EKS-ICT-00384
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ICT-00384
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/PDGFR574.01.2E-172581910330
StatusUnreviewed
Ensembl ProteinENSSTOP00000017130
UniProt AccessionI3MYD4;
Protein Name
Protein Synonyms/Alias
Gene NameCSF1R
Gene Synonyms/Alias CSF1R;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSSTOG00000026851ENSSTOP00000017130ENSSTOT00000022727
OrganismIctidomys tridecemlineatus
Functional Description
Protein Length972
Protein Sequence
(FASTA)
MGPGTLLVLL ATTVWHAGQG VPVIEPSGPE LVVEPGTTVT LRCRGNGSVE WDGPIFPYWT 60
LDPNAPSSVL TTNNATFKNT GTYRCTEPGD PLAGSATIHL FVKDPVRPWN LLAEEVTVFE 120
GQDALLPCLL TDPSLKAGVS LMRVRGRSVL PQTNYSFSPW YGFTIHKAKF IEGRDYQCCA 180
LVDGRMVKTL GIRLNVQKVL PGPPTLTLEP AELVRIRGEA AQIVCSSSNV DVDFDVFLKH 240
GNTKLKIAQQ SDFNDNHYHK VLTLNLDDVG FQDAGNYSCV ATNAQGTHST SMIFQVVESA 300
YLNLTSEQNL LQEVTVGENL NLNVKVEAYP GLQGFNWTYL GPFSDYQHKL DFVTNKETYR 360
YTSSLSLPRL KPSEAGRYSF LAMNAGGSSS LTFELTLCYA PEVSVMWIPI NGSITLFCDV 420
SGYPQPNVTW VQCRGHTEKC DEAQVLKVWV DSQPRVLSQE PFHKVTIQSQ LTIGTWEHNT 480
SYECRAHNSV GNSSQSLRAV SSEAYRQDPD EFLFTPVVVA CMSAMALLLL LLLLLLYKYK 540
QKPKYQVRWK IIESYEGNSY TFIDPTQLPY NEKWEFPRNN LQFGKTLGAG AFGKVVEATA 600
FGLGKEDAVL KVAVKMLKST AHADEKEALM SELKIMSHLG QHENIVNLLG ACTHGGPVLV 660
ITEYCCYGDL LNFLRRKAEA MLGPILDSGQ DPEGDTGYKN IHLEKKYVRR DSGFSSQGMD 720
TYVEMRPVST SSSNDSFSEQ DLNKEDCRPL ELRDLLHFSS QVAQGMAFLA SKNCIHRDVA 780
ARNVLLTNGH VAKIGDFGLA RDIMNDSNYI VKGNARLPVK WMAPESIFDC VYTVQSDVWS 840
YGILLWEIFS LGLNPYPGIL VNSKFYKLVK DGYQMAQPAF APKNIYSIMQ ACWDLEPTRR 900
PTFQQICFLL QEQAQVDRRE QDYANLPSSS SGGSSSSSSS EPEEESSSEH LACCESGEST 960
QPLLQPNNYQ FC 972
Nucleotide Sequence
(FASTA)
ATGGGCCCCG GGACTTTGCT GGTCCTGCTG GCAACCACAG TTTGGCATGC AGGTCAGGGG 60
GTCCCAGTAA TTGAACCCAG CGGCCCTGAG CTGGTGGTGG AGCCGGGAAC CACAGTCACC 120
CTGCGATGCA GGGGCAACGG AAGTGTGGAA TGGGATGGCC CCATCTTCCC CTACTGGACC 180
CTGGACCCTA ATGCTCCCAG CAGTGTCCTG ACCACAAACA ATGCTACCTT CAAAAACACG 240
GGGACCTATC GCTGCACGGA ACCCGGAGAC CCCCTGGCAG GCAGCGCCAC CATCCACCTC 300
TTCGTCAAAG ACCCTGTCCG GCCCTGGAAC CTGTTGGCGG AGGAGGTGAC AGTGTTTGAG 360
GGTCAGGATG CCCTACTGCC CTGCCTGCTC ACCGACCCCT CGCTAAAGGC GGGCGTCTCC 420
CTGATGCGTG TGCGTGGCCG GTCGGTCTTG CCCCAAACCA ACTACTCCTT CTCACCCTGG 480
TATGGCTTCA CCATCCACAA GGCCAAGTTC ATAGAGGGCA GGGACTACCA GTGCTGTGCC 540
TTGGTGGACG GCAGGATGGT GAAGACTCTT GGCATCCGGC TCAATGTGCA GAAAGTCCTC 600
CCAGGGCCCC CAACCTTGAC ACTGGAGCCT GCAGAGCTAG TGCGGATCCG AGGGGAGGCT 660
GCCCAGATTG TGTGCTCATC CAGCAACGTG GACGTGGACT TTGACGTCTT CCTCAAACAT 720
GGAAACACCA AGCTCAAAAT CGCTCAACAA TCGGACTTCA ATGATAACCA TTACCACAAA 780
GTCCTCACCC TCAACCTGGA TGACGTGGGC TTCCAAGACG CTGGCAACTA CTCCTGTGTG 840
GCCACCAATG CCCAGGGCAC CCACTCCACT TCCATGATTT TCCAGGTGGT AGAGAGTGCC 900
TACTTGAATT TGACCTCTGA GCAGAACCTC CTCCAGGAAG TGACTGTGGG TGAGAACCTC 960
