EKS-TAG-00271

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAG-00271

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	283.5	1.1E-84	9	265	257

Status

Unreviewed

Ensembl Protein

ENSTGUP00000000812

UniProt Accession

H0YRA3;

Protein Name

Protein Synonyms/Alias

Gene Name

CHEK1

Gene Synonyms/Alias

CHEK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTGUG00000000790	ENSTGUP00000000812	ENSTGUT00000000823

Organism

Taeniopygia guttata

Functional Description

Protein Length

445

Protein Sequence
(FASTA)

MAVPFVEDWD LVQTLGEGAY GEVQLAVNRR TEEAVAVKIV DMKRAAECPE NIKKEICINK 60

MLSHENVVRF YGHRREGPTQ YLFLEYCRGG ELFDRIEPDV GMPEPEAQRF FQQLIAGVVY 120

LHSMGITHRD LKPENLLLDD RDNLKISDFG LATVFRHNGR ERLLNKMCGS LPYVAPELLR 180

RPEFRAEPVD VWVCGVVLTV MLTRELPWDQ PSDSCQEYSD WKEKKTYLPP WKKIDSTPLA 240

LLHKILTESP TARITIPDIQ KDRWYSRPLK KDVKRARLSS GGVTDSPGGF SKHIRSDTDF 300

SPVKGALGED KASYSTSQPE PGTGGMPWDS GTGSIDQLVQ GFSFSQPACP EHMLVNSQLL 360

GTPGSSQSPW QRLVKRMTRF FTKLDADGSY RALKEVCEKM GYGWKMSCTN QVTISTTDRR 420

NNKLIFKVNL VEMESKILVD FRLSK 445

Nucleotide Sequence
(FASTA)

