EKS-TAG-00272

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAG-00272

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	256.9	1.6E-76	51	311	261

Status

Unreviewed

Ensembl Protein

ENSTGUP00000000924

UniProt Accession

H0YRL5;

Protein Name

Protein Synonyms/Alias

Gene Name

STK11

Gene Synonyms/Alias

STK11;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTGUG00000000898	ENSTGUP00000000924	ENSTGUT00000000936

Organism

Taeniopygia guttata

Functional Description

Protein Length

382

Protein Sequence
(FASTA)

SRMDLQEPQQ LGMFAESELM SVGMDTFIHR IDSTEVIYQP RRKRAKLIGK YLMGDLLGEG 60

SYGKVKEMLD SETLCRRAVK ILKKKKLRRI PNGEANVKKE IQLLRRLRHK NVIQLVDVLY 120

NEEKQKMYMV MEYCVCGMQE MLDSVPEKRF PVFQAHGYFC QLIDGLEYLH SQGIVHKDIK 180

PGNLLLTTNG TLKISDLGVA EALHPFAEDD TCRTSQGSPA FQPPEIANGL DTFSGFKVDI 240

WSAGVTLYNI TTGLYPFEGD NIYKLFENIG KGDYTIPEDC GPPLSDLLRG MLEYDPAKRF 300

SIQQIRQHNW FRKKHAQAEA LVPIPPSPET KDRWRSMTAV PYLEDLHGYN EEEDDDLYDI 360

EDDIIYTQDF TVPGQVPDEE AG 382

Nucleotide Sequence
(FASTA)

TCCAGGATGG ATCTGCAGGA GCCCCAGCAG CTGGGAATGT TTGCGGAGAG CGAGCTGATG 60

TCGGTGGGGA TGGACACGTT CATCCACCGC ATCGACTCCA CCGAGGTCAT TTACCAGCCC 120

CGGCGCAAAC GGGCCAAGCT CATCGGCAAG TACCTCATGG GAGACCTGCT GGGAGAGGGC 180

TCCTACGGCA AAGTCAAGGA GATGCTGGAC TCAGAGACCC TGTGCAGGAG AGCTGTGAAG 240

ATCCTGAAGA AGAAGAAGCT GCGCCGGATC CCCAATGGGG AGGCCAACGT GAAAAAGGAG 300

ATCCAGCTCC TGCGGAGATT ACGGCACAAA AATGTCATCC AGCTGGTAGA TGTGTTGTAC 360

AATGAGGAGA AGCAGAAAAT GTATATGGTG ATGGAGTACT GTGTGTGTGG GATGCAGGAA 420

ATGCTGGACA GTGTCCCAGA AAAGAGGTTT CCAGTGTTTC AGGCTCACGG GTACTTTTGT 480

CAGCTTATAG ATGGCTTAGA ATACTTGCAC AGCCAAGGGA TTGTCCACAA GGATATAAAA 540

CCGGGGAACC TCCTGCTAAC AACCAATGGG ACACTAAAAA TATCTGATTT AGGCGTAGCA 600

GAGGCATTGC ATCCGTTTGC GGAGGACGAC ACGTGCAGGA CAAGCCAAGG GTCGCCAGCA 660

TTCCAGCCCC CAGAAATTGC CAATGGCCTT GACACCTTTT CAGGCTTTAA AGTCGACATC 720

TGGTCTGCAG GGGTGACGCT ATACAACATC ACAACGGGTC TGTACCCTTT TGAAGGGGAT 780

AATATCTATA AATTATTTGA AAACATCGGG AAAGGTGACT ACACAATTCC AGAGGATTGT 840

GGTCCTCCAC TCTCAGACTT ATTGAGAGGG ATGCTTGAAT ACGACCCAGC CAAGAGGTTC 900

TCAATACAGC AGATAAGGCA GCACAACTGG TTTAGGAAGA AACACGCTCA GGCAGAGGCG 960

CTGGTGCCCA TCCCTCCCAG CCCCGAGACA AAGGACAGGT GGAGGAGCAT GACGGCGGTG 1020

CCTTACCTGG AAGATCTGCA TGGCTACAAT GAGGAAGAGG ATGATGACTT GTATGACATT 1080

GAAGATGATA TCATCTACAC TCAGGACTTC ACAGTACCAG GACAGGTGCC TGATGAGGAG 1140

GCCGGC 1146

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkkl..seeslekikrEieilkklkhp  58

