EKS-ICT-00446

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ICT-00446

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	335.1	3.0E-100	22	312	291

Status

Unreviewed

Ensembl Protein

ENSSTOP00000017836

UniProt Accession

I3N0E0;

Protein Name

Protein Synonyms/Alias

Gene Name

MAPK4

Gene Synonyms/Alias

MAPK4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSTOG00000022822	ENSSTOP00000017836	ENSSTOT00000021709

Organism

Ictidomys tridecemlineatus

Functional Description

Protein Length

589

Protein Sequence
(FASTA)

MAERGDCFAS VYGYDLGGRF VDFQPLGFGV NGLVLSATDS HTCRKVAVKK IALSDARSMK 60

HALREIKIIR RLDHDNIVKV YEVLGPKGTD LQGELFKFSV AYIVQEYMET DLARLLEQGT 120

LTEEHAKLFM YQLLRGLKYI HSANVLHRDL KPANIFISTE DLVLKIGDFG LARIVDQHYS 180

HKGYLSEGLV TKWYRSPRLL LSPNNYTKAI DMWAAGCILA EMLTGRMLFA GAHELEQMQL 240

ILETIPVIRE EDKDELLRVM PAFVNSTWEV KRPLRKLLPE VNSEAIDFLE KILTFNPMDR 300

LTAEMGLQHP YMSPYSCPED EPISQHPFRI EDEIDDIVLM AASQSQLSNW DRYLVCSSQR 360

YPVSLSSDLE WRPDRRQDSS EVQRDPRAGS APLAEDVQVD PRKDSQSSSE RFLEQSHSSM 420

ERAFETDYGR SCDYKVGSPS YLDKLLWRDN KPHHYSEPKL ILDLSHWKQA AGAPPMAEVA 480

ADAVAHEDEP ASLFLEIAQW VKSTQGGLDR ASPPPDGPER RLSSSPPESQ TPVGASPQFD 540

LDVFISRALK LCTKPEDLPD NKLGDLNGAC ISEHPGDLVQ TEAFSKERW 589

Nucleotide Sequence
(FASTA)

