EKS-ICT-00367

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ICT-00367

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE11	359.5	1.3E-107	323	575	253

Status

Unreviewed

Ensembl Protein

ENSSTOP00000016995

UniProt Accession

I3MY00;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP3K15

Gene Synonyms/Alias

MAP3K15;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSTOG00000027298	ENSSTOP00000016995	ENSSTOT00000024613

Organism

Ictidomys tridecemlineatus

Functional Description

Protein Length

995

Protein Sequence
(FASTA)

RRNSAGDREK ALQVMLQVLQ SCDHPAPDMF CLCGRIYKDI FLDSDCKDAA SRDSAIEWYR 60

KGFELQSSLY SGINLAVLLI VAGQQFETSM ELRKIGVRLN SLLGRKGSLE KMNNYWDVGQ 120

FFTVSMLAND VGKAVQAAER LFKLKPPVWY LRSLVQNLLL IRRFKKPIIE HSPRQERLTF 180

WLDIIFEATN EVSNGLRFPV LVIEPTKVYQ PSYVSINSEA EERTVSLWHV SPTEMKQIHE 240

WNFAASSIKG ISLSKFDERC CFLYVHDNSD DFQIYFSTED QCSRFCFLVK EMLTNAAGST 300

VELEGEADGD TLEYEYDYDA NGERVVLGKG TYGIVYAGRD LSNQVRIAIK EIPEKDSRQP 360

LHEEIALHKY LKHRNIVQYL GSVSEDGYIK IFMEQVPGGD LSALLRSKWG PMKEPTIKFY 420

TKQILEGLKY LHENQIVHRD IKGDNVLVNT YSGVVKISDF GTSKRLAGVN PCTETFTGTL 480

QYMAPEIIDQ GPRGYGAPAD IWSLGCTIIE MATSKPPFHE LGEPQAAMFK VGMFKIHPEI 540

PEALSTEART FILFCFEPDP QKRATATDLL RESFLRQVNK GKKNRIAFKP SEGTRIVTSA 600

LALPSPGEPL GSSSSEHGSI SPDSDAQPDT FFERTQVPKH QLSHFLSVPD ESSASEDRNA 660

PSSPDDRDQG LFLLRKDSER RAILYKILWE EQNQVVSNLQ ECVTQSSEEL HLSVGHIKQI 720

IGILRDFIRS PEHRVMASTI SKLKVDLDFD SSSINQIHLV LFGFQDAVNK ILRNHLIRPH 780

WMFAMDNIIR RAVQAAITIL IPELRAHFEP TSETEGVDKD TDEVEDDYPL ADLPGSEAHV 840

ASGGRRPGAA VAEEAQPHQQ HLSLQLSKLR QESNRLLEHL VQKEREYQNL LRQTLEQKTQ 900

ELYHLQLQFN CNGMTKNLTP PPRQGTDKEL IDWLQLQGTD ANTIEKIVEE NYTLSDILNN 960

ITKEDLRCLR LRGGVLCRLW HAVSQYRRQA QESSA 995

Nucleotide Sequence
(FASTA)

