EKS-ICT-00150

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ICT-00150

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/RSK	362.1	1.9E-108	67	328	262

Status

Unreviewed

Ensembl Protein

ENSSTOP00000016643

UniProt Accession

I3MWZ8;

Protein Name

Protein Synonyms/Alias

Gene Name

RPS6KB2

Gene Synonyms/Alias

RPS6KB2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSTOG00000026088	ENSSTOP00000016643	ENSSTOT00000019402

Organism

Ictidomys tridecemlineatus

Functional Description

Protein Length

485

Protein Sequence
(FASTA)

MAAVFDLDLE TEEGSEGEGE PEFSPADVCP LTESRAAGLE PVGHYEEVEL TETSVNLGPE 60

RIGPHCFELL RVLGKGGYGK VFQVRKVQGT NLGKIYAMKV LRKAKIVRNA KDTAHTQAER 120

NILESVKHPF IVELAYAFQT GGKLYLILEC LSGGELFTHL EREGIFLEDT ACFYLAEITL 180

ALGHLHSQGI IYRDLKPENI MLNSQGHIKL TDFGLCKESI HEGAVTHTFC GTIEYMAPEI 240

LVRSGHNRVV DWWSLGALMY DMLTGSPPFT AENRKKTMDK IIKGKLVLPP YLTPDARDLI 300

KKFLKRNPSQ RIGGGPGDAA DVQRHPFFRH INWDDLLARR VDPPIRPSLQ SEEDVSQFDT 360

RFTRQTPVDS PDDTTLSESA NQAFLGFTYV APSVLDSIKE GFSFQPKLRS PRRLNSSPRT 420

PISPLKFSPF EGFRPTPGPP EPMEPPLPPL LPPPPPPPIS STAPLPIRPP SGTKKSKRGR 480

ARPGR 485

Nucleotide Sequence
(FASTA)

