EKS-ICT-00248

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ICT-00248

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/PLK	388.9	1.0E-116	12	265	254

Status

Unreviewed

Ensembl Protein

ENSSTOP00000017724

UniProt Accession

I3N028;

Protein Name

Protein Synonyms/Alias

Gene Name

PLK4

Gene Synonyms/Alias

PLK4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSTOG00000027650	ENSSTOP00000017724	ENSSTOT00000024475

Organism

Ictidomys tridecemlineatus

Functional Description

Protein Length

930

Protein Sequence
(FASTA)

MASCIGEKIE DFKVGNLLGK GSFAGVYRAE SIHTGLEVAI KMIDKKAMYK AGMVQRVQNE 60

VKIHCQLKHP SILELYNYFE DNNYVYLVLE MCHNGEMNRY LKNRRKPFSE NEARHFMHQI 120

ITGMLYLHSH GILHRDLTLS NLLLTRNMNI KIADFGLATQ LTMPHEKHYT LCGTPNYISP 180

EIATRSAHGL ESDVWSLGCM FYTLLIGRPP FDTDTVKNTL NKVVLADYEM PTFLSREAKD 240

LIHQLLRRNP ADRLSLSSIL DHPFMSRNSS TKSKDLGTVE DSIDSGHATI STAVTASSST 300

SVSGSLLDRR RLLIGQPLPN KMTVFPKHKN SSDFSSGDGS SFCTQWGNQA HETSNSGRGR 360

VIQDAEERPH SRYLRRAHSS DRSGTSNSQS RAKTYTMERC HSAETLSKPD NNQALSNHLC 420

PGKSPFPFSD QTPQTEIVQQ WFGNLQMNGE IQETTEHNSI SPKRDFLIHP DLQKNMSRNA 480

WRDTRAKKNS DASDNAASVK QLNTMKYVTA QKPEIIQQEP IFGLHPLSEQ IKTRGMESTV 540

GYQKHTLRSI TSPLIAHRLK PIRQKTKKAV VSILDSEEVC VELLKEYASQ EYVKEVLQIS 600

SDGNMITVYY PNDGRDFPLA DKPPLPTDKI SRYNFDNLPE KYWRKYQYAS RFVQLVRSKS 660

PKITYFTRYA KCILMENSPD ADFEVWFYDG AKIHKTEDLI QVIEKTGKSY TLKDENQIHS 720

LKEEIKIYMD HANEAHRICL ALESVISGEE KKSGNAPFFP IIMGRKPGNT SSPKALSPPP 780

CVDPNCAIRD APSLGRLIMN SATTPTQAPI LSPSIVTAEG LGHTTTASGT NVSSNNLKDC 840

LPSSAQLLKS VFVKNVGWAT QLTSGAVWVQ FNDGSQLVVQ AGVSSISYTS PNGQTTRYGD 900

NEKLPEYIKQ KLQCLSSILL MFSNATPGFH 930

Nucleotide Sequence
(FASTA)