AGGAGAAACA GTGCAGGTGA CCGTGAGAAG GCTCTTCAGG TCATGCTCCA GGTTCTGCAG 60

AGCTGTGACC ACCCAGCTCC TGACATGTTT TGCCTGTGTG GGAGGATCTA CAAGGATATC 120

TTCTTGGATT CAGACTGTAA AGATGCTGCC AGCAGAGACA GTGCCATTGA GTGGTATCGC 180

AAGGGGTTTG AACTGCAGTC ATCTCTTTAT TCGGGAATTA ACCTTGCAGT TTTGCTGATT 240

GTTGCTGGAC AACAATTTGA AACTTCCATG GAACTAAGGA AAATAGGTGT TCGACTGAAT 300

AGTTTGTTGG GAAGAAAAGG GAGCTTGGAG AAAATGAACA ATTACTGGGA TGTTGGCCAG 360

TTCTTCACTG TCAGCATGTT GGCCAATGAT GTCGGGAAGG CGGTGCAAGC AGCAGAGAGG 420

CTATTCAAGC TGAAACCTCC AGTCTGGTAT CTGCGATCAT TAGTTCAGAA CTTGTTATTA 480

ATTCGGCGCT TCAAGAAACC CATTATTGAA CATTCACCTA GGCAAGAACG GCTCACCTTC 540

TGGTTAGATA TAATTTTTGA AGCAACAAAT GAAGTTAGTA ATGGACTCAG ATTTCCAGTT 600

CTGGTGATAG AGCCAACCAA AGTCTACCAG CCTTCTTATG TTTCTATCAA CAGTGAAGCT 660

GAGGAGAGAA CAGTTTCTTT ATGGCATGTA TCACCCACAG AAATGAAACA AATCCACGAA 720

TGGAATTTTG CAGCCTCTTC AATTAAAGGA ATAAGCCTAT CTAAGTTTGA TGAACGGTGT 780

TGTTTTCTTT ATGTCCATGA TAACTCTGAT GACTTTCAAA TCTACTTTTC CACTGAAGAC 840

CAGTGTAGTA GGTTTTGCTT TTTGGTGAAA GAGATGCTAA CCAATGCAGC AGGCAGTACA 900

GTGGAGCTGG AAGGAGAGGC TGATGGAGAC ACCTTAGAGT ATGAGTATGA CTACGATGCA 960

AATGGGGAGA GAGTTGTTTT GGGGAAAGGA ACCTACGGGA TTGTGTATGC TGGCCGAGAC 1020

CTAAGCAATC AAGTGCGAAT AGCCATCAAA GAAATCCCAG AGAAAGACAG CAGGCAACCT 1080

CTGCATGAGG AGATAGCCCT GCATAAATAC CTCAAGCACC GCAATATTGT CCAGTACCTG 1140

GGCTCGGTTT CAGAGGATGG CTACATCAAG ATATTTATGG AGCAGGTGCC TGGAGGTGAC 1200

CTCTCTGCTC TTTTGCGATC CAAATGGGGG CCAATGAAGG AGCCCACTAT CAAGTTTTAT 1260

ACCAAACAGA TCCTGGAAGG CCTTAAGTAT CTCCATGAAA ACCAGATAGT GCACAGAGAC 1320

ATAAAGGGTG ATAATGTTCT GGTAAACACC TACAGTGGAG TGGTGAAAAT CTCTGATTTT 1380

GGAACCTCTA AACGACTCGC AGGAGTGAAC CCATGCACAG AAACCTTTAC TGGTACTCTG 1440

CAGTATATGG CACCTGAGAT TATTGATCAA GGACCTCGTG GGTATGGTGC CCCAGCTGAT 1500

ATCTGGTCCC TGGGCTGCAC CATCATTGAG ATGGCCACCA GCAAGCCTCC ATTCCATGAG 1560

CTTGGTGAAC CACAGGCAGC AATGTTCAAA GTGGGAATGT TTAAGATCCA CCCTGAGATT 1620

CCAGAAGCTC TTTCAACTGA AGCCAGAACC TTCATCTTAT TCTGTTTTGA GCCTGACCCT 1680

CAAAAACGGG CCACTGCCAC TGATCTACTC AGAGAGAGTT TCTTAAGGCA GGTGAACAAG 1740

GGCAAGAAGA ACCGAATTGC TTTCAAGCCC TCAGAAGGAA CCCGCATTGT CACCAGTGCC 1800

CTGGCCCTGC CGTCACCAGG GGAACCTCTG GGCAGTAGCA GCAGCGAGCA TGGCTCCATC 1860

TCCCCAGACT CTGATGCCCA GCCTGACACA TTCTTTGAGA GGACACAAGT GCCCAAGCAC 1920

CAGCTCAGTC ACTTTCTCAG CGTTCCAGAC GAGAGCTCAG CCTCAGAAGA CCGGAATGCA 1980

CCTTCTTCCC CAGATGACAG GGACCAGGGC CTCTTTCTGC TGCGCAAGGA CAGTGAGCGC 2040

CGTGCCATCT TGTACAAAAT CCTTTGGGAA GAGCAGAACC AGGTGGTTTC TAACTTGCAG 2100

GAGTGTGTGA CCCAGAGCTC AGAGGAGTTG CATCTCTCAG TTGGTCATAT CAAGCAAATA 2160

ATCGGGATCT TGAGAGACTT CATTCGCTCC CCAGAGCACA GGGTGATGGC ATCCACAATA 2220

TCAAAGTTGA AGGTGGACCT GGATTTTGAC AGCTCATCCA TCAATCAGAT TCACCTGGTA 2280

