EKS-TAG-00472
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-TAG-00472
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/PDGFR573.51.6E-172559916358
StatusUnreviewed
Ensembl ProteinENSTGUP00000000985
UniProt AccessionH0YRS6;
Protein NameTyrosine-protein kinase receptor
Protein Synonyms/Alias
Gene NamePDGFRB
Gene Synonyms/Alias PDGFRB;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSTGUG00000000942ENSTGUP00000000985ENSTGUT00000000997
OrganismTaeniopygia guttata
Functional Description
Protein Length1037
Protein Sequence
(FASTA)
ELVLSLHSTF SLLCYGDREL VWEREGQPLA ASLEQRDGVF VSNLTLRNVT GHHTGEYTCT 60
YSPGQAPEPA ERRALYIYVP DPSLVFLPTS EEIFIFITGY TEVVIPCRVT NPQMEVTLYE 120
KKVENPIQAT YDPQQGFKGF FEDKTYFCRT FVDDQEVDSD TFYVYRIQVS SVNVSISAVQ 180
TMVRQGENIT VMCTVSGNEL VNFNWDYPRK QAGKAVEPVT DFLPGSIYEI RSILIIQNAE 240
LEDSGTYVCN VSEGYHEKTD RKNISVQVIE RGFVHFHTHL PSTIYAEVHK SHTIQVEVEG 300
YPQPSIVWLK NNKTLTMESS SEFTITSRNL SETRYQTALV LVRVKQEEGG FYTIRASNED 360
DEQELSFHLQ INVPAKVVDL KENGSASSGE QTVTCSAEGM PQPEISWSTC SDIKWCSTKG 420
EPTRLLGNES AEIGVQTNAS YHAERQLYRV NSTLQLHRVH EPLLLRCTVH NFLGTNSQDI 480
TLVPHALPFK VVIISVILAL LVLTVISLII LIVLWQKKPR YEIRWKVIES VSSDGHEYIY 540
VDPMQLPYDS TWEVPRDKLV LGRTLGSGAF GRVVEATAHG LSHSRSTMKV AVKMLKSTAR 600
SSEKQALMSE LKIMSHLGPH LNIVNLLGAC TKGGPIYIIT EYCRYGDLVD YLHRNKHTFL 660
QSYGEKARRE AELYGNTPKE DHVHSHLSMS VESDGGYMDM SKDDSLDYVP MSDMKGEVKY 720
ADIESSNYGT PYELDSYSPS APERTDRVTL INESPLLSYM DLVGFSFQVA NGMEFLASKN 780
CVHRDLAARN VLICEGKLVK ICDFGLARDI MRDSNYISKG STFLPLKWMA PESIFNNLYT 840
TLSDVWSFGI LLWEIFTLGG TPYPELPMNE QFYNAIKRGY RMSKPTHASD EIYNIMQKCW 900
EEKFEIRPSF SQLVVLMGNL LVDCYRKRYQ QVDEEFMKSD HPAVVRTRPT IPVLNNARLA 960
ASSPSSNTLY TAVHQNGGEN DYIIPLPDPK PEANAFPQEA SISRASSMLN EANTSSTISC 1020
DSPLGLQQDE EQESDPQ 1037
Nucleotide Sequence
(FASTA)
GAGCTTGTCC TCAGCCTCCA CAGCACCTTC TCCCTCCTGT GCTACGGGGA CAGAGAGCTG 60
GTCTGGGAAC GGGAGGGGCA GCCCCTCGCT GCCTCGCTGG AGCAGAGGGA CGGTGTCTTT 120
GTCAGCAATC TCACCCTCAG GAACGTGACA GGCCATCACA CCGGGGAGTA CACGTGCACC 180
TACAGCCCTG GGCAGGCTCC TGAGCCAGCA GAGAGGAGAG CCCTCTACAT CTATGTTCCA 240
GATCCCTCCC TGGTTTTCCT CCCCACCTCT GAAGAGATCT TTATCTTCAT CACGGGCTAC 300
ACAGAGGTTG TCATCCCATG CCGTGTGACC AACCCACAGA TGGAGGTCAC TCTCTATGAG 360
AAGAAGGTGG AGAACCCCAT CCAAGCTACA TATGATCCAC AACAGGGATT TAAAGGCTTC 420
TTTGAGGATA AAACCTATTT CTGCCGGACA TTTGTGGATG ACCAGGAGGT GGATTCAGAC 480
ACTTTCTACG TCTACAGGAT CCAGGTGTCA TCTGTGAACG TCTCCATCAG CGCAGTGCAG 540