ATGGCGTCTT GCATCGGCGA GAAGATCGAG GATTTTAAAG TCGGAAATCT GCTCGGTAAG 60

GGATCATTTG CTGGTGTCTA CAGAGCTGAG TCCATTCACA CGGGTTTGGA AGTTGCAATC 120

AAAATGATAG ATAAAAAAGC CATGTACAAA GCTGGAATGG TACAGCGTGT CCAAAATGAG 180

GTGAAAATAC ATTGTCAATT GAAACATCCC TCTATCTTGG AGCTATATAA CTATTTTGAA 240

GATAACAATT ATGTGTACCT GGTATTAGAA ATGTGTCACA ATGGTGAAAT GAACAGATAC 300

CTAAAGAATA GAAGGAAACC TTTCTCAGAA AATGAAGCTC GACACTTCAT GCACCAGATC 360

ATCACAGGAA TGTTGTATCT TCATTCTCAT GGTATATTAC ACCGGGACCT CACACTTTCT 420

AACCTCTTAC TTACTCGTAA TATGAATATC AAGATTGCTG ATTTTGGGCT GGCAACTCAA 480

TTGACAATGC CACATGAAAA GCACTATACA TTATGTGGAA CTCCTAATTA CATTTCACCA 540

GAAATTGCAA CTCGAAGTGC ACATGGACTT GAATCTGATG TTTGGTCCTT GGGCTGCATG 600

TTTTATACAT TACTAATTGG GAGACCACCT TTTGACACTG ACACAGTCAA GAACACATTA 660

AATAAAGTCG TATTGGCAGA TTATGAAATG CCAACGTTTT TGTCAAGAGA GGCCAAGGAT 720

CTTATTCACC AGCTACTTCG TAGAAATCCA GCAGATCGTT TAAGTCTGTC TTCAATATTG 780

GACCATCCTT TTATGTCCCG AAATTCTTCA ACAAAAAGTA AAGATTTAGG AACTGTAGAA 840

GACTCAATTG ATAGTGGACA TGCCACAATT TCTACTGCAG TTACGGCTTC TTCCAGTACC 900

AGTGTAAGTG GTAGTTTACT TGACAGAAGA CGACTCTTGA TTGGCCAGCC ACTTCCAAAT 960

AAAATGACTG TATTTCCAAA GCATAAAAAT TCAAGTGACT TTTCTTCAGG AGATGGAAGC 1020

AGTTTTTGTA CTCAGTGGGG AAATCAAGCA CATGAAACCA GTAACAGTGG AAGAGGAAGA 1080

GTAATTCAAG ATGCAGAAGA AAGGCCACAT TCTCGATACC TCCGTAGAGC CCATTCCTCT 1140

GATAGATCTG GCACTTCTAA TAGTCAATCT CGAGCAAAAA CATATACAAT GGAACGATGT 1200

CACTCAGCAG AAACACTTTC AAAACCTGAT AACAACCAAG CACTTTCAAA TCATCTTTGT 1260

CCAGGAAAAA GTCCTTTTCC ATTTTCAGAC CAGACACCTC AAACTGAAAT TGTACAACAG 1320

TGGTTTGGAA ATCTGCAAAT GAATGGTGAA ATTCAAGAAA CTACTGAGCA CAACAGCATT 1380

AGCCCAAAGA GAGATTTTCT TATACATCCA GATTTGCAGA AAAACATGTC AAGAAATGCT 1440

TGGAGAGATA CAAGAGCCAA AAAGAACTCT GATGCTTCTG ATAATGCAGC TTCTGTAAAA 1500

CAGCTGAATA CTATGAAATA TGTGACTGCG CAAAAACCTG AGATAATTCA ACAAGAACCT 1560

ATTTTTGGCT TACATCCTCT TTCAGAACAA ATCAAGACTA GGGGTATGGA GTCAACAGTG 1620

GGATATCAGA AACACACATT GCGAAGCATT ACGTCTCCTT TGATTGCTCA CAGGTTAAAA 1680

CCAATCAGAC AGAAAACTAA AAAGGCTGTG GTGAGCATAC TTGATTCAGA GGAGGTGTGT 1740

GTGGAGCTTC TAAAGGAATA TGCATCTCAA GAATATGTGA AAGAAGTACT TCAAATATCT 1800

AGTGATGGGA ATATGATCAC TGTATATTAT CCAAATGATG GAAGAGACTT TCCTCTTGCT 1860

GATAAACCAC CCTTACCCAC TGATAAAATC AGTAGGTACA ACTTTGACAA TTTACCAGAA 1920

AAATACTGGC GAAAATATCA ATATGCTTCC AGATTTGTAC AGCTTGTAAG ATCTAAATCT 1980

CCCAAAATCA CTTATTTTAC AAGATACGCT AAATGTATTT TGATGGAGAA TTCTCCTGAT 2040

GCTGATTTTG AGGTTTGGTT TTATGATGGA GCAAAAATAC ACAAAACAGA AGATTTAATT 2100

CAAGTAATTG AAAAGACTGG GAAATCTTAC ACTTTAAAGG ATGAAAATCA AATTCATAGC 2160

TTAAAAGAGG AAATAAAAAT ATACATGGAC CATGCTAATG AGGCTCATCG TATTTGTTTA 2220

