EKS-TAG-00294

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAG-00294

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	412.3	9.2E-124	190	478	289

Status

Unreviewed

Ensembl Protein

ENSTGUP00000000561

UniProt Accession

H0YQK4;

Protein Name

Protein Synonyms/Alias

Gene Name

ACVR2B

Gene Synonyms/Alias

ACVR2B;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTGUG00000000545	ENSTGUP00000000561	ENSTGUT00000000570

Organism

Taeniopygia guttata

Functional Description

Protein Length

512

Protein Sequence
(FASTA)

MFASWLTFAV LWGTFCAGPG HGEAETRECI YYNANWELEK TNQSGVERCE GEKDKRLHCY 60

ASWRNNSGSI ELVKKGCWLD DFNCYDRQEC VATEENPQVF FCCCEGNYCN EKFTHLPEVT 120

GPEVIYEPPP PTPSLLNILV YSLLPIAVLS MAILLAFWMY RHRKPPYGHV DIIEDPGPPP 180

PSPLVGLKPL QLLEIKARGR FGCVWKAQLM NDYVAVKIFP IQDKQSWQSE REIFNTPGMK 240

HENLLQFIAA EKRGTNLETE LWLITAFHDK GSLTDYLKGN IISWNELCHV AETMARGLSY 300

LHEDVPWCKG EGHKPAIAHR DFKSKNVLLK NDLTAVLADF GLAVRFEPGK PPGDTHGQVG 360

TRRYMAPEVL EGAINFQRDA FLRIDMYAMG LVLWELVSRC RAVDGPVDEY MLPFEEEIGQ 420

HPSLEDLQEV VVHKKMRPVF KDHWLKHPGL AQLCVTIEEC WDHDAEARLS AGCVEERIAQ 480

IRKSVNGTTS DCLVSIVTSV TNVDLPPKES SI 512

Nucleotide Sequence
(FASTA)

