EKS-ICT-00359

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ICT-00359

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/MLK	316.1	1.7E-94	161	396	236

Status

Unreviewed

Ensembl Protein

ENSSTOP00000017858

UniProt Accession

I3N0G2;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP3K12

Gene Synonyms/Alias

MAP3K12;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSTOG00000023587	ENSSTOP00000017858	ENSSTOT00000028735

Organism

Ictidomys tridecemlineatus

Functional Description

Protein Length

885

Protein Sequence
(FASTA)

MACLHETRTP SPSFGGFVST LSEASMRKLD PDTSDCTPEK DLTPTQCVLR DVVPLGGQGA 60

GGPSPSPGGE PPPEPFANSV LQLHEQETGG SGGATGSPES RASRVRADEV RLQCQSGSGF 120

LEGLFGCLRP VWTMIGKAYS TEHKQQQEDL WEVPFEEILD LQWVGSGAQG AVFLGRFHGE 180

EVAVKKVRDL KETDIKHLRK LKHPNIITFK GVCTQAPCYC ILMEFCAQGQ LYEVLRAGRP 240

VTPSLLVDWS MGIAGGMNYL HLHKIIHRDL KSPNMLITYD DVVKISDFGT SKELSDKSTK 300

MSFAGTVAWM APEVIRNEPV SEKVDIWSFG VVLWELLTGE IPYKDVDSSA IIWGVGSNSL 360

HLPVPSSCPD GFKILLRQCW NSKPRNRPSF RQILLHLDIA SADVLSTPQE TYFKSQAEWR 420

EEVKLHFEKI KSEGTCLHRL EEELVMRRRE ELRHALDIRE HYERKLERAN NLYMELNALM 480

LQLELKEREL LRREQALERR CPGLLKPHPS RGLLHGNTME KLIKKRNVPQ KLSPHSKRPD 540

ILKTESLLPK LDAALSGVGL PGCPKGPPSP GRSRRGKTRH RKSSAKGSCG DLPGLRAAVP 600

PHEPGGPGSP GGLGAGPSAW EACPPALRGL HHDLLLRKMS SSSPDLLSAA LGARGRGSTG 660

AGDPGSPPPA RGDTPPSEGS APGSTSPESP GGAKGEPPPP VGPGEGVGLL GTGREGTAGR 720

GGSRAGSQHL TPAALLYRAA VTRSQKRGIS SEEEEGEVDS EVELTSSQRW PQGMNMRQSL 780

STFSSENPSD GEEGTASEPS PSGTPEVGST NTDERPDERS DDMCSQGSEI PLDPPASEAV 840

PDPSSQPIPH QDLGPPNSED SDCDSTELDN SNSVDALRPP SSLPP 885

Nucleotide Sequence
(FASTA)