ACCATGGTGC GCCAGGGAGA AAACATAACC GTCATGTGCA CCGTGAGCGG CAACGAGCTG 600
GTCAACTTCA ACTGGGATTA TCCCCGCAAG CAAGCAGGGA AGGCTGTGGA GCCCGTGACT 660
GACTTCCTGC CTGGATCCAT TTATGAGATC CGCTCCATCC TCATCATCCA GAATGCAGAG 720
CTGGAGGACA GTGGGACCTA TGTCTGCAAT GTGTCCGAGG GCTACCATGA GAAAACGGAC 780
CGGAAGAACA TCAGTGTCCA AGTGATCGAG CGTGGCTTTG TGCACTTCCA CACCCACCTA 840
CCCAGCACGA TCTATGCCGA GGTCCACAAG AGCCACACTA TCCAGGTGGA AGTGGAGGGT 900
TATCCCCAAC CCAGCATTGT GTGGCTGAAG AACAACAAGA CATTGACCAT GGAGAGCAGC 960
AGCGAGTTCA CCATCACCAG CAGGAACCTG TCAGAAACCA GGTACCAGAC AGCTCTGGTG 1020
CTGGTGCGGG TGAAGCAGGA AGAAGGAGGA TTTTACACCA TTCGAGCTTC CAATGAGGAT 1080
GATGAGCAGG AGCTCTCCTT CCATCTGCAG ATAAATGTGC CAGCCAAAGT GGTGGATCTC 1140
AAGGAGAACG GCAGTGCCAG CAGTGGGGAG CAGACTGTAA CATGCTCTGC TGAAGGCATG 1200
CCCCAGCCAG AGATCAGCTG GTCTACTTGC AGCGACATCA AATGGTGCAG CACCAAGGGA 1260
GAGCCCACCC GGCTGCTGGG GAACGAGTCG GCCGAGATCG GCGTGCAGAC CAACGCCTCG 1320
TACCACGCAG AGCGGCAGCT GTACCGCGTC AACAGCACCC TGCAGCTGCA CAGGGTGCAC 1380
GAGCCCCTGC TCCTCAGGTG CACCGTGCAC AACTTCCTGG GCACCAACTC CCAGGACATC 1440
ACTCTGGTCC CACACGCCTT GCCATTCAAG GTGGTCATCA TTTCTGTCAT CCTGGCCTTG 1500
CTGGTCCTCA CTGTGATCTC CCTGATCATC CTGATCGTGC TGTGGCAGAA GAAACCTCGT 1560
TATGAAATCC GCTGGAAGGT GATTGAGTCA GTCAGCTCTG ATGGGCACGA GTACATCTAT 1620
GTGGATCCCA TGCAGCTCCC TTATGACTCC ACCTGGGAGG TGCCCAGGGA CAAGCTGGTG 1680
TTAGGACGCA CTCTCGGCTC CGGTGCCTTT GGTCGTGTGG TGGAGGCAAC AGCCCATGGC 1740
CTGAGCCATT CACGGTCCAC CATGAAAGTG GCAGTCAAAA TGCTCAAGTC CACAGCCCGC 1800
AGCAGTGAGA AGCAAGCCCT CATGTCTGAG CTGAAGATCA TGAGCCACCT GGGACCTCAC 1860
CTCAACATCG TCAACTTGCT GGGGGCCTGC ACCAAAGGAG GACCCATCTA CATCATCACG 1920
GAGTACTGCC GCTACGGGGA CCTGGTGGAT TACCTGCACC GCAACAAGCA CACCTTCCTG 1980
CAGTCCTACG GGGAGAAGGC ACGGCGAGAG GCAGAGCTCT ACGGGAACAC CCCCAAGGAG 2040
GACCACGTGC ACAGCCACCT CTCCATGTCT GTCGAGAGTG ACGGGGGCTA CATGGACATG 2100
AGCAAGGACG ACTCCCTGGA CTATGTGCCC ATGTCTGACA TGAAGGGTGA AGTCAAGTAC 2160
GCTGACATCG AGTCCTCTAA CTATGGCACT CCCTATGAGC TGGACAGCTA CTCCCCCTCA 2220
GCTCCTGAAA GGACAGACCG GGTGACACTG ATAAATGAGT CTCCACTCCT CAGCTACATG 2280
GACTTGGTGG GCTTCAGCTT CCAGGTGGCC AATGGGATGG AGTTCCTGGC TTCCAAAAAT 2340
TGTGTGCACC GTGACCTGGC TGCCAGGAAT GTCCTCATCT GTGAGGGGAA GCTGGTGAAG 2400
ATCTGTGACT TTGGCCTGGC GAGGGACATC ATGAGGGATT CCAACTATAT CTCCAAAGGC 2460
AGCACCTTCT TGCCTCTTAA GTGGATGGCT CCAGAGAGCA TCTTCAACAA CCTCTACACT 2520
ACCCTGAGTG ATGTGTGGTC TTTTGGGATT CTTCTTTGGG AGATATTCAC TCTAGGAGGG 2580
ACTCCATACC CTGAGCTGCC TATGAATGAG CAGTTCTACA ACGCCATCAA ACGTGGCTAT 2640
