EKS-ICT-00226

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ICT-00226

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Abl	552.3	1.4E-166	236	487	252

Status

Unreviewed

Ensembl Protein

ENSSTOP00000020777

UniProt Accession

I3N8T1;

Protein Name

Protein Synonyms/Alias

Gene Name

ABL2

Gene Synonyms/Alias

ABL2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSTOG00000021312	ENSSTOP00000020777	ENSSTOT00000029626

Organism

Ictidomys tridecemlineatus

Functional Description

Protein Length

1130

Protein Sequence
(FASTA)

DHFASCVEDG FEGDKTGGNS PEALHRPYGC DVESQALNEA IRWSSKENLL GATESDPNLF 60

VALYDFVASG DNTLSITKGE KLRVLGYNQN GEWSEVRSKN GQGWVPSNYI TPVNSLEKHS 120

WYHGPVSRSA AEYLLSSLIN GSFLVRESES SPGQLSISLR YEGRVYHYRI NTTTDGKVYV 180

TAESRFSTLA ELVHHHSTVA DGLVTTLHYP APKCNKPTVY GVSPIHDKWE MERTDITMKH 240

KLGGGQYGEV YVGVWKKYSL TVAVKTLKED TMEVEEFLKE AAVMKEIKHP NLVQLLGVCT 300

LEPPFYIVTE YMPYGNLLDY LRECNREEVT AVVLLYMATQ ISSAMEYLEK KNFIHRDLAA 360

RNCLVGENHV VKVADFGLSR LMTGDTYTAH AGAKFPIKWT APESLAYNTF SIKSDVWAFG 420

VLLWEIATYG MSPYPGIDLS QVYDLLEKGY RMEQPEGCPP KVYELMRACW KWSPADRPSF 480

AETHQAFETM FHDSSISEEV AEELGRAASS SSVVPYLPRL PILPSKMRTL KKQVENKENI 540

EGAQDAAENP ASSSAPGFIR STQASSGSPA LPRKQRDKSP SSLLEDAKET CFTRDRKGGF 600

FSSFMKKRNA PTPPKRSSSF REMENQPHKK YELTGNFSPV ASLQHADGFS FTPAQQETNL 660

VPPKCYGGSF AQRNLCNDDS GGGGGSGAAG GGWSGITGFF TPRLIKKTLG LRAGKPTASD 720

DTSKPFPRSN STSSMSSGLP EQDRMAMTLP RNCQRSKLQL ERTVSASSQP EENVDRASDT 780

LPKKSEEGAA PARERPKAKL LPRGATALPL RAPSGDPAMT EKDSPGVGTA GVAAAPKGKE 840

RNGGARLGTA GVPEDGEQPG WSSPAKAAAV LPTTHNHKVP VLISPTLKHT PADVQLIGTD 900

SQGNKFKLLS EHQVTSSADK DRPRRVKPKC APPPPPVMRL LQHPSVCSDP AEEPAALTAG 960

QSTSETQEGG KKAAPGAVPI SGKAGRPVMP PPQVPLPTSS VSPAKMANGT AGTKVALRKT 1020

KQAAEKISAD KISKEALLEC ADLLSSAITE PVPNSQLVDT GHQLLDYCSG YVDCIPQTRN 1080

KFAFREAVSK LELSLQELQV SSAVAAVPGA NPVLNNLLSC VQEISDVVQR 1130

Nucleotide Sequence
(FASTA)

