EKS-ICT-00018

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ICT-00018

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/InsR	514.9	3.8E-155	979	1246	268

Status

Unreviewed

Ensembl Protein

ENSSTOP00000018697

UniProt Accession

I3N2V1;

Protein Name

Tyrosine-protein kinase receptor

Protein Synonyms/Alias

Gene Name

INSRR

Gene Synonyms/Alias

INSRR;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSTOG00000026953	ENSSTOP00000018697	ENSSTOT00000022289

Organism

Ictidomys tridecemlineatus

Functional Description

Protein Length

1300

Protein Sequence
(FASTA)

MAVPGLWPWG ACHLMILFSL GFGLDTLEVC PSLDIRSEVA ELRRLENCSV VEGHLQILLM 60

FTATGEDFRG LSFPRLTQVT DYLLLFRVYG LESLRDLFPN LAVIRGARLF LGYALVIFEM 120

PHLRDVGLPA LGAVLRGAVR VEKNQELCHL STIDWGLLQP APGANHIVGN KLGEECADVC 180

PGVLGAAGEP CARTTFGGHT DYRCWTSSHC QRGGSGPGGP GCAQDGAVGA GELMCPCPQG 240

LACRACVACR HLYFQGACHT ACPPGTYQQE SWRCVTAERC ASLRSVPGRA STFSIHQGSC 300

LAQCPPGFTR NGSSIFCHKC EGLCPKECKV GTKTIDSVQA AQDLVGCTHV EGSLILNLRQ 360

GYNLEPELQR SLGLVETITG FLKIKHSFAL VSLGFLKNLK LIRGDAMVDG NYTLYVLDNQ 420

NLQQLGSWVA TGLTIPVGKI YFAFNPRLCL EHIYRLEEVT GTRGRQNKAE INPRTNGDRA 480

ACQTRTLRFV SNVTETDRIL LRWERYEPLE ARDLLSFIVY YKESPFQNAT EHVGPDACGT 540

QSWNLLDVEL PLSRTQEPGV TLAPLKPWTQ YAVFVRAITL TTAEDSPHQG AQSPIVYLRT 600

LPAAPTVPQD VISTSNSSSH LLVRWKPPTQ RNGNITYYLV LWQRLAEDGD LYLNDYCHRG 660

LRLPTSNHDS RFDREDGELE AETEPGCCPC QHSPPGQALP PLEAQEASFQ KKFENFLHNA 720

ITIPKSPWKV TSLNKSPERD LVRHRRAAGT LRLGGNSSDF EIQEDKVPRE RAVLSGLRHF 780

TEYRIDIHAC NHAAHTVGCS AATFVFARTM PHREADGIPG KVEWEAASKS SVLLRWLEPP 840

DPNGLILKYE IKYRRSGEEA TVLCVSRLRY AKVGGVHLAL LPPGNYSARV RATSLAGNGS 900

WTDSVAFYIL GPEEEDSGGL HVLLTVTPVG LMLLIILAAL GFFYGRKRSG TLYTSVNPEY 960

FSASEMYVPD EWEVPREQIS IIRELGQGSF GMVYEGLAQG LEAGEKSTPV ALKTVNELAS 1020

PRERIEFLKE ASVMKAFKCH HVVRLLGVVS QGQPTLVIME LMARGDLKSH LRSLRPEAEN 1080

NPGLPQPALE DMIQMAGEIA DGMAYLAANK FVHRDLAARN CMVSQDFTVK IGDFGMTRDV 1140

YETDYYRKGG KGLLPVRWMA PESLKDGIFT THSDVWSFGV VLWEIATLAE QPYQGLSNEQ 1200

VLKFVMDGGV LEELQSCPLQ LQELMSRCWQ QNPRLRPTFT HILDSIQEEL RPSFRLLSFY 1260

YSPECRGGLG SLLPTDAEPD SPLTPKEASE GSPQNGGPGH 1300

Nucleotide Sequence
(FASTA)

