EKS-TAG-00212
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-TAG-00212
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Ror586.85.8E-177439745307
StatusUnreviewed
Ensembl ProteinENSTGUP00000000423
UniProt AccessionH0YQ70;
Protein Name
Protein Synonyms/Alias
Gene NameROR2
Gene Synonyms/Alias ROR2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSTGUG00000000414ENSTGUP00000000423ENSTGUT00000000429
OrganismTaeniopygia guttata
Functional Description
Protein Length908
Protein Sequence
(FASTA)
MEIPDSNDPL GHVDGLERPI PTPKGYFLTF LEPVNNITVV QGQTAILHCK VAGNPSPNVR 60
WLKNDAPVVQ EPRRIIIRKT DYGSRLRIQD LDTTDTGYYQ CVASNGMKTI TATGVLFVRL 120
GPTNSPNHNL QEDYHEDGFC QPYRGIACAR IIGNRTIYVD SLQMQGEIEN RITAAFTMIG 180
TSTHLSDQCS QFAIPSFCHF VFPLCDERSR TPKPRELCRD ECEVLENDLC RQEYNIARSN 240
PLILMQLQLP KCEDLPRPDT LEAANCIRIG IPVERLSRYH QCYNGSGTDY RGTISVTKSG 300
HTCQLWDSQS PHNHDLTSTQ FPELGGGHAY CRNPGGQMDG PWCFTKNKNV RMELCDIPSC 360
SPRDNSKMGI LYILVPSIAI PLVIACLFFL VCMCRNKQKA SAATPQRRQL MASPSQDMEM 420
PLINQHKQAK LKEINLSTVR FMEELGEERF GKVYKGHLFG TAPGEQTQAV AIKTLKDKAE 480
LALREEFKHE AMMRSRLQHP NIVCLLGIVT KEQPVSMIFS YCSHSDLHEF LVMRSPHSDV 540
GSTDDDKTVK STLEPADFFH IVTQIAAGME YLSSHHVVHK DLATRNILVF DKLNVKISDL 600
GLFREVYAAD YYKLMGNSLL PIRWMSPEAI MYGKFSIDSD IWSYGVVLWE VFSYGLQPYC 660
GYSNQDVIEM IRNRQVLPCP DDCPTWIYTL MLECWNEFPN RRPRFKDIHN RLRTWGNLSN 720
YNSSAQTSGA SNTTQTSSLS TSPVSNVSNA RYIGPKQKTP AFPQPQFIQM KGQMRPMVPP 780
PQLYIPVNGY QPMPAYGAYL PNFYPVQIPM QMAPQQIPPQ IIPKPGSHHS GSGSTSTGYV 840
TTAPSNASVA DRAALLSEGT DDTHNGTEDI AQNPVQEEEE EEGSVPETEL LGDNDTLQMD 900
EAEIQSEA 908
Nucleotide Sequence
(FASTA)
ATGGAAATTC CAGATTCAAA TGACCCCTTA GGTCATGTGG ATGGACTTGA GAGACCAATT 60
CCAACACCTA AAGGTTATTT CCTGACCTTC TTGGAACCTG TAAACAATAT CACTGTAGTC 120
CAGGGGCAAA CAGCAATCCT CCACTGCAAG GTAGCAGGAA ATCCATCTCC GAATGTCAGA 180
TGGCTAAAAA ATGACGCTCC AGTGGTTCAG GAGCCAAGAC GGATCATCAT CAGAAAAACA 240
GATTATGGTT CACGTCTAAG AATCCAGGAT CTGGATACCA CAGACACGGG ATACTACCAG 300
TGCGTGGCTT CAAATGGGAT GAAAACAATA ACTGCAACAG GAGTTTTGTT TGTCAGGCTT 360
GGTCCAACAA ACAGCCCAAA TCACAATCTT CAAGAAGATT ACCATGAAGA TGGGTTCTGT 420
CAACCATATA GGGGAATTGC GTGTGCACGA ATCATTGGAA ACAGAACCAT TTATGTGGAC 480
TCCCTCCAGA TGCAAGGGGA AATTGAAAAC CGAATTACTG CTGCGTTTAC CATGATTGGC 540
ACTTCGACAC ATTTGTCCGA CCAGTGCTCG CAGTTCGCTA TACCTTCCTT CTGCCACTTC 600
GTGTTTCCCC TGTGTGATGA ACGCTCTCGG ACCCCTAAGC CACGGGAGCT GTGCCGGGAT 660
GAATGTGAAG TTCTGGAGAA TGATCTCTGT AGGCAGGAGT ACAACATTGC CAGGTCAAAC 720
CCCCTCATCT TGATGCAGCT ACAGCTGCCA AAGTGTGAGG ACCTCCCGCG ACCGGACACC 780
TTGGAAGCCG CCAACTGCAT AAGAATTGGG ATCCCCGTGG AGAGACTGAG CCGATATCAT 840
CAGTGCTACA ATGGCTCTGG AACTGACTAC AGAGGGACCA TCAGTGTTAC CAAGTCAGGC 900
CACACTTGCC AACTCTGGGA CTCACAGAGT CCCCACAACC ATGATCTGAC AAGCACACAG 960
TTTCCAGAGC TAGGTGGAGG ACATGCATAT TGTCGAAATC CTGGAGGTCA AATGGATGGT 1020
CCCTGGTGTT TTACAAAGAA TAAAAACGTA CGCATGGAAC TGTGTGACAT ACCTTCTTGT 1080
AGTCCCCGTG ACAACAGCAA AATGGGAATC CTCTACATCC TTGTTCCCAG CATAGCCATC 1140
