EKS-ICT-00422

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ICT-00422

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/DMPK	495.1	4.6E-149	8	274	267

Status

Unreviewed

Ensembl Protein

ENSSTOP00000013841

UniProt Accession

I3MPS2;

Protein Name

Protein Synonyms/Alias

Gene Name

CDC42BPA

Gene Synonyms/Alias

CDC42BPA;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSTOG00000015415	ENSSTOP00000013841	ENSSTOT00000015454

Organism

Ictidomys tridecemlineatus

Functional Description

Protein Length

1633

Protein Sequence
(FASTA)

MRLHREDFEI LKVIGRGAFG EVAVVKLKNA DKVFAMKILN KWEMLKRAET ACFREERDVL 60

VNGDNKWITT LHYAFQDDNN LYLVMDYYVG GDLLTLLSKF EDRLPEDMAR FYLAEMVIAI 120

DSVHQLHYVH RDIKPDNILM DMNGHIRLAD FGSCLKLMED GTVQSSVAVG TPDYISPEIL 180

QAMEDGKGRY GPECDWWSLG VCMYEMLYGE TPFYAESLVE TYGKIMNHKE RFQFPPQVTD 240

VSENAKDLIR RLICSREHRL GQNGIEDFKK HPFFSGIDWD NIRNCEAPYI PEVSSPTDTS 300

NFDVDDDCLK NSETMPPPTH TAFSGHHLPF VGFTYTSSCV LSDRSCLRVT AGPTSLDLDV 360

NVQRTLDNNL ATEAYERRIK RLEQEKLELS RKLQESTQTV QALQYSTVDG PLTASKDLEI 420

KTLKEEIEKL RKQVEESSHL EQQLEEANSV RRELDDAFRQ IKAYEKQIKT LQQEREELNK 480

ELVQASERLK NQSKELKDAH CQRKLAMQEF MEINERLTEL HTQKQKLARH VRDKEEEVDL 540

VMQKVESLRQ ELRRTERAKK ELEVHTDALV AEASKDRKLR EQSEHYSKQL ENELEGLKQK 600

QISYSPGVCS IEHQQEINKL KTDLEKKSIF YEEELSKREG IHANEIKNLK KELHDSEGQQ 660

LALNKEIMVL KDKLEKTRRE SQSEREEFEN EFKQQYEREK VLLTEENKKL TSELDKLTTL 720

YENLSMRNQQ LEEEVKDIAD KKESVAHWEA QITEIIQWVS DEKDARGYLQ ALASKMTEEL 780

EALRSASLGT RATDMPWKMR RFAKLDMSAR LELQSALDAE IRAKQAIQEE LNKVKAANII 840

TECKLKDSEK KNLELLSEIE QLIKDTEELR SEKASKGRRI ADSAPPPVHT PTLRKKGCPG 900

STGFPPKRKT HQFFVKSFTI PTKCHQCTSL MVGLIRQGCS CEEVCGFSCH ITCVNKAPTA 960

CPVPPEQTKG PLGIDPQKGI GTAYEGHVRI PKPAGVKKGW QRALAVVCDF KLFLYDIAEG 1020

KASQPSVVIS QVIDMRDEEF SVSSVLASDV IHASRKDIPC IFRVTASQLS ASNNKCSILM 1080

LADSENEKSK WVGVLSELHK ILKKNKFRDR SVYVPKEAYD STLPLIKTTQ AAAIIDHERI 1140

ALGNEEGLFV VHVTKDEIIR VGDNKKIHQI ELIPNDQLVA VISGRNRHVR LFPMSALDGR 1200

ETDFYKLAET KGCQTITSGK MRHGALTCLC VAMKRQVLCY ELFQSKTRHR KFKEIQVPYN 1260

VQWMAIFSEQ LCVGFQSGFL KYPLNGEGNP YSMLHSNDHT LSFIAHQPMD AICAVEISSK 1320

EYLLCFNSIG IYTDCQGRRS RQQELMWPAN PSSCCYNAPY LSVYSENAVD IFDVNSMEWI 1380

QTLPLKKVRP LNSEGSLNLL GLETVRLIYF KNKMAETEGD ELVVPETSDN SRKQMVRNIN 1440

NKRRYSFRVP EEERMQQRRE MLRDPEMRNK LISNPTNFNH IAHMGPGDGI QILKDLPMNP 1500

RPQESRTVFS GSVSIPSITK SRPEPGRSMS ASSGLSARSS AQNGSALKRE FSGGSYNSKR 1560

QPMPSPSEGS LSSGGMDQGS DAPARDYDGE DSDSPRHSTA SNSSNLSSPP SPVSPRKTKS 1620

LSLESTDRGS WDP 1633

Nucleotide Sequence
(FASTA)