ATGGCCGAGA GAGGAGACTG CTTTGCCAGC GTCTACGGGT ATGACCTGGG TGGGCGCTTT 60

GTTGACTTCC AACCCCTGGG TTTTGGGGTC AACGGGCTCG TGCTGTCAGC CACAGACAGC 120

CACACCTGCC GGAAGGTGGC TGTGAAGAAG ATCGCCCTGA GCGATGCCCG CAGCATGAAG 180

CACGCTCTCC GGGAGATCAA GATCATCCGG CGCTTGGACC ACGACAACAT CGTGAAGGTG 240

TACGAGGTGT TGGGACCCAA GGGCACTGAC CTTCAGGGCG AGCTGTTCAA GTTCAGCGTG 300

GCCTACATCG TCCAGGAGTA CATGGAGACC GACCTGGCGC GCCTGCTGGA GCAGGGCACG 360

CTGACCGAGG AGCACGCCAA GCTGTTCATG TACCAGCTTC TCCGCGGGCT CAAGTACATC 420

CACTCCGCCA ACGTGCTGCA CAGGGACCTG AAGCCCGCCA ACATCTTCAT CAGCACAGAG 480

GACCTCGTGC TGAAGATAGG GGATTTCGGG TTGGCGAGGA TCGTGGATCA GCATTATTCC 540

CACAAGGGTT ATCTGTCAGA GGGGTTGGTG ACGAAGTGGT ACCGCTCTCC ACGACTGCTC 600

CTGTCCCCCA ACAACTACAC AAAAGCCATC GACATGTGGG CGGCCGGCTG CATCCTGGCC 660

GAGATGCTCA CGGGGAGAAT GCTCTTTGCT GGGGCTCACG AGCTGGAGCA GATGCAGCTC 720

ATCCTGGAGA CCATCCCTGT GATCCGGGAA GAAGACAAGG ACGAGCTGCT CAGGGTGATG 780

CCCGCCTTTG TCAACAGCAC CTGGGAGGTG AAGCGGCCCC TGCGCAAGTT ACTCCCCGAA 840

GTGAACAGTG AAGCCATCGA CTTTCTAGAG AAGATCCTGA CCTTTAACCC CATGGATCGC 900

CTAACGGCTG AGATGGGGCT GCAGCACCCT TACATGAGCC CGTACTCCTG TCCCGAGGAC 960

GAACCCATCT CACAACACCC CTTCCGCATT GAGGATGAGA TTGATGACAT CGTGCTGATG 1020

GCTGCCAGTC AGAGTCAGCT CTCCAACTGG GACAGGTACT TGGTGTGTAG CAGCCAAAGG 1080

TACCCGGTGA GTCTGTCCTC AGATCTGGAG TGGCGGCCCG ATCGACGCCA GGACTCCAGC 1140

GAGGTGCAGC GCGACCCGCG CGCTGGGTCG GCGCCGCTGG CCGAGGACGT GCAGGTGGAC 1200

CCGCGCAAGG ACTCCCAGAG CAGTTCCGAG CGCTTCCTGG AGCAGTCTCA CTCGTCCATG 1260

GAGCGCGCCT TCGAGACGGA CTACGGGCGT TCCTGCGACT ACAAGGTGGG GTCGCCGTCC 1320

TACCTGGACA AGCTGCTGTG GCGCGACAAC AAGCCGCACC ACTACTCGGA GCCCAAGCTC 1380

ATCCTGGACC TGTCACACTG GAAGCAAGCA GCCGGCGCGC CCCCGATGGC CGAGGTGGCA 1440

GCGGACGCGG TGGCACACGA GGACGAGCCC GCCAGCCTCT TCCTGGAGAT CGCGCAGTGG 1500

GTCAAGAGCA CGCAGGGCGG CCTGGATCGA GCCAGTCCGC CCCCAGACGG GCCAGAGCGC 1560

CGCCTGTCCT CCTCTCCCCC GGAGAGCCAG ACCCCGGTAG GCGCCAGCCC TCAGTTTGAC 1620

CTGGACGTGT TTATCTCCCG CGCCCTGAAG CTCTGCACCA AGCCAGAGGA TCTGCCTGAC 1680

AATAAATTGG GCGATCTCAA CGGCGCATGC ATCTCTGAGC ACCCAGGAGA CCTTGTGCAG 1740

ACGGAGGCCT TCTCCAAAGA AAGGTGGTGA 1770

Domain Profile

S: 3     slkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNiik  62

         + +plg G +g+v+sa+d++t ++va+kk++  ++++ s+k++lRE+k++++l+h+Ni+k

Q: 22    DFQPLGFGVNGLVLSATDSHTCRKVAVKKIA--LSDARSMKHALREIKIIRRLDHDNIVK  79

         6799**************************9..9**************************

S: 63    lldvftpee.....eleelkdvYlvtelmetdLkkviksqklsdehiklllyqilrglky  117

         +++v+ p+      el +++  Y+v+e+metdL++++++ +l++eh+kl++yq+lrglky

Q: 80    VYEVLGPKGtdlqgELFKFSVAYIVQEYMETDLARLLEQGTLTEEHAKLFMYQLLRGLKY  139

         *******9888888899*******************************************

S: 118   lHsanviHrDlKPsNllvnedc.elkildFGlarsadkekekk..lteyvatrwYraPei  174

         +Hsanv+HrDlKP+N++++++   lki dFGlar+ d+++++k  l+e ++t+wYr+P++

Q: 140   IHSANVLHRDLKPANIFISTEDlVLKIGDFGLARIVDQHYSHKgyLSEGLVTKWYRSPRL  199

         ******************8765169**************999999***************

S: 175   llslkeytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkiese  234

         lls ++ytka+D+W++GCIlaE+ltg++lf+g++e++q+++ile+++  +ee+ +++ +

Q: 200   LLSPNNYTKAIDMWAAGCILAEMLTGRMLFAGAHELEQMQLILETIPVIREEDKDELLRV  259

         **********************************************************95

S: 235   earnyikslpkkkkkdfeelfpkaseealdLleklLvldpdkRisveeaLehpYl  289

          + ++++s+++ k+ ++++l+p+ ++ea+d+lek+L+++p++R+++e+ L+hpY+

Q: 260   -MPAFVNSTWEVKR-PLRKLLPEVNSEAIDFLEKILTFNPMDRLTAEMGLQHPYM  312

         .999**99999887.9**************************************7

Domain Sequence
(FASTA)

DFQPLGFGVN GLVLSATDSH TCRKVAVKKI ALSDARSMKH ALREIKIIRR LDHDNIVKVY 60

EVLGPKGTDL QGELFKFSVA YIVQEYMETD LARLLEQGTL TEEHAKLFMY QLLRGLKYIH 120

SANVLHRDLK PANIFISTED LVLKIGDFGL ARIVDQHYSH KGYLSEGLVT KWYRSPRLLL 180

SPNNYTKAID MWAAGCILAE MLTGRMLFAG AHELEQMQLI LETIPVIREE DKDELLRVMP 240

AFVNSTWEVK RPLRKLLPEV NSEAIDFLEK ILTFNPMDRL TAEMGLQHPY M 291

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity
GO:0000165	; P:MAPK cascade

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR008350	; MAPK_ERK3/4.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR01771

; ERK3ERK4MAPK.

Created Date

20-Feb-2013