EKS-ICT-00397

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ICT-00397

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/DAPK	468.5	5.2E-141	19	276	258

Status

Unreviewed

Ensembl Protein

ENSSTOP00000013876

UniProt Accession

I3MPU2;

Protein Name

Protein Synonyms/Alias

Gene Name

DAPK1

Gene Synonyms/Alias

DAPK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSTOG00000015490	ENSSTOP00000013876	ENSSTOT00000015501

Organism

Ictidomys tridecemlineatus

Functional Description

Protein Length

1431

Protein Sequence
(FASTA)

AISVLKSHFL VNHQNILSSL FSGQFAVVKK CREKSTGLQY AAKFIKKRRT KSSRRGVSRE 60

DIEREVSILK EIQHPNVITL HEVYENKTDV ILILELVAGG ELFDFLAEKE SLTEEEATEF 120

LKQILNGVCY LHSLQIAHFD LKPENIMLLD RNVPKPRIKI IDFGLAHKID FGNEFKNIFG 180

TPEFVAPEIV NYEPLGLEAD MWSIGVITYI LLSGASPFLG DTKQETLANV SAVNYEFEDE 240

YFSNTSALAK DFIRRLLVKD PKKRMTIQDS LQHPWIKPKD TQQALSRKAS AVNMEKFKKF 300

AARKKWKQSV RLISLCQRLS RSFLSRSNMS VARSDDTLDE EDSFVMKAII HAINDDNVPG 360

LQHLLGSLSN YDVNQPNKHG TPPLLIAAGC GNIQILQLLI KRGSRIDVQD KGGSNAIYWA 420

SRHGHVDTLK FLNENKCPLD VKDKSGETAL HVASRYGHAD VVHLLCCFGS NPNFQDKEEE 480

TPLHCAAWHG YYPVARALCE AGCNVNIKNR EGETPLLTAS ARGYHDIVEC LAEHGADLNA 540

SDKDGHIALH LAVRRCQMEV IKTLISQGCF VDFQDRHGNT PLHVACKDGN VPIVVALCEA 600

NCNLDLSNKY GRTPLHLAAN NGILDVVRYL CLMGANVEAL TSDGKTAEDL AKSEQHEHVA 660

GLLARLRKDA HRGLFIQQLR PTQNLQPRIK LKLFGHSGSG KTTLVESLKC GLLRSFFRRR 720

RPRLSSTNST RFPPSPLTAK PTVSVSINNL YPGCENVSVR SRSMMFEPGL TKGMLEVFVA 780

PSHHPHCSTD DQSTKAIDIQ NAYLNGVGDF SVWEFSGNPV YFCCYDYFAA NDPTSIHVIV 840

FSLEEPYEIQ LNQVIFWLSF LKSLVPVEEP IAFGGKLKNP LRVVLVATHA DIMNVPRPAG 900

GEFGYDKDTS LLKEIKNRFG NDLQISNKLF VLDAGASGSK DIKVLRNHLQ EIRSQIVLGC 960

PPMTHLCEKI ISTLPSWRKL NGPNQLMSLQ QFMYDVQDQL NPLASEEDLR RIAQQLHSTG 1020

EINIIQSETV QDVLLLDPRW LCTNVLGKLL SVETPRALHH YRGRYTMEDI QRLVPDSDVE 1080

ELLQILDAMD ICARDLSSGT MVDVPALIKT DNLQRSWTDE EDEVMVYGGV RIVPVEHLTP 1140

FPCGIFHKVQ VNLCRWIHQQ STEGDADIRL WVSGCKIANR GAELLVLLVN HGQGIEVQVR 1200

GLETEKIKCC LLLDSVCSTI ENVMATTLPG LLTVKHYLSP QQLREHHEPV MIYQPRDFFR 1260

AQTLKESSLT NTMGGYKESF SSITCFGCHD VYSQASLGMD IHASDLNLLT RRKLSRLLDP 1320

PDPMGKDWCL LAMNLGLPDL VAKYNTNTGA PRDFLPSPVH ALLREWTSYP ESTVGVLMSK 1380

LRELGRRDAA DFLLKASSVF KINLDGNGQE AYASSCNSGT SYNSISSVVS R 1431

Nucleotide Sequence
(FASTA)

