EKS-ICT-00189

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ICT-00189

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/MAST	528.4	3.6E-159	389	662	274

Status

Unreviewed

Ensembl Protein

ENSSTOP00000014855

UniProt Accession

I3MRW0;

Protein Name

Protein Synonyms/Alias

Gene Name

MAST3

Gene Synonyms/Alias

MAST3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSTOG00000023373	ENSSTOP00000014855	ENSSTOT00000022251

Organism

Ictidomys tridecemlineatus

Functional Description

Protein Length

1324

Protein Sequence
(FASTA)

MKSRRDKLHI PALTLDLSPS SQSPSLLSPS SPCSPCSPSL GLHPWSCRSG NRKSLVVGTP 60

SPTLSRPLSP LSVPTAGSSP LDSPRNFSAA SAINFPFARR ADGRRWSLAS LPSSGYGTNT 120

PSSTVSSSSS SRERLHQLPF QPTPDELCFL SKHFRSSESV ADEEGHRSPR LRPRSRSLSP 180

GRTSGTFDNE IVMMNHVYRE RFPKATAQME GRLQEFLVAN ATGARLALAD GVLGFIHHQI 240

VELARDCLAK SGENLVTSRY FLEMQEKLER LLQDAHERSD SEEVGFIVQL VRKLLIIISR 300

PARLLECLEF DPEEFYHLLE AAEGQAREGQ GIKTDLPQYI IGQLGLAKDP LEEIEPLSHL 360

DGGQPPAPES PESRALVGPS RRKPCESDFE TIKLISNGAY GAVYLVRHRD TRQRFAIKKI 420

NKQNLILRNQ IQQVFVERDI LTFAENPFVV SMFCSFETRR HLCMVMEYVE GGDCATLLKN 480

MGPLPVDMAR MYFAETVLAL EYLHNYGIVH RDLKPDNLLI TSLGHIKLTD FGLSKIGLMS 540

MATNLYEGHI EKDAREFVDK QVCGTPEYIA PEVIFRQGYG KPVDWWAMGI ILYEFLVGCV 600

PFFGDTPEEL FGQVVSDEII WPEGDEALPA DAQDLITRLL RQSPLDRLGT GGTHEVKQHP 660

FFLALDWAGL LRHKAEFVPQ LEAEDDTSYF DTRSERYRHL GSEDEETNDE ESSTEIPQFS 720

SCSHRFSKVY SSSEFLAVQP TPTFTERSYS EDREEGWERS SEGENGRRPS TEVRLRSWTS 780

SGSSCHSSQP ERGPSPCLLS TISLDTMPKF AFSSEDEGAG AASGDPKKPV FILGEPDPPP 840

PAAPAVPKPS SLSADTAALS HARLRSNSTG ARHSTPRPLD AGRGRRLGGP RDPGPEKSRA 900

SPSSGGGSGG RVPKSASVSA LSLIITADDG SGGPLMSPLS PRSLSSNPSS RDSSPSRDPS 960

PVCGSLRPPI VIHSSGKKYG FSLRAIRVYM GDSDVYTVHH VVWSVEDGSP AQEAGLRAGD 1020

LLTHINGESV LGLVHMDVVE LLLKSGNKLS LRTTALENTS IKVGPARKNV AKGRMARRSK 1080

RSRRRETQDR RKSLFKKISK QPASALHTSR SFSSGLHHSL SSSESLPGSP THSLSPSPTT 1140

PCRSPAPDAP ADTASPPSVS PSSSSPASPA AAGHTRPSSL HGLAAKLGPP RHKTGRRKST 1200

SSIPPSPLAC PPVAAAPPRS PSPLPGHPTP RSPRLRRGQS ADKLGTGERL DAEPGRRSRG 1260

QDSELVVMRR LHLSERRDSF KKQEAVQEVS FDEPPEEGAV LLAAVPQIAV EGAESAPGAP 1320

AAKD 1324

Nucleotide Sequence
(FASTA)

