EKS-ICT-00282

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ICT-00282

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/EGFR	456.4	2.4E-137	680	936	257

Status

Unreviewed

Ensembl Protein

ENSSTOP00000023609

UniProt Accession

I3NGW2;

Protein Name

Protein Synonyms/Alias

Gene Name

ERBB3

Gene Synonyms/Alias

ERBB3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSTOG00000024297	ENSSTOP00000023609	ENSSTOT00000027284

Organism

Ictidomys tridecemlineatus

Functional Description

Protein Length

1314

Protein Sequence
(FASTA)

VCPGTLNGLS VTGDAENQYQ TLHNLYERCE VVMGNLEIVL TGHNADLSFL QWIREVTGYV 60

LVAMNEFSTL PLPNLRVVRG TQVYDGKFAI FVMLNYNTNS SHALRQLRFT QLTEILSGGV 120

YIEKNDKLCH MDTIDWRDIV RDRDAEIVVK DNGRNCLPCH EVCKGRCWGP GPEDCQTLTK 180

TICAPQCNGH CFGPNPNQCC HDECAGGCSG PQDTDCFACR HFNDSGACVP RCPQPLVYNK 240

LTFQLEPNPH TKYQYGGVCV ASCPHNFVVD QTSCVRACPP DKMEVDKNGL KICEPCGGLC 300

PKACEGTGSG SRYQTVDSSN IDGFVNCTKI LGNLDFLITG LNGDPWHKIP ALDPEKLNVF 360

RTVREITGYL NIQSWPPHMH NFSVFSNLTT IGGRSLYNRG FSLLIMKNLN VTSLGLRSLK 420

EISAGRIYIS ANRQLCYHHS LNWTRLLRGP AEERLDIKHN RPRRDCVAEG KVCDPLCSAG 480

GCWGPGPGQC LSCRNYSRGG VCVTHCNFLN GEPREFAQEA ECFSCHPECQ PMEGIATCNG 540

SGSDACAQCA HFRDGPHCVS SCPHGVLGAK GPIYKYPDVQ NECRPCHENC TQGCKGPELK 600

DCLGQTLVLI SKTHLAMALT VGLAVIFLIL GGTFLYWRGR RIQNKRAMRR YLERGESIEP 660

LDPSEKANKV FARIFKETEL RKLKVLGSGV FGTVHKGIWI PEGESIKIPV CIKVIEDKSG 720

RQSFQDVTDH MLAIGSLDHA HIVRLLGLCP GSSLQLVTQY LPLGSLLDHV RQHRGALGPQ 780

LLLNWGVQIA KGMYYLEEHG MVHRNLAARN VLLKSPSQVQ VADFGVADLL PPDDKQLLHS 840

EAKTPIKWMA LESIHFGKYT HQSDVWSYGV TVWELMTFGA EPYAGLRLAE VPDLLEKGER 900

LAQPQICTID VYMVMVKCWM IDENIRPTFK ELANEFTRMA RDPPRYLVIK RESGPGIPPG 960

AEPPALSNKE LEEVELEPEL DLDLDLEAEE DSLATTLGSA LSLPVGTLSR PRGSQSLLSP 1020

SSGYMPMNQS NLGEACQDSA ACGGSDWCPR PVSLHPVPRG RLASESSEGH VTGSEVEFTE 1080

KVSMCRSRSR SRSRSPRPRG DSAYHSQRHS LLTPVTPLSP PGVEEEDING YVMPDTHLKG 1140

TSSSREGTLS SVGLSSVLGT EEEDEDEEYE YMNRKRRHSP PCPPRPGSLE ELGYEYMDVG 1200

SDLSASLGST QSCPLHPVPI MPTAGTTPDE DYEYMNRRRG GSGPGGEYAT MGACPASEQG 1260

YEEMRAFQGP GHQTPHVRYA RLKTLRSLEA TDSAFDNPDY WHSRLFPKAN AQRT 1314

Nucleotide Sequence
(FASTA)

