EKS-TAG-00474
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-TAG-00474
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/PDGFR546.42.8E-164309638330
StatusUnreviewed
Ensembl ProteinENSTGUP00000000996
UniProt AccessionH0YRT7;
Protein Name
Protein Synonyms/Alias
Gene NameCSF1R
Gene Synonyms/Alias CSF1R;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSTGUG00000000965ENSTGUP00000000996ENSTGUT00000001008
OrganismTaeniopygia guttata
Functional Description
Protein Length692
Protein Sequence
(FASTA)
MEDSGKYTCI ANNSAGSRNA STTLQVVERG YVHLIPGQAT SMEVALGESV ELQVHIKAYP 60
KLLQWAWEHR NPLKDSKPTI FKVFLSVSRY NTTLSLHRLK EGEEGFYTFY AFHSVTNESV 120
TFSIFLKSSP KACKIKVPAD DSSTLQCVAV GYPAPRIEWY QCPVHSDRYS EDYRLIRNDS 180
RPQVVNMLPF QEVEVESIIL FEELGDNFTF CCVAINGEGN TSDMFHSLTI TRNVMALPNK 240
LFSPVLSTCI GTLVLLLLLL LFLLYKYNQK PKYQVRWKII EACEGNNYIF IDPTQLPYNE 300
KWEFPRNNLQ FGKTLGAGAF GKVVEATAFG LGKEDSVLKV AVKMLKSSAD RDEQEALMSE 360
LKIMSHLGHH ENIVNLLGAC TCGGPILVIT EYCRYGDLLN FLRKKTESII IQDSALDTSI 420
DSAADYKNIE LEKKYIRSDS GFSSQGLETY VEMRPVSSAA AAAASDSAQA RAREDLRPLN 480
LSDLLQFSSQ VAQGMAFLAS KNCIHRDLAA RNVLISDGRV AKICDFGLAR DIMNDSNYVV 540
KGNARLPVKW MAPESIFDCI YTVQSDVWSY GILLWEIFSL GKSPYPGMVV NSKFYSMVKQ 600
GYQMARPDFA PLEMYSIMQA CWSLEPTRRP TFDQIGCFIQ KELELHKEQD YTNLPSSAEE 660
DSGCDTSGCC EESCEQEESG QPLLKGNNYQ FC 692
Nucleotide Sequence
(FASTA)
ATGGAAGACA GTGGGAAGTA CACCTGTATA GCTAACAATT CAGCAGGATC CAGGAATGCC 60
TCAACAACGC TTCAGGTAGT AGAGAGAGGT TACGTGCACC TGATCCCAGG CCAAGCCACC 120
AGCATGGAGG TTGCTCTGGG AGAGAGTGTG GAGCTGCAGG TCCACATTAA GGCTTACCCA 180
AAACTTCTCC AGTGGGCTTG GGAACACAGG AATCCCTTGA AGGACTCTAA ACCCACCATA 240
TTCAAGGTGT TTCTCTCTGT GAGCAGGTAC AACACCACAC TCTCCCTGCA CCGCCTGAAG 300
GAAGGAGAGG AAGGGTTCTA CACATTTTAT GCCTTCCACA GTGTGACCAA TGAATCAGTT 360
ACCTTCAGTA TCTTTCTGAA ATCTTCTCCA AAGGCCTGCA AAATCAAGGT GCCAGCCGAT 420
GACTCCAGCA CCCTTCAGTG CGTGGCCGTG GGGTACCCTG CCCCACGCAT CGAGTGGTAC 480
CAGTGCCCCG TCCACTCGGA CAGGTACAGC GAGGACTACA GGCTGATACG GAATGACTCC 540
AGACCTCAGG TGGTGAATAT GTTGCCTTTC CAAGAGGTGG AGGTGGAGAG CATCATCCTC 600
TTTGAGGAGC TGGGTGACAA TTTCACCTTC TGCTGCGTGG CCATTAACGG GGAAGGGAAC 660
ACCTCTGACA TGTTTCACTC ACTCACCATC ACCAGGAATG TCATGGCCCT TCCAAACAAG 720
CTCTTCAGCC CTGTTCTCTC CACCTGCATA GGCACATTGG TGCTGCTGCT CCTCCTGCTC 780
CTCTTCCTAC TCTACAAGTA CAACCAGAAA CCCAAGTACC AGGTGCGGTG GAAGATCATC 840