AACCTCAATG TCAAGGTGGA GGCCTACCCT GGCCTACAGG GTTTCAACTG GACATATTTG 1020
GGACCCTTCT CTGACTACCA GCACAAGCTT GATTTTGTCA CCAACAAGGA AACCTACAGG 1080
TACACCTCCA GCCTCTCCCT GCCCCGCCTG AAGCCCTCTG AGGCCGGCCG CTACTCCTTC 1140
CTGGCTATGA ATGCAGGGGG TTCCAGTTCG CTGACCTTTG AACTCACCTT GTGCTATGCC 1200
CCTGAGGTCA GTGTCATGTG GATCCCCATC AATGGCTCTA TCACCCTGTT CTGTGATGTC 1260
TCTGGATACC CCCAGCCCAA TGTGACATGG GTGCAGTGCA GGGGACACAC TGAGAAATGT 1320
GATGAAGCCC AGGTGCTGAA GGTCTGGGTA GACTCCCAGC CCAGAGTCCT GAGCCAGGAG 1380
CCCTTCCACA AAGTGACCAT CCAGAGCCAA CTGACCATTG GGACCTGGGA ACACAACACC 1440
TCCTATGAGT GCAGGGCCCA CAACAGCGTG GGGAACAGCT CTCAGTCCTT AAGGGCCGTC 1500
TCATCAGAAG CCTACAGACA GGACCCGGAC GAGTTCCTCT TCACACCAGT CGTGGTCGCC 1560
TGCATGTCCG CCATGGCCTT GCTGCTGCTA CTGCTGCTGC TGCTCTTGTA CAAGTACAAG 1620
CAGAAGCCCA AATACCAGGT GCGCTGGAAG ATCATCGAGA GCTACGAGGG CAACAGCTAC 1680
ACCTTCATCG ACCCCACCCA GCTGCCCTAC AATGAGAAGT GGGAGTTCCC AAGAAACAAC 1740
CTGCAGTTTG GTAAGACCCT CGGAGCCGGA GCCTTTGGGA AGGTGGTAGA GGCCACAGCC 1800
TTTGGTCTGG GCAAGGAAGA CGCTGTCCTG AAGGTGGCTG TGAAGATGCT GAAGTCCACG 1860
GCTCATGCAG ATGAAAAGGA GGCTCTGATG TCGGAACTGA AGATCATGAG TCACCTGGGC 1920
CAGCACGAGA ACATAGTGAA CCTTCTGGGG GCCTGTACCC ATGGAGGGCC CGTTCTGGTC 1980
ATCACCGAGT ACTGCTGCTA TGGCGACCTG CTCAACTTCC TGCGAAGGAA GGCTGAGGCC 2040
ATGCTGGGAC CCATCCTGGA TTCAGGTCAG GACCCCGAGG GAGACACTGG CTACAAAAAC 2100
ATCCACCTGG AGAAGAAATA TGTCCGCAGG GACAGTGGCT TCTCCAGTCA GGGTATGGAC 2160
ACCTATGTGG AGATGAGGCC TGTTTCCACT TCTTCTTCCA ATGACTCCTT CTCTGAGCAA 2220
GACTTGAACA AGGAGGACTG CCGGCCTCTG GAGCTCCGGG ACCTGCTCCA CTTCTCCAGC 2280
CAAGTGGCAC AGGGCATGGC CTTCCTTGCT TCTAAGAATT GCATCCACCG AGACGTGGCA 2340
GCTCGAAACG TGCTATTGAC CAATGGGCAC GTGGCCAAGA TTGGGGACTT TGGGCTGGCC 2400
AGGGACATCA TGAATGACTC CAACTACATT GTCAAGGGCA ACGCCCGCCT GCCTGTGAAG 2460
TGGATGGCCC CAGAGAGCAT TTTCGACTGT GTCTATACAG TTCAGAGTGA CGTCTGGTCC 2520
TACGGCATCC TCCTCTGGGA AATCTTCTCA CTCGGGCTGA ACCCCTACCC AGGCATCTTG 2580
GTGAACAGCA AGTTCTACAA GCTGGTGAAG GATGGATACC AGATGGCCCA GCCTGCATTT 2640
GCCCCGAAGA ACATATACAG CATAATGCAG GCCTGCTGGG ACCTGGAGCC CACTCGCAGA 2700
CCCACCTTCC AGCAGATTTG CTTCCTCCTC CAGGAACAGG CCCAAGTGGA CAGGAGAGAG 2760
CAGGATTATG CCAACCTGCC AAGCAGCAGC AGCGGTGGCA GCAGCAGCAG CAGCAGCAGT 2820
GAGCCAGAGG AGGAGAGCTC TAGCGAGCAC TTGGCCTGCT GTGAGTCAGG AGAGAGCACC 2880
CAGCCTCTGC TGCAGCCCAA TAACTACCAG TTCTGCTGA 2919
Domain Profile
S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60
         l++Gk+lG+GafGkvveata+Gl+k+davlkvavkmlksta+++ekealmselki+shlG
Q: 581   LQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLG  640
         79**********************************************************
S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120
         +henivnllGact+gGp++viteyccyGdlln+lrrk+e++l   l+  +++e ++ +k+
