EKS-ICT-00347

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ICT-00347

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	448.4	6.1E-135	269	518	250

Status

Unreviewed

Ensembl Protein

ENSSTOP00000017613

UniProt Accession

I3MRX6;

Protein Name

Protein Synonyms/Alias

Gene Name

SRC

Gene Synonyms/Alias

SRC;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSTOG00000023905	ENSSTOP00000014871	ENSSTOT00000019470
ENSSTOG00000023905	ENSSTOP00000017613	ENSSTOT00000022804

Organism

Ictidomys tridecemlineatus

Functional Description

Protein Length

535

Protein Sequence
(FASTA)

MGSNKSKPKD ASQRRRSLEP AESTHAAGGA FPASQTPSKP ASADGLRGPG AAFAPAAAEP 60

KLFGGFNSSD TVTSPQRAGP LAGGVTTFVA LYDYESRTET DLSFKKGERL QIVNNTEGDW 120

WLAHSLSTGQ TGYIPSNYVA PSDSIQAEEW YFGKITRRES ERLLLNTENP RGTFLVRESE 180

TTKGAYCLSV SDFDNAKGLN VKHYKIRKLD SGGFYITSRT QFNSLQQLVA YYSKHADGLC 240

HRLTTVCPTS KPQTQGLAKD AWEIPRESLR LEVKLGQGCF GEVWMGTWNG TTRVAIKTLK 300

PGTMSPEAFL QEAQVMKKLR HEKLVQLYAV VSEEPIYIVT EYMSKGSLLD FLKGETGKYL 360

RLPQLVDMAA QIASGMAYVE RMNYVHRDLR AANILVGENL VCKVADFGLA RLIEDNEYTA 420

RQGAKFPIKW TAPEAALYGR FTIKSDVWSF GILLTELTTK GRVPYPGMVN REVLDQVERG 480

YRMPCPPECP ESLHDLMCQC WRKEPEERPT FEYLQAFLED YFTSTEPQYQ PGENL 535

Nucleotide Sequence
(FASTA)

ATGGGTAGCA ACAAGAGCAA GCCGAAGGAC GCCAGCCAGC GGCGCCGCAG CCTGGAGCCG 60

GCCGAGAGCA CCCACGCGGC GGGCGGCGCC TTCCCGGCCT CGCAGACGCC CAGCAAGCCG 120

GCCTCCGCCG ACGGCCTCCG CGGCCCGGGC GCCGCCTTCG CCCCCGCGGC CGCCGAGCCC 180

AAGCTCTTCG GGGGCTTCAA CTCGTCGGAC ACCGTCACCT CCCCGCAGAG GGCGGGGCCC 240

CTGGCCGGCG GAGTGACCAC CTTTGTGGCC CTCTATGACT ATGAGTCACG GACAGAGACC 300

GACCTGTCCT TCAAGAAAGG GGAGCGGCTC CAGATTGTCA ACAACACAGA GGGAGACTGG 360

TGGCTGGCCC ACTCGCTCAG CACGGGACAG ACCGGCTACA TCCCCAGCAA CTACGTGGCG 420

CCTTCCGACT CCATCCAGGC TGAGGAATGG TATTTTGGCA AGATCACCAG GCGGGAGTCG 480

GAGCGGCTGC TGCTTAACAC GGAGAACCCA AGGGGGACCT TCCTGGTGCG AGAGAGCGAG 540

ACCACGAAAG GTGCCTACTG CCTCTCCGTG TCCGACTTTG ACAACGCCAA GGGCCTCAAC 600

GTGAAGCACT ACAAGATCCG CAAGCTGGAC AGCGGGGGCT TCTACATCAC CTCCCGCACC 660

CAGTTCAACA GCCTGCAGCA GCTGGTGGCC TACTACTCCA AACATGCAGA CGGCCTGTGC 720

CACCGCCTCA CCACCGTGTG CCCCACGTCC AAGCCGCAGA CCCAGGGCCT GGCCAAGGAC 780

GCCTGGGAGA TCCCCCGGGA GTCGCTGCGG CTGGAGGTCA AGCTGGGCCA GGGCTGCTTC 840

GGGGAGGTGT GGATGGGAAC CTGGAACGGC ACCACCAGGG TGGCCATCAA GACCCTGAAG 900

CCGGGCACCA TGTCCCCAGA GGCCTTCCTG CAGGAGGCCC AGGTCATGAA GAAGCTGCGG 960

CACGAGAAGC TGGTGCAGCT GTACGCCGTG GTGTCGGAGG AGCCCATCTA CATCGTCACG 1020

GAGTACATGA GCAAGGGGAG TTTGCTGGAC TTCCTCAAGG GGGAGACGGG CAAGTACCTG 1080

CGCCTGCCAC AGCTGGTGGA CATGGCCGCT CAGATCGCCT CGGGCATGGC ATACGTGGAG 1140

CGGATGAACT ACGTGCACCG GGACCTCCGC GCCGCTAACA TCCTGGTCGG GGAGAACCTG 1200

GTGTGCAAGG TGGCCGACTT CGGGCTGGCC CGGCTCATCG AGGACAACGA GTACACGGCC 1260

CGGCAAGGGG CCAAATTCCC CATCAAGTGG ACGGCTCCAG AAGCCGCCCT CTACGGCCGG 1320

TTCACCATCA AGTCAGATGT GTGGTCCTTT GGAATCTTGC TGACGGAGCT CACGACAAAG 1380

GGACGAGTGC CCTACCCTGG GATGGTGAAT CGCGAGGTGC TGGATCAAGT CGAGCGGGGC 1440

TACCGGATGC CCTGCCCGCC CGAGTGTCCC GAGTCCCTGC ACGACCTCAT GTGCCAGTGC 1500

TGGCGGAAGG AGCCCGAGGA GAGGCCCACC TTTGAGTACC TGCAGGCCTT CCTGGAGGAC 1560

TACTTCACGT CCACGGAGCC CCAGTACCAG CCCGGGGAGA ACCTA 1605

Domain Profile

S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60

         l+l+ klG+G+fGevw+g+w+g+++va+ktlk+gt+speafl+eaq++kklrheklv+ly

Q: 269   LRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLY  328

         68999*******************************************************

S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120

         avvse ePiyivte+m+kGslldflk e+gk+l+lp+lvd+aaq+a+Gmay+e++n++hr

Q: 329   AVVSE-EPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHR  387

         ****9.******************************************************

S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180

         dl+a+n+lvge+lv+kvadfGlarlied+eyta++gak+PikWtaPea+ +g+ftiksdv

Q: 388   DLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDV  447

         ************************************************************

S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240

         WsfGillte++tkG+vPypGm n+evl+qvergyr+p+p ecpe+l++l+++cw+k+pee

Q: 448   WSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEE  507

         ************************************************************

S: 241   rPtfetlqevl  251

         rPtfe+lq++l

Q: 508   RPTFEYLQAFL  518

         *******9876

Domain Sequence
(FASTA)

LRLEVKLGQG CFGEVWMGTW NGTTRVAIKT LKPGTMSPEA FLQEAQVMKK LRHEKLVQLY 60

AVVSEEPIYI VTEYMSKGSL LDFLKGETGK YLRLPQLVDM AAQIASGMAY VERMNYVHRD 120

LRAANILVGE NLVCKVADFG LARLIEDNEY TARQGAKFPI KWTAPEAALY GRFTIKSDVW 180

SFGILLTELT TKGRVPYPGM VNREVLDQVE RGYRMPCPPE CPESLHDLMC QCWRKEPEER 240

PTFEYLQAFL 250

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013