ATGCGATTAC ATAGAGAAGA CTTTGAAATA TTAAAGGTGA TTGGTCGAGG AGCTTTTGGG 60

GAGGTCGCTG TAGTAAAACT AAAAAATGCA GATAAGGTAT TTGCCATGAA AATTTTGAAT 120

AAATGGGAAA TGCTGAAAAG AGCTGAGACA GCATGTTTTC GTGAAGAACG GGATGTGTTA 180

GTGAATGGAG ACAATAAATG GATTACAACT TTGCACTATG CTTTCCAGGA TGACAATAAC 240

TTATACCTGG TTATGGATTA TTATGTTGGT GGGGATTTGC TTACTCTGCT CAGCAAATTT 300

GAAGATAGAT TGCCTGAAGA TATGGCTCGA TTTTACTTGG CTGAGATGGT GATAGCAATT 360

GACTCAGTTC ATCAACTACA TTATGTGCAC AGAGACATCA AACCTGACAA TATATTGATG 420

GATATGAATG GACATATTCG GTTAGCAGAT TTTGGTTCTT GTCTGAAGCT GATGGAAGAT 480

GGAACGGTCC AGTCCTCGGT GGCAGTTGGG ACCCCAGATT ACATTTCTCC TGAAATCCTT 540

CAAGCAATGG AAGATGGAAA AGGCAGATAT GGACCTGAGT GTGACTGGTG GTCTTTGGGG 600

GTCTGTATGT ATGAAATGCT GTATGGAGAA ACACCATTCT ATGCAGAATC TCTGGTGGAG 660

ACATATGGGA AAATTATGAA TCACAAAGAG AGATTTCAGT TTCCACCCCA AGTGACTGAT 720

GTATCTGAAA ATGCTAAGGA TCTTATTCGA AGACTTATTT GTAGCAGAGA GCATCGACTT 780

GGTCAAAATG GAATAGAAGA CTTTAAGAAA CATCCATTTT TTAGTGGAAT TGATTGGGAT 840

AATATTAGAA ACTGTGAAGC ACCTTATATT CCAGAAGTTA GTAGCCCAAC AGATACATCG 900

AATTTTGATG TAGATGATGA CTGTTTAAAA AATTCTGAAA CAATGCCTCC ACCAACACAT 960

ACTGCATTTT CTGGTCATCA TCTGCCATTT GTTGGTTTTA CTTATACTAG TAGTTGTGTT 1020

CTTTCTGATC GGAGCTGTTT AAGAGTCACA GCTGGTCCCA CCTCACTGGA TCTCGATGTT 1080

AATGTCCAGA GGACTCTTGA TAACAACTTA GCAACAGAAG CTTATGAGAG AAGAATTAAG 1140

CGTCTTGAAC AGGAAAAACT TGAACTTAGT AGAAAGCTTC AAGAGTCAAC ACAGACCGTC 1200

CAAGCTCTAC AGTATTCAAC TGTTGATGGT CCACTAACAG CAAGCAAGGA TTTAGAAATA 1260

AAAACCTTAA AAGAAGAAAT TGAAAAACTA AGGAAACAAG TAGAAGAGTC GAGTCATTTG 1320

GAGCAGCAAC TTGAAGAAGC TAATTCTGTG AGGCGAGAAT TAGATGATGC TTTTAGACAA 1380

ATCAAGGCTT ATGAAAAACA AATCAAAACT TTACAACAAG AAAGGGAAGA GCTAAATAAG 1440

GAACTAGTCC AGGCTAGTGA GCGATTAAAA AACCAATCCA AAGAGCTGAA AGACGCACAC 1500

TGTCAGAGGA AACTGGCCAT GCAGGAATTT ATGGAGATCA ATGAGCGGCT AACAGAATTG 1560

CACACCCAAA AACAGAAACT TGCTCGCCAT GTCCGAGATA AGGAAGAAGA GGTGGACCTG 1620

GTGATGCAAA AAGTTGAAAG CTTAAGGCAA GAGCTGCGCA GAACAGAAAG AGCCAAAAAA 1680

GAGCTGGAAG TTCATACTGA CGCTCTAGTT GCTGAAGCAT CTAAAGACAG GAAACTGCGG 1740

GAGCAGAGCG AGCACTACTC TAAACAACTG GAGAATGAAT TGGAAGGACT GAAGCAAAAG 1800

