EKS-TAG-00335

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAG-00335

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	325.0	3.0E-97	36	294	259

Status

Unreviewed

Ensembl Protein

ENSTGUP00000000298

UniProt Accession

H0YPU8;

Protein Name

Protein Synonyms/Alias

Gene Name

STK10

Gene Synonyms/Alias

STK10;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTGUG00000000289	ENSTGUP00000000298	ENSTGUT00000000303

Organism

Taeniopygia guttata

Functional Description

Protein Length

1201

Protein Sequence
(FASTA)

MAFANFRRIL RLSAFEKRRS KEYEHVRRDL DPGEVWEVVG ELGDGAFGKV YKAKNKETGA 60

LAAAKVIETK SEDELEDYMV EIEILATCDH PHIVKLLGAF YWDGKLWIMI EFCPGGAVDA 120

TMLELDRGLT EPQIQVICRQ MLEALHYLHS KRIIHRDLKA GNVLLTQDGD IKLADFGVSA 180

KNMKTLQKRD SFIGTPYWMA PEVVMCETMK DTPYDYKADI WSLGITLIEM AQIEPPHHEL 240

NPMRVLLKIA KSDPPTLSCP SKWSLEFRDF LKKALDKNPE TRPSAAQLLE HPFVSKVSSN 300

RALRELVAEA KAEVMEEIED SRDEAEEDDS SESASVSSFT TLANLEVFSA SKNSSGGRGC 360

LAREGLPRAW RNNSAGGWPR AHSQEGLMER GKKRKINPDT GWRNWKGSKA SSRWRGSGCL 420

AREEKRGKKR KISPDAGWRN WRGSKASSRW RDHHPEEGAG QICPWAWLFE GDISELPGGM 480

FWPPSSFGVQ IPHLPLKDME TSQGRCPKRG ISSQFIVLSG GAKPHLWPSL SLQPPGKHKR 540

DSSEVSQLSL DGEKPPEPSL PKAVNGSVGT GKDTTESQSH KVSDKGVSSD KLESNHSTKP 600

SPASSATQDK PDIILQPGHL GNSAEGNKEP RLGREERKSL GERKSIEERK SIEERKSLEE 660

RKSLGERKSI EERKSLGERK SLGERKSIEE RKSIGERKSI EERKSMVERP ESVFLENFSE 720

EKLANGSLEP LGPFPRSKRD SDSGSTSASE SMDLTISLSA DLSLNRESGS ISLKDSQMHK 780

KTLKRTRKFV VDGVEVSVTT SKIISEDEKK DEEMRFLRQE LRELRLLQKE EHRNQAQLNS 840

KHQLQQEQML RRFEQEMMAK KKFYDTELEN LERQQKQQIE RMEQEHALRR REEAKRIRLE 900

QERDHGRFLE QLKQMKKEVK NEVEKLPRQQ RKGNLKVKMD DFTQKKQTME QEFLAKQKED 960

LEQAMKNIIA QNKREICDKE RECLNKKQQL MRDREACIWD LEERQQQEKH QLIKQQLKDQ 1020

YFLQRHELLR KHEKEREQMQ RYNQRMLEQL KVRQQQERAR LPKIQRSEGK TRMAMYKKSL 1080

HIHSSGSASE QREKIKQFAL QEEKRQKAER LHQQQKHETQ MKDMQAQCES NTSELQHLQN 1140

EKCHLLIEHE TQKLKSLDES HNQHMKEWRD KLRPRKKALE DELNQKKREQ EMFFKLSEEA 1200

D 1201

Nucleotide Sequence
(FASTA)