ATGAAGTCCC GCAGGGACAA GCTGCACATC CCGGCGCTGA CCCTCGATCT GTCTCCGAGC 60

AGCCAGAGCC CGTCGCTGCT GAGCCCCAGC AGCCCCTGCA GCCCCTGTAG CCCCTCCCTG 120

GGCCTGCACC CCTGGAGCTG CCGCAGCGGG AACCGCAAAA GCTTGGTCGT GGGAACACCG 180

TCACCGACTC TATCCCGGCC CCTGTCACCA CTGTCTGTCC CAACCGCAGG CAGCAGCCCC 240

CTGGACAGTC CCCGGAACTT CTCCGCTGCA TCTGCCATTA ACTTCCCCTT TGCCCGGAGG 300

GCAGACGGCA GAAGATGGTC CCTGGCGTCT CTCCCGTCTT CCGGCTATGG AACCAACACG 360

CCCAGCTCCA CCGTTTCGTC AAGCTCGTCC TCCAGGGAGC GTCTCCACCA GCTTCCCTTC 420

CAGCCCACGC CGGACGAGCT CTGCTTCCTG TCCAAGCACT TCCGCAGCTC AGAGAGTGTG 480

GCTGATGAGG AGGGCCACCG CTCCCCGCGC CTGCGCCCCC GCTCCCGCAG CCTCAGTCCT 540

GGGCGCACAT CAGGGACCTT CGACAATGAG ATCGTCATGA TGAATCACGT GTACCGGGAG 600

AGGTTTCCCA AGGCCACAGC ACAGATGGAG GGCCGCCTGC AGGAGTTCCT AGTAGCCAAT 660

GCGACCGGCG CCCGGCTGGC CCTGGCGGAC GGCGTCCTGG GCTTCATCCA TCACCAGATC 720

GTCGAGCTGG CCCGAGACTG CCTGGCCAAG TCTGGCGAGA ACCTGGTCAC CTCCCGCTAC 780

TTCTTGGAGA TGCAGGAGAA GCTGGAGCGG CTGCTGCAGG ACGCGCATGA GCGCTCGGAC 840

AGCGAGGAGG TCGGCTTCAT CGTCCAGCTC GTCCGCAAAC TGCTCATCAT CATCTCGCGG 900

CCGGCCCGGC TCCTCGAGTG CCTGGAGTTC GATCCGGAGG AGTTTTACCA TTTGCTGGAG 960

GCGGCCGAGG GCCAGGCCCG GGAGGGCCAG GGCATCAAGA CGGACCTGCC GCAGTACATC 1020

ATCGGGCAGC TGGGCCTGGC CAAGGACCCG CTGGAGGAGA TTGAGCCTCT GAGTCACCTC 1080

GACGGAGGAC AGCCCCCAGC ACCCGAGTCC CCAGAGAGCC GTGCCCTGGT CGGCCCATCC 1140

CGGAGGAAGC CCTGTGAGAG TGACTTTGAG ACCATCAAGC TCATCAGCAA CGGGGCCTAC 1200

GGGGCTGTCT ACCTGGTGCG ACACCGCGAC ACGCGGCAGC GCTTCGCCAT CAAGAAGATC 1260

AATAAGCAGA ACTTGATCCT GCGCAACCAG ATCCAGCAGG TGTTCGTGGA GCGCGACATC 1320

CTCACCTTCG CCGAGAACCC CTTTGTGGTC AGCATGTTCT GCTCCTTCGA GACGCGGCGC 1380

CACCTGTGCA TGGTCATGGA GTATGTGGAA GGCGGTGACT GCGCCACCCT CCTGAAGAAC 1440

ATGGGCCCGC TGCCCGTGGA CATGGCCCGC ATGTACTTCG CGGAGACGGT GCTGGCGCTC 1500

GAGTACCTGC ACAACTACGG CATCGTGCAC CGCGACCTCA AGCCCGACAA CCTGCTCATC 1560

ACCTCCCTCG GCCACATCAA GCTGACCGAT TTCGGCCTGT CCAAAATCGG CCTCATGAGC 1620

ATGGCCACCA ACCTCTACGA GGGCCACATT GAGAAGGACG CCCGCGAGTT TGTGGACAAG 1680

CAGGTGTGCG GGACCCCCGA GTACATCGCC CCCGAGGTCA TCTTCCGCCA GGGCTACGGG 1740

AAGCCGGTGG ACTGGTGGGC CATGGGGATC ATCCTCTATG AGTTCCTGGT GGGCTGCGTG 1800

CCCTTCTTCG GAGACACCCC TGAAGAGCTC TTCGGCCAGG TGGTCAGCGA TGAGATCATA 1860

TGGCCCGAGG GGGACGAGGC CCTCCCGGCG GATGCCCAGG ACCTCATCAC CAGGCTGTTG 1920