CTGTTTGGAT TTCAGGATGC TGTAAATAAA ATTTTGAGGA ACCACTTAAT TAGGCCCCAC 2340

TGGATGTTTG CAATGGATAA CATCATCCGC AGAGCAGTGC AAGCTGCGAT CACCATTCTC 2400

ATCCCAGAGC TCCGAGCTCA CTTTGAGCCT ACGTCTGAGA CCGAAGGGGT AGATAAGGAC 2460

ACAGATGAAG TGGAAGACGA CTATCCCTTA GCAGACCTGC CCGGAAGTGA AGCACATGTG 2520

GCATCGGGAG GGAGAAGACC TGGTGCAGCT GTTGCAGAGG AGGCCCAGCC CCACCAGCAG 2580

CACCTGAGCC TCCAGCTGAG CAAGCTCAGG CAGGAGAGCA ACAGACTCTT GGAACACCTA 2640

GTCCAAAAAG AGAGAGAGTA CCAGAATCTT CTACGGCAAA CGCTAGAACA GAAAACTCAA 2700

GAATTATATC ACCTTCAATT ACAATTCAAT TGTAATGGTA TGACAAAGAA CCTAACACCC 2760

CCTCCCAGGC AGGGAACAGA TAAAGAGCTT ATAGACTGGC TACAACTGCA AGGAACAGAT 2820

GCAAATACAA TTGAAAAGAT TGTTGAAGAA AATTATACAC TTTCTGATAT TCTTAACAAT 2880

ATCACTAAGG AAGACTTACG ATGCCTTAGA CTACGTGGTG GTGTCCTCTG TCGGCTGTGG 2940

CACGCAGTCT CCCAGTACAG AAGGCAGGCT CAGGAGTCCT CAGCG 2985

Domain Profile

S: 3     krevigkGsfgsvyaaldvdtgellavKeveikpekksekkevkalkeEikllkelkHen  62

         +r v+gkG++g vya++d++++ ++a+Ke+   pek+s+    ++l+eEi+l+k lkH+n

Q: 323   ERVVLGKGTYGIVYAGRDLSNQVRIAIKEI---PEKDSR----QPLHEEIALHKYLKHRN  375

         6899**************************...787774....9****************

S: 63    ivkyyGveveeeelkiflEyvegGslsslle.kygkleesvikkytkqileglayLHekk  121

         iv+y+G+ +e++++kif+E+v+gG ls+ll+ k+g+++e +ik+ytkqilegl+yLHe++

Q: 376   IVQYLGSVSEDGYIKIFMEQVPGGDLSALLRsKWGPMKEPTIKFYTKQILEGLKYLHENQ  435

         *******************************9****************************

S: 122   ivHRDiKgaNillds.sgvvklsDFGaskrlaelntkaaelesltGtlaymaPEvikkke  180

         ivHRDiKg+N+l+++ sgvvk+sDFG+skrla +n++   +e++tGtl+ymaPE+i+++

Q: 436   IVHRDIKGDNVLVNTySGVVKISDFGTSKRLAGVNPC---TETFTGTLQYMAPEIIDQGP  492

         *************************************...8*******************

S: 181   kgygrkaDiWslgcvviemltgkrPfaeldeelaimfkvgakktkPeipeklseegkdfl  240

         +gyg+ aDiWslgc++iem+t+k+Pf+el+e++a+mfkvg+ k++Peipe+ls+e++ f+

Q: 493   RGYGAPADIWSLGCTIIEMATSKPPFHELGEPQAAMFKVGMFKIHPEIPEALSTEARTFI  552

         ************************************************************

S: 241   ekcleldpkkrpsaeeLLkhefl  263

           c+e dp+kr++a++LL+++fl

Q: 553   LFCFEPDPQKRATATDLLRESFL  575

         ********************996

Domain Sequence
(FASTA)

ERVVLGKGTY GIVYAGRDLS NQVRIAIKEI PEKDSRQPLH EEIALHKYLK HRNIVQYLGS 60

VSEDGYIKIF MEQVPGGDLS ALLRSKWGPM KEPTIKFYTK QILEGLKYLH ENQIVHRDIK 120

GDNVLVNTYS GVVKISDFGT SKRLAGVNPC TETFTGTLQY MAPEIIDQGP RGYGAPADIW 180

SLGCTIIEMA TSKPPFHELG EPQAAMFKVG MFKIHPEIPE ALSTEARTFI LFCFEPDPQK 240

RATATDLLRE SFL 253

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR025136	; DUF4071.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR013761	; SAM/pointed.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF13281	; DUF4071; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013