ATGGCTTTCG CCAATTTCCG CCGCATCCTG CGCCTCTCCG CCTTCGAGAA GCGCCGCTCC 60

AAGGAATACG AGCACGTCCG CCGCGACCTG GACCCCGGCG AGGTGTGGGA GGTGGTGGGC 120

GAGCTGGGAG ATGGAGCCTT CGGCAAAGTC TACAAGGCCA AGAACAAGGA AACGGGCGCT 180

CTGGCAGCTG CCAAGGTCAT TGAGACCAAG AGTGAGGACG AGCTGGAGGA TTACATGGTG 240

GAGATTGAGA TCCTGGCCAC CTGCGACCAC CCCCACATCG TCAAGCTGCT GGGAGCCTTC 300

TACTGGGATG GCAAACTCTG GATCATGATC GAGTTCTGCC CCGGCGGGGC CGTGGATGCC 360

ACGATGCTGG AGCTGGACCG GGGCCTGACT GAGCCTCAGA TCCAGGTGAT TTGCCGCCAG 420

ATGTTGGAGG CTCTCCACTA CCTGCACAGC AAAAGGATCA TCCACAGGGA CCTGAAGGCT 480

GGCAACGTGC TCCTCACCCA GGATGGGGAC ATCAAGCTGG CTGACTTTGG AGTGTCTGCC 540

AAGAACATGA AAACCTTGCA GAAGCGAGAT TCCTTCATTG GGACCCCTTA CTGGATGGCC 600

CCGGAGGTGG TGATGTGTGA GACCATGAAG GACACCCCCT ACGACTACAA GGCGGACATC 660

TGGTCCCTGG GGATCACCCT GATCGAGATG GCCCAGATTG AGCCCCCCCA CCATGAGCTC 720

AACCCCATGA GGGTCCTGCT GAAGATCGCC AAGTCCGACC CGCCCACGCT CAGCTGCCCT 780

TCCAAATGGT CCCTGGAGTT CAGAGATTTC CTGAAGAAGG CGCTGGACAA GAACCCAGAG 840

ACCCGGCCCA GTGCTGCCCA GCTGCTGGAG CATCCCTTCG TCAGCAAGGT CAGCAGCAAC 900

AGGGCCCTGC GGGAGCTGGT GGCCGAGGCC AAGGCTGAGG TGATGGAGGA GATCGAGGAC 960

AGCCGGGATG AAGCAGAGGA GGATGACTCC TCGGAGTCTG CCTCGGTGAG CAGCTTCACC 1020

ACTCTGGCTA ACCTGGAGGT TTTTTCGGCT TCCAAAAACT CTTCTGGGGG ACGTGGTTGC 1080

TTGGCCAGGG AAGGGTTGCC AAGGGCGTGG AGAAATAACA GTGCTGGGGG GTGGCCCAGG 1140

GCCCACTCAC AGGAGGGGCT CATGGAAAGG GGGAAAAAGA GGAAAATAAA CCCTGATACA 1200

GGCTGGAGAA ACTGGAAGGG AAGCAAAGCC AGCAGCAGGT GGAGGGGAAG TGGTTGCTTG 1260

GCCAGGGAGG AGAAAAGGGG AAAGAAGAGG AAAATAAGCC CTGATGCAGG CTGGAGAAAC 1320

TGGAGGGGAA GCAAAGCCAG CAGCAGGTGG AGGGACCACC ACCCTGAGGA GGGAGCTGGG 1380

CAGATCTGCC CCTGGGCTTG GCTCTTTGAA GGGGACATCT CAGAGCTGCC TGGGGGCATG 1440

TTTTGGCCTC CCTCCTCTTT TGGTGTGCAA ATTCCTCACC TACCTCTTAA GGATATGGAA 1500

ACATCACAGG GCAGGTGTCC TAAAAGGGGA ATTTCCTCCC AGTTTATTGT GTTGAGTGGT 1560

GGTGCCAAGC CTCACCTCTG GCCTTCCCTG TCTTTGCAGC CCCCTGGGAA GCACAAGCGG 1620

GACTCCTCCG AGGTGAGCCA GCTGAGTTTG GATGGGGAGA AACCTCCGGA GCCGTCCTTG 1680

CCCAAAGCTG TGAACGGCTC CGTGGGGACT GGCAAAGACA CCACAGAGAG CCAGAGCCAC 1740

AAAGTCTCGG ATAAAGGGGT GAGCAGTGAC AAACTGGAGA GCAACCACTC CACAAAACCC 1800

AGCCCGGCCT CCTCGGCCAC CCAGGACAAG CCGGACATCA TCCTGCAGCC GGGACATTTG 1860

GGAAACTCAG CGGAGGGGAA CAAGGAGCCC AGGCTGGGCA GGGAGGAGAG GAAGAGCCTT 1920

GGAGAGAGGA AGAGCATTGA GGAGAGGAAG AGCATTGAGG AGAGGAAGAG CCTTGAGGAG 1980

AGGAAGAGCC TTGGAGAAAG GAAGAGCATT GAGGAGAGGA AGAGCCTTGG AGAGAGGAAG 2040

AGCCTTGGAG AAAGGAAGAG CATTGAGGAG AGGAAGAGCA TCGGGGAGAG GAAGAGCATT 2100

GAGGAGAGGA AGAGCATGGT GGAGCGACCA GAGAGTGTTT TCCTGGAGAA CTTCAGCGAG 2160

GAGAAGCTGG CCAATGGAAG CCTGGAGCCC CTGGGGCCGT TCCCCCGCTC CAAAAGGGAC 2220

TCGGATTCCG GCAGCACCTC GGCCTCCGAG AGCATGGACC TCACCATCTC CTTGTCTGCT 2280

GACCTGTCCC TCAACAGGGA GAGCGGCTCC ATCTCCCTCA AGGACTCCCA GATGCACAAG 2340

AAGACCCTGA AACGCACCCG CAAGTTCGTG GTGGACGGGG TGGAGGTGAG CGTCACCACC 2400

TCCAAGATCA TCAGCGAGGA CGAGAAGAAG GATGAAGAAA TGAGGTTCCT CAGGCAAGAG 2460

CTGCGGGAGC TGCGTCTCCT GCAGAAGGAG GAGCACAGGA ACCAGGCCCA GCTGAACAGC 2520

AAGCACCAGC TGCAGCAGGA GCAGATGCTG CGGCGCTTCG AGCAGGAAAT GATGGCAAAG 2580

AAGAAGTTCT ACGACACGGA GCTGGAGAAC CTGGAGCGGC AGCAGAAGCA GCAGATCGAG 2640

AGGATGGAGC AGGAGCACGC CCTGCGGCGG CGCGAGGAGG CCAAGCGCAT CCGCCTGGAG 2700

