EKS-ICT-00382

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ICT-00382

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/PDGFR	600.8	8.4E-181	601	959	359

Status

Unreviewed

Ensembl Protein

ENSSTOP00000023255

UniProt Accession

I3NFV8;

Protein Name

Tyrosine-protein kinase receptor

Protein Synonyms/Alias

Gene Name

PDGFRB

Gene Synonyms/Alias

PDGFRB;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSTOG00000025211	ENSSTOP00000023255	ENSSTOT00000024810

Organism

Ictidomys tridecemlineatus

Functional Description

Protein Length

1107

Protein Sequence
(FASTA)

MQLPGVTPAL VLRGQLLLLP MLLLLGPQTS QGLTIMPPGP ELVLNLSSTF VLTCLGSAPV 60

VWERLSQVPQ QKVSRTQEGT FSSMLTLANV TGGDTGEYFC TYNSSLGREP SERKRLYIFV 120

PVDPSMGFLP MEPEDLFIFL TEITETTIPC RVTDPQLVVT LHEKKEDIPL PIPYDHQRGF 180

SGTFEDKTYI CRTTIGEREV DSDAYYVYSL QVSTINVSVN AVQTVVRQGE NITIMCIVTG 240

NEVVNFEWTY PRMESGRLVE PVTDFLFDVP SHIRSILHIP SAELDDSGTY ICNVSESVND 300

HRDEKAINVT VVESGYVRLL GDLGAIQIAE LHRSRTLQVV FEAYPPPTVL WFKDNRTLGD 360

SSAGEIALST RNVSETRYVS ELTLVRVKVA EAGYYTMRAF HEDAEAQLSF KLQVNVPVRV 420

LELSESHPAN GEQTVRCRGR GMPQPNITWS TCRDLKRCPR ELPPTPLGNS SEEESQLETN 480

VTYWAEEQEY EVVSTLRLRH VDQPLSVRCM LHNPLGQDVQ EVTVVPHSLP FKVVVISAIL 540

ALVVLTIISL IILIMLWQKK PRYEIRWKVI ESVSSDGHEY IYVDPMQLPY DSTWELPRDQ 600

LVLGRTLGSG AFGQVVEATA HGLSHSQATM KVAVKMLKST ARSSEKQALM SELKIMSHLG 660

PHLNVVNLLG ACTQGGPIYI ITEYCRYGDL VDYLHRNKHS FLQHHSDKHR PPSAELYSNA 720

LPTGLPLPSP MSLTGESDGG YMDMSKDESV DYVPMLDMKG DVKYADIESS NYMAPYDNYV 780

PSAPERTCRA TLINESPVLS YTDLVGFSYQ VANGMEFLAS KNCVHRDLAA RNVLICEGKL 840

VKICDFGLAR DIMRDSNYIS KGSTFLPLKW MAPESIFNSL YTTLSDVWSF GILLWEIFTL 900

GGTPYPELPM NEQFYNAIKR GYRMAQPAHA SAEIYEIMQK CWEEKFEVRP PFSQLVLLLE 960

RLLGEGYRKK YQQVDEEFLR SDHPAILRSQ ARFPGFHSLR SPLDTSSVLY TAVQPSEGDN 1020

DYIIPLPDPK PEAADEGLLE GSPSLASSTL NEANTSSTIS CDSPLDPQEE PEPEPLPQPQ 1080

GDSQMELEPP MDAGCPGPRA EAEDSFL 1107

Nucleotide Sequence
(FASTA)

