EPS-ICT-00013

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-ICT-00013

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
DSP/aDSP	116.9	6.3E-34	29	168	140

Status

Unreviewed

Ensembl Protein

ENSSTOP00000022932

UniProt Accession

I3NEY5;

Protein Name

Protein Synonyms/Alias

Gene Name

DUSP12

Gene Synonyms/Alias

DUSP12;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSTOG00000025153	ENSSTOP00000022932	ENSSTOT00000019420

Organism

Ictidomys tridecemlineatus

Functional Description

Protein Length

339

Protein Sequence
(FASTA)

MLAKEGSSHG CGSWIPHASG TSSAREMLEV RPGLYLGGAA AVAEPDHLKE AGISAVLTVD 60

SEPGFKEGAG FEGLRSLFVP ALDKPETDLL SHLDRCVAFI SQARSEGRAV LVHCHAGISR 120

SVAIVTAFLM KTDRLTFEKA YENLQTIKPE AKMNEGFEYQ LKLYQAMGYE VDTSSAIYKQ 180

YRLQKVTEKY PELQNLPQEL FAVDPTTISQ GLKDEVLYKC RKCRRSLFRS SSILDHNEGS 240

RPIAFAHKRM TPSFMLATGN QAQCTSYFIE PVQWMESTLL GVMDGQLLCP KCSAKLGSFN 300

WYGEQCSCGR WITPAFQIHK NRVDEMKMLP VLGSQTRKL 339

Nucleotide Sequence
(FASTA)

ATGTTGGCAA AGGAGGGCTC GAGCCATGGC TGCGGGAGCT GGATTCCGCA CGCTAGCGGA 60

ACCAGCTCTG CCCGGGAGAT GCTGGAAGTG CGGCCTGGGC TGTACCTGGG TGGGGCGGCG 120

GCAGTCGCAG AGCCGGATCA TTTGAAGGAG GCCGGCATCT CTGCCGTGTT GACGGTAGAC 180

TCAGAACCTG GTTTCAAGGA GGGGGCTGGG TTCGAAGGTC TACGGAGCCT CTTCGTGCCA 240

GCCCTGGACA AACCCGAGAC CGACTTGCTC AGCCATCTGG ATCGGTGCGT GGCCTTCATC 300

AGCCAGGCCC GCTCGGAGGG CCGTGCGGTG CTGGTGCACT GCCATGCAGG CATCAGTCGA 360

AGTGTTGCTA TAGTGACTGC TTTTTTGATG AAGACTGACC GTCTTACCTT TGAAAAAGCC 420

TATGAAAATC TACAGACTAT CAAACCTGAA GCTAAGATGA ATGAGGGGTT TGAATATCAA 480

CTGAAATTAT ACCAGGCAAT GGGATATGAA GTGGATACCT CTAGTGCAAT TTATAAACAG 540

TATCGATTAC AAAAGGTTAC AGAGAAGTAT CCAGAATTGC AAAATTTACC TCAAGAACTC 600

TTTGCTGTTG ATCCAACTAC CATTTCACAA GGATTAAAAG ATGAAGTTCT CTACAAATGT 660

AGAAAATGCA GGCGATCCTT ATTTCGAAGT TCTAGCATTT TGGATCATAA CGAAGGAAGT 720

AGGCCTATAG CCTTTGCCCA CAAGAGAATG ACACCATCTT TCATGCTTGC CACAGGGAAT 780

CAGGCTCAAT GTACATCTTA TTTCATTGAA CCTGTACAGT GGATGGAATC CACTTTGTTG 840

GGAGTGATGG ATGGGCAGCT TCTTTGCCCA AAATGCAGTG CCAAGTTGGG ATCCTTTAAT 900

TGGTATGGTG AACAGTGCTC ATGTGGTAGA TGGATAACAC CTGCCTTTCA AATACATAAG 960

AATAGAGTGG ATGAAATGAA AATGCTGCCA GTTTTGGGAT CACAAACAAG AAAATTATGA 1020

Domain Profile

S: 4     eilpglylgdqataldrreLsklgitvvinasls.vikvqviPeylikkgityknipvdD  62

         e+ pglylg++a + +  +L+++gi+ v+++  +  +k     e    +g + + +p+ D

Q: 29    EVRPGLYLGGAAAVAEPDHLKEAGISAVLTVDSEpGFK-----EGAGFEGLRSLFVPALD  83

         899**************************986551344.....7777899**********

S: 63    sdvtdllqyfdeaaefideakekggkvlvHCaaGvsRSatlvlaYLmkveglslsdAiea  122

         +++tdll+++d++++fi +a+++g++vlvHC+aG+sRS+++v+a+Lmk+  l++++A+e+

Q: 84    KPETDLLSHLDRCVAFISQARSEGRAVLVHCHAGISRSVAIVTAFLMKTDRLTFEKAYEN  143

         ************************************************************

S: 123   vkrkrpsiepnegfleQLlelekkl  147

         +++ +p++++negf  QL +++ ++

Q: 144   LQTIKPEAKMNEGFEYQLKLYQAMG  168

         *********************9886

Domain Sequence
(FASTA)

EVRPGLYLGG AAAVAEPDHL KEAGISAVLT VDSEPGFKEG AGFEGLRSLF VPALDKPETD 60

LLSHLDRCVA FISQARSEGR AVLVHCHAGI SRSVAIVTAF LMKTDRLTFE KAYENLQTIK 120

PEAKMNEGFE YQLKLYQAMG 140

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0008138	; F:protein tyrosine/serine/threonine phosphatase activity
GO:0008270	; F:zinc ion binding
GO:0006470	; P:protein dephosphorylation

KEGG

InterPros

IPR000340	; Dual-sp_phosphatase_cat-dom.
IPR020422	; Dual-sp_phosphatase_subgr_cat.
IPR024950	; DUSP.
IPR016278	; DUSP12.
IPR000387	; Tyr/Dual-specificity_Pase.
IPR007087	; Znf_C2H2.

Pfam

PF00782

; DSPc; 1.

SMARTs

SM00195

; DSPc; 1.

Prosites

PS50056	; TYR_PHOSPHATASE_2; 1.
PS50054	; TYR_PHOSPHATASE_DUAL; 1.
PS50157	; ZINC_FINGER_C2H2_2; 1.

Prints

Created Date

20-Feb-2013