EKS-ICT-00370

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ICT-00370

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE11	340.5	8.0E-102	1059	1322	264

Status

Unreviewed

Ensembl Protein

ENSSTOP00000023871

UniProt Accession

I3NHM4;

Protein Name

Protein Synonyms/Alias

Gene Name

YSK4

Gene Synonyms/Alias

YSK4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSTOG00000022671	ENSSTOP00000023871	ENSSTOT00000028372

Organism

Ictidomys tridecemlineatus

Functional Description

Protein Length

1326

Protein Sequence
(FASTA)

MNSMPKPEKH AESLLDICHD TNSSPTDMMT ITKNQNIILQ SISSSEEFDQ DEDCSHSFLV 60

SEEGDLGGEG KDWSPRTEGV EIIVTFPRDV NHPQEMSQED SKECSQITSV HQEWAQANSV 120

SLPNEIEMVD LRTKMLTMES LLPKKEESSK DLCDVNLDFL LPRRCLEPDI SKTITREEAP 180

HFLKGQQRKL EEFSTSDMKY SSRRIEFPLP PLSLLPMRSG VLTLPQSYKF PKERERNISS 240

LTPFIPKLPA SVSSSDEFSP ANQQQEAPLK RLVDQTLRFS DSSIWSRNMC SFRKSDHHRQ 300

HLEVEVNWKS KEREGWDNME ISLFEKGKSL VSFENIKEGK LSTDREKDIE CHGPEMRKAE 360

ENPQDFSSRK KEDSAASKSE QNAETICTVP SKLQEAQHSE ITPNEDEEVR HNKIDSKSSS 420

VYKGETMRPR DILEEFTALQ SLSSVVSDGP FGKLPEGHND MGTNVKISVA EAMKPEMNGL 480

VPLIHITFPG DGVPEETAIT KPSLQKRKSS IRNNSFNVLA HQENDKRKMK THRSKLDSKT 540

KINNRTPHNF MISIQASIKP NMHKTSIKTQ IFPALEFVDS GPQQSSKFQR RMPPLEKKQS 600

SYWTQKTKKQ SFPCICKNPG IKKPCVPLSV QPTEPRLHYL DLKYSDMFKE INSTANGPGI 660

YEMFGTPVYS HLREAERHEN KYYHEICSVP SGRCISNKCR SSHSERNSNS RARLSQKRPH 720

IKPPKPSLGL KQKHKSSISK EKGCKAIGSH LHDIENSNGI SDADWQIHSS GNVFLSSKDE 780

VQTMNLDQTP EQVPEQNEFL PALDISIVEE ISMEESTDEG DISNNQILAT SLRDLQELEE 840

LHHQIPFVPS ENSWVLPSEK SSNKYAFEEN NNNAPLHKID SSQMLTNYLE FDSVLDNPKT 900

LGGFSFQEEQ ENASSQTYQH WAHSLDYDSL ANKSITYQTL GTTSNDANSI SQEILDSVKK 960

EELTDELLGC LAAELLALDE KDNTSSQMMA NETDPENLNL VLSRKGNTTE ELGRETTNVR 1020

IQRYRNGFGI YDREEKFLNS NEKKTFSENS LKHEEPILWT KGEILGKGAY GTVYCGLTSQ 1080

GQLIAVKQVT LDTSDKLATE KEYRKLQEEV DLLKALKHVN IVAYLGTCLE ENIVSIFMEF 1140

VPGGSISSII NRFGPLPEMV FCKYTKQILQ GVAYLHENCV VHRDIKGNNV MLMPTGIIKL 1200

IDFGCAKRLA WAGLNGTHSD MLKSMHGTPY WMAPEVINES GYGRKSDIWS IGCTVFEMAT 1260

GKPPLASMDR MAAMFYIGAH RGLMPPLPDH FSENASDFVR MCLTRDQHER PSALQLLKHS 1320

FLKRNH 1326

Nucleotide Sequence
(FASTA)