ATGGCAGTGC CTGGTCTGTG GCCTTGGGGA GCCTGCCACC TTATGATTCT CTTCTCCTTG 60

GGATTTGGCC TGGATACACT AGAGGTGTGC CCCAGCCTGG ACATCCGCTC AGAGGTGGCG 120

GAGCTGCGGC GGCTGGAGAA CTGCAGCGTG GTGGAGGGCC ACTTGCAGAT CCTGCTCATG 180

TTCACGGCCA CGGGGGAGGA TTTCCGCGGC CTCAGTTTCC CCCGCCTCAC CCAGGTCACC 240

GACTACCTCC TGCTCTTCCG CGTCTACGGC CTGGAGAGCC TGCGGGACCT CTTCCCCAAC 300

CTCGCGGTGA TCCGGGGGGC GCGCCTCTTC CTGGGCTACG CGCTGGTCAT CTTCGAGATG 360

CCACACCTGC GCGACGTGGG GCTGCCCGCG CTGGGGGCTG TGCTGCGCGG CGCTGTGCGG 420

GTGGAGAAGA ACCAGGAGCT CTGCCACCTG TCCACCATCG ACTGGGGACT GCTGCAGCCT 480

GCGCCCGGTG CCAACCACAT CGTGGGCAAC AAGCTGGGCG AGGAGTGTGC AGATGTGTGC 540

CCAGGGGTGC TGGGAGCCGC TGGTGAGCCC TGTGCCAGGA CCACCTTTGG TGGACACACG 600

GACTACAGGT GCTGGACCTC CAGCCACTGT CAGAGAGGTG GGTCAGGGCC AGGTGGGCCA 660

GGGTGCGCGC AGGATGGTGC AGTGGGTGCA GGAGAGTTAA TGTGTCCCTG CCCCCAAGGC 720

CTGGCCTGCC GTGCCTGCGT GGCCTGCCGC CACCTGTACT TCCAGGGAGC CTGCCACACA 780

GCCTGCCCTC CAGGCACCTA CCAGCAGGAG TCCTGGCGCT GCGTCACGGC CGAGCGCTGT 840

GCCAGCCTGC GCTCGGTGCC CGGCCGCGCC TCTACCTTCA GCATCCACCA GGGCAGCTGC 900

CTGGCCCAGT GCCCGCCAGG CTTCACCCGC AATGGCAGCA GCATATTCTG CCATAAATGC 960

GAGGGGCTGT GCCCGAAAGA ATGCAAGGTG GGCACCAAGA CCATCGACTC GGTGCAGGCG 1020

GCCCAGGACC TGGTGGGCTG CACCCACGTG GAGGGGAGCC TCATCCTCAA CCTCCGCCAG 1080

GGCTACAACC TGGAGCCCGA ACTGCAGCGC AGCCTGGGGC TGGTGGAGAC CATCACTGGC 1140

TTCCTCAAAA TCAAACACTC CTTCGCACTC GTGTCCCTGG GCTTCTTGAA GAACCTCAAG 1200

CTAATCCGGG GGGATGCCAT GGTGGATGGG AACTACACTC TGTACGTGCT GGACAACCAG 1260

AACCTGCAAC AGCTGGGGTC CTGGGTGGCC ACTGGGCTCA CCATTCCTGT GGGCAAGATC 1320

TACTTTGCCT TCAATCCGCG CCTCTGCTTG GAGCACATCT ACCGATTGGA GGAGGTGACG 1380

GGCACCCGGG GTCGGCAAAA CAAGGCTGAG ATCAACCCCC GCACCAATGG AGACCGCGCT 1440

GCCTGCCAGA CTCGCACCCT GCGCTTCGTG TCCAACGTGA CGGAGACGGA CCGCATCCTG 1500

CTGCGCTGGG AGCGCTACGA GCCGCTGGAG GCCCGCGACC TGCTCAGCTT CATCGTCTAC 1560

TACAAGGAGT CCCCATTCCA GAATGCCACA GAGCATGTGG GTCCAGATGC CTGTGGAACT 1620

CAGAGCTGGA ACCTGCTGGA TGTGGAGCTG CCCCTAAGCC GCACCCAAGA GCCAGGGGTC 1680

ACCTTAGCCC CCCTGAAGCC CTGGACACAG TATGCAGTGT TTGTGCGGGC TATCACACTG 1740

ACCACTGCTG AGGACAGCCC TCATCAAGGA GCCCAGAGCC CCATCGTCTA CCTCCGGACC 1800

CTGCCTGCAG CACCCACGGT GCCCCAAGAC GTCATCTCCA CGTCCAACTC CTCCTCCCAC 1860

CTCCTGGTGC GCTGGAAGCC ACCGACCCAG CGCAACGGAA ACATCACCTA CTACCTGGTC 1920

CTGTGGCAGA GGCTGGCGGA GGACGGCGAC CTCTACCTCA ATGACTACTG CCACCGCGGC 1980

