EKS-ICT-00266

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ICT-00266

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	419.6	6.0E-126	192	478	287

Status

Unreviewed

Ensembl Protein

ENSSTOP00000016787

UniProt Accession

I3MXE2;

Protein Name

Protein Synonyms/Alias

Gene Name

ACVR2A

Gene Synonyms/Alias

ACVR2A;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSTOG00000025105	ENSSTOP00000016787	ENSSTOT00000028004

Organism

Ictidomys tridecemlineatus

Functional Description

Protein Length

513

Protein Sequence
(FASTA)

SSFIMIICYS KLLFYYLIGA ILGRSETQEC LFFNANWERD RTNQTGVEPC YGDKDKRRHC 60

FATWKNISGS IEIVKQGCWL DDINCYDRTD CIEKKDSPEV YFCCCEGNMC NEKFSYFPEM 120

EVTQPTSNPV APKPPYYNIL LYSLVPLMLI AGIVICAFWV YRHHKMAYPP VLVPTQDPGP 180

PPPSPLLGLK PLQLLEVKAR GRFGCVWKAQ LLNEYVAVKI FPIQDKQSWQ NEYEVYSLPG 240

MKHENILQFI GAEKRGTSVD VDLWLITAFH EKGSLSDFLK ANVVSWNELC HIAETMARGL 300

AYLHEDIPGL KDGHKPAISH RDIKSKNVLL KNNLTACIAD FGLALKFEAG KSAGDTHGQV 360

GTRRYMAPEV LEGAINFQRD AFLRIDMYAM GLVLWELASR CTAADGPVDE YMLPFEEEIG 420

QHPSLEDMQE VVVHKKKRPV LRDYWQKHAG MAMLCETIEE CWDHDAEARL SAGCVGERIT 480

QMQRLTNIIT TEDIVTVVTM VTNVDFPPKE SSL 513

Nucleotide Sequence
(FASTA)

TCTTCTTTTA TAATGATAAT ATGTTATAGT AAGTTATTGT TTTATTATCT TATAGGTGCT 60

ATACTTGGTA GATCAGAAAC TCAGGAGTGT CTTTTCTTTA ATGCTAATTG GGAAAGAGAC 120

AGAACCAATC AAACTGGTGT TGAACCCTGT TATGGTGACA AAGATAAACG GCGACATTGT 180

TTTGCTACCT GGAAGAATAT TTCTGGTTCC ATTGAAATAG TGAAACAAGG TTGTTGGCTG 240

GATGATATCA ACTGCTATGA CAGGACTGAT TGTATAGAAA AAAAAGACAG TCCTGAAGTC 300

TACTTTTGTT GCTGTGAGGG CAATATGTGT AATGAAAAAT TTTCTTATTT TCCGGAGATG 360

GAAGTCACAC AGCCCACTTC AAATCCAGTT GCACCTAAAC CACCCTATTA CAACATTCTG 420

CTTTATTCCT TGGTGCCACT TATGTTAATT GCGGGGATTG TCATATGTGC ATTTTGGGTA 480

TACAGGCATC ACAAGATGGC CTACCCTCCT GTACTTGTTC CAACTCAAGA CCCAGGACCA 540

CCCCCACCTT CTCCATTACT AGGTTTGAAG CCACTGCAAT TATTAGAAGT GAAAGCAAGG 600

GGAAGATTTG GTTGTGTTTG GAAAGCCCAG TTGCTCAATG AATATGTTGC CGTTAAAATA 660

TTCCCAATAC AGGATAAACA GTCATGGCAA AATGAATATG AAGTCTATAG TTTACCTGGA 720

ATGAAGCATG AAAACATATT ACAGTTCATC GGTGCAGAAA AACGAGGCAC CAGTGTTGAT 780

GTGGACCTTT GGCTAATAAC AGCATTTCAT GAAAAGGGCT CACTGTCAGA CTTTCTTAAG 840

GCTAATGTGG TCTCTTGGAA TGAACTGTGT CATATTGCAG AAACCATGGC TAGAGGGTTG 900

GCATATTTAC ATGAGGATAT ACCTGGCCTC AAAGATGGCC ACAAACCCGC AATATCTCAC 960

AGGGACATCA AAAGTAAAAA TGTGCTGTTG AAAAACAATC TGACGGCTTG CATTGCTGAC 1020

TTTGGGTTGG CATTAAAATT TGAGGCTGGC AAGTCTGCAG GTGACACCCA CGGACAGGTT 1080

GGTACCCGAA GGTATATGGC TCCAGAGGTA TTAGAAGGTG CTATAAACTT CCAAAGGGAT 1140

GCATTTTTGA GGATAGATAT GTACGCCATG GGATTAGTCC TGTGGGAACT GGCTTCTCGC 1200

TGTACTGCTG CAGATGGACC TGTAGATGAG TACATGTTGC CATTTGAGGA GGAAATTGGC 1260

CAGCATCCAT CTCTTGAAGA TATGCAGGAA GTTGTTGTAC ATAAAAAAAA GAGGCCTGTT 1320

TTAAGAGATT ATTGGCAGAA ACATGCTGGA ATGGCGATGC TCTGTGAAAC GATAGAAGAA 1380

TGTTGGGATC ATGATGCAGA AGCCAGGTTA TCAGCAGGAT GTGTAGGTGA AAGAATTACC 1440

CAGATGCAGA GACTCACAAA TATCATTACT ACAGAGGACA TTGTAACAGT GGTCACGATG 1500

GTGACAAATG TTGACTTTCC TCCCAAAGAA TCTAGTCTAT GA 1542

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         l+lle+ ++Gr+g+Vwka+l +e+vAvKif+ +d++sw++E e+y+++ ++henilqfi+

Q: 192   LQLLEVKARGRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLPGMKHENILQFIG  251

         6899********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         a+k+ +++ ++l+l+t++hekgsLsd+Lk+++++++el+++a+++a+Gla+LHe+i+g k

Q: 252   AEKRGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGLAYLHEDIPGLK  311

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         + +Kpai+HRD+kskN+l+k++lt+ciaD+GLalk+e+ k++ d  ++ qvGt+RYmaPE

Q: 312   DGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGD--THGQVGTRRYMAPE  369

         *****************************************888..79************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vle+a+n+++ +af r+D+Y++gLvlWE+asRc+++d+ v+ey+lpfee++g++Psle+m

Q: 370   VLEGAINFQR-DAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIGQHPSLEDM  428

         *********9.9************************************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkr  290

         +evvv+kk+rP +++ w+k++ +++l++++eecWd+d+eaRl+a +v +r

Q: 429   QEVVVHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSAGCVGER  478

         ***********************************************987

Domain Sequence
(FASTA)

LQLLEVKARG RFGCVWKAQL LNEYVAVKIF PIQDKQSWQN EYEVYSLPGM KHENILQFIG 60

AEKRGTSVDV DLWLITAFHE KGSLSDFLKA NVVSWNELCH IAETMARGLA YLHEDIPGLK 120

DGHKPAISHR DIKSKNVLLK NNLTACIADF GLALKFEAGK SAGDTHGQVG TRRYMAPEVL 180

EGAINFQRDA FLRIDMYAMG LVLWELASRC TAADGPVDEY MLPFEEEIGQ HPSLEDMQEV 240

VVHKKKRPVL RDYWQKHAGM AMLCETIEEC WDHDAEARLS AGCVGER 287

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0017002	; F:activin-activated receptor activity
GO:0005524	; F:ATP binding
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0023014	; P:signal transduction by phosphorylation

KEGG

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR015768	; Activin_II_recpt.
IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.

SMARTs

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013