Q: 641   QHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPILDSGQDPEGDTGYKN  700
         ************************************************************
S: 121   l.ladkslrsksslssesseeyvdlkkdvsdvssskadklasekkksalerevkaaleee  179
         + l++k++r++s +ss++ ++yv++++    vs+s+++   se+            l++e
Q: 701   IhLEKKYVRRDSGFSSQGMDTYVEMRP----VSTSSSNDSFSEQ-----------DLNKE  745
         *999***********************....6666555444444...........37799
S: 180   dsevleledllsfsyqvakGmeflaskncvhrdlaarnvllteGkvvkicdfGlardimk  239
         d ++lel+dll+fs+qva+Gm+flasknc+hrd+aarnvllt+G+v+ki+dfGlardim+
Q: 746   DCRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMN  805
         9***********************************************************
S: 240   dsnyvvkGnarlpvkwmapesifdslytvksdvwsyGillweifslGstpypgllvdskf  299
         dsny+vkGnarlpvkwmapesifd++ytv+sdvwsyGillweifslG +pypg+lv+skf
Q: 806   DSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKF  865
         ************************************************************
S: 300   yklikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlvell  344
         ykl+k+Gy+maqpa+a+++iy+imq+cw+ ep++rp+f+q++ ll
Q: 866   YKLVKDGYQMAQPAFAPKNIYSIMQACWDLEPTRRPTFQQICFLL  910
         ******************************************986
Domain Sequence
(FASTA)
LQFGKTLGAG AFGKVVEATA FGLGKEDAVL KVAVKMLKST AHADEKEALM SELKIMSHLG 60
QHENIVNLLG ACTHGGPVLV ITEYCCYGDL LNFLRRKAEA MLGPILDSGQ DPEGDTGYKN 120
IHLEKKYVRR DSGFSSQGMD TYVEMRPVST SSSNDSFSEQ DLNKEDCRPL ELRDLLHFSS 180
QVAQGMAFLA SKNCIHRDVA ARNVLLTNGH VAKIGDFGLA RDIMNDSNYI VKGNARLPVK 240
WMAPESIFDC VYTVQSDVWS YGILLWEIFS LGLNPYPGIL VNSKFYKLVK DGYQMAQPAF 300
APKNIYSIMQ ACWDLEPTRR PTFQQICFLL 330
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00376
EKS-ANC-00391
EKS-BOT-00405
EKS-CAJ-00409
EKS-CAF-00405
EKS-CAP-00434
EKS-DAR-00788
EKS-EQC-00397
EKS-FEC-00389
EKS-GAG-00342
EKS-GAA-00492
EKS-GOG-00397
EKS-HOS-00411
EKS-LAC-00420
EKS-LOA-00414
EKS-MAM-00404
EKS-MEG-00336
EKS-MOD-00393
EKS-MUM-00437
EKS-MUP-00398
EKS-MYL-00400
EKS-ORN-00515
EKS-ORC-00380
EKS-ORL-00473
EKS-OTG-00407
EKS-PAT-00383
EKS-PES-00359
EKS-POA-00396
EKS-PTV-00115
EKS-RAN-00419
EKS-SAH-00375
EKS-SUS-00355
EKS-TAG-00474
EKS-TAR-00511
EKS-TEN-00512
EKS-TUT-00118
EKS-XET-00514
EKS-XIM-00507
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR003599; Ig_sub.
IPR003598; Ig_sub2.
IPR013151; Immunoglobulin.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016243; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824; Tyr_kinase_rcpt_3_CS.
Pfam
PF00047; ig; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 3.
SM00408; IGc2; 1.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 3.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00240; RECEPTOR_TYR_KIN_III; 1.
Prints
Created Date20-Feb-2013