GCCATATCTG TGCTGAAATC TCATTTTTTA GTAAACCATC AAAACATTCT ATCTTCTCTT 60

TTCAGTGGAC AGTTTGCAGT GGTGAAGAAA TGCCGTGAGA AAAGCACTGG TCTGCAGTAT 120

GCTGCCAAGT TCATTAAGAA AAGGAGGACC AAGTCTAGCC GGCGTGGCGT GAGCCGCGAG 180

GACATTGAGC GAGAGGTCAG CATCCTGAAG GAGATCCAGC ACCCCAACGT TATCACCCTG 240

CATGAGGTCT ATGAGAACAA GACAGATGTC ATTCTGATCC TGGAACTTGT TGCAGGTGGT 300

GAACTCTTTG ACTTCTTAGC TGAAAAAGAA TCTTTGACTG AAGAGGAAGC AACTGAATTT 360

CTCAAACAAA TTCTCAATGG TGTTTGCTAC CTGCACTCCC TCCAGATTGC CCACTTTGAT 420

CTTAAGCCTG AGAACATAAT GCTTTTGGAT AGAAACGTCC CTAAACCTCG GATCAAGATT 480

ATCGACTTTG GCTTGGCCCA TAAAATTGAC TTTGGAAATG AATTCAAGAA CATATTTGGG 540

ACACCAGAGT TTGTTGCTCC TGAGATAGTC AACTATGAAC CTCTTGGTCT TGAGGCGGAT 600

ATGTGGAGTA TTGGGGTAAT AACTTATATT CTCCTAAGTG GGGCCTCCCC ATTTCTTGGA 660

GACACTAAGC AAGAAACATT AGCAAATGTA TCTGCTGTCA ACTATGAATT TGAGGATGAG 720

TACTTCAGTA ACACCAGTGC CCTAGCCAAA GATTTCATCA GAAGACTTCT GGTCAAGGAT 780

CCAAAGAAGA GAATGACAAT TCAAGATAGT TTGCAGCATC CTTGGATCAA GCCTAAAGAT 840

ACGCAACAGG CACTTAGTAG AAAAGCATCT GCAGTAAATA TGGAGAAGTT TAAGAAGTTT 900

GCAGCCCGAA AAAAATGGAA ACAATCTGTT CGCTTGATAT CACTGTGCCA AAGATTATCC 960

AGATCATTCT TGTCCAGAAG TAACATGAGT GTTGCCAGAA GCGATGATAC TCTGGATGAG 1020

GAAGACTCCT TTGTAATGAA AGCCATCATC CATGCCATCA ATGACGACAA TGTCCCAGGC 1080

CTGCAGCACC TGCTGGGATC ATTGTCCAAC TATGATGTTA ACCAACCCAA CAAGCATGGG 1140

ACACCTCCAT TGCTCATTGC TGCTGGCTGT GGGAATATTC AAATACTACA GTTACTTATC 1200

AAACGAGGCT CAAGAATTGA TGTCCAAGAT AAGGGTGGAT CAAATGCCAT CTACTGGGCC 1260

TCTCGTCATG GTCACGTGGA CACTTTGAAA TTTCTCAATG AGAACAAATG CCCTTTGGAT 1320

GTTAAAGACA AGTCTGGAGA GACAGCCCTT CATGTGGCAT CCCGCTATGG CCATGCTGAT 1380

GTGGTTCACT TATTGTGCTG CTTCGGCTCT AATCCCAATT TCCAGGACAA GGAAGAAGAA 1440

ACCCCTCTGC ACTGTGCTGC CTGGCATGGG TATTACCCTG TTGCCAGAGC CCTTTGTGAA 1500

GCCGGCTGTA ATGTGAACAT TAAGAACAGA GAAGGAGAGA CGCCCCTTCT GACAGCCTCT 1560

GCCAGGGGCT ACCATGACAT TGTGGAGTGT CTGGCTGAAC ATGGAGCTGA CCTTAATGCC 1620

TCTGACAAGG ATGGACACAT TGCCCTTCAT CTTGCTGTAC GACGCTGCCA GATGGAGGTC 1680

ATTAAGACTC TCATCAGCCA GGGGTGTTTT GTGGATTTTC AAGACAGACA TGGCAACACA 1740

CCGCTCCATG TGGCCTGCAA GGATGGCAAT GTGCCTATTG TGGTGGCCCT CTGTGAAGCA 1800

AATTGTAATT TGGACCTCTC AAACAAGTAT GGGCGAACGC CTCTACACCT TGCAGCCAAC 1860

AACGGGATCC TGGATGTAGT CAGGTACCTC TGCCTGATGG GAGCCAATGT GGAGGCGTTG 1920

ACCTCGGATG GAAAGACGGC AGAGGATCTT GCTAAATCAG AACAGCATGA GCACGTGGCT 1980

GGTCTACTTG CCAGACTCCG AAAGGATGCT CACAGAGGGC TCTTCATCCA GCAGCTCCGA 2040

CCCACACAGA ATCTTCAGCC AAGAATCAAG CTCAAGCTAT TTGGCCACTC AGGTTCTGGG 2100