GAGGCCTGTG AAGGCAATAA TTACATCTTT ATCGATCCCA CTCAGCTGCC ATACAATGAA 900
AAATGGGAGT TTCCAAGGAA CAACCTCCAG TTTGGAAAAA CTCTTGGAGC AGGAGCCTTT 960
GGAAAAGTGG TAGAAGCCAC AGCTTTTGGG CTGGGCAAAG AAGATTCGGT GCTCAAAGTG 1020
GCTGTGAAGA TGTTAAAGTC TTCAGCAGAC AGGGATGAGC AGGAGGCTCT CATGTCTGAG 1080
CTGAAGATCA TGAGTCACTT GGGACACCAC GAGAACATTG TTAACCTGCT GGGGGCATGC 1140
ACCTGCGGAG GCCCAATCCT TGTCATCACC GAGTACTGTC GCTATGGAGA TCTGCTGAAT 1200
TTCCTGAGGA AGAAGACTGA ATCTATAATT ATTCAGGATT CTGCCCTGGA CACCTCTATA 1260
GACAGTGCTG CTGATTACAA AAACATTGAG CTAGAGAAAA AATACATCCG CAGTGACAGT 1320
GGCTTTTCAA GCCAGGGTTT GGAAACGTAT GTTGAAATGA GGCCTGTGTC ATCAGCAGCA 1380
GCAGCAGCAG CATCAGATTC TGCGCAAGCC AGGGCCAGGG AGGATCTCCG TCCCCTCAAT 1440
CTCTCTGACC TGCTACAGTT CTCCAGCCAG GTGGCCCAGG GCATGGCGTT CCTCGCATCA 1500
AAGAACTGCA TCCACCGTGA CCTAGCAGCC AGGAATGTGC TCATATCAGA TGGACGGGTA 1560
GCCAAGATCT GTGACTTTGG CCTGGCCCGG GACATCATGA ATGATTCCAA TTATGTTGTA 1620
AAAGGCAATG CCCGCCTGCC CGTGAAATGG ATGGCCCCAG AGAGCATCTT TGACTGCATT 1680
TACACAGTGC AGAGTGATGT GTGGTCTTAT GGCATCCTGC TCTGGGAGAT CTTCTCCCTC 1740
GGGAAGAGCC CCTATCCTGG CATGGTGGTG AACAGCAAGT TCTACAGCAT GGTGAAGCAG 1800
GGATACCAGA TGGCCAGGCC TGACTTCGCT CCCTTGGAGA TGTACAGCAT CATGCAGGCA 1860
TGTTGGAGCC TGGAGCCCAC ACGGAGACCC ACCTTCGACC AGATTGGCTG CTTCATCCAG 1920
AAAGAGCTGG AGCTGCATAA GGAGCAGGAC TACACCAACC TCCCCTCCAG TGCTGAGGAA 1980
GACAGTGGCT GTGACACCTC TGGCTGCTGT GAGGAGTCCT GCGAGCAAGA GGAGAGCGGG 2040
CAGCCGCTTC TCAAGGGCAA CAACTACCAG TTCTGTTAG 2079
Domain Profile
S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60
         l++Gk+lG+GafGkvveata+Gl+k+d+vlkvavkmlks+a+ +e+ealmselki+shlG
Q: 309   LQFGKTLGAGAFGKVVEATAFGLGKEDSVLKVAVKMLKSSADRDEQEALMSELKIMSHLG  368
         79**********************************************************
S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120
         +henivnllGact gGpi+viteyc+yGdlln+lr+k es++ + +   +  ++++d+k+
Q: 369   HHENIVNLLGACTCGGPILVITEYCRYGDLLNFLRKKTESIIIQDSALDTSIDSAADYKN  428
         ******************************************9999999999999*****
S: 121   l.ladkslrsksslssesseeyvdlkkdvsdvssskadklasekkksalerevkaaleee  179
         + l++k++rs+s +ss++ e+yv++++    vss+ a + +++           +a   e
Q: 429   IeLEKKYIRSDSGFSSQGLETYVEMRP----VSSAAAAAASDSA----------QARARE  474
         *999***********************....4444443333332..........234567
S: 180   dsevleledllsfsyqvakGmeflaskncvhrdlaarnvllteGkvvkicdfGlardimk  239