CAAATTAGTT ATTCACCTGG AGTTTGCAGC ATAGAACATC AGCAAGAGAT AAACAAACTA 1860

AAGACTGATT TAGAAAAGAA AAGTATCTTT TATGAAGAAG AATTATCTAA AAGAGAAGGA 1920

ATACATGCAA ATGAGATTAA AAATCTGAAG AAAGAACTGC ATGATTCAGA AGGCCAGCAA 1980

CTTGCTCTCA ACAAAGAAAT TATGGTTTTA AAAGACAAAC TGGAAAAAAC CAGGAGAGAA 2040

AGTCAAAGTG AAAGAGAAGA ATTTGAAAAT GAGTTTAAAC AACAGTATGA ACGAGAAAAA 2100

GTGTTACTAA CTGAAGAAAA TAAAAAGTTG ACAAGTGAAC TTGATAAGCT TACTACTTTG 2160

TATGAGAATT TAAGTATGCG CAACCAACAG TTAGAAGAAG AGGTGAAAGA TATAGCAGAC 2220

AAGAAAGAAT CAGTTGCACA TTGGGAAGCC CAAATCACGG AAATAATTCA GTGGGTCAGT 2280

GATGAAAAGG ATGCACGAGG CTATCTTCAG GCCTTAGCTT CTAAAATGAC TGAAGAATTG 2340

GAAGCATTAA GAAGTGCCAG CTTGGGTACA CGAGCAACTG ATATGCCCTG GAAAATGCGT 2400

CGTTTTGCAA AACTGGATAT GTCAGCTAGA CTGGAATTGC AGTCAGCTCT GGATGCAGAA 2460

ATAAGAGCCA AACAGGCCAT CCAAGAAGAG CTGAATAAAG TTAAAGCAGC TAACATCATA 2520

ACAGAATGTA AACTAAAAGA TTCAGAGAAG AAGAACTTGG AACTCCTATC AGAAATCGAA 2580

CAACTGATAA AGGACACTGA AGAGCTTAGA TCTGAAAAGG CTAGCAAAGG CAGACGTATT 2640

GCAGACAGTG CTCCACCTCC AGTTCACACA CCAACCTTAA GGAAAAAGGG ATGCCCTGGT 2700

TCAACTGGTT TTCCACCTAA GCGCAAGACT CACCAGTTTT TTGTAAAATC ATTCACTATT 2760

CCTACTAAAT GTCATCAGTG TACCTCTTTG ATGGTGGGTT TGATAAGACA GGGTTGCTCA 2820

TGTGAAGAAG TGTGTGGATT CTCATGTCAT ATAACTTGTG TAAATAAGGC TCCAACCGCT 2880

TGTCCAGTTC CCCCTGAGCA GACAAAAGGT CCCCTGGGTA TTGATCCACA GAAAGGAATA 2940

GGAACAGCAT ATGAAGGTCA TGTCAGGATC CCTAAGCCAG CTGGAGTGAA GAAAGGATGG 3000

CAGAGAGCAC TTGCTGTGGT TTGTGACTTC AAACTTTTTC TATACGATAT TGCTGAAGGA 3060

AAAGCATCTC AGCCCAGTGT TGTCATTAGT CAAGTAATTG ACATGAGAGA TGAAGAATTT 3120

TCTGTGAGTT CAGTCTTGGC CTCTGATGTT ATTCATGCAA GTCGAAAAGA TATACCCTGT 3180

ATATTTAGAG TCACAGCTTC CCAGCTGTCA GCATCCAATA ACAAGTGTTC AATCCTGATG 3240

CTAGCAGATA GTGAGAATGA GAAGAGTAAG TGGGTGGGAG TGCTGAGTGA ATTGCACAAG 3300

ATACTGAAGA AAAACAAATT CAGAGACCGC TCAGTCTATG TTCCCAAAGA GGCTTATGAT 3360

AGCACTCTAC CCCTCATTAA AACAACCCAG GCAGCTGCAA TCATAGATCA CGAAAGAATA 3420

GCTTTAGGAA ATGAAGAAGG GTTATTTGTT GTACATGTCA CCAAAGATGA AATTATCAGA 3480

GTTGGTGACA ATAAGAAGAT TCATCAGATT GAACTTATTC CAAATGATCA GCTTGTTGCT 3540

GTGATCTCAG GACGAAATCG TCACGTACGA CTTTTTCCTA TGTCAGCTTT GGACGGGCGA 3600