ATGGCGGTGC CCTTCGTGGA GGACTGGGAC CTGGTGCAGA CGCTGGGTGA AGGCGCCTAC 60

GGGGAGGTGC AGCTGGCCGT GAACCGCCGC ACCGAGGAGG CCGTGGCCGT GAAAATCGTG 120

GACATGAAAC GCGCGGCCGA GTGCCCGGAG AACATCAAGA AGGAAATCTG CATCAACAAG 180

ATGCTGAGCC ACGAGAACGT CGTCCGGTTC TACGGACACC GGCGGGAGGG GCCCACGCAG 240

TACCTGTTCC TGGAGTACTG CCGCGGCGGA GAGCTCTTCG ACCGCATCGA GCCGGATGTC 300

GGCATGCCGG AGCCGGAGGC GCAGCGGTTC TTCCAGCAGC TGATTGCCGG CGTGGTGTAC 360

CTGCACAGCA TGGGCATCAC CCACCGGGAC CTGAAGCCAG AGAACCTGCT GCTGGACGAT 420

CGAGACAACC TGAAGATCTC GGATTTCGGC CTGGCCACGG TGTTCCGGCA CAACGGGCGG 480

GAGCGGCTGC TGAACAAGAT GTGTGGGAGC CTGCCCTACG TGGCCCCCGA GCTGCTGCGA 540

CGACCCGAGT TCCGCGCCGA GCCCGTCGAC GTCTGGGTCT GCGGCGTGGT GCTGACAGTC 600

ATGCTGACTC GAGAGCTGCC TTGGGACCAG CCCAGCGACA GCTGCCAGGA ATACAGCGAC 660

TGGAAGGAGA AGAAAACCTA CCTCCCACCT TGGAAGAAGA TTGATTCCAC TCCCTTGGCA 720

CTGCTGCACA AGATCCTGAC GGAGAGCCCC ACGGCGAGGA TCACCATTCC TGACATCCAG 780

AAGGACCGGT GGTACAGCAG ACCCCTCAAG AAGGATGTCA AGCGGGCCCG GCTCTCCTCG 840

GGCGGAGTCA CAGATTCCCC TGGAGGCTTC TCCAAGCACA TCCGATCCGA TACAGACTTC 900

TCTCCCGTGA AGGGAGCGCT GGGTGAGGAC AAGGCAAGCT ATTCCACATC ACAGCCGGAG 960

CCCGGCACGG GCGGGATGCC CTGGGACAGT GGCACAGGAA GCATCGACCA GCTGGTGCAG 1020

GGCTTCAGCT TCTCACAGCC CGCCTGCCCC GAGCACATGC TGGTCAACAG CCAGCTCCTG 1080

GGCACCCCAG GCTCCTCCCA GAGCCCGTGG CAGCGGCTGG TGAAGCGGAT GACGCGGTTT 1140

TTCACCAAGC TGGACGCCGA CGGCTCCTAC CGCGCGCTGA AGGAGGTGTG TGAGAAGATG 1200

GGATACGGCT GGAAGATGAG CTGCACCAAC CAGGTCACCA TCTCGACCAC AGACAGGAGG 1260

AACAACAAAC TCATCTTCAA GGTGAACCTG GTGGAGATGG AGAGCAAGAT TCTGGTGGAT 1320

TTTCGCCTCT CCAAG 1335

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkklseeslekikrEieilkklkhpni  60

         ++l++tlGeg++g+V+la++++t+e+vavKi++ k++  e  e+ik+Ei i k+l+h+n+

Q: 9     WDLVQTLGEGAYGEVQLAVNRRTEEAVAVKIVDMKRAA-ECPENIKKEICINKMLSHENV  67

         7899******************************7775.5579*****************

S: 61    ikllevietkkklylvleyasggeLfdyieekgrlkekearklfkqlvsavkYlhskgiv  120

         ++++   ++  + yl+ley++ggeLfd+ie +  ++e ea+++f+ql+++v Ylhs gi+

Q: 68    VRFYGHRREGPTQYLFLEYCRGGELFDRIEPDVGMPEPEAQRFFQQLIAGVVYLHSMGIT  127

         ************************************************************

S: 121   HrDlKpeNllldkkenikiaDFGlanlfkeg...klletfcGsppYaaPellkgkkYegp  177

         HrDlKpeNllld+++n+ki+DFGla++f+++   +ll+++cGs+pY+aPell++ +++++

Q: 128   HRDLKPENLLLDDRDNLKISDFGLATVFRHNgreRLLNKMCGSLPYVAPELLRRPEFRAE  187

         **************************999988889*************************

S: 178   kvDvWslGvvLyalvtgklPfdee..nlkellekilkgkleipkk.lskelesLlrklLv  234

         +vDvW +GvvL +++t++lP+d++  +++e++++ +k+++  p k ++++   Ll+k+L+

Q: 188   PVDVWVCGVVLTVMLTRELPWDQPsdSCQEYSDWKEKKTYLPPWKkIDSTPLALLHKILT  247

         ***********************97567777666666666555558**************

S: 235   vdpekRatieeilkhewl  252

         ++p+ R+ti +i+k++w+

Q: 248   ESPTARITIPDIQKDRWY  265

         *****************5

Domain Sequence
(FASTA)

WDLVQTLGEG AYGEVQLAVN RRTEEAVAVK IVDMKRAAEC PENIKKEICI NKMLSHENVV 60

RFYGHRREGP TQYLFLEYCR GGELFDRIEP DVGMPEPEAQ RFFQQLIAGV VYLHSMGITH 120

RDLKPENLLL DDRDNLKISD FGLATVFRHN GRERLLNKMC GSLPYVAPEL LRRPEFRAEP 180

VDVWVCGVVL TVMLTRELPW DQPSDSCQEY SDWKEKKTYL PPWKKIDSTP LALLHKILTE 240

SPTARITIPD IQKDRWY 257

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005813	; C:centrosome
GO:0000785	; C:chromatin
GO:0000781	; C:chromosome, telomeric region
GO:0000794	; C:condensed nuclear chromosome
GO:0005657	; C:replication fork
GO:0005524	; F:ATP binding
GO:0035402	; F:histone kinase activity (H3-T11 specific)
GO:0071260	; P:cellular response to mechanical stimulus
GO:0048096	; P:chromatin-mediated maintenance of transcription
GO:0000077	; P:DNA damage checkpoint
GO:0006281	; P:DNA repair
GO:0000086	; P:G2/M transition of mitotic cell cycle
GO:0045839	; P:negative regulation of mitosis
GO:0010569	; P:regulation of double-strand break repair via homologous recombination
GO:2000615	; P:regulation of histone H3-K9 acetylation
GO:0046602	; P:regulation of mitotic centrosome separation
GO:0010767	; P:regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013