         y +++ lGegs+gkVk++ ++et  + avKi+kkkkl    +   ++k+Ei++l++l+h+

Q: 51    YLMGDLLGEGSYGKVKEMLDSETLCRRAVKILKKKKLrrIPNGEANVKKEIQLLRRLRHK  110

         778999******************************965334567***************

S: 59    niikllevi..etkkklylvleyasgg..eLfdyieekgrlkekearklfkqlvsavkYl  114

         n+i+l++v+  e+k+k+y+v+ey+  g  e++d +  ++r++  +a+ +f ql+++++Yl

Q: 111   NVIQLVDVLynEEKQKMYMVMEYCVCGmqEMLDSV-PEKRFPVFQAHGYFCQLIDGLEYL  169

         ********9888999********998888*****6.8899********************

S: 115   hskgivHrDlKpeNllldkkenikiaDFGlan...lfkegklletfcGsppYaaPellkg  171

         hs+givH+D+Kp Nlll++++++ki+D+G+a+    f e+++++t++Gsp++++Pe+ +g

Q: 170   HSQGIVHKDIKPGNLLLTTNGTLKISDLGVAEalhPFAEDDTCRTSQGSPAFQPPEIANG  229

         *******************************966567788******************99

S: 172   .kkYegpkvDvWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlr  230

          ++++g kvD+Ws+Gv+Ly++ tg +Pf+++n+ +l+e+i kg+++ip+ + + l++Llr

Q: 230   lDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGKGDYTIPEDCGPPLSDLLR  289

         899*********************************************************

S: 231   klLvvdpekRatieeilkhewl  252

          +L+ dp+kR++i++i++h+w+

Q: 290   GMLEYDPAKRFSIQQIRQHNWF  311

         *********************7

Domain Sequence
(FASTA)

YLMGDLLGEG SYGKVKEMLD SETLCRRAVK ILKKKKLRRI PNGEANVKKE IQLLRRLRHK 60

NVIQLVDVLY NEEKQKMYMV MEYCVCGMQE MLDSVPEKRF PVFQAHGYFC QLIDGLEYLH 120

SQGIVHKDIK PGNLLLTTNG TLKISDLGVA EALHPFAEDD TCRTSQGSPA FQPPEIANGL 180

DTFSGFKVDI WSAGVTLYNI TTGLYPFEGD NIYKLFENIG KGDYTIPEDC GPPLSDLLRG 240

MLEYDPAKRF SIQQIRQHNW F 261

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005829	; C:cytosol
GO:0016020	; C:membrane
GO:0005739	; C:mitochondrion
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0030295	; F:protein kinase activator activity
GO:0004674	; F:protein serine/threonine kinase activity
GO:0043276	; P:anoikis
GO:0060070	; P:canonical Wnt receptor signaling pathway
GO:0007050	; P:cell cycle arrest
GO:0030010	; P:establishment of cell polarity
GO:0042593	; P:glucose homeostasis
GO:0051645	; P:Golgi localization
GO:0072332	; P:intrinsic apoptotic signaling pathway by p53 class mediator
GO:0030308	; P:negative regulation of cell growth
GO:0060770	; P:negative regulation of epithelial cell proliferation involved in prostate gland development
GO:0030511	; P:positive regulation of transforming growth factor beta receptor signaling pathway
GO:0046777	; P:protein autophosphorylation
GO:0051896	; P:regulation of protein kinase B signaling cascade
GO:0030111	; P:regulation of Wnt receptor signaling pathway
GO:0010212	; P:response to ionizing radiation

KEGG

InterPros

IPR020636	; Ca/CaM-dep_Ca-dep_prot_Kinase.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013