GATCACTTTG CCAGCTGTGT GGAGGATGGA TTTGAGGGAG ACAAGACTGG AGGCAATAGT 60

CCAGAAGCTT TGCACCGCCC TTATGGTTGT GATGTTGAAT CCCAGGCACT GAACGAAGCT 120

ATCAGGTGGA GTTCCAAGGA GAACTTGCTT GGAGCCACTG AGAGTGACCC TAATCTCTTT 180

GTTGCACTTT ATGATTTTGT AGCAAGTGGT GATAACACAC TCAGCATCAC TAAAGGTGAA 240

AAACTACGAG TTCTTGGTTA TAACCAGAAT GGCGAGTGGA GTGAAGTTCG TTCTAAGAAT 300

GGACAGGGTT GGGTGCCAAG CAACTATATC ACCCCAGTAA ATAGCCTGGA AAAACATTCC 360

TGGTACCATG GGCCTGTATC ACGCAGTGCA GCCGAGTATC TACTCAGCAG TCTAATCAAT 420

GGCAGTTTCC TGGTGCGAGA AAGTGAGAGC AGCCCTGGGC AGCTGTCCAT CTCGCTCAGG 480

TATGAGGGGC GTGTGTATCA CTACAGGATC AATACCACCA CAGACGGCAA GGTGTATGTG 540

ACTGCTGAGA GCCGCTTTAG CACTTTGGCA GAGCTTGTTC ACCATCATTC CACAGTGGCT 600

GATGGGCTGG TGACAACATT ACACTACCCA GCACCCAAGT GTAATAAGCC AACAGTCTAT 660

GGTGTATCCC CCATCCATGA CAAATGGGAA ATGGAACGAA CAGATATTAC CATGAAGCAC 720

AAACTTGGGG GCGGTCAGTA TGGAGAGGTT TATGTTGGTG TCTGGAAAAA ATATAGCCTT 780

ACAGTTGCTG TGAAAACACT GAAGGAAGAT ACCATGGAGG TTGAAGAATT CCTAAAAGAA 840

GCTGCAGTGA TGAAGGAAAT CAAGCATCCT AATCTGGTGC AACTATTAGG TGTGTGTACT 900

TTGGAGCCAC CATTTTATAT TGTGACTGAA TACATGCCAT ATGGAAATCT GCTTGATTAT 960

CTCAGAGAAT GCAACCGAGA AGAGGTGACT GCAGTTGTAC TGCTTTACAT GGCCACTCAG 1020

ATCTCTTCTG CAATGGAGTA TTTAGAGAAG AAGAATTTTA TCCATAGAGA TCTTGCAGCA 1080

CGCAATTGCC TAGTGGGAGA AAACCATGTG GTAAAAGTGG CTGACTTTGG CTTAAGTAGA 1140

CTGATGACTG GAGATACCTA TACTGCTCAT GCTGGAGCCA AATTTCCTAT TAAATGGACA 1200

GCACCAGAGA GTCTTGCCTA CAATACTTTC TCAATTAAAT CAGATGTCTG GGCTTTTGGG 1260

GTACTATTAT GGGAAATCGC TACATATGGA ATGTCACCAT ACCCAGGTAT TGACCTGTCT 1320

CAGGTCTATG ATCTACTGGA AAAAGGATAT CGAATGGAAC AACCTGAGGG ATGCCCTCCT 1380

AAAGTTTATG AACTTATGAG GGCATGCTGG AAATGGAGCC CTGCTGACAG GCCCTCTTTT 1440

GCTGAAACAC ATCAAGCTTT TGAAACCATG TTCCATGACT CTAGCATTTC TGAAGAGGTA 1500

GCCGAGGAGC TTGGGAGAGC TGCCTCCTCC TCGTCGGTGG TTCCATACCT GCCCCGATTA 1560

CCTATACTTC CTTCCAAGAT GCGGACCCTG AAAAAACAGG TGGAGAACAA AGAGAACATT 1620

GAAGGAGCAC AAGATGCCGC AGAAAATCCT GCCTCCAGTT CAGCACCAGG GTTCATTAGA 1680

AGTACACAGG CCTCCAGTGG GTCCCCAGCA CTGCCTCGAA AACAGAGAGA CAAGTCACCC 1740

AGCAGCCTCT TGGAAGATGC CAAAGAGACA TGCTTCACCA GGGATAGGAA GGGAGGCTTC 1800

TTCAGTTCCT TCATGAAAAA GAGAAATGCT CCCACACCCC CTAAACGCAG CAGCTCTTTC 1860

CGAGAAATGG AGAATCAGCC CCACAAGAAA TATGAACTCA CGGGTAACTT CTCACCTGTT 1920

GCTTCTCTAC AGCATGCTGA CGGGTTCTCT TTCACTCCTG CCCAGCAAGA GACGAACCTG 1980

GTGCCACCCA AGTGCTATGG GGGGAGCTTT GCACAGAGGA ACCTCTGTAA TGACGACAGT 2040

GGCGGGGGTG GGGGCAGTGG CGCTGCTGGG GGTGGGTGGT CTGGCATCAC AGGCTTCTTT 2100

ACACCTCGCT TAATCAAAAA GACACTGGGC TTACGAGCAG GTAAACCTAC AGCCAGTGAT 2160

GACACTTCCA AGCCTTTTCC AAGGTCCAAC TCTACATCTT CCATGTCCTC AGGGCTTCCA 2220

GAGCAGGATA GGATGGCAAT GACCCTTCCC AGGAACTGCC AGAGGTCCAA ACTCCAGCTG 2280

GAAAGGACAG TGTCCGCCTC TTCTCAGCCA GAAGAGAATG TGGACAGGGC CAGTGACACG 2340

CTTCCAAAAA AATCAGAGGA AGGTGCTGCT CCAGCCAGGG AGAGACCAAA AGCCAAACTG 2400

TTGCCCAGAG GAGCCACAGC ACTTCCTCTG AGAGCCCCTT CTGGGGACCC TGCCATGACC 2460

GAGAAGGACT CTCCAGGGGT GGGAACGGCT GGAGTGGCAG CTGCACCCAA GGGCAAGGAG 2520

