EKS-ICT-00159
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ICT-00159
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CAMK/RSKb430.32.3E-129415674260
StatusUnreviewed
Ensembl ProteinENSSTOP00000023182
UniProt AccessionI3NFN5;
Protein NameRibosomal protein S6 kinase
Protein Synonyms/Alias
Gene NameRPS6KA4
Gene Synonyms/Alias RPS6KA4;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSSTOG00000026269ENSSTOP00000023182ENSSTOT00000026339
OrganismIctidomys tridecemlineatus
Functional Description
Protein Length771
Protein Sequence
(FASTA)
MGDEDEDEGC AVELQIIEAN LTGHEEKVSV ENFELLKVLG TGAYGKVFLV RKAGGHDAGK 60
LYAMKVLRKA ALVQRAKTQE HTRTERSVLE LVRQAPFLVT LHYAFQTDAK LHLILDYVSG 120
GEMFTHLYQR QYFKEAEVRV YGGEIVLALE HLHKLGIIYR DLKLENVLLD SEGHIVLTDF 180
GLSKEFLTEE KERTFSFCGT IEYMAPEIIR SKTGHGKAVD WWSLGILLFE LLTGASPFTL 240
EGERNTQAEV SRRILKCSPP FPPRIGPVAQ DLLQRLLCKD PKKRLGAGPQ GAQEVKNHPF 300
FQGLDWAALA ARKIPAPFRP QIRSELDVGN FAEEFTRLEP VYSPAGSPPA GDPRIFQGYS 360
FVAPSILFDH NNAVMIDALE APSAGDRPGR AAVARSAMMQ DSPFFQQYEL DLREPALGQG 420
SFSVCRRCRQ RQSGQEFAVK ILSRRLETNT QREVAALKLC QSHPNVVNLH EVHHDQLHTY 480
LVLELLRGGE LLEHIRKKRH FSESEASQIL RSLVSAVSFM HEEAGVVHRD LKPENILYAD 540
DSPGAPVKII DFGFARLRPQ SPAGPMQTPC FTLQYAAPEL LAQQGYDESC DLWSLGVILY 600
MMLSGQVPFQ GASGQGGQSQ AAEIMCKIRE GRFSLDGEAW QGVSEEAKEL VRGLLTVDPA 660
KRLKLEGLRG SSWLQDGSAR SSPPLRTPDV LESSGPAVRS GLNATFMAFN RGKREGFFLK 720
SVENAPLAKR RKQKLRSAAA SRRGSPAPAA PGRAPAAKGA SRRANGPLPP S 771
Nucleotide Sequence
(FASTA)
ATGGGGGACG AGGATGAGGA CGAGGGCTGC GCGGTAGAAC TGCAGATCAT CGAAGCCAAC 60
CTGACCGGAC ACGAGGAGAA GGTGAGCGTG GAGAACTTCG AGCTGCTCAA GGTGCTGGGC 120
ACGGGAGCCT ACGGGAAGGT GTTCCTGGTG CGAAAGGCGG GCGGGCACGA CGCGGGGAAG 180
CTGTATGCCA TGAAGGTGCT GCGGAAGGCG GCGCTGGTAC AGCGCGCCAA GACGCAGGAG 240
CACACGCGCA CCGAGCGCTC TGTGTTGGAG CTGGTGCGCC AGGCGCCCTT CCTGGTCACG 300
CTGCACTACG CCTTCCAAAC CGATGCCAAG CTGCACCTCA TTCTGGACTA CGTGAGTGGC 360
GGTGAGATGT TCACCCACCT CTACCAGCGC CAGTACTTCA AGGAGGCCGA GGTGCGCGTG 420
TATGGGGGTG AGATCGTGCT GGCTTTGGAA CACCTGCACA AGCTGGGCAT CATCTACCGA 480
GACCTGAAGC TGGAGAATGT GCTGCTGGAT TCCGAGGGCC ACATCGTCCT CACGGACTTC 540
GGCCTGAGCA AAGAGTTCCT GACGGAAGAG AAAGAGCGGA CCTTCTCCTT CTGTGGCACC 600
ATCGAATACA TGGCCCCGGA GATCATTCGT AGCAAGACGG GGCATGGCAA GGCGGTGGAC 660
TGGTGGAGCC TGGGCATCCT GCTCTTCGAG CTGCTGACGG GTGCCTCGCC CTTCACACTG 720