CGGCAGAGCC CCCTGGACCG GCTGGGCACC GGTGGCACCC ACGAGGTGAA GCAGCACCCC 1980

TTCTTCCTGG CCCTGGACTG GGCGGGGCTC CTGCGACACA AGGCCGAGTT TGTCCCGCAG 2040

CTGGAAGCCG AGGACGACAC CAGCTACTTC GACACGCGTT CAGAACGGTA CCGCCACCTG 2100

GGCTCCGAGG ATGAGGAGAC CAACGACGAG GAGTCCTCCA CTGAGATCCC CCAGTTCTCC 2160

TCCTGCTCCC ACCGGTTCAG CAAGGTCTAC AGCAGCTCTG AGTTCCTGGC CGTCCAGCCC 2220

ACACCTACCT TCACTGAGAG GAGCTACAGT GAGGACCGAG AGGAAGGGTG GGAGCGCAGC 2280

AGCGAAGGGG AGAATGGCCG TCGGCCGAGC ACTGAAGTCC GGCTAAGGTC CTGGACGTCC 2340

TCCGGTTCCT CCTGTCACTC GTCGCAGCCT GAGCGGGGCC CCAGCCCATG CCTCCTGAGC 2400

ACCATCAGCC TAGACACGAT GCCCAAGTTT GCCTTCTCTT CAGAGGACGA GGGGGCGGGC 2460

GCAGCCTCTG GGGACCCTAA GAAGCCCGTC TTCATTCTGG GGGAGCCCGA CCCCCCTCCG 2520

CCAGCCGCCC CAGCGGTGCC CAAGCCCTCA AGCCTTTCCG CTGACACAGC GGCCCTGAGC 2580

CACGCGCGCC TGCGGAGCAA CAGCACGGGC GCCCGCCACT CCACGCCGCG GCCCCTGGAT 2640

GCCGGCCGGG GCCGCCGCCT CGGGGGCCCG AGGGACCCAG GCCCCGAGAA GTCCCGGGCC 2700

TCCCCCAGCA GTGGCGGGGG CAGCGGGGGA CGTGTGCCCA AGTCAGCGTC CGTCTCCGCC 2760

CTGTCGCTCA TCATCACAGC AGATGACGGC AGCGGTGGCC CCCTCATGAG CCCCCTGTCC 2820

CCGCGCTCCC TGTCCTCGAA CCCGTCCTCC CGAGACTCCT CGCCCAGCCG GGACCCGTCC 2880

CCCGTGTGCG GCAGCCTGCG GCCTCCCATC GTCATCCACA GCTCCGGCAA GAAGTACGGC 2940

TTCAGCTTGC GCGCCATCCG CGTCTACATG GGTGACAGTG ACGTCTACAC CGTGCACCAC 3000

GTTGTCTGGA GCGTGGAGGA CGGGAGCCCC GCCCAGGAGG CGGGCCTGCG CGCCGGCGAC 3060

CTGCTCACGC ATATCAACGG GGAGTCGGTG CTGGGGCTGG TGCACATGGA CGTGGTGGAG 3120

CTGCTGCTGA AGAGCGGTAA CAAGCTCTCC CTGCGGACCA CGGCCCTGGA GAACACGTCC 3180

ATCAAGGTGG GCCCGGCGCG GAAGAACGTG GCCAAGGGCC GCATGGCGCG CAGGAGCAAG 3240

CGGAGCCGCC GGCGGGAGAC CCAGGACCGG CGAAAGTCGC TCTTCAAGAA GATCTCCAAG 3300

CAGCCGGCCT CCGCGCTGCA CACCAGCCGC AGCTTCTCCT CCGGCCTCCA CCACTCGCTG 3360

TCCTCCAGCG AGAGCCTCCC GGGCTCGCCC ACGCACAGCC TCTCCCCCAG CCCCACCACG 3420

CCCTGCCGCA GCCCCGCCCC CGACGCCCCA GCAGATACCG CATCCCCACC CAGCGTGTCC 3480

CCGAGCTCCA GCAGCCCTGC CTCCCCAGCC GCTGCTGGCC ACACCCGCCC CAGCTCCCTG 3540

CACGGCCTGG CTGCCAAACT GGGGCCGCCA CGCCACAAGA CTGGCCGCCG CAAGTCCACG 3600

AGCAGCATCC CTCCGTCCCC GCTGGCCTGT CCACCCGTGG CTGCAGCCCC ACCGCGCTCG 3660

CCCTCGCCCC TGCCCGGGCA CCCCACCCCC CGGTCCCCGC GGCTGCGTCG GGGCCAGTCA 3720

GCCGACAAGC TGGGCACAGG GGAGCGGCTG GATGCAGAGC CCGGGCGCCG CAGCCGCGGG 3780

CAGGACTCGG AGCTGGTGGT GATGCGGCGG CTGCACCTGT CCGAGCGCCG AGACTCCTTC 3840

