EKS-ICT-00249

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ICT-00249

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/PLK	365.2	1.8E-109	28	278	251

Status

Unreviewed

Ensembl Protein

ENSSTOP00000020484

UniProt Accession

I3N7Y8;

Protein Name

Protein Synonyms/Alias

Gene Name

PLK5

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSSTOG00000028771	ENSSTOP00000020484	ENSSTOT00000029654

Organism

Ictidomys tridecemlineatus

Functional Description

Protein Length

595

Protein Sequence
(FASTA)

MEPGPRRRRQ SHQPVAAFLR DPSSGRVYRR GKLIGKGAFS RCYKLTDMST STVFALKVVP 60

RAGRLPSRGK VEREIALHSR LRHHNIVAFH GHFADRDHVY MVLEYCSRQS LAHVLKARQT 120

LTEPEVRYYL RGVIGGLRYL HQRRIVHRDL KLSNLLLNKK MEVKIGDLGL ATRLGPGGRC 180

HRVLCGTPNL LAPEVVSRKG HSCPSDIWAL GCIMYTVLTG TPPFAAASLS EMYQNICDGH 240

YPEPAHLSPN ARRLIARLLA PDPAERPNLD HLLQDDFFTQ GFTPERMPPH SRHSPPVFTF 300

PQPLGSLFRK VGQLLSTQCG PPCPFTSKEA SGPGEGPEPD SVDWGSEASL SERRAHCPQA 360

LVHLLTQGTL RSDPAGPQES PETEVAAAIR NLQLCLDAGP VATQDPPGGQ QPPLWAPRWV 420

DYSSKYGFGY QLSDGGSGVL FRDGTHMALR PPGSHICYLP TRGRLETFAL RDVPRALGAK 480

LAVLRLLTGY LQRRLREEGA SPAPQPPAAL GLCLLRFVGT SQALLLLFSD GTLQVSFGGL 540

QTQLVLSGEG QGLLLTHWAR GQPGASYSLG TLQRRECAPA ALQHLRRTLH LLQSL 595

Nucleotide Sequence
(FASTA)