AAAACCACCC TGGTAGAATC TCTCAAGTGC GGTCTGCTGA GGAGCTTTTT CAGAAGGCGC 2160

CGGCCCAGAC TCTCCTCCAC CAACTCCACC AGATTCCCAC CATCTCCCCT AACTGCTAAG 2220

CCGACAGTCT CTGTGAGCAT CAACAACTTG TACCCTGGCT GTGAGAACGT GAGTGTGAGG 2280

AGCCGCAGCA TGATGTTTGA GCCGGGCCTC ACTAAAGGAA TGTTGGAGGT GTTCGTGGCC 2340

CCATCCCACC ACCCGCACTG CTCGACCGAT GACCAATCCA CCAAGGCCAT CGACATCCAG 2400

AATGCCTATT TGAATGGAGT CGGGGATTTC AGCGTGTGGG AATTCTCTGG AAATCCCGTA 2460

TATTTCTGCT GCTATGACTA TTTTGCTGCA AATGATCCCA CGTCCATCCA TGTCATCGTT 2520

TTTAGTCTAG AAGAACCCTA TGAGATCCAG CTGAACCAAG TGATTTTCTG GCTCAGTTTC 2580

CTGAAGTCTC TGGTCCCAGT TGAAGAACCC ATAGCCTTTG GCGGCAAGCT GAAGAACCCA 2640

CTCCGAGTTG TCCTGGTGGC CACTCATGCT GACATCATGA ATGTCCCTCG TCCAGCTGGA 2700

GGCGAGTTTG GATATGACAA AGACACTTCC TTGCTGAAAG AGATCAAGAA CAGGTTTGGG 2760

AATGATCTTC AAATTTCAAA TAAGCTGTTT GTGCTGGATG CTGGAGCTTC TGGGTCTAAG 2820

GACATAAAAG TTCTTCGGAA TCACCTGCAA GAAATTCGGA GTCAGATTGT TTTGGGCTGC 2880

CCTCCCATGA CACACCTCTG TGAGAAAATC ATCTCCACGC TGCCTTCTTG GAGGAAGCTC 2940

AATGGGCCCA ATCAACTGAT GTCACTGCAG CAGTTCATGT ATGATGTGCA GGACCAGTTG 3000

AACCCCTTGG CCAGTGAGGA GGACCTCAGG CGCATCGCAC AACAGCTCCA CAGCACCGGT 3060

GAGATCAACA TAATACAGAG TGAAACTGTG CAGGATGTGC TGCTCCTAGA TCCCCGCTGG 3120

CTCTGCACCA ATGTCCTGGG GAAACTGCTT TCGGTGGAAA CTCCCAGGGC CCTGCACCAT 3180

TACAGGGGCC GCTACACCAT GGAGGACATC CAGCGCTTGG TACCTGATAG TGATGTGGAA 3240

GAACTGCTGC AGATCCTGGA TGCCATGGAC ATCTGTGCCC GTGACCTGAG CAGTGGGACC 3300

ATGGTGGATG TCCCTGCATT GATCAAGACA GATAACCTGC AGCGCTCCTG GACAGATGAA 3360

GAGGACGAGG TGATGGTGTA CGGTGGTGTT CGCATTGTTC CTGTGGAGCA TCTTACTCCC 3420

TTCCCGTGTG GCATCTTTCA TAAAGTTCAG GTGAACCTGT GTCGGTGGAT TCACCAGCAG 3480

AGCACAGAGG GTGATGCAGA CATTCGCCTG TGGGTAAGCG GCTGCAAGAT TGCCAACCGT 3540

GGGGCAGAGC TACTGGTGCT GCTGGTCAAC CATGGCCAGG GCATCGAAGT ACAGGTACGC 3600

GGGCTAGAGA CTGAGAAGAT CAAGTGCTGC CTGCTGCTGG ACTCGGTGTG CAGTACTATT 3660

GAGAATGTCA TGGCCACCAC ATTGCCGGGG CTATTGACAG TGAAGCACTA CCTGAGCCCC 3720

CAGCAGCTGC GAGAGCACCA TGAGCCCGTT ATGATCTACC AGCCACGAGA TTTCTTCCGA 3780

GCACAGACCC TGAAGGAGAG TTCCCTGACG AATACCATGG GTGGGTACAA GGAGAGCTTC 3840

AGCAGCATCA CCTGCTTTGG GTGTCATGAT GTCTACTCAC AGGCTAGTCT TGGCATGGAC 3900

ATCCACGCAT CAGATTTGAA CCTCCTGACC CGAAGGAAAC TGAGTCGCCT ACTGGATCCA 3960

CCTGACCCTA TGGGGAAAGA CTGGTGCCTT CTGGCCATGA ACTTGGGCCT CCCGGACCTT 4020

GTGGCTAAGT ACAACACCAA TACTGGGGCC CCTAGGGATT TCCTCCCTAG CCCAGTTCAT 4080

GCCCTGCTAC GGGAGTGGAC CTCCTACCCT GAGAGCACAG TGGGCGTCCT CATGTCCAAA 4140

CTGAGGGAGC TGGGTCGCAG GGATGCCGCA GACTTTTTAC TGAAGGCATC CTCTGTGTTC 4200

AAAATTAACC TGGATGGCAA TGGCCAGGAA GCCTATGCAT CAAGCTGCAA TAGTGGCACG 4260