GAGGGCGAGA GGAACACGCA GGCCGAGGTG TCCCGACGGA TCCTGAAGTG CTCCCCTCCC 780
TTCCCCCCCC GGATTGGGCC CGTGGCGCAG GACCTGCTGC AGCGGCTGCT GTGCAAGGAC 840
CCTAAGAAGC GATTGGGTGC AGGTCCCCAG GGGGCACAGG AGGTCAAGAA CCATCCCTTC 900
TTCCAGGGTC TAGACTGGGC TGCTCTGGCT GCCAGGAAGA TCCCGGCCCC ATTCCGGCCC 960
CAGATCCGCT CAGAGCTGGA TGTGGGCAAC TTCGCTGAGG AATTTACTCG GCTGGAGCCT 1020
GTCTACTCAC CCGCTGGCAG CCCCCCGGCT GGGGACCCTC GAATCTTTCA GGGATACTCT 1080
TTCGTGGCGC CATCCATCCT GTTTGACCAC AACAATGCTG TGATGATTGA CGCGCTGGAA 1140
GCCCCCAGTG CTGGAGACCG GCCTGGCCGG GCAGCGGTGG CCAGGAGTGC CATGATGCAG 1200
GACTCGCCAT TCTTCCAGCA GTACGAGCTG GACCTTCGGG AGCCGGCTCT GGGTCAGGGC 1260
AGCTTCTCTG TGTGTCGTCG CTGCCGCCAG CGCCAGAGCG GTCAGGAGTT TGCAGTCAAG 1320
ATCCTCAGTC GCAGGCTTGA GACAAACACG CAGCGCGAAG TGGCCGCCCT GAAGCTGTGC 1380
CAGTCGCACC CCAACGTGGT GAATCTGCAT GAGGTTCATC ACGACCAGCT GCACACATAC 1440
CTGGTCCTGG AGCTGCTGCG GGGCGGGGAG CTGCTGGAGC ACATCCGCAA GAAGCGGCAC 1500
TTCAGCGAGT CGGAGGCGAG CCAGATCCTG CGCAGCCTCG TGTCAGCCGT GAGCTTCATG 1560
CACGAGGAGG CGGGCGTGGT GCACCGCGAC CTCAAGCCCG AGAACATCCT GTACGCGGAT 1620
GACTCGCCCG GGGCGCCGGT GAAGATCATC GACTTCGGGT TCGCGCGACT GCGGCCGCAG 1680
AGCCCCGCCG GGCCCATGCA GACGCCCTGC TTCACGCTGC AGTATGCGGC CCCCGAGCTG 1740
CTGGCGCAGC AAGGTTACGA CGAGTCCTGC GACCTTTGGA GCCTGGGCGT CATTCTGTAC 1800
ATGATGCTGT CGGGGCAGGT GCCCTTCCAG GGGGCCTCAG GCCAGGGCGG GCAGAGCCAG 1860
GCAGCCGAAA TCATGTGCAA GATCCGCGAG GGGCGCTTCT CCCTGGACGG GGAGGCCTGG 1920
CAGGGCGTGT CAGAGGAAGC CAAGGAGCTG GTCCGAGGGC TGCTGACTGT GGACCCCGCC 1980
AAGCGGCTGA AGCTCGAGGG GCTGCGGGGT AGCTCTTGGC TGCAGGACGG CAGCGCGCGC 2040
TCCTCGCCCC CACTGCGGAC GCCGGACGTG CTGGAGTCCT CTGGGCCAGC GGTGCGCTCG 2100
GGGCTCAACG CCACCTTCAT GGCGTTCAAT CGCGGCAAGC GGGAGGGCTT CTTCCTGAAG 2160
AGCGTGGAGA ACGCGCCCCT CGCCAAGCGG CGCAAGCAGA AGCTGCGGAG CGCAGCCGCC 2220
TCCCGCCGCG GCTCCCCCGC GCCTGCCGCC CCGGGCCGGG CCCCTGCCGC CAAGGGAGCC 2280
TCCCGCCGAG CCAACGGCCC CCTGCCCCCC TCCTAG 2316
Domain Profile
S: 5     edlGvGsysvckrcvhkatnqefavkiidks.krdtseeieillryeqhpnivtlkdvyd  63
           lG+Gs+svc+rc++++++qefavki++++ +++t++e+++l+++++hpn+v+l++v++
Q: 415   PALGQGSFSVCRRCRQRQSGQEFAVKILSRRlETNTQREVAALKLCQSHPNVVNLHEVHH  474
         579*********************************************************
S: 64    dgkyvylvlellkGGelldrikkkkffsereasailrtlvkaveylheq.Gvvhrdlkpe  122
         d++++ylvlell+GGell++i+kk++fse+eas+ilr+lv+av+++he+ Gvvhrdlkpe