ATGGCCTGCC TCCATGAGAC CCGCACACCC TCCCCTTCTT TTGGGGGCTT CGTGTCTACC 60

CTAAGTGAGG CTTCCATGCG CAAGTTGGAC CCAGACACTT CAGACTGCAC CCCTGAGAAG 120

GACCTGACAC CCACCCAGTG TGTACTTCGT GATGTAGTGC CTCTTGGTGG ACAGGGCGCA 180

GGTGGGCCCA GCCCCTCCCC AGGTGGAGAG CCACCTCCTG AGCCTTTTGC CAATAGTGTC 240

CTGCAGCTAC ATGAGCAGGA AACAGGGGGT TCAGGAGGAG CCACTGGATC ACCTGAGAGT 300

CGGGCATCTA GAGTCCGAGC TGACGAGGTG AGGCTACAGT GCCAGAGTGG CAGTGGCTTC 360

CTTGAAGGCC TCTTCGGCTG CCTGCGCCCA GTCTGGACCA TGATTGGCAA AGCCTACTCC 420

ACGGAACACA AGCAGCAGCA GGAAGACCTT TGGGAGGTTC CTTTTGAGGA AATCCTGGAC 480

CTGCAGTGGG TAGGCTCCGG GGCCCAGGGA GCTGTCTTCC TGGGGCGCTT CCATGGGGAG 540

GAGGTAGCTG TGAAGAAAGT ACGAGACCTC AAGGAGACCG ACATCAAGCA CCTGCGAAAG 600

CTGAAGCACC CCAACATCAT CACTTTCAAG GGTGTGTGTA CCCAGGCGCC CTGCTACTGC 660

ATCCTCATGG AGTTCTGCGC CCAGGGCCAG CTATATGAGG TGCTGCGGGC TGGCCGCCCT 720

GTCACCCCGT CCTTGCTGGT TGACTGGTCC ATGGGCATTG CCGGAGGCAT GAACTACCTG 780

CACCTGCACA AGATCATCCA CAGAGACCTC AAGTCCCCCA ACATGCTAAT CACATATGAC 840

GACGTGGTGA AGATCTCAGA TTTTGGCACT TCCAAGGAGC TGAGTGACAA GAGCACCAAG 900

ATGTCCTTTG CAGGGACGGT AGCCTGGATG GCCCCTGAGG TGATCCGCAA TGAGCCTGTG 960

TCTGAGAAGG TTGACATCTG GTCCTTTGGT GTGGTGCTAT GGGAACTCCT GACTGGTGAG 1020

ATCCCTTACA AAGATGTAGA TTCCTCAGCC ATCATCTGGG GTGTAGGAAG CAACAGTCTC 1080

CATCTGCCTG TACCCTCCAG CTGCCCAGAT GGCTTCAAAA TCTTACTTCG TCAGTGCTGG 1140

AACAGCAAAC CAAGAAATCG TCCATCATTC CGACAGATCC TGCTGCATCT GGACATTGCC 1200

TCAGCTGACG TACTCTCCAC ACCCCAGGAG ACTTACTTTA AGTCCCAGGC AGAGTGGAGG 1260

GAAGAGGTAA AGCTGCACTT TGAGAAGATC AAGTCTGAAG GAACCTGTCT GCACCGCCTA 1320

GAAGAGGAGC TGGTAATGAG GAGGAGGGAG GAGCTCAGAC ATGCCCTGGA TATCAGGGAG 1380

CACTATGAAC GGAAATTGGA GAGAGCTAAC AACCTATACA TGGAACTAAA TGCCCTCATG 1440

TTGCAGCTGG AACTCAAGGA GCGGGAGCTG CTCAGGCGAG AACAAGCTTT AGAGCGGAGA 1500

TGCCCAGGGC TGCTAAAGCC ACACCCTTCT CGGGGCCTCC TTCATGGGAA CACAATGGAG 1560

AAACTCATCA AGAAGAGGAA TGTGCCACAG AAACTGTCAC CCCATAGCAA AAGGCCAGAT 1620

ATCCTGAAGA CAGAGTCCTT GCTACCTAAA CTAGATGCAG CACTAAGTGG CGTGGGGCTT 1680

CCAGGGTGTC CTAAGGGTCC CCCCTCACCA GGACGGAGTC GCCGTGGCAA GACACGTCAC 1740

CGCAAGTCCA GCGCCAAGGG CAGCTGTGGG GACCTCCCTG GGCTTCGTGC AGCTGTGCCA 1800

CCCCATGAAC CTGGAGGACC AGGAAGCCCA GGGGGCCTAG GAGCAGGACC CTCAGCTTGG 1860

GAGGCTTGTC CTCCTGCCCT CCGTGGGCTC CACCATGACC TTCTGCTCCG CAAGATGTCT 1920

TCTTCATCCC CAGACCTGCT GTCAGCAGCA CTGGGAGCTC GGGGTCGGGG GTCCACAGGA 1980

GCTGGGGATC CTGGCTCACC ACCTCCAGCC CGCGGTGACA CCCCCCCAAG TGAAGGCTCA 2040

GCCCCTGGTT CCACCAGCCC TGAGTCACCT GGGGGGGCCA AAGGGGAGCC GCCTCCACCA 2100

GTAGGGCCTG GCGAAGGTGT AGGGCTGCTG GGAACTGGAA GGGAAGGGAC AGCGGGCCGG 2160

GGAGGAAGCC GGGCTGGGTC CCAGCACTTG ACTCCAGCTG CACTGCTCTA CAGGGCTGCT 2220

