EKS-TAG-00179

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAG-00179

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/NDR	518.9	3.2E-156	89	382	294

Status

Unreviewed

Ensembl Protein

ENSTGUP00000000947

UniProt Accession

H0YRN8;

Protein Name

Protein Synonyms/Alias

Gene Name

STK38

Gene Synonyms/Alias

STK38;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTGUG00000000925	ENSTGUP00000000947	ENSTGUT00000000959

Organism

Taeniopygia guttata

Functional Description

Protein Length

465

Protein Sequence
(FASTA)

MAMTGPTPCS SMSNHTKERV TMTKVTLENF YSNLIAQHEE REMRQKKLEQ MMEEEGLKDE 60

EKRIRRSAHA QKETEFLRLK RTRLGLEDFE SLKVIGRGAF GEVRLVQKKD TGHVYAMKIL 120

RKADMLEKEQ VGHIRAERDI LVEADSLWVV KMFYSFQDKL NLYLIMEFLP GGDMMTLLMK 180

KDTLTEEETQ FYIAETVLAI DSIHQLGFIH RDIKPDNLLL DSKGHVKLSD FGLCTGLKKA 240

HRTEFYRNLN HSLPSDFTFQ NMNSKRKAET WKRNRRQLAF STVGTPDYIA PEVFMQTGYN 300

KLCDWWSLGV IMYEMLIGYP PFCSETPQET YKKVMNWKET LTFPPEVPIS DKAKDLILRF 360

CCEWEHRIGA SGVEEIKSNP FFEGVDWEHI RERPAAISIE IKSIDDTSNF DEFPESDILK 420

PTVATSNHPE TDYKNKDWVF INYTYKRFEG LTARGAIPSY MKGGK 465

Nucleotide Sequence
(FASTA)