ATGGAGCCCG GGCCGAGGCG GCGGCGCCAG AGCCACCAGC CAGTGGCAGC CTTCTTGCGC 60

GACCCCAGCT CCGGGCGCGT CTACCGGCGC GGGAAGCTGA TCGGCAAGGG TGCCTTCAGC 120

CGCTGCTACA AGCTGACAGA CATGTCCACC AGCACTGTGT TTGCCCTTAA GGTGGTGCCG 180

CGGGCTGGGA GGCTTCCCTC CAGAGGAAAG GTGGAGCGCG AGATCGCCCT GCACAGCCGC 240

CTGCGGCACC ACAACATAGT GGCCTTCCAC GGACACTTCG CTGACCGTGA CCATGTGTAC 300

ATGGTGCTGG AGTACTGCAG CCGACAGTCC TTGGCCCATG TGCTGAAGGC GCGGCAGACC 360

CTGACGGAGC CCGAGGTGCG CTACTACCTG CGGGGCGTGA TCGGTGGCCT GCGCTACCTC 420

CATCAGCGGC GCATCGTGCA CAGAGACCTG AAGCTCAGTA ATTTACTCCT CAACAAGAAG 480

ATGGAGGTGA AAATTGGAGA CCTGGGACTG GCCACCAGGT TGGGGCCAGG GGGCCGCTGC 540

CACAGGGTGC TCTGCGGGAC TCCAAACCTC CTGGCCCCAG AGGTGGTGTC CAGAAAGGGG 600

CACTCCTGCC CATCAGACAT CTGGGCCCTG GGCTGCATCA TGTACACAGT GCTGACTGGC 660

ACCCCACCTT TTGCGGCGGC ATCCCTGTCA GAGATGTACC AGAACATCTG TGATGGCCAC 720

TATCCAGAGC CTGCCCACCT GTCGCCCAAT GCCCGCCGCC TCATTGCCCG CCTCCTGGCA 780

CCTGATCCAG CTGAGAGGCC CAACTTGGAC CACCTGCTGC AGGATGACTT CTTCACACAG 840

GGCTTCACTC CCGAGCGGAT GCCCCCCCAC TCCCGCCACA GCCCCCCGGT CTTCACCTTC 900

CCACAACCTC TGGGCAGCCT CTTCCGGAAA GTGGGCCAGC TACTGTCGAC CCAGTGTGGA 960

CCTCCCTGCC CCTTCACCTC CAAAGAGGCC TCGGGCCCAG GAGAAGGGCC AGAACCTGAC 1020

TCCGTGGACT GGGGCAGCGA GGCCTCCCTG TCTGAGAGAC GGGCTCACTG TCCCCAGGCC 1080

CTCGTCCACT TGCTCACACA AGGGACCCTC CGGAGCGACC CGGCAGGTCC ACAGGAGAGC 1140

CCAGAGACGG AGGTGGCAGC CGCCATCAGG AACCTACAGC TCTGCCTGGA CGCTGGCCCT 1200

GTGGCCACAC AGGACCCCCC AGGGGGGCAG CAGCCCCCCC TCTGGGCTCC CAGGTGGGTG 1260

GACTACTCCA GCAAGTACGG CTTTGGCTAC CAGCTGTCGG ATGGGGGCAG TGGAGTCCTG 1320

TTTCGGGATG GCACCCACAT GGCCCTGCGC CCCCCAGGAA GCCACATCTG CTACCTGCCC 1380

ACCCGCGGGA GGCTGGAGAC CTTCGCCCTG AGGGACGTGC CCCGGGCGCT GGGCGCCAAG 1440

CTGGCCGTCC TGCGGCTCCT CACCGGCTAC CTGCAGAGGC GCCTGCGGGA GGAGGGGGCC 1500

TCGCCTGCCC CCCAGCCGCC CGCCGCGCTG GGCCTCTGCC TGCTGCGCTT TGTGGGGACC 1560

TCGCAGGCGC TGCTGCTGCT GTTCAGCGAC GGGACCCTGC AGGTCAGCTT CGGTGGGCTG 1620

CAGACCCAGC TGGTGCTGAG TGGCGAGGGC CAGGGGCTGC TGCTCACCCA CTGGGCGCGG 1680

GGTCAGCCAG GGGCCTCCTA CTCCCTGGGC ACCCTGCAGC GCCGCGAGTG TGCCCCGGCT 1740

GCCCTGCAGC ACCTGCGCCG CACACTCCAC CTGCTGCAGA GCTTATAG 1788

Domain Profile

S: 1     yergkllGkGgfakcyelkdletkevfavkvvpksllakekqrekvekeieihrslkhkn  60

         y+rgkl+GkG+f++cy+l+d++t++vfa+kvvp++   +   r kve+ei++h++l+h+n

Q: 28    YRRGKLIGKGAFSRCYKLTDMSTSTVFALKVVPRAG--RLPSRGKVEREIALHSRLRHHN  85

         99*******************************975..67889*****************

S: 61    ivklyeffedkenvylvlelcsrrslaellkrrkaltepevryylrqivsglkylhekri  120

         iv+++ +f+d+++vy+vle+csr+sla++lk+r++ltepevryylr ++ gl+ylh++ri

Q: 86    IVAFHGHFADRDHVYMVLEYCSRQSLAHVLKARQTLTEPEVRYYLRGVIGGLRYLHQRRI  145

         ************************************************************

S: 121   lhrdlklgnlflneelevkigdfGlatrlekeeerkktlcGtPnyiaPevlskkghslev  180

         +hrdlkl+nl+ln+++evkigd+Glatrl + ++++++lcGtPn +aPev+s+kghs+ +

Q: 146   VHRDLKLSNLLLNKKMEVKIGDLGLATRLGPGGRCHRVLCGTPNLLAPEVVSRKGHSCPS  205

         ************************************************************

S: 181   diWslGcilytllvGkPPfetkelketyekikkaeyslPsslskeaksliakllkkePee  240

         diW+lGci+yt+l+G+PPf++++l+e+y++i + +y  P++ls++a++lia+ll+++P+e

Q: 206   DIWALGCIMYTVLTGTPPFAAASLSEMYQNICDGHYPEPAHLSPNARRLIARLLAPDPAE  265

         ************************************************************

S: 241   rpsleevlkdefl  253

         rp+l+++l+d+f+

Q: 266   RPNLDHLLQDDFF  278

         ************8

Domain Sequence
(FASTA)

YRRGKLIGKG AFSRCYKLTD MSTSTVFALK VVPRAGRLPS RGKVEREIAL HSRLRHHNIV 60

AFHGHFADRD HVYMVLEYCS RQSLAHVLKA RQTLTEPEVR YYLRGVIGGL RYLHQRRIVH 120

RDLKLSNLLL NKKMEVKIGD LGLATRLGPG GRCHRVLCGT PNLLAPEVVS RKGHSCPSDI 180

WALGCIMYTV LTGTPPFAAA SLSEMYQNIC DGHYPEPAHL SPNARRLIAR LLAPDPAERP 240

NLDHLLQDDF F 251

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Loxodonta africana"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ornithorhynchus anatinus"; ?>Otolemur garnettii"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000959	; POLO_box_duplicated_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00659	; POLO_box; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50078	; POLO_BOX; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013