ATGTTTGCTT CGTGGCTGAC TTTCGCCGTG CTCTGGGGAA CTTTCTGTGC AGGGCCAGGC 60

CACGGGGAGG CTGAGACAAG GGAGTGCATC TACTACAATG CCAACTGGGA GCTGGAGAAG 120

ACCAACCAGA GCGGCGTGGA GCGCTGCGAG GGGGAGAAGG ACAAGCGGCT CCACTGCTAC 180

GCCTCCTGGA GAAACAACTC GGGCTCCATC GAGCTGGTGA AGAAAGGCTG CTGGTTAGAT 240

GACTTCAACT GCTATGACAG GCAGGAGTGT GTAGCCACAG AAGAAAACCC TCAGGTGTTT 300

TTCTGCTGCT GCGAGGGCAA CTATTGCAAT GAGAAATTTA CCCATTTGCC TGAAGTCACC 360

GGCCCAGAAG TCATATACGA GCCACCGCCA CCCACGCCCT CCCTGCTGAA CATCCTGGTG 420

TACTCCCTGC TGCCCATCGC CGTGCTGTCC ATGGCCATCC TGTTGGCCTT CTGGATGTAC 480

CGCCACCGGA AGCCTCCCTA CGGCCACGTG GACATCATTG AGGATCCTGG CCCACCACCC 540

CCTTCTCCCC TGGTTGGCCT AAAGCCCCTG CAGCTCTTGG AGATCAAGGC AAGGGGACGC 600

TTTGGCTGTG TGTGGAAGGC TCAGCTGATG AATGACTACG TAGCAGTGAA AATCTTCCCT 660

ATTCAGGATA AGCAATCTTG GCAGAGTGAG AGGGAGATTT TCAACACTCC TGGCATGAAG 720

CATGAAAACC TTTTGCAATT TATCGCAGCA GAGAAAAGGG GGACAAACCT GGAGACAGAG 780

CTCTGGCTGA TCACAGCTTT CCATGACAAG GGATCTCTGA CAGATTACCT GAAGGGCAAC 840

ATTATCAGCT GGAATGAGCT CTGCCATGTT GCAGAAACAA TGGCCCGTGG CTTGTCCTAC 900

CTTCATGAAG ATGTCCCCTG GTGCAAAGGT GAAGGACACA AACCTGCCAT AGCACACAGG 960

GACTTCAAGA GTAAAAATGT CTTGCTGAAG AATGACTTGA CAGCTGTGCT AGCTGATTTT 1020

GGACTGGCTG TACGGTTTGA ACCTGGAAAA CCTCCAGGGG ACACTCATGG ACAGGTGGGA 1080

ACAAGGAGGT ACATGGCTCC TGAAGTGTTG GAGGGAGCAA TCAACTTCCA ACGAGACGCC 1140

TTCCTGAGAA TAGACATGTA TGCAATGGGA CTGGTGCTGT GGGAGCTAGT CTCCAGATGT 1200

AGAGCAGTTG ATGGTCCAGT GGATGAATAC ATGCTGCCTT TTGAAGAAGA AATAGGTCAG 1260

CACCCATCCC TTGAGGACCT GCAAGAAGTG GTGGTTCACA AGAAGATGCG CCCCGTGTTC 1320

AAGGATCACT GGCTAAAACA TCCCGGCCTG GCGCAGCTCT GCGTGACCAT CGAAGAGTGC 1380

TGGGACCACG ACGCGGAGGC GCGGCTCTCG GCCGGCTGCG TCGAGGAGCG CATCGCGCAG 1440

ATCCGCAAAT CCGTCAACGG CACTACCTCG GACTGCCTCG TCTCCATCGT GACGTCCGTC 1500

ACCAACGTGG ACTTGCCACC CAAAGAGTCT AGTATCTGA 1539

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         l+lle+ ++Gr+g+Vwka+l++++vAvKif+ +d++sw++E+ei++t+ ++hen+lqfia

Q: 190   LQLLEIKARGRFGCVWKAQLMNDYVAVKIFPIQDKQSWQSEREIFNTPGMKHENLLQFIA  249

         6899********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         a+k+ ++++tel+l+t++h+kgsL+dyLk ++++++el+++a+++a+Gl++LHe+++++k

Q: 250   AEKRGTNLETELWLITAFHDKGSLTDYLKGNIISWNELCHVAETMARGLSYLHEDVPWCK  309

         ************************************************************

S: 121   g.kkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaP  179

         g  +KpaiaHRD+kskN+l+k+dlt+++aD+GLa+++e  k   d  ++ qvGt+RYmaP

Q: 310   GeGHKPAIAHRDFKSKNVLLKNDLTAVLADFGLAVRFEPGKPPGD--THGQVGTRRYMAP  367

         *99***************************************888..79***********

S: 180   EvleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPslee  239

         Evle+a+n+++ +af r+D+Y++gLvlWE++sRc++vd+ v+ey+lpfee++g++Psle+

Q: 368   EVLEGAINFQR-DAFLRIDMYAMGLVLWELVSRCRAVDGPVDEYMLPFEEEIGQHPSLED  426

         **********9.9***********************************************

S: 240   mkevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         ++evvv+kk+rP ++++w k++ l++l+ ++eecWd+d+eaRl+a +v++r+

Q: 427   LQEVVVHKKMRPVFKDHWLKHPGLAQLCVTIEECWDHDAEARLSAGCVEERI  478

         *************************************************985

Domain Sequence
(FASTA)

LQLLEIKARG RFGCVWKAQL MNDYVAVKIF PIQDKQSWQS EREIFNTPGM KHENLLQFIA 60

AEKRGTNLET ELWLITAFHD KGSLTDYLKG NIISWNELCH VAETMARGLS YLHEDVPWCK 120

GEGHKPAIAH RDFKSKNVLL KNDLTAVLAD FGLAVRFEPG KPPGDTHGQV GTRRYMAPEV 180

LEGAINFQRD AFLRIDMYAM GLVLWELVSR CRAVDGPVDE YMLPFEEEIG QHPSLEDLQE 240

VVVHKKMRPV FKDHWLKHPG LAQLCVTIEE CWDHDAEARL SAGCVEERI 289

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0009986	; C:cell surface
GO:0005737	; C:cytoplasm
GO:0016020	; C:membrane
GO:0017002	; F:activin-activated receptor activity
GO:0005524	; F:ATP binding
GO:0004712	; F:protein serine/threonine/tyrosine kinase activity
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0032147	; P:activation of protein kinase activity
GO:0030509	; P:BMP signaling pathway
GO:0030073	; P:insulin secretion
GO:0035265	; P:organ growth
GO:0032927	; P:positive regulation of activin receptor signaling pathway
GO:0030501	; P:positive regulation of bone mineralization
GO:0045669	; P:positive regulation of osteoblast differentiation
GO:0009749	; P:response to glucose stimulus
GO:0023014	; P:signal transduction by phosphorylation

KEGG

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR015768	; Activin_II_recpt.
IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.

SMARTs

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013