EKS-ICT-00184

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ICT-00184

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/LISK	475.3	4.8E-143	310	579	270

Status

Unreviewed

Ensembl Protein

ENSSTOP00000020688

UniProt Accession

I3N8J2;

Protein Name

Protein Synonyms/Alias

Gene Name

LIMK2

Gene Synonyms/Alias

LIMK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSTOG00000024986	ENSSTOP00000020688	ENSSTOT00000020548

Organism

Ictidomys tridecemlineatus

Functional Description

Protein Length

617

Protein Sequence
(FASTA)

MGSYLSVPAY FTSRDPFRCS ECQDSLTNWY YEKDGKLYCH KDYWRKFGEF CHGCSLLMTG 60

PVMVAGEFKY HPECFACMSC KVIIEDGDAY ALVQHATLYC GKCHNEVVLA PMFERLSTES 120

VQDQLPYSVT LISMPATTED RRGFSVSVES ACSNYATTVQ VKEVNRMHIS PNNRNAIHPG 180

DRILEINGTP VRTLQVEEVE DAISQTSQTL QLLIEHDPVS QRLDQLRLDA RLSPHIQNDG 240

HSHTLSTLDT KDNLEGTLRR RSLRRSNSIS KSPGPSSPKE PLLLSRDISR SESLRCSSSY 300

SQQIFRPCDL IHGEVLGKGF FGQAIKVTHK ATGKVMVMKE LIRCDEETQK TFLTEVKVMR 360

SLDHPNVLKF IGVLYKDKKL NLLTEYIEGG TLKDFLRSVD PFPWQQKVRF AKGIASGMAY 420

LHSMCIIHRD LNSHNCLIKL DKTVVVADFG LSRLIVEERK RPPVEKATTK KRTLRKNDRK 480

KRYTVVGNPY WMAPEMLNGK SYDETVDVFS FGIVLCEIIG QVYADPDCLP RTLDFGLNVK 540

LFWEKFVPTD CPPAFFPLAA ICCKLEPESR PAFSKLEDSF EALSLYLGEL GIPLPAELEE 600

LDHTVSMQYG LTRDSPP 617

Nucleotide Sequence
(FASTA)