CAGGAGCGCG ACCACGGCCG CTTCCTGGAG CAGCTCAAGC AGATGAAGAA GGAGGTCAAG 2760

AACGAGGTTG AGAAGCTGCC ACGGCAGCAG CGCAAAGGGA ACCTGAAGGT GAAGATGGAC 2820

GACTTCACCC AGAAAAAACA AACCATGGAG CAGGAGTTTT TGGCCAAGCA GAAGGAGGAC 2880

CTGGAGCAGG CCATGAAGAA CATCATTGCC CAGAACAAAA GAGAGATCTG TGACAAGGAG 2940

CGTGAGTGCC TCAACAAGAA GCAGCAGCTG ATGAGAGACC GGGAAGCTTG CATCTGGGAT 3000

CTGGAAGAGC GTCAGCAGCA GGAGAAGCAC CAGCTCATCA AGCAGCAGCT GAAGGACCAA 3060

TATTTCCTCC AGAGACACGA GCTGCTCCGG AAGCATGAGA AGGAGAGGGA GCAGATGCAG 3120

CGCTACAACC AGCGCATGCT GGAGCAGCTG AAGGTGCGGC AGCAGCAGGA GAGGGCCCGG 3180

CTGCCCAAAA TCCAGCGCAG CGAGGGCAAG ACGCGCATGG CCATGTACAA GAAGAGCCTC 3240

CACATCCACT CCAGCGGCAG CGCCTCCGAG CAGAGGGAGA AGATCAAACA GTTTGCTCTG 3300

CAGGAGGAGA AGAGGCAGAA AGCAGAGCGG CTGCACCAGC AGCAGAAGCA CGAGACACAG 3360

ATGAAGGACA TGCAGGCCCA GTGTGAGAGC AACACCAGCG AGCTCCAGCA TCTCCAGAAT 3420

GAGAAGTGTC ACCTCCTGAT CGAGCACGAA ACCCAGAAGC TGAAGTCCCT GGATGAGAGC 3480

CACAACCAGC ACATGAAGGA GTGGCGGGAC AAGCTGAGAC CACGGAAGAA GGCCCTGGAG 3540

GACGAGCTGA ACCAGAAGAA GCGTGAGCAG GAGATGTTCT TCAAGCTGAG CGAGGAGGCC 3600

GAT 3603

Domain Profile

S: 1     yelleeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkhpnive  60

         +e++ e+g+Ga+gkvy+a++k+tg+l+a k+i+++++++le+++ ei++l +++hp+iv+

Q: 36    WEVVGELGDGAFGKVYKAKNKETGALAAAKVIETKSEDELEDYMVEIEILATCDHPHIVK  95

         78999*******************************************************

S: 61    ylesflkeeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkvi  120

         +l++f+ + +lw+++e++ gG+++  +  el+++l+E qi++i+r++l+aL+ylHsk++i

Q: 96    LLGAFYWDGKLWIMIEFCPGGAVDATML-ELDRGLTEPQIQVICRQMLEALHYLHSKRII  154

         ***********************99998.9******************************

S: 121   HrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqe...ekgY  177

         Hrd+ka+n+Llt++g++kL+dfgv+a+  kt +kr++++gtpywmAPEv+ +e   ++ Y

Q: 155   HRDLKAGNVLLTQDGDIKLADFGVSAKNMKTLQKRDSFIGTPYWMAPEVVMCEtmkDTPY  214

         ****************************************************9998999*

S: 178   dekaDiwslGItaielaegepPfkdleplkallkilkneppklkskkkfskefkefvekc  237

         d+kaDiwslGIt+ie+a+ epP+++l+p+++llki+k++pp+l+ ++k+s ef++f++k+

Q: 215   DYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKSDPPTLSCPSKWSLEFRDFLKKA  274

         ************************************************************

S: 238   lqknpekRpsasellkhkFl  257

         l+knpe+Rpsa++ll+h+F+

Q: 275   LDKNPETRPSAAQLLEHPFV  294

         *******************7

Domain Sequence
(FASTA)

WEVVGELGDG AFGKVYKAKN KETGALAAAK VIETKSEDEL EDYMVEIEIL ATCDHPHIVK 60

LLGAFYWDGK LWIMIEFCPG GAVDATMLEL DRGLTEPQIQ VICRQMLEAL HYLHSKRIIH 120

RDLKAGNVLL TQDGDIKLAD FGVSAKNMKT LQKRDSFIGT PYWMAPEVVM CETMKDTPYD 180

YKADIWSLGI TLIEMAQIEP PHHELNPMRV LLKIAKSDPP TLSCPSKWSL EFRDFLKKAL 240

DKNPETRPSA AQLLEHPFV 259

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0071593	; P:lymphocyte aggregation
GO:0046777	; P:protein autophosphorylation
GO:2000401	; P:regulation of lymphocyte migration

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR022165	; PKK.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF12474	; PKK; 2.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013