ATGAATTCTA TGCCAAAACC AGAAAAACAT GCTGAATCAT TGCTTGACAT TTGTCATGAT 60

ACAAATTCTT CTCCAACTGA TATGATGACA ATTACCAAAA ATCAAAACAT TATCTTGCAA 120

AGCATCAGCA GCAGTGAGGA ATTTGACCAA GATGAAGACT GCAGTCATTC CTTTTTGGTT 180

AGTGAAGAAG GAGATCTCGG GGGTGAAGGA AAAGACTGGT CACCCAGGAC AGAAGGTGTG 240

GAGATTATTG TGACTTTTCC AAGAGATGTC AATCATCCCC AAGAAATGAG CCAAGAAGAT 300

TCGAAAGAAT GCAGTCAGAT AACCTCAGTG CATCAAGAAT GGGCACAGGC AAATTCTGTC 360

TCTCTCCCAA ATGAAATCGA GATGGTGGAC CTCAGGACAA AGATGCTGAC CATGGAGTCT 420

TTACTTCCAA AGAAAGAAGA AAGTTCCAAG GATCTCTGTG ATGTGAACTT GGACTTTTTG 480

TTGCCCAGAC GTTGCTTAGA ACCAGACATC TCTAAGACTA TAACCAGGGA AGAGGCTCCT 540

CATTTTCTGA AGGGGCAGCA AAGAAAATTA GAAGAGTTTT CTACCTCTGA TATGAAATAC 600

AGTAGCCGAA GAATCGAGTT CCCTCTGCCT CCACTGTCAC TCTTGCCCAT GAGATCTGGT 660

GTCCTCACTC TCCCCCAAAG TTACAAGTTC CCAAAAGAGA GAGAAAGAAA TATTTCAAGC 720

CTTACGCCCT TCATACCTAA ACTCCCAGCA TCGGTCAGTT CATCTGATGA GTTTAGTCCA 780

GCAAACCAGC AGCAGGAAGC CCCGCTGAAA AGGTTGGTGG ATCAGACTCT CAGGTTTTCT 840

GATAGCTCCA TTTGGTCAAG AAACATGTGC TCTTTTCGGA AGTCTGATCA TCACAGACAA 900

CACCTGGAGG TGGAGGTGAA TTGGAAATCC AAGGAAAGAG AAGGATGGGA CAACATGGAA 960

ATATCTCTCT TTGAAAAAGG GAAATCTTTG GTGTCCTTTG AGAATATTAA GGAAGGCAAA 1020

CTTTCTACAG ATAGGGAAAA GGATATTGAA TGTCATGGTC CTGAAATGAG AAAAGCAGAA 1080

GAGAACCCTC AAGATTTTTC ATCAAGAAAG AAAGAGGATT CAGCAGCCAG TAAATCTGAA 1140

CAAAATGCAG AAACTATATG TACTGTTCCA AGCAAGCTCC AAGAAGCTCA GCATTCAGAA 1200

ATAACACCAA ATGAGGATGA AGAAGTTAGA CATAACAAAA TTGATTCAAA AAGCTCTTCA 1260

GTATATAAGG GTGAAACAAT GAGACCAAGA GATATTTTAG AAGAGTTTAC AGCACTTCAA 1320

AGCTTGTCCA GTGTAGTCTC CGATGGCCCC TTTGGAAAGC TTCCAGAAGG TCATAATGAC 1380

ATGGGGACAA ATGTAAAAAT ATCAGTGGCA GAAGCAATGA AACCAGAGAT GAATGGGCTG 1440

GTGCCTCTTA TACACATCAC TTTCCCTGGA GATGGAGTCC CCGAGGAAAC AGCGATAACC 1500

AAGCCAAGCC TCCAAAAAAG GAAGAGCTCT ATTCGTAACA ATAGCTTCAA TGTTCTTGCA 1560

CACCAAGAAA ATGACAAACG TAAGATGAAG ACCCATAGAA GTAAGTTGGA TTCAAAGACC 1620

AAGATAAACA ACAGGACACC TCACAATTTC ATGATTTCCA TTCAAGCTTC TATTAAGCCT 1680

AATATGCATA AAACTAGCAT AAAAACTCAG ATTTTCCCTG CATTGGAGTT TGTTGACTCT 1740

GGCCCTCAGC AATCATCCAA GTTTCAAAGG AGAATGCCAC CATTAGAAAA GAAGCAATCC 1800