ATGGCCATGA CAGGCCCTAC GCCATGCTCA TCCATGAGTA ACCACACCAA GGAGAGAGTC 60

ACAATGACAA AGGTGACGTT GGAAAACTTC TACAGCAACC TCATAGCTCA GCACGAGGAG 120

CGAGAGATGA GACAAAAGAA ACTAGAACAA ATGATGGAAG AAGAAGGCCT AAAAGATGAA 180

GAGAAAAGAA TCAGGAGGTC GGCACATGCA CAAAAGGAGA CAGAGTTCCT TCGCCTGAAG 240

AGGACCAGGC TTGGACTGGA GGACTTTGAG TCTCTAAAAG TAATAGGCAG AGGAGCATTT 300

GGAGAGGTGC GCCTGGTGCA GAAGAAGGAC ACGGGGCACG TTTATGCCAT GAAGATCCTA 360

CGCAAAGCTG ATATGCTTGA GAAGGAGCAG GTTGGCCACA TCCGTGCAGA ACGGGACATC 420

CTGGTGGAGG CAGACAGCTT GTGGGTTGTG AAGATGTTCT ACAGTTTTCA GGACAAGCTA 480

AACCTCTACC TGATCATGGA GTTCCTGCCT GGAGGTGACA TGATGACACT GCTGATGAAG 540

AAGGACACTC TGACAGAGGA GGAGACGCAG TTCTACATCG CCGAGACCGT GCTCGCCATT 600

GACTCCATCC ACCAGCTGGG ATTCATCCAT CGTGACATAA AACCAGACAA CCTCCTCCTG 660

GACAGCAAGG GCCATGTGAA ACTCTCAGAT TTTGGTCTTT GTACTGGACT GAAGAAAGCT 720

CACAGGACAG AATTTTACAG GAACTTGAAT CACAGTCTTC CCAGTGACTT CACTTTCCAG 780

AACATGAATT CCAAAAGGAA AGCAGAGACT TGGAAGAGGA ATCGCCGGCA GCTGGCTTTT 840

TCTACGGTGG GAACTCCAGA TTACATTGCT CCTGAGGTTT TCATGCAGAC TGGATACAAC 900

AAGCTGTGTG ACTGGTGGTC CCTGGGGGTC ATCATGTACG AGATGTTGAT TGGTTATCCA 960

CCATTCTGTT CCGAGACTCC TCAAGAGACC TACAAGAAAG TGATGAACTG GAAGGAGACC 1020

CTGACATTTC CTCCAGAGGT TCCAATCTCT GATAAAGCAA AGGATCTTAT TTTAAGATTT 1080

TGCTGTGAAT GGGAGCACAG AATTGGTGCA TCTGGTGTGG AGGAAATAAA GAGTAACCCA 1140

TTCTTTGAAG GGGTTGATTG GGAGCACATC AGAGAGAGAC CTGCTGCAAT TTCAATAGAA 1200

ATTAAAAGCA TTGATGATAC CTCAAACTTT GATGAATTTC CAGAATCTGA TATCCTTAAA 1260

CCAACAGTGG CAACAAGCAA CCACCCAGAG ACAGACTACA AGAACAAAGA CTGGGTTTTT 1320

ATCAATTACA CCTACAAGCG TTTCGAGGGC CTGACGGCCC GAGGAGCAAT TCCATCCTAT 1380

ATGAAAGGAG GGAAGTAA 1398

Domain Profile

S: 1     feklkvigkGafGevrlvrkkdtkevyalkilrkkdllkknqvahvkaerdilaeadsew  60

         fe+lkvig+GafGevrlv+kkdt++vya+kilrk+d+l+k+qv h++aerdil+eads w

Q: 89    FESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILVEADSLW  148

         899*********************************************************

S: 61    vvklyysfqdkenlylvmeylPGGdlmtllikkeilkeelarfyiaelvlavesvhklGf  120

         vvk++ysfqdk nlyl+me+lPGGd+mtll+kk++l+ee+++fyiae+vla++s+h+lGf

Q: 149   VVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLAIDSIHQLGF  208

         ************************************************************

S: 121   ihrdlkPdnllidakGhikltdfGlctGlkkthrseyykelekakeddleaseelkvler  180

         ihrd+kPdnll+d+kGh+kl+dfGlctGlkk+hr+e+y++l+++ ++d+ ++    ++++

Q: 209   IHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQ----NMNS  264

         *************************************************555....5555

S: 181   rkk....kknrrllayslvGtpdyiapevlekkgynklcdwWslGvilyemlvGypPfla  236

         ++k    k+nrr+la+s+vGtpdyiapev++++gynklcdwWslGvi+yeml+GypPf++

Q: 265   KRKaetwKRNRRQLAFSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPPFCS  324

         5544556*****************************************************

S: 237   etpqetykkvinwketlkfpeevelseeakdlierliadaekrlgkkGvdeikkhpff  294

         etpqetykkv+nwketl+fp+ev++s++akdli r+++++e+r+g++Gv+eik++pff

Q: 325   ETPQETYKKVMNWKETLTFPPEVPISDKAKDLILRFCCEWEHRIGASGVEEIKSNPFF  382

         *********************************************************9

Domain Sequence
(FASTA)

FESLKVIGRG AFGEVRLVQK KDTGHVYAMK ILRKADMLEK EQVGHIRAER DILVEADSLW 60

VVKMFYSFQD KLNLYLIMEF LPGGDMMTLL MKKDTLTEEE TQFYIAETVL AIDSIHQLGF 120

IHRDIKPDNL LLDSKGHVKL SDFGLCTGLK KAHRTEFYRN LNHSLPSDFT FQNMNSKRKA 180

ETWKRNRRQL AFSTVGTPDY IAPEVFMQTG YNKLCDWWSL GVIMYEMLIG YPPFCSETPQ 240

ETYKKVMNWK ETLTFPPEVP ISDKAKDLIL RFCCEWEHRI GASGVEEIKS NPFF 294

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0070688	; C:MLL5-L complex
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007243	; P:intracellular protein kinase cascade
GO:0043407	; P:negative regulation of MAP kinase activity

KEGG

tgu:100231774

;

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013