EKS-TAG-00138
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-TAG-00138
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Tec439.62.6E-132363612250
StatusUnreviewed
Ensembl ProteinENSTGUP00000000679
UniProt AccessionH0YQX2;
Protein Name
Protein Synonyms/Alias
Gene NameITK
Gene Synonyms/Alias ITK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSTGUG00000000655ENSTGUP00000000679ENSTGUT00000000690
OrganismTaeniopygia guttata
Functional Description
Protein Length620
Protein Sequence
(FASTA)
MNNCVLLEEL LIKKSQQKRR TSPSNFKVRF FVLTKSKLAY YEHRHGKKRT LKGSVELSRI 60
KCVEIVRSDI IIPCQYKYPF QIVHDSYILY VFAPNRESRQ RWVLTLKEEI RYNNSLASKC 120
HPDFWLDGKW RCCAQTEKMA AGCVIYDPTK NASKKPLPPT PEDNWKLLLD PREAVVIAIY 180
DYEAQNPQEL TLQYNEEYYV IDSSEEHWWL IQDKNGHEGY VPSSYLAEKS PENLQVYEWY 240
NKNISRSKAE TLLREEGREG AFMVRDSRQP GMYTVSVFTK ALSTDNNPVI KHYHINETTD 300
FPKRYYLAEK HVFDSIPDLI NYHQHNAAGL VTRLRYAVSS WRKQAPITAG LSYGKLVISA 360
SELTRVQEIG SGQFGVVYLG YLLDKTKVAI KTIREGAMSE EDFIEEAKVL MKLSHPKLVQ 420
LYGVCFEEAP ICLVFEFMEN GCLSDYLRSQ RGSFSKETLL GMCLDVCEGM AYLEQNSVIH 480
RDLAARNCLV GESHVVKVSD FGMSRIVLDD QYTSSTGTKF PVKWSAPEVF SYSNYSTKSD 540
IWSFGVLMWE VFSEGKIPYE NRTNAEVVEE INAGFRLYKP KLASRAIYEV MSHCWRMGKD 600
ERPSFSLLLF QLSEISEFDV 620
Nucleotide Sequence
(FASTA)
ATGAATAACT GTGTGCTCCT GGAGGAACTG CTGATCAAGA AATCCCAGCA GAAGAGAAGG 60
ACTTCACCCT CCAACTTTAA AGTGCGCTTC TTTGTCCTGA CCAAATCCAA GCTGGCTTAC 120
TACGAACATC GCCATGGGAA AAAAAGGACT TTGAAGGGTT CTGTGGAACT TTCCAGGATT 180
AAATGTGTGG AAATTGTGAG AAGCGACATC ATCATTCCCT GTCAGTACAA ATACCCTTTC 240
CAGATTGTCC ATGACAGCTA CATCCTCTAC GTGTTTGCCC CCAACCGCGA GAGCCGGCAG 300
AGATGGGTCC TCACACTGAA GGAAGAAATC AGATACAACA ACAGTTTGGC TTCAAAGTGT 360
CATCCAGACT TTTGGCTGGA TGGCAAGTGG AGATGCTGTG CTCAGACAGA GAAGATGGCA 420
GCTGGCTGTG TGATATATGA CCCCACCAAA AATGCCTCAA AGAAGCCTCT TCCTCCCACT 480
CCTGAAGATA ACTGGAAATT GTTGCTGGAC CCAAGGGAAG CAGTGGTCAT AGCCATATAT 540
GACTATGAAG CCCAGAACCC ACAGGAGCTG ACATTACAAT ATAATGAGGA ATATTATGTG 600
ATTGACAGCT CTGAGGAACA TTGGTGGCTG ATTCAAGATA AGAATGGGCA TGAAGGCTAC 660
GTGCCAAGCA GCTACCTGGC AGAAAAATCA CCTGAGAATC TGCAAGTTTA TGAGTGGTAC 720
AATAAGAACA TCAGCAGAAG CAAAGCAGAA ACACTGCTCA GGGAAGAGGG TAGAGAAGGG 780
GCCTTCATGG TGAGAGATTC AAGGCAGCCT GGCATGTACA CAGTCTCTGT TTTCACCAAA 840
GCATTAAGCA CGGACAACAA TCCTGTTATA AAGCATTATC ACATCAATGA GACAACTGAC 900
TTTCCCAAGC GATACTACCT GGCAGAAAAG CACGTGTTTG ACTCCATCCC TGACCTCATC 960
AACTACCACC AGCACAATGC AGCAGGTCTC GTGACGCGGC TGCGGTACGC GGTCTCCTCC 1020
TGGAGGAAAC AGGCCCCCAT CACCGCAGGG CTCAGCTATG GAAAATTGGT GATTAGTGCC 1080
TCTGAGCTCA CCCGTGTGCA GGAGATTGGC AGTGGTCAGT TTGGGGTGGT CTACCTTGGC 1140
TACTTGCTGG ACAAGACAAA AGTAGCCATA AAGACCATCC GTGAAGGAGC CATGTCTGAG 1200
GAGGATTTCA TCGAGGAAGC CAAAGTCTTG ATGAAGCTGT CTCACCCCAA GCTAGTCCAG 1260
CTTTATGGTG TGTGCTTTGA GGAGGCTCCC ATCTGCCTGG TGTTCGAGTT CATGGAGAAC 1320
GGCTGCTTGT CCGACTACCT CAGGAGCCAG CGGGGCAGCT TCTCCAAGGA AACCCTGCTG 1380
GGGATGTGCC TGGATGTGTG TGAAGGAATG GCTTATCTGG AACAAAACTC TGTCATCCAC 1440
AGAGACCTGG CTGCCAGGAA CTGCCTGGTG GGGGAATCCC ACGTGGTCAA AGTGTCTGAC 1500
TTTGGGATGT CGAGGATTGT CCTGGATGAC CAGTACACCA GTTCCACAGG TACCAAGTTT 1560
CCCGTCAAGT GGTCTGCCCC AGAGGTTTTC TCCTACAGCA ACTATAGCAC CAAATCTGAC 1620