TCTTACAATT CCATTAGCTC TGTGGTGTCC CGGTGA 4296

Domain Profile

S: 6     elgsGkfavvrkcrekstGkeyaakflkkrrlkssrrgvsreeierevavlkeirsepnv  65

          l sG+favv+kcrekstG +yaakf+kkrr+kssrrgvsre+ierev++lkei+ +pnv

Q: 19    SLFSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVSILKEIQ-HPNV  77

         5779***************************************************.****

S: 66    inlhevyenksdvililelvaGGelfdllaekeslseeeatellkqilegvkylhskkiv  125

         i+lhevyenk+dvililelvaGGelfd+laekesl+eeeate+lkqil+gv ylhs +i+

Q: 78    ITLHEVYENKTDVILILELVAGGELFDFLAEKESLTEEEATEFLKQILNGVCYLHSLQIA  137

         ************************************************************

S: 126   hldlkPenillldkkvpkgdiklidfGlsrkieegaelkeilGtPefvaPeivnyeplsl  185

         h+dlkPeni+lld++vpk++ik+idfGl++ki+ g+e+k+i+GtPefvaPeivnyepl+l

Q: 138   HFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGTPEFVAPEIVNYEPLGL  197

         ************************************************************

S: 186   etdmwsiGvityillsgasPflGdtkqetllnisavnldfseelfssvselakdfirrll  245

         e+dmwsiGvityillsgasPflGdtkqetl+n+savn++f++e+fs++s lakdfirrll

Q: 198   EADMWSIGVITYILLSGASPFLGDTKQETLANVSAVNYEFEDEYFSNTSALAKDFIRRLL  257

         ************************************************************

S: 246   vkdpekrltieeclehswl  264

         vkdp+kr+ti+++l+h+w+

Q: 258   VKDPKKRMTIQDSLQHPWI  276

         ******************8

Domain Sequence
(FASTA)

SLFSGQFAVV KKCREKSTGL QYAAKFIKKR RTKSSRRGVS REDIEREVSI LKEIQHPNVI 60

TLHEVYENKT DVILILELVA GGELFDFLAE KESLTEEEAT EFLKQILNGV CYLHSLQIAH 120

FDLKPENIML LDRNVPKPRI KIIDFGLAHK IDFGNEFKNI FGTPEFVAPE IVNYEPLGLE 180

ADMWSIGVIT YILLSGASPF LGDTKQETLA NVSAVNYEFE DEYFSNTSAL AKDFIRRLLV 240

KDPKKRMTIQ DSLQHPWI 258

Keyword

ANK repeat; Complete proteome; Reference proteome; Repeat.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007165	; P:signal transduction

KEGG

InterPros

IPR002110	; Ankyrin_rpt.
IPR020683	; Ankyrin_rpt-contain_dom.
IPR000488	; Death.
IPR020676	; Death-assoc_prot_kinase.
IPR011029	; DEATH-like.
IPR011009	; Kinase-like_dom.
IPR020675	; Myosin_light_ch_kinase-rel.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00023	; Ank; 1.
PF12796	; Ank_2; 3.
PF00531	; Death; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00248	; ANK; 9.
SM00005	; DEATH; 1.
SM00220	; S_TKc; 1.

Prosites

PS50297	; ANK_REP_REGION; 1.
PS50088	; ANK_REPEAT; 7.
PS50017	; DEATH_DOMAIN; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR01415

; ANKYRIN.

Created Date

20-Feb-2013