CGGATGTCCA AACCCACCCA TGCCTCTGAT GAGATCTACA ACATCATGCA GAAGTGCTGG 2700
GAGGAGAAGT TTGAGATCAG GCCATCCTTC TCACAGCTGG TGGTGCTTAT GGGAAACCTC 2760
CTGGTGGATT GCTACAGGAA GAGGTACCAG CAGGTGGATG AAGAGTTCAT GAAGAGTGAC 2820
CACCCCGCTG TTGTCCGCAC AAGACCCACA ATTCCTGTGC TGAACAACGC CCGCCTTGCT 2880
GCCAGCTCCC CCAGCAGCAA CACCCTCTAC ACAGCTGTGC ACCAGAACGG GGGCGAGAAT 2940
GATTATATCA TCCCTCTTCC CGACCCCAAA CCTGAGGCAA ACGCCTTCCC TCAGGAGGCC 3000
TCCATCAGCC GGGCCAGCTC TATGCTGAAC GAAGCCAACA CATCATCTAC AATATCCTGT 3060
GACAGCCCTC TGGGCCTCCA GCAGGACGAG GAGCAGGAAT CTGACCCACA A 3111
Domain Profile
S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60
         l+lG++lGsGafG+vveata+Gls+s +++kvavkmlkstarssek+almselki+shlG
Q: 559   LVLGRTLGSGAFGRVVEATAHGLSHSRSTMKVAVKMLKSTARSSEKQALMSELKIMSHLG  618
         78**********************************************************
S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120
         +h+nivnllGactkgGpiy+iteyc+yGdl++yl+r++++fl+++ ek + +e+el + +
Q: 619   PHLNIVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQSYGEKAR-REAEL-YGN  676
         ******************************************99999954.44455.455
S: 121   lladkslrsksslssesseeyvdlkkd................vsdvssskadklas..e  162
          +++ +++s+ s+s+es++ y+d++kd                ++d++ss++ ++++  +
Q: 677   TPKEDHVHSHLSMSVESDGGYMDMSKDdsldyvpmsdmkgevkYADIESSNYGTPYEldS  736
         899*************************************************99986115
S: 163   kkksalerevkaaleeedsevleledllsfsyqvakGmeflaskncvhrdlaarnvllte  222
         +  sa er+ + +l++e s  l+++dl+ fs+qva+Gmeflaskncvhrdlaarnvl++e
Q: 737   YSPSAPERTDRVTLINE-SPLLSYMDLVGFSFQVANGMEFLASKNCVHRDLAARNVLICE  795
         5678999**9*999999.99****************************************
S: 223   GkvvkicdfGlardimkdsnyvvkGnarlpvkwmapesifdslytvksdvwsyGillwei  282
         Gk+vkicdfGlardim+dsny++kG+++lp+kwmapesif++lyt+ sdvws+Gillwei
Q: 796   GKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNNLYTTLSDVWSFGILLWEI  855
         ************************************************************
S: 283   fslGstpypgllvdskfyklikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlve  342
         f+lG+tpyp+l+++++fy++ik+Gyrm++p++a++eiy+imqkcwe+++e rpsf+qlv 
Q: 856   FTLGGTPYPELPMNEQFYNAIKRGYRMSKPTHASDEIYNIMQKCWEEKFEIRPSFSQLVV  915
         **********************************************************98
S: 343   l  343
         l
Q: 916   L  916
         7
Domain Sequence
(FASTA)
