EKS-ICT-00139

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ICT-00139

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Csk	472.6	2.0E-142	195	440	246

Status

Unreviewed

Ensembl Protein

ENSSTOP00000020072

UniProt Accession

I3N6S6;

Protein Name

Protein Synonyms/Alias

Gene Name

CSK

Gene Synonyms/Alias

CSK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSTOG00000022236	ENSSTOP00000020072	ENSSTOT00000021025

Organism

Ictidomys tridecemlineatus

Functional Description

Protein Length

450

Protein Sequence
(FASTA)

MSAIQAAWPS GTECIAKYNF HGTAEQDLPF CKGDVLTIVA VTKDPNWYKA KNKVGREGII 60

PANYVQKREG VKAGTKLSLM PWFHGKITRE QAERLLYPPE TGLFLVREST NYPGDYTLCV 120

SCDGKVEHYR IMYHASKLSI DEEVYFENLM QLVEHYTTDA DGLCTRLIKP KVMEGTVAAQ 180

DEFYRSGWAL NMKELKLLQT IGKGEFGDVM LGDYRGNKVA VKCIKNDATA QAFLAEASVM 240

TQLRHSNLVQ LLGVILEEKG GLYIVTEYMA KGSLVDYLRS RGRSVLGGDC LLKFSLDVCE 300

AMEYLEGNNF VHRDLAARNV LVSEDNVAKV SDFGLTKEAS STQDTGKLPV KWTAPEALRE 360

KKFSTKSDVW SFGILLWEIY SFGRVPYPRI PLKDVVPRVE KGYKMDAPDG CPPAVYEVMK 420

NCWHLDAATR PSFLQLREQL EHIKAHELHL 450

Nucleotide Sequence
(FASTA)

ATGTCGGCAA TACAGGCCGC CTGGCCATCC GGTACAGAAT GTATTGCCAA GTACAACTTC 60

CATGGCACTG CTGAACAGGA CCTTCCCTTC TGCAAAGGAG ATGTGCTCAC CATTGTGGCT 120

GTCACCAAGG ACCCCAACTG GTACAAGGCC AAAAACAAGG TGGGCCGTGA AGGCATCATC 180

CCAGCCAACT ATGTCCAGAA GCGGGAGGGC GTGAAGGCAG GCACCAAACT CAGCCTCATG 240

CCCTGGTTCC ATGGCAAGAT CACACGGGAG CAGGCTGAGC GGCTTCTATA CCCACCGGAG 300

ACAGGCCTGT TCCTGGTGCG GGAAAGTACC AACTACCCCG GGGACTACAC ACTGTGCGTA 360

AGCTGTGACG GCAAGGTGGA GCACTACCGC ATCATGTACC ATGCCAGCAA ACTCAGCATT 420

GACGAAGAAG TGTACTTCGA GAACTTAATG CAGCTGGTGG AGCACTACAC CACTGATGCA 480

GATGGACTCT GCACACGCCT CATCAAACCA AAGGTCATGG AGGGCACAGT GGCAGCCCAG 540

GATGAATTTT ACCGCAGTGG CTGGGCACTG AACATGAAGG AGCTGAAGCT GCTGCAGACC 600

ATTGGGAAGG GAGAGTTTGG AGATGTAATG CTGGGTGATT ACCGGGGGAA CAAAGTTGCT 660

GTCAAGTGCA TTAAGAATGA TGCCACCGCC CAGGCCTTCC TGGCTGAAGC CTCTGTCATG 720

ACGCAACTTC GGCACAGCAA CCTGGTACAG CTTCTCGGTG TAATTCTAGA GGAGAAGGGC 780

GGGCTCTACA TTGTCACTGA ATACATGGCC AAGGGCAGCC TGGTGGACTA CCTGAGATCT 840

CGGGGTAGGT CGGTGCTGGG CGGAGACTGT CTCCTGAAGT TCTCACTAGA CGTCTGTGAG 900

GCCATGGAAT ACCTAGAGGG CAACAACTTT GTACACCGGG ACCTGGCTGC CAGAAATGTG 960

CTGGTGTCTG AGGACAATGT GGCCAAGGTC AGCGACTTCG GCCTCACCAA GGAGGCCTCC 1020

AGCACCCAGG ACACAGGCAA ACTGCCAGTC AAGTGGACAG CCCCCGAGGC TCTGAGAGAG 1080

AAGAAATTCT CCACCAAGTC TGACGTGTGG AGCTTTGGAA TCCTTCTCTG GGAAATCTAC 1140

TCCTTTGGGC GAGTGCCTTA CCCAAGAATT CCCCTGAAGG ACGTTGTCCC TCGGGTGGAA 1200

AAGGGCTATA AGATGGACGC CCCAGATGGC TGCCCACCCG CAGTCTATGA GGTCATGAAG 1260

AACTGCTGGC ATCTGGATGC CGCCACACGG CCCTCCTTCC TCCAGCTTCG AGAGCAGCTT 1320

GAACACATCA AAGCCCATGA GCTGCACCTG TGA 1353

Domain Profile

S: 1     lklgetigkgefgdvllgeyrgekvavkvikndataqafldeasvmtklehenlvkllgv  60

         lkl +tigkgefgdv+lg+yrg+kvavk+ikndataqafl+easvmt+l+h+nlv+llgv

Q: 195   LKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLLGV  254

         6899********************************************************

S: 61    ileek.glylvteyvakgslvdylrsrgrallekkqllkfaldvaegmeyleskklvhrd  119

         ileek gly+vtey+akgslvdylrsrgr++l+ ++llkf+ldv+e+meyle++++vhrd

Q: 255   ILEEKgGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRD  314

         *****99*****************************************************

S: 120   laarnvlvsedlvakvsdfglakeeskdldsgklpvkwtapealkekkfstksdvwsfgi  179

         laarnvlvsed+vakvsdfgl+ke+s+++d+gklpvkwtapeal+ekkfstksdvwsfgi

Q: 315   LAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGI  374

         ************************************************************

S: 180   llweifsfgrvpypriplkdvvkavekgykmeapegcppevyelmkeaweleaakrpsfa  239

         llwei+sfgrvpypriplkdvv++vekgykm+ap+gcpp+vye+mk++w+l+aa+rpsf

Q: 375   LLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNCWHLDAATRPSFL  434

         ************************************************************

S: 240   klkekl  245

         +l+e+l

Q: 435   QLREQL  440

         ***997

Domain Sequence
(FASTA)

LKLLQTIGKG EFGDVMLGDY RGNKVAVKCI KNDATAQAFL AEASVMTQLR HSNLVQLLGV 60

ILEEKGGLYI VTEYMAKGSL VDYLRSRGRS VLGGDCLLKF SLDVCEAMEY LEGNNFVHRD 120

LAARNVLVSE DNVAKVSDFG LTKEASSTQD TGKLPVKWTA PEALREKKFS TKSDVWSFGI 180

LLWEIYSFGR VPYPRIPLKD VVPRVEKGYK MDAPDGCPPA VYEVMKNCWH LDAATRPSFL 240

QLREQL 246

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013