EKS-ICT-00306

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ICT-00306

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	324.5	4.8E-97	36	294	259

Status

Unreviewed

Ensembl Protein

ENSSTOP00000019630

UniProt Accession

I3N5I4;

Protein Name

Protein Synonyms/Alias

Gene Name

STK10

Gene Synonyms/Alias

STK10;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSTOG00000026208	ENSSTOP00000019630	ENSSTOT00000028232

Organism

Ictidomys tridecemlineatus

Functional Description

Protein Length

976

Protein Sequence
(FASTA)

MAFANFRRIL RLSTFEKRKS REYEHVRRDL DPNEVWEIVG ELGDGAFGKV YKAKNKETGA 60

LAAAKVIETK SEEELEDYIV EIEILATCDH PYIVKLLGAY YYDTKLWIMI EFCPGGAVDA 120

IMLELERGLT EPQIQVVCRQ MLEALSFLHS KRIIHRDLKA GNVLMTLEGD IRLADFGVSA 180

KNLKTLQKRD SFIGTPYWMA PEVVLCETMK DTPYDYKADI WSLGITLIEM AQIEPPHHEL 240

NPMRVLLKIA KSDPPTLLTP SKWSVEFRDF LKTALDKNPE TRPSAAQLLE HPFVSNVTSN 300

KALRELVAEA KAEVMEEIED GRDEGEEEDV VDSAPALGNH TQESSEANQL SLGADKPPQE 360

PSSAPLPTSQ PQDSGNGPCS QPSADGSLQT PSPPDGAPAN ENGLAMPVPL RKSRPVSMDA 420

RIQVAEEKQA KDQAGDLSPA ASRSQKASQS RPNSSALETL GGEKLVNGSL ELPAQAAPGP 480

ANRASDSSSL STSESMDYST SLSTDLSLNR ETGSLSLKDS RLHNKTLKRT RKFVVDGVEV 540

SITTSKIISD DEKKDEEMRF LRQAGQGHCQ RQELRELRLL QKEEHRNQSQ LSSKHELQLE 600

QLHRRFEQES NAKKKFFDTE LENLERQQKQ QVEKMEQDHA VRRREEAKRI RLEQERDYAR 660

FQEQLKLMKK EVKSEVEKLP RQQRKESLKQ KMEEHTQKKQ LLDRDFLAKQ KEDLELAMKR 720

LTAENRREIC DRERECLNRK QELLRDREAA LWEMEEHQLQ EKHQLVKQQL KDQYFLQRHQ 780

LLRKHEKERE QMQRYNQRML EQLKVRQQQE KARLPKIQRS EGKTRMAMYK KSLHINGGGS 840

AAEQRDKIKQ FSQQEEKRQK SERLQQQHKH ENQMRDMMAQ CESNMSELQQ LQNEKCHLLV 900

EHEAQKLKAL DESHNQHLKE WRDKLRPRKK ALEEDLNQKK REQEMFFKLG EEAGCPSPTT 960

PSKTSKFLPY GASDAS 976

Nucleotide Sequence
(FASTA)