ATGGGGAGTT ACTTGTCCGT CCCAGCTTAC TTCACCTCCA GAGACCCTTT TCGGTGTTCA 60

GAATGCCAGG ATTCCCTCAC CAACTGGTAC TACGAGAAGG ATGGGAAGCT TTATTGCCAC 120

AAGGACTACT GGAGGAAGTT TGGGGAGTTC TGCCATGGGT GCTCCCTGCT AATGACAGGA 180

CCTGTCATGG TGGCTGGGGA ATTCAAGTAC CATCCAGAGT GTTTTGCTTG TATGAGCTGC 240

AAGGTGATCA TCGAGGATGG GGATGCATAT GCCCTGGTAC AGCATGCCAC ACTCTACTGT 300

GGAAAATGCC ACAATGAGGT GGTGTTGGCA CCCATGTTTG AGAGGCTCTC CACAGAATCT 360

GTTCAGGACC AGCTGCCCTA CTCTGTCACA CTCATCTCCA TGCCAGCTAC CACTGAGGAC 420

AGGCGGGGCT TCTCCGTGTC TGTAGAAAGT GCCTGCTCCA ACTATGCCAC CACCGTGCAA 480

GTAAAAGAGG TCAACCGGAT GCACATCAGT CCCAACAACC GCAATGCCAT CCACCCTGGG 540

GACCGCATCC TGGAGATCAA TGGCACCCCT GTCCGCACAC TCCAAGTGGA GGAGGTGGAA 600

GATGCAATTA GCCAAACAAG CCAGACACTT CAGCTGTTGA TTGAACATGA CCCCGTCTCC 660

CAGCGCCTGG ACCAGCTGCG GTTAGATGCC CGGCTTTCTC CCCACATACA GAATGATGGA 720

CATTCTCACA CCCTAAGCAC TCTGGACACC AAGGACAATC TGGAGGGGAC ACTGAGGAGA 780

CGCTCCCTGA GGCGCAGTAA TAGCATCTCT AAGTCCCCTG GCCCAAGCTC CCCCAAGGAG 840

CCCCTGCTGC TCAGCCGAGA CATCAGCCGC TCAGAATCCC TCCGCTGTTC TAGCAGCTAC 900

TCACAGCAGA TCTTCCGACC ATGTGACCTG ATCCATGGAG AGGTCCTGGG AAAGGGCTTC 960

TTTGGGCAGG CCATAAAGGT GACACACAAA GCCACAGGCA AAGTGATGGT CATGAAGGAG 1020

TTAATTCGAT GTGATGAGGA GACACAGAAG ACTTTCCTGA CTGAGGTGAA AGTGATGCGC 1080

AGCCTAGACC ACCCCAACGT GCTCAAGTTC ATTGGTGTGC TGTACAAGGA CAAGAAGCTG 1140

AACCTGCTGA CGGAATACAT TGAGGGGGGT ACACTGAAGG ATTTTCTGCG CAGTGTGGAT 1200

CCATTCCCCT GGCAGCAGAA GGTCAGATTT GCAAAAGGCA TCGCCTCCGG AATGGCCTAT 1260

TTGCACTCCA TGTGCATCAT CCACCGGGAT CTGAATTCAC ACAACTGCCT CATCAAGTTG 1320

GACAAGACTG TGGTGGTAGC AGACTTTGGG CTGTCACGGC TTATAGTGGA AGAGAGGAAA 1380

AGGCCCCCAG TAGAGAAGGC CACCACCAAG AAACGCACCT TGCGCAAGAA TGACCGCAAA 1440

AAACGCTACA CAGTGGTGGG AAACCCTTAC TGGATGGCTC CTGAGATGCT GAATGGAAAG 1500

AGCTACGATG AGACAGTGGA TGTCTTCTCT TTTGGGATCG TTCTCTGCGA GATCATTGGG 1560

CAAGTGTATG CAGATCCTGA TTGCCTGCCT CGTACACTGG ACTTTGGCCT GAACGTGAAG 1620

CTTTTCTGGG AGAAGTTTGT TCCCACAGAC TGCCCCCCAG CCTTCTTTCC CCTGGCTGCT 1680

ATCTGCTGCA AACTGGAGCC TGAGAGCAGA CCAGCATTCT CAAAACTGGA GGATTCCTTT 1740

GAGGCCCTCT CCCTGTATCT GGGAGAGCTG GGCATCCCAC TGCCTGCAGA GCTGGAGGAG 1800

CTGGACCACA CTGTGAGCAT GCAGTACGGC CTGACCCGGG ATTCACCCCC CTAG 1854

Domain Profile

S: 1     livgeklGkGffsevfkvthrasGevmvlkeliradeenrknllkevkllrklehpnvlk  60

         li+ge+lGkGff++++kvth+a+G+vmv+kelir+dee++k++l+evk++r+l+hpnvlk

Q: 310   LIHGEVLGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLK  369

         689*********************************************************

S: 61    fiGvlvkdkklhllteyiegGtlkellkskeslpwtqrvrlakdiasGlsylhskgiihr  120

         fiGvl+kdkkl+llteyiegGtlk++l+s +++pw+q+vr+ak+iasG++ylhs++iihr

Q: 370   FIGVLYKDKKLNLLTEYIEGGTLKDFLRSVDPFPWQQKVRFAKGIASGMAYLHSMCIIHR  429

         ************************************************************

S: 121   dlnsknclvredksvvvadfGlarlvveerkks......eklrslkkkdrkkrltvvGsP  174

         dlns+ncl++ dk+vvvadfGl+rl+veerk++      +k+r+l+k+drkkr+tvvG+P

Q: 430   DLNSHNCLIKLDKTVVVADFGLSRLIVEERKRPpvekatTKKRTLRKNDRKKRYTVVGNP  489

         *******************************999999999********************

S: 175   ywmaPevlkgksydekvdvfsfGivlceiiarveadPdylPrtedfgldvkafreklvae  234

         ywmaPe+l+gksyde+vdvfsfGivlceii++v+adPd+lPrt dfgl+vk f+ek+v++

Q: 490   YWMAPEMLNGKSYDETVDVFSFGIVLCEIIGQVYADPDCLPRTLDFGLNVKLFWEKFVPT  549

         ************************************************************

S: 235   dcPeaflklavvccdldpesrpsfeelekk  264

         dcP+af++la++cc+l+pesrp+f++le++

Q: 550   DCPPAFFPLAAICCKLEPESRPAFSKLEDS  579

         ***************************986

Domain Sequence
(FASTA)

LIHGEVLGKG FFGQAIKVTH KATGKVMVMK ELIRCDEETQ KTFLTEVKVM RSLDHPNVLK 60

FIGVLYKDKK LNLLTEYIEG GTLKDFLRSV DPFPWQQKVR FAKGIASGMA YLHSMCIIHR 120

DLNSHNCLIK LDKTVVVADF GLSRLIVEER KRPPVEKATT KKRTLRKNDR KKRYTVVGNP 180

YWMAPEMLNG KSYDETVDVF SFGIVLCEII GQVYADPDCL PRTLDFGLNV KLFWEKFVPT 240

DCPPAFFPLA AICCKLEPES RPAFSKLEDS 270

Keyword

Complete proteome; LIM domain; Metal-binding; Reference proteome; Zinc.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004672	; F:protein kinase activity
GO:0008270	; F:zinc ion binding

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR001478	; PDZ.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR001781	; Znf_LIM.

Pfam

PF00412	; LIM; 2.
PF00595	; PDZ; 1.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00132	; LIM; 1.
SM00228	; PDZ; 1.

Prosites

PS00478	; LIM_DOMAIN_1; 1.
PS50023	; LIM_DOMAIN_2; 1.
PS50106	; PDZ; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013