TTGCGGCTGC CCACCAGCAA CCACGACTCC CGCTTCGACC GCGAAGATGG GGAACTCGAG 2040

GCCGAGACCG AACCGGGCTG CTGCCCCTGC CAGCACTCAC CTCCTGGACA GGCCCTGCCG 2100

CCGCTGGAGG CGCAGGAGGC CTCGTTCCAG AAGAAGTTTG AAAACTTTCT GCACAACGCC 2160

ATCACCATCC CCAAGTCCCC TTGGAAAGTG ACCTCCCTCA ACAAGAGCCC TGAAAGGGAC 2220

TTGGTGCGGC ACCGCCGGGC CGCCGGGACC CTCAGACTAG GGGGCAACAG CTCGGATTTT 2280

GAGATCCAGG AGGACAAGGT TCCCCGAGAG CGGGCTGTGC TGAGCGGCTT GCGCCACTTC 2340

ACCGAGTACC GGATCGACAT CCACGCCTGC AACCACGCGG CGCACACCGT GGGCTGCAGC 2400

GCGGCCACCT TTGTCTTTGC GCGCACCATG CCCCACAGAG AGGCTGATGG TATCCCAGGG 2460

AAGGTGGAGT GGGAGGCAGC CAGCAAGAGC AGTGTTCTCC TGAGGTGGCT TGAGCCACCG 2520

GACCCCAATG GACTCATCCT CAAGTATGAA ATCAAGTACC GTCGCTCAGG AGAGGAAGCC 2580

ACAGTGCTGT GCGTGTCCCG GCTGAGATAT GCCAAAGTTG GTGGGGTCCA CCTGGCCCTG 2640

CTTCCCCCTG GGAATTACTC TGCGAGGGTT CGTGCCACTT CCCTGGCTGG CAATGGCTCT 2700

TGGACGGACA GTGTTGCCTT CTACATCCTT GGCCCAGAGG AGGAAGACTC CGGCGGTCTG 2760

CACGTCCTCC TCACTGTCAC CCCCGTGGGC CTCATGCTGC TCATCATTCT TGCTGCCCTC 2820

GGTTTCTTCT ACGGCAGGAA GAGAAGTGGC ACCCTGTATA CCTCTGTGAA TCCGGAGTAC 2880

TTCAGCGCCT CTGAGATGTA CGTCCCTGAT GAGTGGGAGG TGCCCCGGGA GCAGATCTCC 2940

ATCATCCGGG AGCTGGGCCA AGGCTCCTTT GGGATGGTCT ATGAGGGCCT GGCACAAGGA 3000

CTCGAGGCTG GAGAGAAGTC CACGCCGGTA GCCCTGAAGA CGGTGAATGA GCTGGCCAGC 3060

CCACGGGAAC GCATCGAATT CCTTAAGGAA GCGTCTGTCA TGAAGGCATT CAAGTGTCAC 3120

CACGTGGTGC GTCTCCTGGG AGTCGTGTCT CAAGGCCAGC CAACTCTGGT CATCATGGAG 3180

CTAATGGCCC GGGGGGACCT CAAGAGCCAT CTTCGGTCTT TGAGGCCTGA AGCAGAGAAC 3240

AACCCCGGGC TCCCACAGCC AGCACTAGAG GACATGATCC AGATGGCGGG TGAGATCGCG 3300

GATGGCATGG CTTACCTGGC CGCCAACAAG TTCGTGCACC GAGACCTGGC AGCCCGTAAC 3360

TGCATGGTGT CCCAGGACTT CACTGTCAAG ATCGGGGACT TCGGGATGAC TCGGGACGTG 3420

TATGAGACAG ACTATTACCG CAAGGGTGGG AAGGGGCTGC TGCCCGTGCG CTGGATGGCC 3480

CCCGAGTCCC TCAAAGATGG AATCTTCACC ACCCACTCAG ATGTCTGGTC CTTTGGTGTG 3540

GTGCTCTGGG AGATCGCGAC CCTGGCCGAA CAACCCTACC AGGGCCTGTC CAATGAGCAA 3600

GTGCTCAAAT TTGTCATGGA TGGCGGGGTC CTGGAGGAGC TGCAGAGCTG TCCCCTTCAG 3660

CTGCAGGAGC TGATGAGCCG TTGCTGGCAG CAGAACCCAC GCCTGCGCCC GACCTTCACC 3720

CACATCCTGG ACAGCATACA GGAGGAGCTG AGGCCCTCCT TCCGCCTGCT CTCCTTCTAC 3780

TACAGCCCAG AGTGCCGCGG AGGCCTGGGC TCCTTGCTAC CCACTGACGC AGAGCCCGAC 3840

TCCCCACTAA CTCCAAAAGA GGCCTCAGAG GGCAGCCCCC AAAACGGGGG TCCAGGGCAT 3900

TAA 3903

Domain Profile

S: 1     ivllrelGqGsfGmvyeGvakdvvkgeeetrvaiktvneaassrerieflkeasvmkefk  60