ATGGCTTTCG CCAATTTCCG CCGCATCCTG CGCCTGTCTA CCTTCGAGAA GAGAAAATCC 60

CGCGAATATG AGCACGTCCG CCGGGACCTG GACCCCAACG AGGTGTGGGA GATCGTGGGC 120

GAGCTGGGCG ACGGCGCCTT CGGCAAGGTT TACAAGGCCA AGAATAAGGA GACGGGCGCC 180

CTGGCCGCAG CCAAGGTCAT CGAGACCAAG AGCGAGGAGG AGCTGGAGGA CTACATCGTG 240

GAGATTGAGA TCCTGGCCAC CTGCGACCAC CCCTACATCG TGAAGCTCCT GGGCGCCTAC 300

TACTACGACA CGAAGCTGTG GATCATGATC GAGTTCTGCC CCGGGGGAGC GGTGGACGCC 360

ATCATGCTGG AGCTGGAACG TGGCCTCACG GAGCCCCAGA TCCAGGTGGT CTGCCGCCAG 420

ATGCTGGAGG CCCTCAGCTT CCTGCACAGC AAGAGGATCA TCCACCGCGA CCTGAAGGCA 480

GGCAACGTCC TGATGACCCT CGAGGGAGAC ATCCGGCTGG CTGACTTTGG TGTGTCTGCC 540

AAGAATCTGA AAACCCTGCA GAAGCGAGAT TCCTTCATAG GAACACCCTA CTGGATGGCC 600

CCCGAGGTGG TGCTCTGCGA GACCATGAAG GACACCCCGT ACGACTACAA GGCCGACATC 660

TGGTCCCTGG GCATCACCCT GATCGAGATG GCGCAGATCG AGCCCCCTCA CCACGAGCTC 720

AACCCCATGC GCGTCCTGCT CAAGATCGCC AAGTCTGACC CCCCGACGCT GCTCACCCCC 780

TCTAAGTGGT CTGTGGAGTT CCGAGACTTC CTGAAGACTG CTCTGGATAA GAACCCCGAG 840

ACCCGACCCA GCGCCGCGCA GCTGCTGGAG CATCCCTTCG TCAGTAACGT CACCAGTAAC 900

AAGGCCCTGC GGGAGCTGGT GGCCGAGGCC AAGGCCGAGG TGATGGAGGA GATCGAAGAT 960

GGCAGGGACG AAGGAGAAGA GGAGGATGTC GTGGACTCTG CCCCCGCCCT GGGGAACCAC 1020

ACGCAGGAGT CTTCTGAGGC GAATCAGCTG AGCCTGGGGG CCGACAAGCC CCCCCAGGAA 1080

CCATCCTCGG CCCCACTGCC AACCAGCCAA CCTCAGGACA GTGGGAATGG GCCCTGCAGC 1140

CAGCCCTCTG CAGACGGATC CCTCCAAACC CCCAGCCCCC CAGACGGGGC CCCTGCAAAT 1200

GAGAATGGCC TCGCGATGCC TGTTCCCCTC CGAAAATCCC GGCCAGTGTC AATGGATGCC 1260

AGAATCCAGG TAGCCGAGGA GAAGCAAGCC AAGGACCAGG CTGGGGACCT CAGTCCTGCA 1320

GCCAGTAGGT CTCAAAAGGC CAGCCAGAGC CGGCCCAACA GCAGCGCCCT GGAGACGCTG 1380

GGCGGGGAGA AGCTGGTCAA TGGCAGTCTA GAGCTCCCTG CCCAGGCCGC ACCGGGTCCC 1440

GCCAACAGGG CCTCGGACAG CAGCAGCCTG TCCACCTCTG AGAGCATGGA CTACAGCACC 1500

TCCCTGTCCA CCGACCTCTC CCTGAACAGA GAGACGGGCT CGCTGTCCCT TAAGGACTCA 1560

AGGCTGCACA ACAAAACCCT GAAGCGGACA CGCAAATTTG TGGTGGATGG CGTCGAGGTG 1620

AGCATCACCA CCTCCAAGAT CATCAGCGAT GACGAAAAGA AGGACGAGGA GATGAGATTC 1680

CTCAGGCAAG CCGGGCAGGG CCACTGTCAG CGCCAGGAAC TCCGGGAGCT GCGGCTGCTG 1740

CAGAAGGAGG AGCATCGCAA CCAGAGCCAG CTCAGCAGCA AGCACGAGCT GCAGCTGGAG 1800

CAGCTGCACA GGCGCTTTGA GCAGGAGAGC AACGCCAAGA AGAAGTTCTT TGACACAGAA 1860

CTGGAGAACC TGGAGCGTCA GCAAAAGCAG CAGGTAGAGA AGATGGAGCA AGATCACGCC 1920

GTGCGCCGCC GGGAGGAGGC CAAGCGGATT CGCCTGGAGC AGGAAAGGGA CTATGCCAGG 1980

TTCCAAGAGC AGCTCAAACT GATGAAGAAA GAGGTGAAGA GCGAGGTGGA GAAGCTCCCC 2040

CGGCAGCAGC GGAAGGAGAG CTTGAAGCAG AAGATGGAGG AGCACACGCA GAAGAAGCAG 2100

CTTCTCGACC GGGACTTCCT GGCCAAGCAG AAGGAGGACC TGGAGCTGGC CATGAAGAGG 2160

CTCACTGCAG AGAACCGGCG GGAGATCTGT GACCGGGAGC GCGAGTGTCT CAACAGGAAG 2220

CAGGAGCTCC TTCGAGACCG GGAGGCAGCC CTGTGGGAGA TGGAGGAGCA CCAGCTGCAG 2280