AGCTATTGGA CTCAGAAAAC TAAAAAGCAG TCATTTCCTT GCATATGTAA AAATCCAGGA 1860

ATAAAAAAGC CATGTGTTCC TCTCTCTGTT CAACCAACAG AACCAAGACT ACATTACCTA 1920

GATCTTAAAT ATAGTGACAT GTTCAAGGAA ATCAATTCAA CTGCTAATGG ACCTGGAATC 1980

TATGAAATGT TTGGGACCCC TGTTTATAGT CACTTGCGAG AGGCTGAACG GCATGAAAAC 2040

AAGTATTACC ATGAGATATG TTCAGTTCCA TCAGGCAGAT GTATCTCCAA TAAATGTCGA 2100

TCTTCACACA GTGAGAGGAA CAGCAATAGC AGAGCAAGAC TTTCTCAGAA AAGACCACAT 2160

ATTAAACCTC CAAAGCCTTC ACTTGGCCTT AAACAAAAGC ATAAAAGTTC AATTTCTAAG 2220

GAAAAGGGCT GCAAGGCTAT AGGTAGCCAC TTACACGACA TTGAAAATAG TAATGGTATT 2280

TCAGATGCAG ATTGGCAGAT ACACTCTTCA GGAAATGTCT TTCTATCTTC CAAAGATGAA 2340

GTTCAGACTA TGAACTTGGA CCAAACTCCT GAGCAGGTCC CTGAGCAAAA TGAGTTTCTT 2400

CCTGCCCTAG ATATATCTAT AGTTGAAGAA ATATCTATGG AAGAGTCTAC GGATGAAGGT 2460

GACATTTCCA ATAATCAAAT CCTTGCCACA AGTCTTAGAG ACCTGCAAGA ACTTGAAGAG 2520

TTACATCACC AGATCCCATT TGTCCCTTCA GAAAACAGCT GGGTCTTGCC CAGTGAGAAG 2580

AGTTCTAACA AGTATGCATT TGAAGAAAAT AATAATAATG CACCTCTTCA TAAAATAGAT 2640

TCCAGCCAAA TGTTAACAAA TTATCTTGAG TTTGATAGTG TTTTGGATAA CCCCAAAACA 2700

CTTGGGGGTT TCTCTTTCCA AGAGGAACAA GAAAATGCAT CTTCCCAAAC ATATCAACAC 2760

TGGGCACATT CTTTGGATTA TGATAGTTTA GCAAATAAGT CAATCACATA TCAAACACTT 2820

GGAACAACTT CAAATGATGC AAATTCAATT TCCCAAGAAA TTCTGGACTC AGTAAAGAAA 2880

GAAGAATTGA CAGATGAATT ATTAGGTTGT CTGGCTGCAG AACTGTTAGC TCTTGATGAA 2940

AAAGACAATA CCTCTTCCCA AATGATGGCA AATGAAACTG ATCCTGAGAA CCTAAATCTT 3000

GTCCTCAGTA GGAAAGGAAA TACTACGGAA GAACTGGGCA GAGAGACAAC AAATGTCAGA 3060

ATACAGAGGT ATAGAAATGG GTTCGGGATA TATGACAGGG AAGAGAAATT TCTCAACTCA 3120

AATGAAAAGA AGACATTTTC TGAAAATAGT TTAAAGCATG AAGAACCTAT CCTGTGGACT 3180

AAGGGTGAGA TCCTTGGCAA GGGAGCCTAC GGCACAGTAT ACTGTGGTCT CACTAGCCAA 3240

GGGCAGCTAA TAGCTGTAAA ACAGGTGACC TTGGATACCT CTGATAAATT GGCTACTGAA 3300

AAAGAATACC GGAAACTGCA GGAAGAAGTA GATTTACTTA AAGCACTGAA ACATGTCAAC 3360

ATTGTGGCTT ATTTGGGGAC TTGCTTGGAA GAGAACATTG TAAGCATTTT CATGGAGTTT 3420

GTTCCTGGTG GCTCAATTTC TAGTATTATA AACCGTTTTG GACCATTGCC TGAGATGGTG 3480

TTCTGTAAAT ATACAAAACA AATTCTGCAA GGTGTTGCTT ATCTCCATGA GAACTGTGTG 3540

GTCCATCGAG ATATTAAAGG AAATAATGTT ATGCTCATGC CAACTGGAAT CATAAAGCTG 3600

ATCGATTTTG GCTGTGCTAA GCGTTTGGCT TGGGCAGGTT TAAATGGCAC TCACAGTGAC 3660