         i+++relGqGsfGmvyeG+a+++++ge++t+va+ktvne as rerieflkeasvmk+fk

Q: 979   ISIIRELGQGSFGMVYEGLAQGLEAGEKSTPVALKTVNELASPRERIEFLKEASVMKAFK  1038

         6799********************************************************

S: 61    thhvvrllGvvskgqpalvvmelmkkGdlksylrslrpeeeneaalappaldkliqmaae  120

         +hhvvrllGvvs+gqp+lv+melm++Gdlks+lrslrpe+en+++l++pal+++iqma+e

Q: 1039  CHHVVRLLGVVSQGQPTLVIMELMARGDLKSHLRSLRPEAENNPGLPQPALEDMIQMAGE  1098

         ************************************************************

S: 121   iadGmayleakkfvhrdlaarncmvaedltvkiGdfGmtrdiyetdyyrkggkgllpvrw  180

         iadGmayl+a+kfvhrdlaarncmv++d+tvkiGdfGmtrd+yetdyyrkggkgllpvrw

Q: 1099  IADGMAYLAANKFVHRDLAARNCMVSQDFTVKIGDFGMTRDVYETDYYRKGGKGLLPVRW  1158

         ************************************************************

S: 181   mspeslkdGvftsksdvwsfGvvlweivtlaeqpyqGlsneqvlkfvldggvlekpencp  240

         m+peslkdG+ft++sdvwsfGvvlwei+tlaeqpyqGlsneqvlkfv+dggvle++++cp

Q: 1159  MAPESLKDGIFTTHSDVWSFGVVLWEIATLAEQPYQGLSNEQVLKFVMDGGVLEELQSCP  1218

         ************************************************************

S: 241   elltelmrlcwqynpklrpsfleivell  268

          +l+elm++cwq np+lrp+f++i++++

Q: 1219  LQLQELMSRCWQQNPRLRPTFTHILDSI  1246

         ************************9976

Domain Sequence
(FASTA)

ISIIRELGQG SFGMVYEGLA QGLEAGEKST PVALKTVNEL ASPRERIEFL KEASVMKAFK 60

CHHVVRLLGV VSQGQPTLVI MELMARGDLK SHLRSLRPEA ENNPGLPQPA LEDMIQMAGE 120

IADGMAYLAA NKFVHRDLAA RNCMVSQDFT VKIGDFGMTR DVYETDYYRK GGKGLLPVRW 180

MAPESLKDGI FTTHSDVWSF GVVLWEIATL AEQPYQGLSN EQVLKFVMDG GVLEELQSCP 240

LQLQELMSRC WQQNPRLRPT FTHILDSI 268

Keyword

ATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0046777	; P:protein autophosphorylation
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

InterPros

IPR000494	; EGF_rcpt_L.
IPR003961	; Fibronectin_type3.
IPR006211	; Furin-like_Cys-rich_dom.
IPR009030	; Growth_fac_rcpt.
IPR013783	; Ig-like_fold.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016246	; Tyr_kinase_insulin-like_rcpt.
IPR002011	; Tyr_kinase_rcpt_2_CS.

Pfam

PF00041	; fn3; 1.
PF00757	; Furin-like; 1.
PF07714	; Pkinase_Tyr; 1.
PF01030	; Recep_L_domain; 2.

SMARTs

SM00060	; FN3; 3.
SM00219	; TyrKc; 1.

Prosites

PS50853	; FN3; 4.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00239	; RECEPTOR_TYR_KIN_II; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013