AAGAAGCAGG AGGCGGTGCA GGAGGTGAGC TTCGACGAGC CGCCGGAGGA GGGCGCTGTG 3900

CTGCTCGCCG CGGTGCCGCA GATCGCCGTG GAAGGCGCCG AGAGCGCGCC CGGAGCCCCG 3960

GCCGCGAAGG ACTGA 3975

Domain Profile

S: 1     feiiklisrGayGavylvrhketrkrfavkkikkqdlilknqvqqvfaerdilalaenpf  60

         fe+iklis+GayGavylvrh++tr+rfa+kki+kq+lil+nq+qqvf+erdil++aenpf

Q: 389   FETIKLISNGAYGAVYLVRHRDTRQRFAIKKINKQNLILRNQIQQVFVERDILTFAENPF  448

         99**********************************************************

S: 61    vvslyysletrrnlylvmeyveGGdvksllkniGaldvemarlyiaevvlaleylhryGi  120

         vvs+++s+etrr+l++vmeyveGGd+++llkn+G+l+v+mar+y+ae+vlaleylh+yGi

Q: 449   VVSMFCSFETRRHLCMVMEYVEGGDCATLLKNMGPLPVDMARMYFAETVLALEYLHNYGI  508

         ************************************************************

S: 121   vhrdlkPdnllitseGhikltdfGlskvglmslttnlyegyidkdarefldkqvcgtPey  180

         vhrdlkPdnllits GhikltdfGlsk+glms++tnlyeg+i+kdaref+dkqvcgtPey

Q: 509   VHRDLKPDNLLITSLGHIKLTDFGLSKIGLMSMATNLYEGHIEKDAREFVDKQVCGTPEY  568

         ************************************************************

S: 181   iaPevilrqgygkpvdwwalgiilyeflvgivpffgdtpeelfaqvlsdeivwPekdeal  240

         iaPevi+rqgygkpvdwwa+giilyeflvg+vpffgdtpeelf+qv+sdei+wPe+deal

Q: 569   IAPEVIFRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVVSDEIIWPEGDEAL  628

         ************************************************************

S: 241   ssealelisellesnPrerlgtgsaaevkqhefl  274

         +++a++li++ll+++P +rlgtg+++evkqh+f+

Q: 629   PADAQDLITRLLRQSPLDRLGTGGTHEVKQHPFF  662

         ********************************97

Domain Sequence
(FASTA)

FETIKLISNG AYGAVYLVRH RDTRQRFAIK KINKQNLILR NQIQQVFVER DILTFAENPF 60

VVSMFCSFET RRHLCMVMEY VEGGDCATLL KNMGPLPVDM ARMYFAETVL ALEYLHNYGI 120

VHRDLKPDNL LITSLGHIKL TDFGLSKIGL MSMATNLYEG HIEKDAREFV DKQVCGTPEY 180

IAPEVIFRQG YGKPVDWWAM GIILYEFLVG CVPFFGDTPE ELFGQVVSDE IIWPEGDEAL 240

PADAQDLITR LLRQSPLDRL GTGGTHEVKQ HPFF 274

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR015022	; MA_Ser/Thr_Kinase_dom.
IPR023142	; MAST_pre-PK_dom.
IPR001478	; PDZ.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF08926	; DUF1908; 1.
PF00595	; PDZ; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00228	; PDZ; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS50106	; PDZ; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013