Q: 475   DQLHTYLVLELLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEaGVVHRDLKPE  534
         ***********************************************999**********
S: 123   nilyvdesdnaesikiidfGfaklkraeng.llktpcytlnfvapevlkrqGydeacdlw  181
         nily+d+s++a+ +kiidfGfa+l+++++  +++tpc+tl+++ape+l++qGyde+cdlw
Q: 535   NILYADDSPGAP-VKIIDFGFARLRPQSPAgPMQTPCFTLQYAAPELLAQQGYDESCDLW  593
         ************.*************99755*****************************
S: 182   slGvllytmlaGyvpf....angpedtaeeilakikeGkfslsGeawdsvseeakdlvsk  237
         slGv+ly+ml+G+vpf    ++g++++a+ei++ki+eG+fsl+Geaw++vseeak+lv++
Q: 594   SLGVILYMMLSGQVPFqgasGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKELVRG  653
         ****************999889**************************************
S: 238   lltvdpakrlkleqllkhswl  258
         lltvdpakrlkle+l+ +swl
Q: 654   LLTVDPAKRLKLEGLRGSSWL  674
         ********************7
Domain Sequence
(FASTA)
PALGQGSFSV CRRCRQRQSG QEFAVKILSR RLETNTQREV AALKLCQSHP NVVNLHEVHH 60
DQLHTYLVLE LLRGGELLEH IRKKRHFSES EASQILRSLV SAVSFMHEEA GVVHRDLKPE 120
NILYADDSPG APVKIIDFGF ARLRPQSPAG PMQTPCFTLQ YAAPELLAQQ GYDESCDLWS 180
LGVILYMMLS GQVPFQGASG QGGQSQAAEI MCKIREGRFS LDGEAWQGVS EEAKELVRGL 240
LTVDPAKRLK LEGLRGSSWL 260
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>
EKS-AIM-00156
EKS-ANC-00159
EKS-BOT-00164
EKS-CAJ-00168
EKS-CAF-00171
EKS-CAP-00163
EKS-DAR-00453
EKS-EQC-00155
EKS-FEC-00154
EKS-GAA-00194
EKS-HOS-00170
EKS-LOA-00163
EKS-MAM-00162
EKS-MAE-00060
EKS-MUM-00169
EKS-MUP-00168
EKS-NOL-00157
EKS-ORN-00204
EKS-OTG-00168
EKS-PAT-00154
EKS-PES-00145
EKS-RAN-00161
EKS-SAH-00158
EKS-SUS-00141
EKS-TAR-00211
EKS-TEN-00204
Gene Ontology
GO:0005524; F:ATP binding
GO:0000287; F:magnesium ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0007243; P:intracellular protein kinase cascade
KEGG
InterPros
IPR000961; AGC-kinase_C.
IPR011009; Kinase-like_dom.
IPR017892; Pkinase_C.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR016239; Ribosomal_S6_kinase_II.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 2.
PF00433; Pkinase_C; 1.
SMARTs
SM00133; S_TK_X; 1.
SM00220; S_TKc; 2.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS00107; PROTEIN_KINASE_ATP; 2.
PS50011; PROTEIN_KINASE_DOM; 2.
PS00108; PROTEIN_KINASE_ST; 2.
Prints
Created Date20-Feb-2013