EKS-ICT-00268

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ICT-00268

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	394.8	2.1E-118	244	537	294

Status

Unreviewed

Ensembl Protein

ENSSTOP00000023691

UniProt Accession

I3NH44;

Protein Name

Protein Synonyms/Alias

Gene Name

TGFBR2

Gene Synonyms/Alias

TGFBR2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSTOG00000019376	ENSSTOP00000023691	ENSSTOT00000028455

Organism

Ictidomys tridecemlineatus

Functional Description

Protein Length

567

Protein Sequence
(FASTA)

MGRGLLRGLW PLHIVLWTRI ASTIPPHVQK SVNNDMMVTE NNGAVKLPQL CKFCDVRSST 60

CDNQKSCMSN CSITSICEKP HEVCVAVWRK NDENITLETV CHDPKLTYHG FILEDAASPK 120

CIMKEKKVLG ETFFMCSCSS DECNDHIIFS EEYTTNSPDL LLVIFQVTGV SLLPPLGIAI 180

AVIITFYCYR VHRQQKLSPS WETSKSGKLI EFSEHCAIIL EDDRSDISST CANNINHNTE 240

LLPIELDTLV GKGRFAEVYK AKLKQNTSEQ FETVAVKIFP YEEYASWKTE KDIFSDINLK 300

HENILQFLTA EERKTELGKQ YWLITAFHAK GNLQEYLTRH VISWEDLRKL GSSLSRGIAH 360

LHSDHTPCGR PKMPIVHRDL KSSNILVKND LTCCLCDFGL SLRLDPTLSV DDLANSGQVG 420

TARYMAPEVL ESRMNLENVE SFKQTDVYSM ALVLWEMTSR CNAVGEVKDY EPPFGSKVRE 480

HPCVESMKDN VLRDRGRPEI PSFWLNHQGI QMVCETLTEC WDHDPEARLT AQCVAERFSE 540

LEHLDRLSGR SCSEEKIPED GSLNTTK 567

Nucleotide Sequence
(FASTA)

