: 848   DCWQKDRNHRPKFGQIVNTL  867
         *****************975
Domain Sequence
(FASTA)
VKIEQVIGAG EFGEVCSGHL KLPGKREIFV AIKTLKSGYT EKQRRDFLSE ASIMGQFDHP 60
NVIHLEGVVT KSTPVMIITE FMENGSLDSF LRQNDGQFTV IQLVGMLRGI AAGMKYLADM 120
NYVHRDLAAR NILVNSNLVC KVSDFGLSRF LEDDTSDPTY TSALGGKIPI RWTAPEAIQY 180
RKFTSASDVW SYGIVMWEVM SYGERPYWDM TNQDVINAIE QDYRLPPPMD CPSALHQLML 240
DCWQKDRNHR PKFGQIVNTL 260
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>
EKS-BOT-00004
EKS-CAF-00005
EKS-CAP-00004
EKS-CIS-00002
EKS-DAR-00002
EKS-EQC-00005
EKS-GAG-00005
EKS-GAA-00006
EKS-GOG-00004
EKS-HOS-00006
EKS-LOA-00005
EKS-MEG-00004
EKS-MOD-00005
EKS-MUM-00005
EKS-MUP-00004
EKS-MYL-00005
EKS-ORN-00004
EKS-ORC-00004
EKS-ORL-00005
EKS-OTG-00003
EKS-PAT-00005
EKS-PES-00010
EKS-PEM-00001
EKS-POA-00013
EKS-PTV-00003
EKS-RAN-00005
EKS-SAH-00004
EKS-SUS-00004
EKS-TAG-00009
EKS-TAR-00006
EKS-TEN-00005
EKS-TUT-00002
EKS-XIM-00002
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005003; F:ephrin receptor activity
KEGG
InterPros
IPR001090; Ephrin_rcpt_lig-bd_dom.
IPR003961; Fibronectin_type3.
IPR008979; Galactose-bd-like.
IPR009030; Growth_fac_rcpt.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001660; SAM.
IPR013761; SAM/pointed.
IPR021129; SAM_type1.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016257; Tyr_kinase_ephrin_rcpt.
IPR001426; Tyr_kinase_rcpt_V_CS.
Pfam
PF01404; Ephrin_lbd; 1.
PF00041; fn3; 2.
PF07699; GCC2_GCC3; 1.
PF07714; Pkinase_Tyr; 1.
PF00536; SAM_1; 1.
SMARTs
SM00615; EPH_lbd; 1.
SM00060; FN3; 2.
SM00454; SAM; 1.
SM00219; TyrKc; 1.
Prosites
PS51550; EPH_LBD; 1.
PS50853; FN3; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00790; RECEPTOR_TYR_KIN_V_1; 1.
PS00791; RECEPTOR_TYR_KIN_V_2; 1.
PS50105; SAM_DOMAIN; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013