GCACTGGAAT CTGTAATTTC AGGAGAGGAA AAGAAGAGTG GGAATGCTCC CTTTTTCCCA 2280

ATAATTATGG GAAGAAAACC TGGTAATACT AGTTCACCTA AGGCCCTGTC ACCACCTCCT 2340

TGTGTGGATC CAAACTGCGC AATAAGAGAT GCACCATCTT TGGGTAGATT GATCATGAAT 2400

AGTGCTACTA CTCCAACCCA GGCACCCATA CTTAGTCCTT CTATAGTTAC AGCTGAAGGA 2460

CTTGGCCATA CCACTACAGC TTCAGGAACA AACGTCTCTT CTAATAATCT AAAAGATTGT 2520

CTTCCTTCAT CAGCACAACT TTTGAAGTCT GTTTTTGTGA AAAATGTTGG TTGGGCTACA 2580

CAGTTAACTA GTGGAGCTGT GTGGGTTCAG TTTAATGATG GGTCCCAGCT GGTTGTCCAG 2640

GCAGGAGTAT CTTCTATCAG TTACACGTCA CCAAATGGTC AAACAACTAG GTATGGAGAC 2700

AATGAAAAAT TACCGGAATA CATCAAACAG AAATTACAGT GTCTGTCTTC CATCCTGTTG 2760

ATGTTTTCTA ATGCAACTCC TGGTTTTCAT TAA 2793

Domain Profile

S: 1     yergkllGkGgfakcyelkdletkevfavkvvpksllakekqrekvekeieihrslkhkn  60

         +++g+llGkG+fa +y++++++t+ ++a+k+++k++++k+ + ++v++e++ih++lkh++

Q: 12    FKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKHPS  71

         6899********************************************************

S: 61    ivklyeffedkenvylvlelcsrrslaellkrr.kaltepevryylrqivsglkylhekr  119

         i++ly++fed+++vylvle+c++++++++lk+r k+++e+e+r++++qi++g++ylh++

Q: 72    ILELYNYFEDNNYVYLVLEMCHNGEMNRYLKNRrKPFSENEARHFMHQIITGMLYLHSHG  131

         ******************************98879*************************

S: 120   ilhrdlklgnlflneelevkigdfGlatrlekeeerkktlcGtPnyiaPevlskkghsle  179

         ilhrdl+l+nl+l++++++ki+dfGlat+l +++e+++tlcGtPnyi+Pe++++++h+le

Q: 132   ILHRDLTLSNLLLTRNMNIKIADFGLATQLTMPHEKHYTLCGTPNYISPEIATRSAHGLE  191

         ************************************************************

S: 180   vdiWslGcilytllvGkPPfetkelketyekikkaeyslPsslskeaksliakllkkePe  239

         +d+WslGc++ytll+G+PPf+t+++k+t++k++ a+y++P+ ls+eak+li++ll+++P+

Q: 192   SDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPTFLSREAKDLIHQLLRRNPA  251

         ************************************************************

S: 240   erpsleevlkdefl  253

         +r+sl+++l+++f+

Q: 252   DRLSLSSILDHPFM  265

         ************98

Domain Sequence
(FASTA)

FKVGNLLGKG SFAGVYRAES IHTGLEVAIK MIDKKAMYKA GMVQRVQNEV KIHCQLKHPS 60

ILELYNYFED NNYVYLVLEM CHNGEMNRYL KNRRKPFSEN EARHFMHQII TGMLYLHSHG 120

ILHRDLTLSN LLLTRNMNIK IADFGLATQL TMPHEKHYTL CGTPNYISPE IATRSAHGLE 180

SDVWSLGCMF YTLLIGRPPF DTDTVKNTLN KVVLADYEMP TFLSREAKDL IHQLLRRNPA 240

DRLSLSSILD HPFM 254

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000959	; POLO_box_duplicated_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008266	; Tyr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00659	; POLO_box; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50078	; POLO_BOX; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

Created Date

20-Feb-2013