ATGGGTCGGG GGCTGCTCAG GGGCCTGTGG CCGCTGCACA TCGTCCTGTG GACGCGCATC 60

GCCAGCACGA TCCCACCGCA CGTTCAGAAG TCGGTTAACA ATGACATGAT GGTCACTGAA 120

AACAACGGTG CAGTCAAGCT TCCACAGCTG TGCAAATTTT GTGACGTGAG ATCTTCCACC 180

TGTGACAACC AGAAATCCTG CATGAGCAAC TGCAGCATCA CATCCATCTG TGAGAAGCCA 240

CACGAAGTCT GTGTGGCCGT GTGGAGGAAG AATGATGAGA ACATAACACT AGAGACGGTT 300

TGCCACGACC CTAAGCTCAC TTACCATGGA TTCATTCTGG AAGATGCTGC TTCTCCAAAG 360

TGTATTATGA AGGAAAAAAA AGTGCTTGGC GAGACTTTCT TCATGTGCTC CTGTAGCTCT 420

GATGAGTGCA ACGACCACAT CATCTTCTCG GAAGAATATA CCACCAACAG TCCTGACCTG 480

CTGTTAGTCA TCTTCCAAGT GACAGGCGTT AGCCTCCTGC CACCGCTGGG AATCGCCATA 540

GCGGTCATCA TCACCTTCTA CTGTTACCGC GTCCACCGGC AGCAAAAGCT GAGCCCATCC 600

TGGGAAACCA GCAAGTCCGG GAAGCTCATC GAGTTCAGCG AGCACTGCGC CATCATTCTG 660

GAGGATGACC GCTCGGACAT CAGCTCCACG TGCGCCAACA ACATCAACCA CAACACGGAG 720

CTGCTGCCCA TCGAGCTGGA CACCCTGGTG GGGAAAGGCC GCTTCGCCGA GGTCTACAAG 780

GCCAAGTTGA AGCAGAACAC TTCGGAGCAG TTTGAGACCG TGGCGGTCAA GATCTTCCCC 840

TATGAGGAGT ACGCGTCTTG GAAAACCGAG AAGGACATCT TCTCCGACAT CAACCTGAAG 900

CATGAGAACA TCCTCCAGTT CCTGACCGCG GAGGAGCGGA AGACAGAGTT GGGCAAACAG 960

TACTGGCTGA TCACCGCTTT CCACGCGAAG GGCAACCTGC AGGAGTACCT CACACGGCAC 1020

GTCATCAGCT GGGAGGACCT GCGCAAGCTG GGCAGCTCCC TCTCCCGGGG CATTGCGCAC 1080

CTGCACAGTG ACCACACCCC CTGCGGGAGG CCCAAGATGC CCATTGTGCA CAGGGACCTT 1140

AAGAGCTCCA ATATCCTGGT GAAGAACGAC CTGACCTGTT GCCTGTGCGA CTTTGGGCTC 1200

TCCCTGCGGC TGGATCCTAC TCTGTCTGTA GACGACCTGG CTAACAGTGG GCAGGTGGGA 1260

ACTGCAAGAT ACATGGCCCC AGAAGTCCTA GAATCCAGGA TGAATCTGGA GAATGTTGAG 1320

TCCTTTAAGC AGACCGATGT CTACTCCATG GCTCTGGTGC TCTGGGAAAT GACATCTCGC 1380

TGTAATGCGG TGGGAGAAGT GAAAGATTAC GAGCCTCCCT TCGGTTCCAA AGTGCGGGAG 1440

CACCCCTGTG TTGAGAGCAT GAAGGACAAT GTGTTGAGAG ACCGAGGACG ACCAGAAATC 1500

CCCAGCTTCT GGCTCAATCA CCAGGGCATC CAAATGGTGT GCGAGACGCT GACTGAGTGC 1560

TGGGACCACG ACCCGGAGGC CCGGCTCACC GCCCAGTGTG TGGCCGAGCG CTTCAGTGAG 1620

CTGGAGCACC TGGACAGACT CTCGGGGAGA AGCTGCTCTG AGGAGAAGAT TCCAGAAGAC 1680

GGCTCACTGA ACACTACCAA ATAG 1704

Domain Profile

S: 1     lklleligkGrygeVwkaklrg......eevAvKifstedeaswkrEkeiyqtvllrhen  54

         ++l +l+gkGr++eV+kakl++      e+vAvKif++e+ aswk+Ek+i++ ++l+hen

Q: 244   IELDTLVGKGRFAEVYKAKLKQntseqfETVAVKIFPYEEYASWKTEKDIFSDINLKHEN  303

         678899***************99999999*******************************

S: 55    ilqfiaadkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHe  114

         ilqf++a+++++++ ++++l+t++h kg+L++yL+r+++++e+l +l +sl++G+ahLH+

Q: 304   ILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLSRGIAHLHS  363

         ************************************************************

S: 115   eivgtkgkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtk  174

         + ++ +g+ K+ i+HRDlks Nilvk+dltcc++D+GL+l+l+ + ++ dla++ qvGt

Q: 364   D-HTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTA  422

         *.8999******************************************************

S: 175   RYmaPEvleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsd  234

         RYmaPEvle+++nl+++e+fk++DvYs++LvlWE++sRc++  +ev++y++pf ++v+++

Q: 423   RYMAPEVLESRMNLENVESFKQTDVYSMALVLWEMTSRCNA-VGEVKDYEPPFGSKVREH  481

         *****************************************.999***************

S: 235   PsleemkevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkr  290

         P++e+mk+ v++++ rP+ip+ w +++ +++++++l+ecWd+dpeaRlta++v++r

Q: 482   PCVESMKDNVLRDRGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQCVAER  537

         *****************************************************987

Domain Sequence
(FASTA)

IELDTLVGKG RFAEVYKAKL KQNTSEQFET VAVKIFPYEE YASWKTEKDI FSDINLKHEN 60

ILQFLTAEER KTELGKQYWL ITAFHAKGNL QEYLTRHVIS WEDLRKLGSS LSRGIAHLHS 120

DHTPCGRPKM PIVHRDLKSS NILVKNDLTC CLCDFGLSLR LDPTLSVDDL ANSGQVGTAR 180

YMAPEVLESR MNLENVESFK QTDVYSMALV LWEMTSRCNA VGEVKDYEPP FGSKVREHPC 240

VESMKDNVLR DRGRPEIPSF WLNHQGIQMV CETLTECWDH DPEARLTAQC VAER 294

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0043235	; C:receptor complex
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005026	; F:transforming growth factor beta receptor activity, type II
GO:0023014	; P:signal transduction by phosphorylation
GO:0007179	; P:transforming growth factor beta receptor signaling pathway

KEGG

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR017194	; Transform_growth_fac-b_typ-2.
IPR015013	; Transforming_GF_b_rcpt_2_ecto.

Pfam

PF08917	; ecTbetaR2; 1.
PF00069	; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013