GAGACAGATT TTTACAAGTT GGCAGAAACT AAAGGGTGTC AAACTATAAC TTCTGGAAAG 3660

ATGCGCCATG GAGCTCTTAC ATGCCTGTGT GTGGCTATGA AAAGGCAGGT TCTCTGTTAT 3720

GAACTATTTC AGAGCAAGAC CCGTCACAGA AAATTTAAAG AAATTCAAGT CCCATATAAT 3780

GTCCAGTGGA TGGCAATCTT CAGCGAACAG CTCTGTGTGG GATTCCAGTC AGGATTTCTA 3840

AAATACCCCT TGAATGGAGA AGGAAATCCA TACAGTATGC TCCATTCAAA TGACCACACA 3900

CTATCATTTA TTGCACATCA ACCAATGGAT GCTATCTGCG CAGTTGAGAT CTCCAGTAAA 3960

GAATACCTGC TGTGTTTTAA CAGCATTGGG ATATACACTG ACTGCCAGGG CCGAAGATCT 4020

AGACAACAGG AATTGATGTG GCCAGCAAAT CCTTCCTCTT GTTGTTACAA TGCACCATAT 4080

CTCTCAGTGT ATAGTGAAAA TGCAGTTGAT ATCTTCGATG TGAATTCCAT GGAATGGATT 4140

CAGACTCTTC CTCTCAAAAA GGTTCGACCT TTAAACAGTG AAGGATCTTT AAATCTTTTA 4200

GGATTGGAGA CAGTTAGATT GATATATTTC AAAAATAAGA TGGCAGAAAC AGAAGGGGAT 4260

GAACTGGTGG TTCCTGAAAC ATCAGATAAT AGTCGGAAAC AAATGGTTAG AAATATCAAC 4320

AACAAACGAC GTTACTCCTT CAGAGTCCCA GAAGAAGAAA GGATGCAACA GAGGAGGGAG 4380

ATGCTGCGGG ATCCAGAGAT GAGAAATAAA TTAATTTCTA ACCCAACTAA TTTTAACCAC 4440

ATAGCCCACA TGGGACCTGG AGATGGAATA CAGATTCTAA AAGACCTACC TATGAACCCT 4500

CGTCCTCAGG AAAGCCGAAC AGTATTCAGT GGCTCAGTCA GTATTCCATC AATCACCAAA 4560

TCCCGCCCTG AGCCAGGTCG GTCCATGAGT GCTAGCAGCG GCCTGTCAGC AAGGTCATCT 4620

GCACAGAATG GCAGCGCATT GAAGAGGGAA TTCTCTGGAG GAAGCTACAA TTCAAAGCGG 4680

CAGCCCATGC CTTCCCCGTC AGAGGGCTCT TTGTCTTCTG GAGGTATGGA CCAAGGAAGC 4740

GATGCCCCAG CAAGGGATTA TGACGGAGAG GACTCTGATT CTCCAAGGCA TTCCACAGCT 4800

TCCAACAGTT CCAACCTGAG CAGCCCCCCA AGCCCAGTTT CACCCCGAAA GACCAAGAGC 4860

CTCTCTCTGG AGAGCACCGA CCGTGGGAGC TGGGACCCGT GA 4902

Domain Profile

S: 1     feilkviGrGafgevavvrekatekvyamkilkklellkraesaffreerdvlvkadsew  60

         feilkviGrGafgevavv+ k+++kv+amkil+k+e+lkrae+a+freerdvlv++d++w

Q: 8     FEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVNGDNKW  67

         89**********************************************************

S: 61    ivqlqyafqdekylylvmeylvGGdlltllskyedklpeelarfylaelvlaldsvhelg  120

         i++l+yafqd+++lylvm+y+vGGdlltllsk+ed+lpe++arfylae+v+a+dsvh+l+

Q: 68    ITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMARFYLAEMVIAIDSVHQLH  127

         ************************************************************