ATGCAGCTTC CAGGTGTGAC GCCAGCTCTG GTCCTCAGAG GCCAGTTGCT GTTGCTGCCC 60

ATGCTATTGC TGCTAGGTCC ACAGACCTCC CAGGGCCTGA CCATCATGCC CCCGGGGCCA 120

GAGCTTGTAC TTAATCTCTC AAGTACCTTT GTTCTGACCT GCCTGGGTTC AGCTCCAGTG 180

GTGTGGGAAC GGCTATCTCA GGTGCCTCAG CAGAAAGTGT CCAGGACCCA GGAGGGCACC 240

TTCTCCAGCA TGCTAACCCT GGCCAATGTC ACTGGAGGTG ACACAGGAGA GTACTTTTGT 300

ACCTACAACA GCTCCCTTGG GCGGGAGCCC AGTGAGCGGA AGCGGCTCTA CATCTTTGTG 360

CCTGTAGATC CCTCCATGGG CTTCCTCCCT ATGGAGCCCG AGGACCTATT CATCTTTCTC 420

ACGGAAATAA CTGAGACCAC AATTCCATGC CGAGTGACAG ACCCCCAGCT AGTGGTGACA 480

CTGCATGAGA AGAAAGAGGA CATCCCGCTG CCTATCCCCT ATGACCACCA ACGAGGCTTC 540

TCTGGTACCT TTGAGGACAA GACCTATATC TGCCGAACCA CCATTGGGGA GAGGGAAGTG 600

GATTCCGATG CCTATTACGT CTACAGCCTC CAGGTTTCCA CCATCAATGT CTCAGTGAAT 660

GCAGTGCAGA CTGTGGTTCG CCAGGGTGAG AACATTACCA TCATGTGCAT TGTGACGGGG 720

AATGAGGTGG TCAATTTTGA GTGGACCTAC CCCCGCATGG AGAGTGGGCG CCTCGTAGAG 780

CCAGTGACAG ATTTCCTCTT TGATGTGCCC TCCCACATTC GCTCCATCCT CCACATCCCC 840

AGTGCTGAGC TGGATGACTC AGGGACCTAC ATCTGCAATG TGTCAGAGAG TGTGAATGAC 900

CATCGAGATG AAAAGGCCAT CAATGTCACT GTGGTCGAGA GTGGCTACGT GCGGCTTCTG 960

GGAGACTTGG GCGCTATACA AATTGCTGAG CTGCACAGGA GTCGGACACT ACAAGTGGTG 1020

TTCGAAGCCT ACCCGCCACC TACTGTGCTG TGGTTCAAGG ACAACCGCAC CCTGGGTGAT 1080

TCCAGCGCCG GCGAGATCGC CCTGTCCACG CGCAATGTGT CTGAGACCCG ATATGTATCA 1140

GAACTGACAC TGGTGCGGGT GAAGGTGGCA GAGGCTGGCT ACTATACCAT GCGGGCCTTC 1200

CATGAGGATG CTGAGGCCCA ACTTTCCTTC AAGCTGCAGG TCAATGTCCC TGTCCGTGTG 1260

CTGGAGCTGA GCGAGAGTCA CCCTGCCAAC GGGGAGCAGA CAGTCCGCTG TCGTGGCCGA 1320

GGCATGCCCC AGCCAAATAT CACCTGGTCT ACCTGCAGAG ACCTCAAAAG GTGTCCACGC 1380

GAGCTGCCGC CCACACCGCT GGGGAACAGT TCCGAGGAGG AAAGCCAGTT GGAGACTAAT 1440

GTGACATACT GGGCGGAGGA GCAGGAATAT GAGGTGGTGA GCACGCTGCG CCTGCGCCAC 1500

GTGGATCAGC CACTGTCGGT GCGCTGCATG CTGCACAACC CACTGGGCCA GGATGTGCAG 1560

GAGGTTACCG TGGTGCCGCA TTCCCTCCCC TTCAAGGTGG TGGTGATCTC AGCCATCCTG 1620

GCCTTGGTGG TTCTCACAAT CATCTCCCTC ATCATCCTCA TCATGCTCTG GCAGAAGAAG 1680

CCACGCTATG AGATTCGATG GAAGGTGATT GAGTCTGTGA GCTCTGATGG CCATGAGTAC 1740

ATCTATGTGG ACCCCATGCA GCTGCCCTAC GATTCCACCT GGGAACTGCC ACGGGACCAG 1800

CTTGTGCTTG GACGCACCCT CGGCTCTGGG GCCTTTGGGC AGGTGGTGGA GGCCACGGCT 1860

CATGGCCTGA GCCATTCCCA GGCCACCATG AAAGTGGCTG TCAAGATGCT GAAATCCACA 1920

GCCCGCAGCA GTGAGAAGCA AGCCCTCATG TCAGAGCTGA AGATCATGAG CCACCTGGGA 1980

CCCCACCTGA ACGTGGTCAA CCTGCTGGGG GCCTGCACCC AGGGAGGCCC CATCTACATC 2040

ATCACGGAGT ACTGCCGCTA TGGGGACCTG GTGGACTACC TGCACCGCAA CAAGCACAGC 2100

TTCCTGCAGC ACCACTCGGA CAAGCACCGC CCACCCAGTG CTGAGCTCTA CAGCAACGCC 2160

CTGCCCACGG GGCTCCCTCT GCCCAGCCCC ATGTCCCTGA CTGGGGAGAG CGATGGTGGC 2220

TACATGGACA TGAGCAAGGA CGAGTCAGTG GACTACGTGC CCATGCTGGA CATGAAAGGA 2280

GACGTCAAAT ACGCAGACAT CGAATCCTCC AACTACATGG CCCCTTATGA TAACTACGTC 2340

CCCTCTGCTC CTGAGAGGAC TTGTCGGGCC ACTTTGATCA ACGAGTCCCC AGTGCTTAGC 2400

TACACAGACC TTGTGGGCTT CAGCTACCAG GTGGCCAATG GCATGGAGTT CCTGGCCTCT 2460

AAGAATTGTG TTCATCGGGA CCTGGCAGCC AGGAATGTGC TCATCTGTGA GGGCAAGCTG 2520

GTCAAGATCT GTGACTTTGG CCTGGCTCGA GACATCATGC GGGACTCAAA CTACATCTCC 2580

AAAGGCAGTA CCTTCCTACC TCTGAAGTGG ATGGCCCCAG AGAGCATCTT CAATAGCCTC 2640

TACACCACCC TGAGCGATGT GTGGTCCTTC GGGATCCTGC TCTGGGAGAT CTTCACATTG 2700

GGTGGCACCC CTTACCCGGA GCTGCCCATG AACGAGCAGT TCTACAATGC CATCAAGCGC 2760

GGTTACCGCA TGGCACAGCC GGCTCACGCC TCTGCTGAGA TCTACGAGAT CATGCAGAAG 2820