GTGTGTCCCG GGACCCTGAA TGGGCTGAGT GTGACTGGTG ATGCTGAGAA CCAATACCAG 60

ACACTACACA ATCTATATGA GCGATGTGAA GTAGTGATGG GGAACCTTGA GATTGTGCTC 120

ACAGGACACA ATGCTGACCT CAGCTTCTTA CAGTGGATCC GAGAAGTGAC AGGCTATGTC 180

CTTGTGGCCA TGAATGAATT TTCTACTCTA CCACTGCCCA ACCTCCGAGT GGTGAGAGGG 240

ACCCAGGTCT ATGATGGGAA GTTTGCCATC TTTGTCATGT TGAACTACAA CACCAACTCT 300

AGCCACGCTC TGCGCCAGCT CCGCTTCACT CAGCTCACCG AGATTCTGTC AGGGGGCGTT 360

TATATTGAGA AGAATGATAA GCTTTGCCAC ATGGACACAA TTGACTGGAG GGACATCGTG 420

AGAGACCGAG ATGCTGAGAT AGTGGTGAAG GACAATGGCA GAAACTGTCT CCCCTGTCAT 480

GAGGTCTGCA AAGGGCGATG TTGGGGTCCT GGACCAGAAG ACTGCCAGAC ATTAACCAAG 540

ACCATCTGTG CCCCTCAATG TAATGGCCAC TGCTTTGGGC CCAACCCCAA CCAGTGCTGT 600

CATGATGAGT GTGCAGGGGG CTGCTCAGGC CCTCAGGACA CTGACTGCTT TGCCTGCCGA 660

CACTTCAATG ACAGTGGAGC CTGTGTGCCC CGGTGCCCAC AGCCCCTTGT GTACAACAAG 720

CTAACTTTCC AGCTGGAACC CAATCCTCAC ACCAAGTACC AGTATGGAGG AGTTTGTGTA 780

GCCAGTTGTC CCCATAACTT TGTGGTGGAT CAGACCTCCT GTGTCAGAGC ATGTCCTCCT 840

GACAAGATGG AAGTAGATAA AAATGGGCTG AAGATATGTG AGCCTTGTGG TGGGCTATGC 900

CCTAAGGCCT GTGAGGGGAC AGGCTCTGGG AGCCGCTACC AAACTGTGGA CTCCAGCAAC 960

ATCGATGGGT TTGTGAATTG CACCAAGATC CTGGGCAACT TGGACTTTCT TATCACTGGC 1020

CTCAATGGAG ATCCCTGGCA CAAGATCCCT GCACTGGACC CTGAGAAGCT CAATGTCTTC 1080

CGGACAGTAC GAGAGATCAC AGGTTACCTG AACATCCAGT CTTGGCCTCC TCACATGCAT 1140

AACTTCAGTG TTTTTTCCAA CCTGACAACC ATTGGAGGCA GAAGCCTTTA CAACCGGGGC 1200

TTCTCATTAT TGATTATGAA GAACTTGAAT GTCACATCTC TGGGCCTGCG ATCCCTAAAG 1260

GAAATTAGTG CTGGGCGTAT CTACATAAGT GCCAATCGGC AGCTCTGCTA CCACCACTCT 1320

CTGAACTGGA CCAGGCTGCT TCGGGGGCCT GCAGAAGAAA GACTAGACAT CAAGCATAAT 1380

CGGCCCCGCA GAGACTGTGT GGCAGAGGGC AAAGTGTGTG ACCCACTGTG CTCCGCTGGA 1440

GGATGCTGGG GCCCAGGCCC TGGTCAGTGC TTATCCTGTC GAAACTACAG CCGAGGGGGT 1500

GTCTGTGTGA CCCACTGCAA CTTTCTAAAT GGGGAGCCTC GTGAGTTTGC CCAGGAGGCT 1560

GAATGCTTCT CCTGCCACCC GGAATGCCAA CCCATGGAAG GCATTGCCAC ATGCAATGGC 1620

TCGGGCTCTG ATGCTTGTGC CCAGTGTGCC CATTTTCGAG ATGGGCCCCA CTGTGTGAGC 1680

AGCTGCCCTC ATGGAGTCCT AGGTGCTAAG GGCCCCATCT ACAAGTACCC GGATGTTCAG 1740

AATGAATGTC GGCCCTGCCA TGAGAACTGC ACCCAGGGGT GTAAGGGACC AGAGCTAAAA 1800

GATTGTTTAG GCCAAACACT GGTGCTGATC AGCAAAACCC ATCTGGCAAT GGCTTTGACA 1860

GTAGGTTTGG CAGTGATTTT CCTGATTCTG GGCGGCACTT TTCTGTATTG GCGTGGGCGC 1920

CGGATTCAGA ATAAAAGGGC TATGAGACGC TATTTGGAAC GGGGTGAGAG TATAGAGCCT 1980