AGGAATGGTG GGGCACGCCT TGGGACGGCT GGAGTCCCGG AGGATGGAGA GCAGCCAGGC 2580

TGGTCTTCTC CAGCCAAGGC TGCGGCCGTC CTTCCAACCA CTCACAACCA CAAAGTGCCA 2640

GTCCTCATCT CGCCCACTCT CAAACACACT CCAGCGGACG TGCAGCTCAT TGGCACAGAC 2700

TCTCAGGGGA ATAAATTCAA GCTCTTATCT GAGCATCAGG TCACATCCTC TGCAGACAAG 2760

GATCGCCCCC GACGGGTAAA ACCAAAGTGT GCCCCACCTC CACCGCCGGT GATGAGACTC 2820

CTGCAGCATC CGTCCGTGTG CTCAGACCCT GCGGAAGAGC CAGCTGCCCT GACTGCAGGA 2880

CAGTCCACGT CAGAAACACA GGAAGGAGGG AAAAAGGCAG CTCCAGGGGC AGTGCCCATC 2940

AGTGGGAAAG CTGGGAGGCC GGTGATGCCT CCACCCCAAG TGCCTCTGCC CACATCTTCC 3000

GTCTCGCCAG CCAAGATGGC CAATGGCACA GCAGGTACTA AGGTGGCTCT GAGAAAAACC 3060

AAACAGGCAG CTGAGAAAAT CTCAGCAGAC AAAATCAGCA AAGAGGCCCT GCTGGAATGT 3120

GCTGACCTAC TGTCCAGTGC AATCACAGAA CCTGTGCCCA ATAGCCAGCT GGTCGACACT 3180

GGACACCAGC TGCTCGACTA CTGCTCAGGC TATGTGGACT GCATCCCCCA GACTCGCAAC 3240

AAATTCGCCT TCCGAGAGGC TGTAAGCAAA CTGGAGCTCA GCCTGCAGGA GCTGCAGGTG 3300

TCCTCAGCAG TTGCTGCTGT GCCCGGGGCA AACCCTGTCC TTAATAACTT ACTGTCCTGT 3360

GTACAGGAAA TCAGTGACGT GGTGCAGAGG TAG 3393

Domain Profile

S: 1     iimkhklgggqygevyegvwkkysltvavktlkedtmeveeflkeaavmkelkhpnlvql  60

         i+mkhklgggqygevy+gvwkkysltvavktlkedtmeveeflkeaavmke+khpnlvql

Q: 236   ITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQL  295

         89**********************************************************

S: 61    lgvctreppfyiitefmsygnlldylreadreeveavvllymatqissameylekknfih  120

         lgvct eppfyi+te+m+ygnlldylre++reev+avvllymatqissameylekknfih

Q: 296   LGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIH  355

         ************************************************************

S: 121   rdlaarnclvgenklvkvadfglsrlmkedtytahagakfpikwtapeslaynkfsiksd  180

         rdlaarnclvgen++vkvadfglsrlm++dtytahagakfpikwtapeslayn+fsiksd

Q: 356   RDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSD  415

         ************************************************************

S: 181   vwafgvllweiatygmspypgidlsqvyellekgyrmerpegcppkvyelmracwkwsps  240

         vwafgvllweiatygmspypgidlsqvy+llekgyrme+pegcppkvyelmracwkwsp+

Q: 416   VWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPA  475

         ************************************************************

S: 241   drpsfaeihqal  252

         drpsfae+hqa+

Q: 476   DRPSFAETHQAF  487

         *********986

Domain Sequence
(FASTA)

ITMKHKLGGG QYGEVYVGVW KKYSLTVAVK TLKEDTMEVE EFLKEAAVMK EIKHPNLVQL 60

LGVCTLEPPF YIVTEYMPYG NLLDYLRECN REEVTAVVLL YMATQISSAM EYLEKKNFIH 120

RDLAARNCLV GENHVVKVAD FGLSRLMTGD TYTAHAGAKF PIKWTAPESL AYNTFSIKSD 180

VWAFGVLLWE IATYGMSPYP GIDLSQVYDL LEKGYRMEQP EGCPPKVYEL MRACWKWSPA 240

DRPSFAETHQ AF 252

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity

KEGG

InterPros

IPR015015	; F-actin_binding.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF08919	; F_actin_bind; 1.
PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00808	; FABD; 1.
SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013