EKS-TAG-00178
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-TAG-00178
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/FGFR521.63.2E-157403678276
StatusUnreviewed
Ensembl ProteinENSTGUP00000000448
UniProt AccessionH0YQ95;
Protein NameFibroblast growth factor receptor
Protein Synonyms/Alias
Gene NameFGFR4
Gene Synonyms/Alias FGFR4;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSTGUG00000000438ENSTGUP00000000448ENSTGUT00000000454
OrganismTaeniopygia guttata
Functional Description
Protein Length691
Protein Sequence
(FASTA)
WYKETRPLVS GGRIHLRQSL LEISEVTYED SGLYVCRARG TGEVLRNFTI SVVDSLASGD 60
DDEDIYVHRG QCHTRALQER AAPYWTHPHR MDKKLYAVPA GNTVKFRCPA SGSPSPSIRW 120
FKNGREFRGE HRIGGIRLRH QHWSLVMESV VPSDRGNYTC LVENRFGSIR YSYLLDVLER 180
SPHRPILQAG LPANTTALVG SDVEFFCKVY SDAQPHIQWL KHIEVNGSNY GPDGVPYVQV 240
LKTADINSSE VEVLYLRNVS MEDAGEYTCL AGNSIGLSYQ SAWLTVLPEE ELVREAEAPE 300
TKYTDIIIYT SGSLAVAMAI IIMVLCRMQT QSSKQHLEPM AVHKLSKFPL IRQFSLDSSS 360
SGKSSTSLMR VTRLSSSCAP MLAGVMELDL PLDAKWEFPR DKLVLGKPLG EGCFGQVRAE 420
AYGIDRDWPD RAITVAVKML KDNATDKDLA DLISEMEMMK LMDKHKNIIN LLGVCTQDGP 480
LYVIVEFAAK GNLREYLRAR RPPTPDYAFD AMTMPEEQLS FKDLVSCVYQ VARGMEYLES 540
KRCIHRDLAA RNVLVTAESV MKIADFGLAR DVHDIDYYKK TSNGRLPVKW MAPEALFDRV 600
YTHQSDVWSF GILMWEIFTL GGSPYPGIPV EELFKLLKEG HRMDRPSNCT HELYMLMREC 660
WHAVPSQRPT FKQLVEGLDK ILAAVSEEYL D 691
Nucleotide Sequence
(FASTA)
TGGTACAAGG AGACCCGTCC GCTCGTCTCG GGGGGTCGCA TCCACCTCCG TCAGAGCCTG 60
CTGGAGATCT CAGAGGTCAC CTACGAGGAC TCAGGGCTCT ACGTGTGCCG GGCACGGGGA 120
ACTGGAGAGG TCCTGCGCAA CTTCACCATC TCTGTCGTGG ACTCCCTGGC ATCAGGTGAT 180
GATGATGAAG ATATCTATGT GCACAGAGGT CAGTGCCACA CCAGGGCACT ACAGGAGAGG 240
GCAGCTCCCT ACTGGACTCA CCCACACCGG ATGGACAAGA AGCTGTATGC AGTCCCTGCG 300
GGGAACACGG TGAAGTTCCG CTGCCCGGCC TCAGGCAGCC CCAGCCCCAG CATTCGCTGG 360
TTCAAGAATG GTCGTGAGTT CCGAGGGGAG CACCGCATCG GGGGCATCCG GCTCCGGCAC 420
CAGCACTGGA GCCTGGTGAT GGAGAGTGTG GTGCCCTCTG ACCGCGGCAA CTACACTTGC 480
CTGGTGGAAA ACAGGTTTGG CAGCATCCGC TACAGCTACC TCCTGGATGT GCTGGAGAGG 540
TCCCCGCACA GGCCCATCTT GCAGGCTGGG CTGCCTGCCA ACACCACAGC CCTGGTGGGC 600
AGCGATGTGG AGTTCTTCTG CAAGGTCTAC AGTGATGCCC AGCCTCACAT CCAGTGGCTG 660
AAGCACATTG AAGTGAATGG CAGCAACTAC GGCCCCGACG GGGTCCCCTA TGTGCAAGTG 720
CTCAAGACTG CAGATATCAA CAGCTCTGAG GTGGAGGTGC TGTACCTGCG CAATGTGTCC 780
ATGGAGGATG CTGGCGAGTA CACCTGCCTG GCAGGGAACT CTATCGGCCT CTCCTACCAG 840
TCTGCCTGGC TCACTGTCCT GCCAGAAGAG GAGCTGGTGA GGGAAGCTGA GGCCCCTGAG 900