CTGGATCCCA GTGAGAAAGC TAACAAAGTC TTCGCCAGAA TCTTCAAAGA GACAGAGCTG 2040

AGGAAGCTTA AAGTACTGGG TTCAGGCGTC TTTGGAACAG TGCACAAAGG AATATGGATC 2100

CCCGAAGGTG AATCAATCAA GATTCCAGTT TGCATTAAAG TCATTGAGGA CAAGAGTGGA 2160

CGACAAAGTT TCCAAGATGT AACAGATCAT ATGCTGGCCA TTGGCAGCCT AGACCATGCA 2220

CACATTGTTC GGTTGCTGGG ACTATGCCCA GGGTCATCTC TGCAACTTGT CACTCAGTAC 2280

TTGCCTCTGG GTTCCCTACT GGATCATGTG AGACAACACC GGGGGGCACT GGGGCCACAG 2340

CTGCTACTCA ACTGGGGAGT ACAAATTGCC AAGGGTATGT ACTACCTTGA GGAACATGGT 2400

ATGGTGCACA GGAACCTGGC TGCCCGAAAT GTGTTACTCA AGTCACCCAG TCAGGTTCAA 2460

GTGGCAGATT TTGGTGTGGC TGACCTGCTG CCACCTGATG ATAAGCAGCT CTTACACAGT 2520

GAGGCCAAGA CTCCAATTAA GTGGATGGCC CTTGAGAGTA TCCACTTTGG GAAATACACA 2580

CACCAGAGTG ACGTCTGGAG CTACGGTGTG ACAGTTTGGG AGTTGATGAC CTTTGGGGCC 2640

GAGCCCTATG CAGGGCTCCG ACTGGCTGAA GTACCAGACC TGCTAGAGAA GGGGGAGCGG 2700

TTAGCACAGC CCCAGATCTG CACCATTGAT GTCTACATGG TTATGGTCAA GTGTTGGATG 2760

ATTGATGAGA ATATTCGCCC AACCTTTAAA GAACTAGCAA ATGAGTTTAC CAGGATGGCC 2820

CGTGATCCAC CAAGGTATCT TGTCATAAAG AGAGAGAGTG GGCCTGGAAT ACCACCTGGG 2880

GCGGAGCCCC CTGCTTTGTC AAACAAGGAA CTGGAGGAAG TAGAGTTGGA GCCAGAACTT 2940

GACCTAGACC TAGACTTGGA GGCAGAGGAG GACAGCCTGG CAACCACACT GGGCTCTGCC 3000

CTCAGCCTAC CAGTTGGAAC ACTTAGTCGG CCACGTGGGA GCCAGAGCCT TTTAAGTCCA 3060

TCATCTGGAT ACATGCCCAT GAATCAGAGT AACCTTGGGG AGGCTTGCCA GGATTCTGCA 3120

GCTTGTGGGG GGAGTGATTG GTGTCCCCGT CCAGTCTCTC TGCACCCAGT GCCACGAGGA 3180

CGCCTGGCAT CAGAGTCATC AGAGGGCCAT GTGACAGGAT CTGAGGTTGA GTTCACAGAG 3240

AAGGTGTCAA TGTGTAGAAG CCGGAGCCGG AGCCGGAGCC GGAGCCCACG GCCACGTGGA 3300

GATAGCGCCT ACCATTCCCA GCGCCACAGC CTGCTTACTC CTGTCACCCC ACTCTCCCCA 3360

CCAGGGGTAG AGGAAGAAGA TATCAATGGT TATGTCATGC CAGATACACA CCTCAAAGGT 3420

ACTTCTTCCT CCCGGGAAGG CACTCTTTCT TCAGTGGGTC TCAGTTCTGT CCTGGGTACT 3480

GAAGAAGAAG ATGAAGATGA GGAGTATGAA TACATGAACC GGAAGAGAAG GCACAGTCCA 3540

CCTTGTCCTC CTAGGCCTGG TTCCCTTGAG GAGCTGGGTT ATGAGTACAT GGATGTGGGA 3600

TCAGACCTTA GTGCCTCGCT GGGCAGCACA CAGAGTTGCC CACTCCACCC TGTGCCCATC 3660

ATGCCTACTG CTGGCACAAC TCCAGATGAA GACTATGAAT ATATGAATCG GCGGCGTGGT 3720

GGAAGTGGTC CAGGTGGAGA ATATGCAACC ATGGGGGCCT GTCCAGCATC TGAACAAGGG 3780

TATGAAGAAA TGAGAGCTTT CCAGGGACCT GGACACCAAA CTCCTCATGT TCGTTATGCC 3840

CGCCTCAAAA CTCTACGTAG CTTAGAAGCT ACTGACTCCG CTTTTGATAA CCCCGATTAC 3900

TGGCATAGCA GGCTTTTCCC TAAGGCTAAT GCCCAGAGAA CATAA 3945

Domain Profile

