EKS-ICT-00050

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ICT-00050

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/RAF	339.5	1.5E-101	440	705	266

Status

Unreviewed

Ensembl Protein

ENSSTOP00000019750

UniProt Accession

I3MRZ1;

Protein Name

Protein Synonyms/Alias

Gene Name

KSR1

Gene Synonyms/Alias

KSR1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSTOG00000021257	ENSSTOP00000014886	ENSSTOT00000027456
ENSSTOG00000021257	ENSSTOP00000019750	ENSSTOT00000019930

Organism

Ictidomys tridecemlineatus

Functional Description

Protein Length

726

Protein Sequence
(FASTA)

EIPRGLTLDA LLEMNEAKMK ETLRRCGASA EECGRLQQAL TCLRKVTGLG GEHKEDSGWS 60

SLDARRESTC PPPGSSQLGR VGSSGQGPRS ISVSALPALD SPAPGLGEGL SDTCIPLHAS 120

GRLTPRALHS FITPPTTPQL RRHAKLKPPR TPPPPSRKVF QLLPSFPTLT RSKSHESQLG 180

NRIDEVSPMR FDLPHGSPQM VRRDIGLSVT HRFSTKSWLS QVCHVCQKSM MFGVKCKHCR 240

LKCHNKCTKE APACRISFLP LTRLRRTESV PSDINNPVDR AAEPHFGTLP KALTKKEHPP 300

AMNPLDSSSN PSSATSSTPS SPAPFPTPTN PSSATTPPNP SPGQRDSRFN FPDISAFPPP 360

APIPDSADSA RLDDPPKADV LEFPEVEAEE PEAGKSEAED DEDEVDDLPS SRRPWRGPIS 420

RKASQTSVYL QEWDIPFEQV ELGEPIGQGR WGRVHRGRWH GEVAIRLLEM DGHNQDHLKL 480

FKKEVMNYRQ TRHENVVLFM GACMNPPHLA IITSFCKGRT LHSFVRDPKT SLDINKTRQI 540

AQEIIKGMGY LHAKGIVHKD LKSKNVFYDN GKVVITDFGL FGISGVVREE RRENQLKLSH 600

DWLCYLAPEI AEEGSPPATL HSLGPQAGAH LWRPHRTVWY ELQARDWPFK HQPAEALIWQ 660

IGSGEGMKRI LASVSLGKEV TEILSACWAF DLQERPSFSL LMDMLEKLPK LNRRLSHPGH 720

FWKSAE 726

Nucleotide Sequence
(FASTA)