GTCACTCGGA GTCAGAAACG AGGAATCTCT TCAGAAGAGG AAGAAGGAGA AGTAGACAGT 2280

GAAGTAGAGC TGACATCAAG CCAGAGGTGG CCTCAGGGCA TGAATATGCG CCAGTCACTA 2340

TCTACCTTCA GCTCAGAGAA TCCATCAGAT GGGGAGGAGG GCACAGCTAG TGAGCCTTCC 2400

CCCAGTGGCA CACCTGAAGT TGGCAGCACC AACACTGATG AACGGCCAGA TGAACGGTCT 2460

GACGACATGT GTTCCCAGGG TTCAGAAATC CCACTGGACC CACCTGCCTC AGAGGCTGTT 2520

CCTGACCCTT CCTCCCAGCC CATACCACAT CAGGACCTAG GCCCTCCTAA TTCTGAGGAC 2580

TCAGACTGTG ACAGCACTGA ATTGGACAAC TCCAACAGCG TTGATGCCTT GCGGCCCCCA 2640

TCCTCACTCC CTCCA 2655

Domain Profile

S: 4     eeligsgafgkvykakwrkkevavKklreeaeekekleklereakllsklshpniiellG  63

          +++gsga+g+v+ ++++++evavKk+r+ +e+         ++k+l+kl+hpnii+++G

Q: 161   LQWVGSGAQGAVFLGRFHGEEVAVKKVRDLKET---------DIKHLRKLKHPNIITFKG  211

         689**************************9999.........******************

S: 64    vcleepnlllvmeyveggsLsnvlhekskreidlevlvswalqiArGmaYLhseapkkii  123

         vc++ p+++++me++++g+L++vl++   r ++++ lv+w++ iA Gm+YLh +   kii

Q: 212   VCTQAPCYCILMEFCAQGQLYEVLRA--GRPVTPSLLVDWSMGIAGGMNYLHLH---KII  266

         **************************..99************************...9**

S: 124   hrdLksknvLlseekktlkicdFGtarelsk.stkmsaagtlawmaPEvlkeekvseksD  182

         hrdLks+n+L+ + ++++ki+dFGt++els+ stkms+agt+awmaPEv+++e+vsek+D

Q: 267   HRDLKSPNMLI-TYDDVVKISDFGTSKELSDkSTKMSFAGTVAWMAPEVIRNEPVSEKVD  325

         ***********.99****************99****************************

S: 183   vwSygvvLWelltrevPykdlselaiaykvalkglrlpipsscpeklkkLmkecwnedpe  242

         +wS+gvvLWellt+e+Pykd+++ ai+++v++++l+lp+psscp+ +k L+++cwn++p+

Q: 326   IWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSKPR  385

         ************************************************************

S: 243   kRpsfseivks  253

         +Rpsf++i+ +

Q: 386   NRPSFRQILLH  396

         ********876

Domain Sequence
(FASTA)

LQWVGSGAQG AVFLGRFHGE EVAVKKVRDL KETDIKHLRK LKHPNIITFK GVCTQAPCYC 60

ILMEFCAQGQ LYEVLRAGRP VTPSLLVDWS MGIAGGMNYL HLHKIIHRDL KSPNMLITYD 120

DVVKISDFGT SKELSDKSTK MSFAGTVAWM APEVIRNEPV SEKVDIWSFG VVLWELLTGE 180

IPYKDVDSSA IIWGVGSNSL HLPVPSSCPD GFKILLRQCW NSKPRNRPSF RQILLH 236

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004709	; F:MAP kinase kinase kinase activity
GO:0000186	; P:activation of MAPKK activity
GO:0000165	; P:MAPK cascade
GO:0046777	; P:protein autophosphorylation

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR017419	; MAP3K12_MAP3K13.
IPR000719	; Prot_kinase_cat_dom.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF07714

; Pkinase_Tyr; 1.

SMARTs

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013