S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60

         l+klkvlGsG+fGtv+kGiwipege++kipv+ikv+e+k+g++++++++d++l+++sldh

Q: 680   LRKLKVLGSGVFGTVHKGIWIPEGESIKIPVCIKVIEDKSGRQSFQDVTDHMLAIGSLDH  739

         69**********************************************************

S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyleek  120

         a++vrllglc  s+lqlvtq+lplG+lld+vr+h+++lG+q llnw+vqiakGm+ylee+

Q: 740   AHIVRLLGLCPGSSLQLVTQYLPLGSLLDHVRQHRGALGPQLLLNWGVQIAKGMYYLEEH  799

         ************************************************************

S: 121   rlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkrky  180

          +vhr+laarnvl+ksp++v+++dfG+a+ll  d+k+l ++++k+pikw+alesi++ ky

Q: 800   GMVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLLHSEAKTPIKWMALESIHFGKY  859

         ************************************************************

S: 181   thqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlvkcw  240

         thqsdvwsyGvtvwel+tfGa+py+g++++e+pdllekGerlaqp+ictidvymv+vkcw

Q: 860   THQSDVWSYGVTVWELMTFGAEPYAGLRLAEVPDLLEKGERLAQPQICTIDVYMVMVKCW  919

         ************************************************************

S: 241   midaesrpkfkelaeef  257

         mid+++rp+fkela+ef

Q: 920   MIDENIRPTFKELANEF  936

         ****************9

Domain Sequence
(FASTA)

LRKLKVLGSG VFGTVHKGIW IPEGESIKIP VCIKVIEDKS GRQSFQDVTD HMLAIGSLDH 60

AHIVRLLGLC PGSSLQLVTQ YLPLGSLLDH VRQHRGALGP QLLLNWGVQI AKGMYYLEEH 120

GMVHRNLAAR NVLLKSPSQV QVADFGVADL LPPDDKQLLH SEAKTPIKWM ALESIHFGKY 180

THQSDVWSYG VTVWELMTFG AEPYAGLRLA EVPDLLEKGE RLAQPQICTI DVYMVMVKCW 240

MIDENIRPTF KELANEF 257

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004716	; F:receptor signaling protein tyrosine kinase activity
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0023014	; P:signal transduction by phosphorylation
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

InterPros

IPR000494	; EGF_rcpt_L.
IPR006211	; Furin-like_Cys-rich_dom.
IPR006212	; Furin_repeat.
IPR009030	; Growth_fac_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR020635	; Tyr_kinase_cat_dom.
IPR016245	; Tyr_kinase_EGF/ERB/XmrK_rcpt.

Pfam

PF00757	; Furin-like; 1.
PF07714	; Pkinase_Tyr; 1.
PF01030	; Recep_L_domain; 2.

SMARTs

SM00261	; FU; 5.
SM00219	; TyrKc; 1.

Prosites

PS50011

; PROTEIN_KINASE_DOM; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013