GAGAAGCACC AGCTGGTGAA GCAGCAGCTC AAAGATCAGT ACTTCCTCCA GCGGCACCAG 2340

CTGCTGCGCA AGCACGAGAA GGAGCGGGAG CAGATGCAGC GCTACAACCA GCGCATGCTG 2400

GAGCAGCTGA AGGTGCGGCA GCAGCAGGAG AAGGCGCGGC TGCCCAAGAT CCAGAGGAGT 2460

GAGGGCAAGA CGCGCATGGC CATGTACAAG AAGAGCCTGC ACATCAACGG CGGGGGCAGC 2520

GCTGCTGAGC AGCGCGACAA GATCAAGCAG TTCTCCCAGC AGGAGGAGAA GAGGCAGAAG 2580

TCTGAGAGGC TGCAGCAGCA ACACAAGCAT GAGAACCAGA TGCGGGACAT GATGGCGCAG 2640

TGCGAGAGCA ACATGAGTGA GCTGCAGCAG CTACAGAATG AAAAATGTCA CCTCTTGGTG 2700

GAGCATGAAG CCCAGAAGCT GAAGGCCCTG GACGAGAGCC ACAACCAGCA CTTAAAGGAG 2760

TGGAGGGACA AGCTGCGGCC GCGCAAAAAG GCTCTGGAAG AGGATTTGAA TCAGAAGAAG 2820

CGGGAGCAGG AGATGTTCTT CAAGCTGGGC GAGGAGGCCG GGTGCCCGAG CCCCACCACC 2880

CCGAGCAAGA CCTCCAAGTT CCTCCCGTAC GGCGCTTCGG ATGCGTCCTA A 2931

Domain Profile

S: 1     yelleeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkhpnive  60

         +e++ e+g+Ga+gkvy+a++k+tg+l+a k+i+++++e+le+++ ei++l +++hp+iv+

Q: 36    WEIVGELGDGAFGKVYKAKNKETGALAAAKVIETKSEEELEDYIVEIEILATCDHPYIVK  95

         78999*******************************************************

S: 61    ylesflkeeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkvi  120

         +l++++++++lw+++e++ gG+++ ++  el+++l+E qi++++r++l+aL++lHsk++i

Q: 96    LLGAYYYDTKLWIMIEFCPGGAVDAIML-ELERGLTEPQIQVVCRQMLEALSFLHSKRII  154

         ***************************9.9******************************

S: 121   HrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqe...ekgY  177

         Hrd+ka+n+L+t eg+++L+dfgv+a+  kt +kr++++gtpywmAPEv+ +e   ++ Y

Q: 155   HRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVLCEtmkDTPY  214

         ****************************************************9998999*

S: 178   dekaDiwslGItaielaegepPfkdleplkallkilkneppklkskkkfskefkefvekc  237

         d+kaDiwslGIt+ie+a+ epP+++l+p+++llki+k++pp+l +++k+s ef++f++++

Q: 215   DYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKSDPPTLLTPSKWSVEFRDFLKTA  274

         ************************************************************

S: 238   lqknpekRpsasellkhkFl  257

         l+knpe+Rpsa++ll+h+F+

Q: 275   LDKNPETRPSAAQLLEHPFV  294

         *******************7

Domain Sequence
(FASTA)

WEIVGELGDG AFGKVYKAKN KETGALAAAK VIETKSEEEL EDYIVEIEIL ATCDHPYIVK 60

LLGAYYYDTK LWIMIEFCPG GAVDAIMLEL ERGLTEPQIQ VVCRQMLEAL SFLHSKRIIH 120

RDLKAGNVLM TLEGDIRLAD FGVSAKNLKT LQKRDSFIGT PYWMAPEVVL CETMKDTPYD 180

YKADIWSLGI TLIEMAQIEP PHHELNPMRV LLKIAKSDPP TLLTPSKWSV EFRDFLKTAL 240

DKNPETRPSA AQLLEHPFV 259

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR022165	; PKK.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF12474	; PKK; 2.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013