ACCAAGTACA CAGACATTAT CATCTACACC TCGGGCTCAC TCGCCGTGGC CATGGCCATT 960
ATTATTATGG TGCTGTGCCG GATGCAGACT CAATCAAGCA AGCAGCACCT GGAGCCTATG 1020
GCAGTCCACA AGCTCTCCAA ATTCCCACTC ATCCGACAGT TCTCCCTGGA TTCCAGCTCC 1080
TCTGGGAAGT CCAGCACATC CCTGATGCGG GTCACCCGTC TCTCCTCCAG CTGTGCCCCA 1140
ATGCTGGCTG GTGTCATGGA GCTGGACCTG CCCCTTGACG CCAAGTGGGA GTTCCCCCGA 1200
GACAAGCTGG TGCTGGGGAA GCCCTTGGGG GAAGGCTGCT TTGGCCAGGT GCGGGCAGAG 1260
GCTTATGGCA TAGACAGAGA CTGGCCAGAC AGAGCCATCA CCGTGGCCGT CAAAATGCTG 1320
AAAGACAACG CCACCGACAA GGACCTGGCT GACCTCATAT CCGAGATGGA GATGATGAAG 1380
CTCATGGACA AGCACAAGAA CATCATCAAC CTCCTGGGAG TCTGCACACA GGATGGGCCG 1440
CTGTACGTGA TTGTGGAGTT TGCTGCGAAG GGCAACCTGC GTGAGTACCT CCGTGCCCGC 1500
CGCCCCCCGA CACCTGACTA CGCTTTTGAT GCCATGACAA TGCCTGAGGA GCAGCTCTCT 1560
TTCAAGGATC TGGTCTCCTG CGTCTACCAG GTGGCCCGTG GCATGGAGTA CCTGGAGTCC 1620
AAACGGTGCA TCCACCGTGA CCTGGCTGCC CGCAACGTGC TGGTGACAGC AGAGAGCGTG 1680
ATGAAAATCG CTGACTTTGG CTTGGCCAGG GACGTTCACG ACATCGACTA CTACAAGAAA 1740
ACCAGCAACG GTCGCCTGCC AGTGAAGTGG ATGGCCCCCG AAGCCCTGTT TGACCGTGTC 1800
TACACCCACC AGAGCGATGT GTGGTCCTTT GGGATCCTGA TGTGGGAGAT CTTCACGCTG 1860
GGGGGCTCCC CATACCCTGG CATCCCTGTG GAGGAGCTGT TCAAGCTGCT GAAGGAGGGG 1920
CACCGCATGG ACCGGCCATC CAACTGCACC CACGAGCTGT ACATGCTGAT GAGGGAGTGC 1980
TGGCACGCTG TGCCCTCACA GCGCCCCACC TTCAAGCAGC TTGTGGAGGG GCTGGACAAG 2040
ATCCTGGCAG CTGTTTCAGA GGAGTACCTG GAC 2073
Domain Profile
S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60
         lvlgk+lGeG+fGqv +aea g+d+d +++++tvavkmlk++atdkdladl+seme++kl
Q: 403   LVLGKPLGEGCFGQV-RAEAYGIDRDWPDRAITVAVKMLKDNATDKDLADLISEMEMMKL  461
         79************7.79999***************************************
S: 61    iGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeaskdkskaseeqlte  120
         + khkniinllG+ctq+Gplyvive+aakGnlre+lrarrp++ ++  d+  ++eeql++
Q: 462   MDKHKNIINLLGVCTQDGPLYVIVEFAAKGNLREYLRARRPPTPDYAFDAMTMPEEQLSF  521
         ************************************************************
S: 121   kdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyykkt  180
         kdlvs+ yqvarGmeyl+sk+cihrdlaarnvlvt ++v+kiadfGlardvh+idyykkt
Q: 522   KDLVSCVYQVARGMEYLESKRCIHRDLAARNVLVTAESVMKIADFGLARDVHDIDYYKKT  581
         ************************************************************
S: 181   tnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllkeGh  240
         +nGrlpvkwmapealfdrvyt+qsdvwsfG+l+wei+tlGgspypgi+veelfkllkeGh