ATGGCGGCCG TGTTCGATCT GGACTTGGAG ACCGAGGAAG GCAGCGAGGG CGAGGGCGAG 60

CCAGAGTTCA GTCCTGCGGA CGTGTGTCCC CTTACCGAAT CGAGGGCTGC CGGCCTGGAG 120

CCCGTGGGAC ACTATGAGGA GGTGGAGCTG ACCGAGACCA GTGTGAACCT GGGCCCTGAG 180

CGCATTGGGC CGCACTGCTT TGAACTGCTG CGAGTGCTGG GCAAGGGGGG CTATGGCAAG 240

GTGTTCCAGG TACGAAAAGT GCAAGGCACC AACTTGGGCA AAATATATGC CATGAAAGTC 300

CTGAGGAAGG CCAAAATTGT GCGCAATGCC AAGGATACCG CACACACACA GGCTGAACGG 360

AACATTCTAG AGTCAGTGAA GCACCCCTTT ATTGTGGAAC TGGCCTATGC CTTCCAGACG 420

GGTGGCAAGC TCTACCTCAT CCTGGAGTGC CTCAGTGGTG GTGAGCTCTT CACACATCTG 480

GAGCGAGAGG GCATCTTCTT GGAGGACACT GCCTGCTTCT ACCTGGCTGA GATCACACTG 540

GCCCTGGGCC ATCTCCATTC CCAAGGCATC ATCTATCGGG ACCTTAAGCC TGAGAACATC 600

ATGCTCAACA GCCAGGGCCA CATCAAACTG ACGGATTTTG GACTCTGCAA GGAGTCCATT 660

CACGAGGGTG CCGTCACTCA CACCTTCTGT GGCACCATTG AGTACATGGC CCCTGAGATC 720

CTGGTGCGCA GTGGCCACAA CCGGGTGGTG GACTGGTGGA GCCTGGGGGC CCTGATGTAC 780

GACATGCTCA CTGGATCGCC ACCCTTCACT GCAGAGAACC GGAAGAAAAC CATGGATAAA 840

ATAATCAAGG GGAAGCTGGT GCTGCCTCCC TACCTCACCC CAGATGCCAG GGACCTTATC 900

AAAAAGTTTC TGAAGCGGAA TCCCAGCCAA CGGATTGGCG GTGGCCCAGG GGATGCTGCT 960

GATGTGCAGA GGCACCCCTT CTTCCGGCAC ATCAATTGGG ATGACCTCTT GGCTCGCCGT 1020

GTGGACCCTC CTATCAGGCC AAGTCTGCAG TCAGAGGAGG ACGTGAGCCA GTTTGACACG 1080

CGCTTCACAC GGCAGACACC AGTGGACAGT CCTGATGACA CAACGCTGAG TGAAAGTGCT 1140

AACCAAGCCT TCCTGGGTTT CACGTACGTG GCACCCTCAG TCCTGGACAG CATCAAAGAG 1200

GGCTTCTCCT TCCAGCCCAA GCTGCGCTCC CCCAGGCGCC TCAACAGCAG CCCCCGAACC 1260

CCCATCAGCC CCCTCAAGTT CTCCCCCTTT GAGGGGTTCC GGCCCACCCC TGGCCCACCA 1320

GAGCCCATGG AGCCACCTCT ACCTCCACTG CTGCCGCCGC CGCCACCACC ACCGATCTCG 1380

AGCACTGCTC CCCTCCCCAT CCGTCCCCCC TCAGGGACCA AGAAGTCTAA GAGGGGCCGA 1440

GCCCGCCCCG GGCGGTAG 1458

Domain Profile

S: 1     fellkvlgkGaygkvflvrkvekkdtgklyavKvlkkaelvk..kkkertkeereiLeev  58

         fell+vlgkG+ygkvf+vrkv++++ gk+ya+Kvl+ka++v+  k++++t++er+iLe+v

Q: 67    FELLRVLGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAKIVRnaKDTAHTQAERNILESV  126

         89***************************************999****************

S: 59    ehpfivklheafqdekklylvlellkGgeLlerlkkkklfseeeasfilaelvlaleylH  118

         +hpfiv+l +afq+  klyl+le+l+GgeL+++l+++++f e++a+f+lae++lal +lH

Q: 127   KHPFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFLEDTACFYLAEITLALGHLH  186

         ************************************************************

S: 119   skgvvyrDLkpeNilldeeghvkltDfglakekiaeneekaysfcgTleyvaPevlkrkg  178

         s+g++yrDLkpeNi+l+++gh+kltDfgl+ke+i +++  +++fcgT+ey+aPe+l r+g

Q: 187   SQGIIYRDLKPENIMLNSQGHIKLTDFGLCKESI-HEGAVTHTFCGTIEYMAPEILVRSG  245

         *********************************9.9999999******************

S: 179   ydeavDlwslGvllyemLtGktPftgeerketlarilkgkfslklpaweelseeakdlvk  238

         +++ vD+wslG+l+y+mLtG++Pft+e+rk+t+++i kgk  l lp +  l+++a+dl+k

Q: 246   HNRVVDWWSLGALMYDMLTGSPPFTAENRKKTMDKIIKGK--LVLPPY--LTPDARDLIK  301

         ****************************************..9*****..**********

S: 239   klLkkdpakRlga...taeeikehkfl  262

         k+Lk++p++R+g    +a+++++h+f+

Q: 302   KFLKRNPSQRIGGgpgDAADVQRHPFF  328

         ***********99999*********97

Domain Sequence
(FASTA)

FELLRVLGKG GYGKVFQVRK VQGTNLGKIY AMKVLRKAKI VRNAKDTAHT QAERNILESV 60

KHPFIVELAY AFQTGGKLYL ILECLSGGEL FTHLEREGIF LEDTACFYLA EITLALGHLH 120

SQGIIYRDLK PENIMLNSQG HIKLTDFGLC KESIHEGAVT HTFCGTIEYM APEILVRSGH 180

NRVVDWWSLG ALMYDMLTGS PPFTAENRKK TMDKIIKGKL VLPPYLTPDA RDLIKKFLKR 240

NPSQRIGGGP GDAADVQRHP FF 262

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007165	; P:signal transduction

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR016238	; Ribosomal_S6_kinase.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013