S: 121   yvhrdikpdnilldksGhikladfGsclklnedgtvkssvavGtpdyispevlkaleegk  180

         yvhrdikpdnil+d++Ghi+ladfGsclkl+edgtv+ssvavGtpdyispe+l+a+e+gk

Q: 128   YVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEILQAMEDGK  187

         ************************************************************

S: 181   geygkecdwwslGvilyellvgetpfyaeslvetyskilnhkeslkfpede.kvseeakd  239

         g+yg+ecdwwslGv++ye+l+getpfyaeslvety+ki+nhke+++fp ++ +vse+akd

Q: 188   GRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERFQFPPQVtDVSENAKD  247

         ************************************************9988********

S: 240   likklltsreerlgregiedlkkhpff  266

         li++l++sre+rlg++gied+kkhpff

Q: 248   LIRRLICSREHRLGQNGIEDFKKHPFF  274

         **************************9

Domain Sequence
(FASTA)

FEILKVIGRG AFGEVAVVKL KNADKVFAMK ILNKWEMLKR AETACFREER DVLVNGDNKW 60

ITTLHYAFQD DNNLYLVMDY YVGGDLLTLL SKFEDRLPED MARFYLAEMV IAIDSVHQLH 120

YVHRDIKPDN ILMDMNGHIR LADFGSCLKL MEDGTVQSSV AVGTPDYISP EILQAMEDGK 180

GRYGPECDWW SLGVCMYEML YGETPFYAES LVETYGKIMN HKERFQFPPQ VTDVSENAKD 240

LIRRLICSRE HRLGQNGIED FKKHPFF 267

Keyword

ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0005543	; F:phospholipid binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0005083	; F:small GTPase regulator activity
GO:0031532	; P:actin cytoskeleton reorganization
GO:0035556	; P:intracellular signal transduction

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR001180	; Citron.
IPR011009	; Kinase-like_dom.
IPR014930	; Myotonic_dystrophy_kinase_coil.
IPR000095	; PAK_box_Rho-bd.
IPR011993	; PH_like_dom.
IPR017892	; Pkinase_C.
IPR001849	; Pleckstrin_homology.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR026611	; Ser/Thr_kinase_MRCK.

Pfam

PF00130	; C1_1; 1.
PF00780	; CNH; 1.
PF08826	; DMPK_coil; 1.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00109	; C1; 1.
SM00036	; CNH; 1.
SM00285	; PBD; 1.
SM00233	; PH; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS50219	; CNH; 1.
PS50108	; CRIB; 1.
PS50003	; PH_DOMAIN; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50081	; ZF_DAG_PE_2; 1.

Prints

Created Date

20-Feb-2013