Q: 582   SNGRLPVKWMAPEALFDRVYTHQSDVWSFGILMWEIFTLGGSPYPGIPVEELFKLLKEGH  641
         ************************************************************
S: 241   rmekpakctkelyvlmrecwhakaserptfkqlvedl  277
         rm++p++ct+ely+lmrecwha++s+rptfkqlve l
Q: 642   RMDRPSNCTHELYMLMRECWHAVPSQRPTFKQLVEGL  678
         **********************************965
Domain Sequence
(FASTA)
LVLGKPLGEG CFGQVRAEAY GIDRDWPDRA ITVAVKMLKD NATDKDLADL ISEMEMMKLM 60
DKHKNIINLL GVCTQDGPLY VIVEFAAKGN LREYLRARRP PTPDYAFDAM TMPEEQLSFK 120
DLVSCVYQVA RGMEYLESKR CIHRDLAARN VLVTAESVMK IADFGLARDV HDIDYYKKTS 180
NGRLPVKWMA PEALFDRVYT HQSDVWSFGI LMWEIFTLGG SPYPGIPVEE LFKLLKEGHR 240
MDRPSNCTHE LYMLMRECWH AVPSQRPTFK QLVEGL 276
KeywordATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00141
EKS-ANC-00141
EKS-BOT-00149
EKS-CAJ-00153
EKS-CAP-00150
EKS-DAR-00435
EKS-EQC-00148
EKS-FEC-00139
EKS-GAM-00077
EKS-GAA-00174
EKS-ICT-00143
EKS-LAC-00159
EKS-LOA-00148
EKS-MOD-00149
EKS-MUM-00154
EKS-MUP-00154
EKS-MYL-00158
EKS-ORN-00184
EKS-ORC-00140
EKS-ORL-00172
EKS-POA-00145
EKS-RAN-00148
EKS-SAH-00144
EKS-SUS-00130
EKS-TAR-00193
EKS-TEN-00185
EKS-XET-00138
EKS-XIM-00178
Gene Ontology
GO:0005911; C:cell-cell junction
GO:0005783; C:endoplasmic reticulum
GO:0005887; C:integral to plasma membrane
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0005007; F:fibroblast growth factor-activated receptor activity
GO:0008201; F:heparin binding
GO:0016477; P:cell migration
GO:0042593; P:glucose homeostasis
GO:0001759; P:organ induction
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0055062; P:phosphate ion homeostasis
GO:0008284; P:positive regulation of cell proliferation
GO:2000573; P:positive regulation of DNA biosynthetic process
GO:0070374; P:positive regulation of ERK1 and ERK2 cascade
GO:0048554; P:positive regulation of metalloenzyme activity
GO:0045862; P:positive regulation of proteolysis
GO:0046777; P:protein autophosphorylation
GO:0070857; P:regulation of bile acid biosynthetic process
GO:2000188; P:regulation of cholesterol homeostasis
GO:0010715; P:regulation of extracellular matrix disassembly
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003598; Ig_sub2.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016248; Tyr_kinase_fibroblast_GF_rcpt.
Pfam
PF07679; I-set; 2.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00408; IGc2; 2.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 3.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013