TGCTGGGAGG AGAAGTTTGA GGTTCGGCCC CCCTTCTCCC AGCTGGTGCT GCTCCTGGAG 2880

AGGCTGCTTG GCGAGGGCTA CAGAAAGAAG TACCAGCAGG TGGACGAGGA GTTTCTGAGG 2940

AGTGACCACC CAGCCATCCT GAGGTCCCAA GCCCGCTTCC CTGGATTCCA CAGCCTCCGA 3000

TCTCCCCTGG ACACCAGCTC TGTCCTCTAC ACTGCCGTGC AGCCCAGCGA GGGTGACAAC 3060

GACTATATCA TCCCCCTGCC TGACCCCAAA CCAGAGGCCG CTGATGAGGG TCTGCTGGAG 3120

GGTTCCCCCA GCCTCGCCAG CTCCACCCTG AATGAAGCCA ACACCTCCTC TACCATCTCC 3180

TGTGACAGTC CTCTCGACCC CCAGGAAGAA CCAGAGCCAG AACCCCTGCC CCAGCCCCAG 3240

GGGGACTCCC AGATGGAGCT GGAGCCACCA ATGGATGCAG GCTGCCCTGG GCCTCGGGCC 3300

GAAGCAGAGG ACAGCTTTCT GTAG 3324

Domain Profile

S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60

         l+lG++lGsGafG+vveata+Gls+s+a++kvavkmlkstarssek+almselki+shlG

Q: 601   LVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLG  660

         78**********************************************************

S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120

         +h+n+vnllGact+gGpiy+iteyc+yGdl++yl+r+++sfl+++++k++++++el+s+a

Q: 661   PHLNVVNLLGACTQGGPIYIITEYCRYGDLVDYLHRNKHSFLQHHSDKHRPPSAELYSNA  720

         ************************************************************

S: 121   lladkslrsksslssesseeyvdlkkd................vsdvssskadklasekk  164

         l+++  l s +sl+ es++ y+d++kd                ++d++ss++++++++++

Q: 721   LPTGLPLPSPMSLTGESDGGYMDMSKDesvdyvpmldmkgdvkYADIESSNYMAPYDNYV  780

         ************************************************************

S: 165   ksalerevkaaleeedsevleledllsfsyqvakGmeflaskncvhrdlaarnvllteGk  224

          sa er+++a+l++e s vl+++dl+ fsyqva+Gmeflaskncvhrdlaarnvl++eGk

Q: 781   PSAPERTCRATLINE-SPVLSYTDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGK  839

         **************9.9*******************************************

S: 225   vvkicdfGlardimkdsnyvvkGnarlpvkwmapesifdslytvksdvwsyGillweifs  284

         +vkicdfGlardim+dsny++kG+++lp+kwmapesif+slyt+ sdvws+Gillweif+

Q: 840   LVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFT  899

         ************************************************************

S: 285   lGstpypgllvdskfyklikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlvell  344

         lG+tpyp+l+++++fy++ik+Gyrmaqpa+a++eiyeimqkcwe+++e rp+f+qlv ll

Q: 900   LGGTPYPELPMNEQFYNAIKRGYRMAQPAHASAEIYEIMQKCWEEKFEVRPPFSQLVLLL  959

         ********************************************************9986

Domain Sequence
(FASTA)

LVLGRTLGSG AFGQVVEATA HGLSHSQATM KVAVKMLKST ARSSEKQALM SELKIMSHLG 60

PHLNVVNLLG ACTQGGPIYI ITEYCRYGDL VDYLHRNKHS FLQHHSDKHR PPSAELYSNA 120

LPTGLPLPSP MSLTGESDGG YMDMSKDESV DYVPMLDMKG DVKYADIESS NYMAPYDNYV 180

PSAPERTCRA TLINESPVLS YTDLVGFSYQ VANGMEFLAS KNCVHRDLAA RNVLICEGKL 240

VKICDFGLAR DIMRDSNYIS KGSTFLPLKW MAPESIFNSL YTTLSDVWSF GILLWEIFTL 300

GGTPYPELPM NEQFYNAIKR GYRMAQPAHA SAEIYEIMQK CWEEKFEVRP PFSQLVLLL 359

Keyword

ATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

InterPros

IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR003599	; Ig_sub.
IPR003598	; Ig_sub2.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016243	; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824	; Tyr_kinase_rcpt_3_CS.

Pfam

PF07714

; Pkinase_Tyr; 1.

SMARTs

SM00409	; IG; 2.
SM00408	; IGc2; 1.
SM00219	; TyrKc; 1.

Prosites

PS50835	; IG_LIKE; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00240	; RECEPTOR_TYR_KIN_III; 1.

Prints

Created Date

20-Feb-2013