ATGCTTAAGT CCATGCATGG GACTCCATAT TGGATGGCCC CAGAAGTCAT CAATGAGTCT 3720

GGCTATGGAA GGAAATCAGA CATTTGGAGC ATTGGTTGCA CTGTGTTTGA GATGGCTACA 3780

GGGAAGCCTC CACTGGCTTC CATGGACAGG ATGGCAGCCA TGTTTTACAT TGGAGCCCAC 3840

CGAGGGCTGA TGCCTCCTTT ACCAGACCAC TTCTCAGAAA ATGCATCAGA TTTTGTTCGC 3900

ATGTGCCTGA CCAGGGACCA GCATGAGCGA CCTTCAGCTC TCCAGCTCCT GAAGCACTCC 3960

TTCTTGAAGA GAAATCACTG A 3981

Domain Profile

S: 1     wqkrevigkGsfgsvyaaldvdtgellavKeveikp.ekksekkevkalkeEikllkelk  59

         w+k+e++gkG++g+vy++l+ ++g+l+avK+v++++ +k +++ke+++l+eE++llk+lk

Q: 1059  WTKGEILGKGAYGTVYCGLT-SQGQLIAVKQVTLDTsDKLATEKEYRKLQEEVDLLKALK  1117

         89*****************8.89***********8614556778****************

S: 60    HenivkyyGveveeeelkiflEyvegGslssllekygkleesvikkytkqileglayLHe  119

         H niv y+G++ ee+ ++if+E+v+gGs+ss+++++g+l e+v++kytkqil+g+ayLHe

Q: 1118  HVNIVAYLGTCLEENIVSIFMEFVPGGSISSIINRFGPLPEMVFCKYTKQILQGVAYLHE  1177

         ************************************************************

S: 120   kkivHRDiKgaNilldssgvvklsDFGaskrlaelntkaae...lesltGtlaymaPEvi  176

         +++vHRDiKg+N++l+ +g++kl DFG++krla++  + ++   l+s++Gt+++maPEvi

Q: 1178  NCVVHRDIKGNNVMLMPTGIIKLIDFGCAKRLAWAGLNGTHsdmLKSMHGTPYWMAPEVI  1237

         **********************************999988877899**************

S: 177   kkkekgygrkaDiWslgcvviemltgkrPfaeldeelaimfkvgakk.tkPeipeklsee  235

         +++  gygrk+DiWs+gc+v+em+tgk+P a++ +++a+mf +ga++  +P++p+++se+

Q: 1238  NES--GYGRKSDIWSIGCTVFEMATGKPPLASM-DRMAAMFYIGAHRgLMPPLPDHFSEN  1294

         988..****************************.9**********9979***********

S: 236   gkdflekcleldpkkrpsaeeLLkhefl  263

         + df++ cl++d+++rpsa +LLkh+fl

Q: 1295  ASDFVRMCLTRDQHERPSALQLLKHSFL  1322

         **************************96

Domain Sequence
(FASTA)

WTKGEILGKG AYGTVYCGLT SQGQLIAVKQ VTLDTSDKLA TEKEYRKLQE EVDLLKALKH 60

VNIVAYLGTC LEENIVSIFM EFVPGGSISS IINRFGPLPE MVFCKYTKQI LQGVAYLHEN 120

CVVHRDIKGN NVMLMPTGII KLIDFGCAKR LAWAGLNGTH SDMLKSMHGT PYWMAPEVIN 180

ESGYGRKSDI WSIGCTVFEM ATGKPPLASM DRMAAMFYIG AHRGLMPPLP DHFSENASDF 240

VRMCLTRDQH ERPSALQLLK HSFL 264

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013