LVLGRTLGSG AFGRVVEATA HGLSHSRSTM KVAVKMLKST ARSSEKQALM SELKIMSHLG 60
PHLNIVNLLG ACTKGGPIYI ITEYCRYGDL VDYLHRNKHT FLQSYGEKAR REAELYGNTP 120
KEDHVHSHLS MSVESDGGYM DMSKDDSLDY VPMSDMKGEV KYADIESSNY GTPYELDSYS 180
PSAPERTDRV TLINESPLLS YMDLVGFSFQ VANGMEFLAS KNCVHRDLAA RNVLICEGKL 240
VKICDFGLAR DIMRDSNYIS KGSTFLPLKW MAPESIFNNL YTTLSDVWSF GILLWEIFTL 300
GGTPYPELPM NEQFYNAIKR GYRMSKPTHA SDEIYNIMQK CWEEKFEIRP SFSQLVVL 358
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00377
EKS-ANC-00390
EKS-BOT-00403
EKS-CAJ-00406
EKS-CAF-00403
EKS-CAP-00431
EKS-DAR-00792
EKS-EQC-00395
EKS-FEC-00387
EKS-GAG-00340
EKS-GAA-00491
EKS-GOG-00395
EKS-HOS-00408
EKS-ICT-00382
EKS-LAC-00418
EKS-LOA-00411
EKS-MAM-00401
EKS-MEG-00334
EKS-MOD-00394
EKS-MUM-00434
EKS-MUP-00396
EKS-MYL-00398
EKS-NOL-00367
EKS-OCP-00083
EKS-ORN-00513
EKS-ORA-00353
EKS-ORC-00377
EKS-ORL-00471
EKS-OTG-00404
EKS-PES-00358
EKS-POA-00393
EKS-RAN-00417
EKS-SAH-00371
EKS-SUS-00358
EKS-TAR-00509
EKS-TEN-00510
EKS-XET-00513
EKS-XIM-00505
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005019; F:platelet-derived growth factor beta-receptor activity
GO:0005021; F:vascular endothelial growth factor-activated receptor activity
GO:0060326; P:cell chemotaxis
GO:0006807; P:nitrogen compound metabolic process
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0046488; P:phosphatidylinositol metabolic process
GO:0048015; P:phosphatidylinositol-mediated signaling
GO:0030335; P:positive regulation of cell migration
GO:0038091; P:positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway
GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity
GO:0010863; P:positive regulation of phospholipase C activity
GO:0032516; P:positive regulation of phosphoprotein phosphatase activity
GO:0046777; P:protein autophosphorylation
GO:0050730; P:regulation of peptidyl-tyrosine phosphorylation
GO:0048010; P:vascular endothelial growth factor receptor signaling pathway
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003599; Ig_sub.
IPR003598; Ig_sub2.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016243; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824; Tyr_kinase_rcpt_3_CS.
IPR009134; Tyr_kinase_VEGFR_rcpt_N.
Pfam
PF07679; I-set; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 1.
SM00408; IGc2; 1.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 4.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00240; RECEPTOR_TYR_KIN_III; 1.
Prints
PR01832; VEGFRECEPTOR.
Created Date20-Feb-2013