GAGATCCCTC GAGGACTCAC CTTGGATGCC CTGCTGGAGA TGAACGAGGC CAAGATGAAG 60

GAGACGTTGC GGCGCTGCGG GGCCAGTGCC GAGGAGTGTG GCCGTCTGCA GCAAGCCCTC 120

ACGTGCCTGC GGAAGGTGAC AGGCCTGGGA GGTGAGCACA AAGAGGACTC AGGCTGGAGT 180

TCGTTGGATG CTCGGCGAGA AAGTACCTGC CCTCCACCGG GGAGCTCGCA GCTGGGCCGA 240

GTGGGCAGCA GTGGCCAGGG CCCTCGCTCC ATCTCCGTGT CAGCGCTGCC TGCTCTGGAC 300

TCGCCAGCCC CTGGCCTTGG AGAGGGCCTC TCGGACACCT GTATCCCCCT GCACGCCAGC 360

GGCCGCCTGA CGCCCCGCGC CCTGCACAGC TTCATCACCC CGCCCACCAC GCCCCAGCTG 420

CGACGGCACG CCAAGCTGAA GCCACCACGG ACACCCCCGC CGCCCAGCCG CAAGGTCTTC 480

CAGCTGCTGC CCAGCTTCCC CACGCTCACC CGGAGCAAGT CCCACGAGTC TCAGCTGGGG 540

AACCGCATCG ACGAGGTCTC CCCAATGAGG TTTGATCTTC CACATGGATC CCCACAGATG 600

GTACGAAGGG ACATCGGCCT CTCGGTGACA CATAGGTTCT CCACCAAGTC CTGGCTGTCG 660

CAGGTCTGCC ACGTGTGCCA GAAGAGCATG ATGTTTGGAG TGAAGTGCAA GCACTGCAGG 720

TTGAAGTGTC ACAACAAGTG CACGAAAGAA GCCCCGGCCT GTAGAATATC CTTCCTCCCA 780

CTAACAAGGC TCCGGAGGAC GGAATCCGTC CCCTCGGACA TCAACAACCC TGTGGACAGA 840

GCAGCCGAAC CCCACTTTGG AACCCTCCCC AAGGCACTGA CGAAAAAGGA GCACCCTCCC 900

GCCATGAACC CCCTGGACTC CAGCAGCAAC CCCTCCTCCG CCACGTCCTC CACGCCCTCC 960

TCGCCAGCGC CCTTCCCGAC ACCAACGAAC CCCTCCAGCG CCACCACGCC CCCCAACCCC 1020

TCGCCTGGCC AGCGGGACAG CAGGTTCAAC TTCCCAGACA TTTCAGCCTT CCCGCCGCCA 1080

GCCCCGATCC CCGACTCAGC CGACAGTGCC CGGCTCGACG ACCCACCCAA AGCCGATGTG 1140

TTGGAGTTTC CTGAGGTGGA GGCTGAGGAG CCAGAGGCTG GAAAGTCAGA GGCGGAAGAT 1200

GACGAGGACG AGGTGGACGA CTTGCCCAGC TCCCGCCGGC CCTGGCGGGG CCCCATCTCT 1260

CGAAAGGCCA GCCAGACCAG CGTGTACCTG CAGGAGTGGG ACATCCCCTT TGAGCAGGTG 1320

GAGCTGGGCG AGCCCATCGG GCAGGGCCGC TGGGGCCGGG TGCACCGTGG CCGCTGGCAC 1380

GGCGAGGTGG CCATTCGCCT GCTGGAGATG GACGGCCACA ATCAGGACCA CCTGAAACTC 1440

TTCAAGAAGG AGGTGATGAA TTACCGGCAG ACGCGGCACG AGAACGTGGT GCTCTTCATG 1500

GGGGCCTGCA TGAACCCCCC CCACCTGGCC ATCATCACCA GCTTCTGCAA GGGGCGGACG 1560

TTGCACTCAT TTGTGAGGGA CCCCAAGACG TCTCTGGACA TCAACAAGAC GAGGCAGATT 1620

GCTCAGGAGA TCATCAAGGG CATGGGGTAT CTTCACGCCA AGGGCATCGT GCACAAGGAT 1680

CTCAAATCCA AGAATGTCTT TTACGACAAT GGCAAAGTGG TCATCACAGA CTTTGGGCTG 1740

TTTGGGATAT CAGGAGTGGT CCGAGAAGAA CGGCGTGAGA ACCAGCTCAA GCTGTCCCAC 1800

GACTGGCTGT GCTACCTGGC CCCTGAGATT GCCGAGGAAG GCTCACCCCC AGCCACTCTG 1860

CACTCTCTGG GGCCCCAGGC AGGAGCTCAC CTATGGCGAC CCCACAGGAC TGTCTGGTAT 1920

GAACTACAAG CAAGAGACTG GCCCTTTAAG CACCAGCCCG CAGAGGCCTT GATCTGGCAG 1980

ATCGGAAGCG GGGAAGGCAT GAAGAGAATC CTGGCCTCCG TCAGCCTGGG GAAGGAAGTC 2040

ACCGAGATCC TGTCTGCCTG CTGGGCATTC GACCTGCAGG AGAGACCCAG CTTCAGCCTG 2100

CTGATGGACA TGCTGGAGAA GCTGCCCAAG CTGAACCGCA GGCTCTCCCA CCCTGGACAC 2160

TTCTGGAAGT CCGCTGAGTA A 2181

Domain Profile

S: 1     velaekiGsGrfGtvyrgkwhGdvavkllnveelseeqleaFkkevaaykktRhenivLF  60

         vel+e iG+Gr+G+v+rg+whG+va++ll+++ +++++l+ Fkkev++y++tRhen+vLF

Q: 440   VELGEPIGQGRWGRVHRGRWHGEVAIRLLEMDGHNQDHLKLFKKEVMNYRQTRHENVVLF  499

         67899*******************************************************

S: 61    mG.yvskpelaivtslckgssLykllheqetkldlaklidiarqiaqgmdYLhakkilhk  119

         mG ++++p+lai+ts+ckg++L++++++ +t+ld++k+++ia++i++gm+YLhak+i+hk

Q: 500   MGaCMNPPHLAIITSFCKGRTLHSFVRDPKTSLDINKTRQIAQEIIKGMGYLHAKGIVHK  559

         ************************************************************

S: 120   DlksknilleeglkvvitDFgllsvkrllsg.rrekqleipkgwilylapeviralsidl  178

         Dlkskn+++++g kvvitDFgl+ ++ ++++ rre+ql+++++w++ylape++++ s+

Q: 560   DLKSKNVFYDNG-KVVITDFGLFGISGVVREeRRENQLKLSHDWLCYLAPEIAEEGSPPA  618

         ************.***************9977***********************99988

S: 179   eqdelpfskesDvy.afGivlyellarelpykeesadqilfavgrG..lkpdlskvkskl  235

         + ++l     +  +  + +v+yel+ar++p+k+++a++ ++++g+G  +k+ l++v  +l

Q: 619   TLHSLGPQAGAHLWrPHRTVWYELQARDWPFKHQPAEALIWQIGSGegMKRILASV--SL  676

         888887777777773689*************************99988********..**

S: 236   pkelkellleClkfekeeRPlftqilkkl  264

         +ke++e+l++C++f+ +eRP+f+ ++++l

Q: 677   GKEVTEILSACWAFDLQERPSFSLLMDML  705

         *************************9985

Domain Sequence
(FASTA)

VELGEPIGQG RWGRVHRGRW HGEVAIRLLE MDGHNQDHLK LFKKEVMNYR QTRHENVVLF 60

MGACMNPPHL AIITSFCKGR TLHSFVRDPK TSLDINKTRQ IAQEIIKGMG YLHAKGIVHK 120

DLKSKNVFYD NGKVVITDFG LFGISGVVRE ERRENQLKLS HDWLCYLAPE IAEEGSPPAT 180

LHSLGPQAGA HLWRPHRTVW YELQARDWPF KHQPAEALIW QIGSGEGMKR ILASVSLGKE 240

VTEILSACWA FDLQERPSFS LLMDML 266

Keyword

Complete proteome; Metal-binding; Reference proteome; Zinc.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0035556	; P:intracellular signal transduction

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR025561	; KSR_SAM-like_dom.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF13543	; KSR1-SAM; 1.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00109

; C1; 1.

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS00479	; ZF_DAG_PE_1; 1.
PS50081	; ZF_DAG_PE_2; 1.

Prints

Created Date

20-Feb-2013