EKS-ICT-00253

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ICT-00253

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/DYRK	448.6	1.2E-134	159	479	321

Status

Unreviewed

Ensembl Protein

ENSSTOP00000014458

UniProt Accession

I3MR02;

Protein Name

Protein Synonyms/Alias

Gene Name

DYRK1A

Gene Synonyms/Alias

DYRK1A;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSTOG00000016151	ENSSTOP00000014458	ENSSTOT00000016153

Organism

Ictidomys tridecemlineatus

Functional Description

Protein Length

763

Protein Sequence
(FASTA)

MHTGGETSAC KPSSVRLAPS FSFHAAGLQM AGQMPHSHQY SDRRQPNISD QQVSALSYSD 60

QIQQPLTNQV MPDIVMLQRR MPQTFRDPAT APLRKLSVDL IKTYKHINEV YYAKKKRRHQ 120

QGQGDDSSHK KERKVYNDGY DDDNYDYIVK NGEKWMDRYE IDSLIGKGSF GQVVKAYDRV 180

EQEWVAIKII KNKKAFLNQA QIEVRLLELM NKHDTEMKYY IVHLKRHFMF RNHLCLVFEM 240

LSYNLYDLLR NTNFRGVSLN LTRKFAQQMC TALLFLATPE LSIIHCDLKP ENILLCNPKR 300

SAIKIVDFGS SCQLGQRIYQ YIQSRFYRSP EVLLGMPYDL AIDMWSLGCI LVEMHTGEPL 360

FSGANEVDQM NKIVEVLGIP PAHILDQAPK ARKFFEKLPD GTWNLKKTKD GKREYKPPAT 420

RKLHNILGVE TGGPGGRRAG ESGHTVADYL KFKDLILRML DYDPKTRIQP YYALQHSFFK 480

KTADEGTNTS NSVSTSPAME QSQSSGTTSS TSSSSGGSSG TSNSGRARSD PTHQHRHSGG 540

HFTAAVQAMD CETHSPQVRQ QFPAPLGWSG TEAPTQVTVE THPVQETTFH VAPQQNALHH 600

HHGNSSHHHH HHHHHHHHHG QQALGNRTRP RVYNSPTNSS STQDSMEVGH SHHSMTSLSS 660

STTSSSTSSS STGNQGNQAY QNRPVAANTL DFGQNGAMDV NLTVYSNPRQ ETGIAGHPTY 720

QFSANTGPAH YMTEGHLTMR QGADREESPM TGVCVQQSPV ASS 763

Nucleotide Sequence
(FASTA)