CCTCTGGTGA TAGCCTGCCT TTTCTTCCTG GTCTGCATGT GCAGAAACAA GCAGAAGGCA 1200
TCTGCTGCTA CACCACAGCG CCGCCAGCTG ATGGCATCTC CCAGCCAAGA TATGGAAATG 1260
CCACTCATTA ATCAACACAA ACAGGCTAAG CTTAAAGAAA TTAATCTGTC CACTGTGAGA 1320
TTTATGGAGG AACTAGGAGA GGAGAGGTTT GGAAAAGTCT ACAAGGGGCA TCTCTTTGGT 1380
ACAGCCCCAG GTGAACAGAC ACAAGCTGTT GCCATTAAGA CACTTAAAGA CAAAGCAGAA 1440
CTGGCTCTTC GGGAAGAATT TAAACATGAG GCAATGATGA GATCACGATT ACAGCACCCA 1500
AACATAGTTT GTTTGCTGGG AATAGTGACA AAGGAACAAC CTGTAAGTAT GATATTTAGT 1560
TATTGTTCCC ACAGTGATCT CCATGAATTC TTGGTGATGA GATCTCCTCA CTCGGATGTT 1620
GGCAGCACCG ATGATGACAA GACAGTAAAA TCCACTCTGG AACCAGCAGA CTTTTTTCAC 1680
ATTGTGACTC AGATAGCTGC AGGAATGGAA TATCTTTCTA GCCACCATGT TGTCCACAAG 1740
GACTTGGCCA CTAGAAATAT ACTGGTGTTC GATAAGCTGA ATGTGAAAAT ATCTGATTTA 1800
GGCCTTTTCA GGGAAGTTTA TGCTGCTGAT TACTACAAAC TGATGGGAAA TTCCCTTCTT 1860
CCTATCCGGT GGATGTCCCC TGAGGCTATT ATGTATGGCA AGTTTTCTAT TGATTCGGAT 1920
ATATGGTCAT ACGGAGTTGT GTTGTGGGAA GTCTTCAGCT ATGGCCTGCA GCCTTACTGT 1980
GGTTATTCCA ATCAGGATGT CATTGAGATG ATCAGGAACC GACAAGTTTT GCCATGTCCC 2040
GACGACTGCC CCACATGGAT ATACACTTTG ATGTTGGAGT GTTGGAATGA ATTTCCCAAC 2100
AGAAGACCAA GATTTAAAGA TATACATAAC AGACTAAGAA CATGGGGGAA CCTTTCTAAT 2160
TACAACAGCT CAGCGCAAAC TTCTGGGGCA AGCAATACCA CACAAACAAG TTCTCTCAGC 2220
ACAAGCCCTG TTAGCAATGT CAGCAATGCT AGATACATTG GACCAAAGCA GAAAACTCCA 2280
GCCTTCCCTC AACCTCAGTT CATACAAATG AAAGGCCAGA TGAGACCAAT GGTCCCACCT 2340
CCTCAGCTCT ACATTCCAGT CAATGGTTAC CAGCCAATGC CTGCCTATGG TGCTTACTTG 2400
CCAAATTTTT ATCCCGTCCA AATTCCAATG CAAATGGCTC CTCAGCAAAT ACCTCCCCAG 2460
ATCATTCCTA AACCAGGCTC CCACCACAGC GGGAGTGGAT CTACTAGCAC AGGCTATGTA 2520
ACAACAGCAC CTTCCAATGC ATCAGTGGCC GACAGGGCCG CTCTGCTGTC AGAAGGCACG 2580
GATGACACAC ACAATGGAAC GGAAGATATC GCCCAGAACC CTGTCCAGGA GGAGGAGGAA 2640
GAAGAGGGCT CTGTGCCTGA AACAGAATTG CTGGGTGATA ACGACACACT TCAGATGGAT 2700
GAAGCAGAAA TTCAATCAGA AGCC 2724
Domain Profile
S: 1     vrfleelGegafGkvykGhlfapek.ektqavaiktlkdkaeakereefkqeielvaelk  59
         vrf+eelGe++fGkvykGhlf+ ++ e+tqavaiktlkdkae + reefk+e++++++l+
Q: 439   VRFMEELGEERFGKVYKGHLFGTAPgEQTQAVAIKTLKDKAELALREEFKHEAMMRSRLQ  498
         89********************99999*********************************
S: 60    hpnivcllGvvtkdqpllmlfeylshGdlheflivrsphsdvgssdedrtvkssleeadf  119
         hpnivcllG+vtk+qp++m+f+y+sh dlhefl++rsphsdvgs+d+d+tvks+le+adf
Q: 499   HPNIVCLLGIVTKEQPVSMIFSYCSHSDLHEFLVMRSPHSDVGSTDDDKTVKSTLEPADF  558
         ************************************************************
S: 120   lhiaiqiaaGmeylsshsfvhkdlaarnvlvgdkltvkisdlGlsreiysadyykllsks  179
         +hi++qiaaGmeylssh++vhkdla+rn+lv dkl+vkisdlGl+re+y+adyykl+++s
Q: 559   FHIVTQIAAGMEYLSSHHVVHKDLATRNILVFDKLNVKISDLGLFREVYAADYYKLMGNS  618
         ************************************************************
S: 180   llpirwmskeailyGkfsedsdiwsfGvvlweifsfGlqpyeGfsnqevielvrkrqlle  239
         llpirwms+eai+yGkfs+dsdiws+Gvvlwe+fs+Glqpy+G+snq+vie++r+rq+l+
Q: 619   LLPIRWMSPEAIMYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVIEMIRNRQVLP  678
         ************************************************************
S: 240   cpedcpaavyslmiecwneipsrrprfkdirsrlrswenlssytssattsgasattqtss  299
         cp+dcp+++y+lm+ecwne+p+rrprfkdi++rlr+w+nls+y+ssa+tsgas+ttqtss
Q: 679   CPDDCPTWIYTLMLECWNEFPNRRPRFKDIHNRLRTWGNLSNYNSSAQTSGASNTTQTSS  738
         ************************************************************
S: 300   lsaspvs  306
         ls+spvs
Q: 739   LSTSPVS  745
         *****97
Domain Sequence
(FASTA)
VRFMEELGEE RFGKVYKGHL FGTAPGEQTQ AVAIKTLKDK AELALREEFK HEAMMRSRLQ 60
HPNIVCLLGI VTKEQPVSMI FSYCSHSDLH EFLVMRSPHS DVGSTDDDKT VKSTLEPADF 120
FHIVTQIAAG MEYLSSHHVV HKDLATRNIL VFDKLNVKIS DLGLFREVYA ADYYKLMGNS 180
LLPIRWMSPE AIMYGKFSID SDIWSYGVVL WEVFSYGLQP YCGYSNQDVI EMIRNRQVLP 240
CPDDCPTWIY TLMLECWNEF PNRRPRFKDI HNRLRTWGNL SNYNSSAQTS GASNTTQTSS 300
LSTSPVS 307
KeywordComplete proteome; Disulfide bond; Immunoglobulin domain; Kringle; Membrane; Receptor; Reference proteome; Transmembrane; Transmembrane helix.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00176
EKS-ANC-00180
EKS-BOT-00186
EKS-CAE-00176
EKS-CAJ-00193
EKS-CAF-00193
EKS-CAP-00212
EKS-CII-00120
EKS-CIS-00218
EKS-DAR-00486
EKS-DRM-00096
EKS-EQC-00182
EKS-FEC-00175
EKS-GAG-00160
EKS-GAA-00230
EKS-GOG-00184
EKS-HOS-00193
EKS-ICT-00180
EKS-LAC-00197
EKS-LOA-00184
EKS-MAM-00188
EKS-MEG-00144
EKS-MOD-00185
EKS-MUM-00190
EKS-MUP-00189
EKS-MYL-00192
EKS-NOL-00177
EKS-ORN-00238
EKS-ORC-00170
EKS-OTG-00193
EKS-PAT-00178
EKS-PES-00163
EKS-POA-00181
EKS-PTV-00164
EKS-RAN-00182
EKS-SAH-00180
EKS-SUS-00161
EKS-TAR-00244
EKS-XET-00218
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0030154; P:cell differentiation
GO:0007254; P:JNK cascade
GO:0090090; P:negative regulation of canonical Wnt receptor signaling pathway
GO:0008285; P:negative regulation of cell proliferation
GO:0090263; P:positive regulation of canonical Wnt receptor signaling pathway
GO:0030335; P:positive regulation of cell migration
GO:0045893; P:positive regulation of transcription, DNA-dependent
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007223; P:Wnt receptor signaling pathway, calcium modulating pathway
GO:0060071; P:Wnt receptor signaling pathway, planar cell polarity pathway
KEGG
tgu:100219935;
InterPros
IPR020067; Frizzled_dom.
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003598; Ig_sub2.
IPR011009; Kinase-like_dom.
IPR000001; Kringle.
IPR013806; Kringle-like.
IPR018056; Kringle_CS.
IPR000719; Prot_kinase_cat_dom.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016247; Tyr_kinase_rcpt_ROR.
Pfam
PF01392; Fz; 1.
PF07679; I-set; 1.
PF00051; Kringle; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00408; IGc2; 1.
SM00130; KR; 1.
SM00219; TyrKc; 1.
Prosites
PS50038; FZ; 1.
PS50835; IG_LIKE; 1.
PS00021; KRINGLE_1; 1.
PS50070; KRINGLE_2; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013