ATTTGGTCAT TCGGAGTGCT GATGTGGGAG GTTTTCAGTG AAGGCAAAAT TCCCTATGAG 1680
AACCGCACCA ATGCAGAAGT GGTGGAAGAA ATCAATGCAG GATTTCGGCT CTACAAACCC 1740
AAGCTGGCCT CCAGGGCAAT TTATGAGGTG ATGAGCCACT GCTGGAGGAT GGGGAAAGAC 1800
GAGCGGCCAT CCTTTTCTCT TCTGCTGTTT CAGCTGAGTG AAATCTCTGA GTTTGATGTG 1860
TAA 1863
Domain Profile
S: 1     ltllkelgsgqfgvvklgkwrakidvaikaikegamseedfieeakvmmklshpklvqly  60
         lt ++e+gsgqfgvv lg+   k++vaik+i+egamseedfieeakv+mklshpklvqly
Q: 363   LTRVQEIGSGQFGVVYLGYLLDKTKVAIKTIREGAMSEEDFIEEAKVLMKLSHPKLVQLY  422
         5779********************************************************
S: 61    gvclkqkpiyivteylengcllnylrekkkklekelllemckdvcegmeylerksfihrd  120
         gvc +++pi++v+e++engcl++ylr+++++++ke+ll mc dvcegm+yle++s+ihrd
Q: 423   GVCFEEAPICLVFEFMENGCLSDYLRSQRGSFSKETLLGMCLDVCEGMAYLEQNSVIHRD  482
         ************************************************************
S: 121   laarnclvdeelvvkvsdfglaryvlddqyvssvgakfpvkwsppevlsyskyssksdvw  180
         laarnclv+e++vvkvsdfg++r vlddqy+ss+g+kfpvkws+pev+sys+ys+ksd+w
Q: 483   LAARNCLVGESHVVKVSDFGMSRIVLDDQYTSSTGTKFPVKWSAPEVFSYSNYSTKSDIW  542
         ************************************************************
S: 181   afgvlmwevfsegklpyekksnsevvekvsrglrlyrpklaskkvyevmkscwkekpeer  240
         +fgvlmwevfsegk+pye+++n+evve+++ g+rly+pklas+ +yevm +cw+   +er
Q: 543   SFGVLMWEVFSEGKIPYENRTNAEVVEEINAGFRLYKPKLASRAIYEVMSHCWRMGKDER  602
         ************************************************************
S: 241   ptfkellsal  250
         p+f+ ll +l
Q: 603   PSFSLLLFQL  612
         ******9887
Domain Sequence
(FASTA)
LTRVQEIGSG QFGVVYLGYL LDKTKVAIKT IREGAMSEED FIEEAKVLMK LSHPKLVQLY 60
GVCFEEAPIC LVFEFMENGC LSDYLRSQRG SFSKETLLGM CLDVCEGMAY LEQNSVIHRD 120
LAARNCLVGE SHVVKVSDFG MSRIVLDDQY TSSTGTKFPV KWSAPEVFSY SNYSTKSDIW 180
SFGVLMWEVF SEGKIPYENR TNAEVVEEIN AGFRLYKPKL ASRAIYEVMS HCWRMGKDER 240
PSFSLLLFQL 250
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00101
EKS-ANC-00099
EKS-BOT-00110
EKS-CAJ-00111
EKS-CAF-00112
EKS-CAP-00105
EKS-DAR-00357
EKS-EQC-00108
EKS-FEC-00105
EKS-GAG-00090
EKS-GAA-00128
EKS-GOG-00111
EKS-HOS-00113
EKS-ICT-00105
EKS-LAC-00114
EKS-LOA-00106
EKS-MAM-00105
EKS-MEG-00085
EKS-MOD-00106
EKS-MUM-00112
EKS-MUP-00113
EKS-MYL-00124
EKS-NOL-00103
EKS-OCP-00072
EKS-ORA-00089
EKS-ORC-00102
EKS-ORL-00125
EKS-OTG-00112
EKS-PAT-00100
EKS-PES-00093
EKS-POA-00103
EKS-RAN-00108
EKS-SAH-00102
EKS-TAR-00137
EKS-TEN-00127
EKS-XET-00091
Gene Ontology
GO:0005622; C:intracellular
GO:0005524; F:ATP binding
GO:0005543; F:phospholipid binding
GO:0004713; F:protein tyrosine kinase activity
GO:0035556; P:intracellular signal transduction
KEGG
tgu:100229084;
InterPros
IPR011009; Kinase-like_dom.
IPR011993; PH_like_dom.
IPR001849; Pleckstrin_homology.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR001562; Znf_Btk_motif.
Pfam
PF00779; BTK; 1.
PF00169; PH; 1.
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00107; BTK; 1.
SM00233; PH; 1.
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS50003; PH_DOMAIN; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
PS51113; ZF_BTK; 1.
Prints
PR00401; SH2DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013