ATGCATACAG GAGGAGAGAC TTCAGCATGC AAACCTTCAT CTGTTCGGCT TGCACCGTCA 60

TTTTCATTCC ATGCTGCTGG CCTTCAGATG GCTGGACAGA TGCCCCATTC ACATCAGTAC 120

AGTGACCGTC GCCAGCCAAA CATAAGTGAC CAACAGGTTT CTGCCTTATC ATATTCTGAC 180

CAGATTCAGC AACCTCTAAC TAACCAGGTG ATGCCTGATA TTGTCATGTT ACAGAGGCGG 240

ATGCCCCAAA CCTTCCGTGA TCCAGCAACT GCTCCCCTGA GAAAACTTTC TGTGGACTTG 300

ATCAAAACAT ATAAGCATAT TAATGAGGTT TACTATGCAA AAAAGAAGCG GAGACACCAA 360

CAGGGTCAGG GAGACGATTC CAGTCATAAG AAGGAGCGGA AGGTTTACAA TGATGGTTAT 420

GATGATGACA ACTATGATTA TATTGTAAAA AACGGAGAAA AGTGGATGGA TCGTTACGAA 480

ATTGACTCCT TGATAGGCAA AGGTTCCTTT GGACAGGTTG TAAAGGCGTA TGATCGGGTA 540

GAGCAAGAAT GGGTTGCCAT TAAAATAATA AAGAACAAGA AAGCTTTTCT AAATCAAGCC 600

CAGATAGAAG TGCGACTTCT TGAGCTCATG AACAAGCATG ACACAGAAAT GAAATACTAC 660

ATAGTGCATT TGAAACGCCA CTTTATGTTT CGGAACCATC TCTGTTTAGT TTTTGAAATG 720

CTGTCCTACA ACCTCTATGA CTTGTTAAGG AACACCAATT TCCGAGGGGT CTCTTTGAAC 780

CTCACAAGAA AATTTGCGCA ACAGATGTGC ACTGCACTGC TTTTCCTTGC GACTCCAGAA 840

CTTAGTATCA TTCACTGTGA CCTAAAACCT GAGAATATCC TTCTTTGTAA CCCCAAACGC 900

AGTGCAATCA AGATTGTTGA CTTTGGCAGT TCTTGTCAGT TGGGGCAGAG GATATACCAG 960

TATATTCAGA GTCGCTTTTA TCGGTCTCCA GAGGTGCTAC TGGGAATGCC TTATGATCTT 1020

GCTATCGACA TGTGGTCCCT TGGGTGTATT TTGGTTGAAA TGCACACTGG AGAACCTCTA 1080

TTCAGTGGTG CCAATGAGGT AGATCAGATG AATAAAATAG TGGAAGTTCT GGGTATTCCA 1140

CCTGCTCATA TTCTTGACCA AGCACCAAAA GCAAGAAAGT TCTTTGAGAA GTTGCCAGAT 1200

GGCACTTGGA ACTTAAAGAA GACCAAAGAT GGAAAACGGG AGTACAAACC ACCAGCAACC 1260

CGTAAACTTC ATAATATTCT TGGAGTAGAA ACAGGAGGAC CTGGTGGGCG ACGTGCTGGG 1320

GAGTCGGGTC ATACGGTAGC TGACTACTTG AAGTTCAAAG ACCTCATTTT AAGGATGCTT 1380

GATTATGACC CCAAAACTCG GATTCAACCT TATTATGCCC TGCAGCACAG TTTTTTCAAG 1440

AAAACAGCTG ATGAAGGTAC AAATACAAGT AATAGTGTAT CCACAAGCCC TGCGATGGAG 1500

CAGTCACAGT CTTCAGGCAC CACCTCCAGT ACATCGTCAA GCTCAGGTGG ATCATCGGGG 1560

ACAAGCAACA GCGGGAGAGC CAGGTCAGAC CCGACGCACC AGCATCGGCA CAGCGGTGGG 1620

CATTTCACGG CTGCCGTCCA GGCCATGGAC TGTGAGACAC ACAGTCCCCA GGTGCGTCAG 1680

CAATTTCCAG CTCCTCTTGG CTGGTCAGGC ACTGAAGCTC CTACACAAGT CACTGTTGAA 1740

ACCCATCCTG TTCAAGAAAC AACCTTTCAT GTAGCCCCTC AGCAGAATGC ATTGCATCAT 1800

CACCATGGAA ACAGTTCCCA TCACCACCAC CACCACCACC ACCACCACCA CCACCATGGA 1860

CAGCAAGCCT TGGGTAACCG GACCAGGCCA AGGGTCTACA ATTCTCCAAC AAATAGCTCC 1920

TCTACCCAGG ATTCTATGGA GGTTGGCCAC AGTCACCACT CCATGACATC CCTGTCTTCC 1980

TCAACAACTT CTTCCTCGAC ATCTTCCTCC TCTACTGGTA ATCAAGGCAA TCAGGCCTAC 2040

CAGAACCGCC CAGTGGCTGC TAACACCTTG GACTTTGGAC AGAATGGAGC TATGGACGTA 2100

AATTTGACCG TCTACTCCAA TCCCCGCCAA GAGACTGGCA TAGCTGGACA TCCAACATAC 2160

CAATTTTCTG CTAATACAGG TCCTGCACAT TACATGACTG AAGGACATCT GACGATGAGG 2220

CAAGGGGCTG ACAGAGAAGA GTCCCCCATG ACAGGAGTGT GTGTGCAACA GAGTCCTGTA 2280

GCTAGCTCGT GA 2292

Domain Profile

S: 1     yevlevigkGsfgqVvkaldkktkeivaikiiknkkrfarqaqeEveiLeklnkkdkeek  60

         ye++++igkGsfgqVvka+d+ ++e+vaikiiknkk+f++qaq+Ev++Le +nk+d+e+k

Q: 159   YEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMK  218

         9***********************************************************

S: 61    ynvvrllelfvfrnhlclvfellsqnLyellkknkfsglslklvrklaqqilkaLklLk.  119

         y++v+l+++f+frnhlclvfe+ls+nLy+ll++++f+g+sl+l+rk+aqq+++aL +L+

Q: 219   YYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLAt  278

         **********************************************************99

S: 120   .elkiiHaDlKPeNillvekkrsevkviDFGsssavsqkeiytyiqsrfYraPEiilglk  178

          el+iiH+DlKPeNill+++krs++k++DFGss++  q+ iy+yiqsrfYr+PE++lg++

Q: 279   pELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQR-IYQYIQSRFYRSPEVLLGMP  337

         99*************************************.********************

S: 179   ydeaiDmWSlGcvlaElftGkpLfpGenevdqlalivevlglppekllekakkakkfftk  238

         yd aiDmWSlGc+l+E++tG+pLf+G+nevdq+++ivevlg+pp+++l++a ka+kff+k

Q: 338   YDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEK  397

         ************************************************************

S: 239   keapkyilktk.........ksdrkkklvlnvkkaakkrkaplskelgealkekedkl.f  288

           + ++ lk++          ++rk +++l+v++ +     p+ +++ge+ ++++d+l f

Q: 398   LPDGTWNLKKTkdgkreykpPATRKLHNILGVETGG-----PGGRRAGESGHTVADYLkF  452

         ********9997666666655566666666666655.....999****************

S: 289   kdllkrmleldpakRitpkealkhpfv  315

         kdl+ rml++dp++Ri+p++al+h+f+

Q: 453   KDLILRMLDYDPKTRIQPYYALQHSFF  479

         **************************7

Domain Sequence
(FASTA)

YEIDSLIGKG SFGQVVKAYD RVEQEWVAIK IIKNKKAFLN QAQIEVRLLE LMNKHDTEMK 60

YYIVHLKRHF MFRNHLCLVF EMLSYNLYDL LRNTNFRGVS LNLTRKFAQQ MCTALLFLAT 120

PELSIIHCDL KPENILLCNP KRSAIKIVDF GSSCQLGQRI YQYIQSRFYR SPEVLLGMPY 180

DLAIDMWSLG CILVEMHTGE PLFSGANEVD QMNKIVEVLG IPPAHILDQA PKARKFFEKL 240

PDGTWNLKKT KDGKREYKPP ATRKLHNILG VETGGPGGRR AGESGHTVAD YLKFKDLILR 300

MLDYDPKTRI QPYYALQHSF F 321

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013