         d ++l+l+dll+fs+qva+Gm+flasknc+hrdlaarnvl+++G+v+kicdfGlardim+
Q: 475   DLRPLNLSDLLQFSSQVAQGMAFLASKNCIHRDLAARNVLISDGRVAKICDFGLARDIMN  534
         89**********************************************************
S: 240   dsnyvvkGnarlpvkwmapesifdslytvksdvwsyGillweifslGstpypgllvdskf  299
         dsnyvvkGnarlpvkwmapesifd++ytv+sdvwsyGillweifslG +pypg++v+skf
Q: 535   DSNYVVKGNARLPVKWMAPESIFDCIYTVQSDVWSYGILLWEIFSLGKSPYPGMVVNSKF  594
         ************************************************************
S: 300   yklikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlvel  343
         y ++k+Gy+ma+p++a+ e+y+imq+cw  ep++rp+f q+  +
Q: 595   YSMVKQGYQMARPDFAPLEMYSIMQACWSLEPTRRPTFDQIGCF  638
         ****************************************9766
Domain Sequence
(FASTA)
LQFGKTLGAG AFGKVVEATA FGLGKEDSVL KVAVKMLKSS ADRDEQEALM SELKIMSHLG 60
HHENIVNLLG ACTCGGPILV ITEYCRYGDL LNFLRKKTES IIIQDSALDT SIDSAADYKN 120
IELEKKYIRS DSGFSSQGLE TYVEMRPVSS AAAAAASDSA QARAREDLRP LNLSDLLQFS 180
SQVAQGMAFL ASKNCIHRDL AARNVLISDG RVAKICDFGL ARDIMNDSNY VVKGNARLPV 240
KWMAPESIFD CIYTVQSDVW SYGILLWEIF SLGKSPYPGM VVNSKFYSMV KQGYQMARPD 300
FAPLEMYSIM QACWSLEPTR RPTFDQIGCF 330
KeywordATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00376
EKS-ANC-00391
EKS-BOT-00405
EKS-CAJ-00409
EKS-CAF-00405
EKS-CAP-00434
EKS-DAR-00788
EKS-EQC-00397
EKS-FEC-00389
EKS-GAG-00342
EKS-GAA-00492
EKS-GOG-00397
EKS-HOS-00411
EKS-ICT-00384
EKS-LAC-00420
EKS-LOA-00414
EKS-MAM-00404
EKS-MEG-00336
EKS-MOD-00393
EKS-MUM-00437
EKS-MUP-00398
EKS-MYL-00400
EKS-ORN-00515
EKS-ORC-00380
EKS-OTG-00407
EKS-PAT-00383
EKS-PES-00359
EKS-PTV-00115
EKS-RAN-00419
EKS-SAH-00375
EKS-SUS-00355
EKS-TEN-00512
EKS-TUT-00118
EKS-XET-00514
EKS-XIM-00507
Gene Ontology
GO:0009986; C:cell surface
GO:0016021; C:integral to membrane
GO:0005886; C:plasma membrane
GO:0043235; C:receptor complex
GO:0005524; F:ATP binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0008283; P:cell proliferation
GO:0045217; P:cell-cell junction maintenance
GO:0038145; P:macrophage colony-stimulating factor signaling pathway
GO:0046488; P:phosphatidylinositol metabolic process
GO:0048015; P:phosphatidylinositol-mediated signaling
GO:0030335; P:positive regulation of cell migration
GO:0090197; P:positive regulation of chemokine secretion
GO:0070374; P:positive regulation of ERK1 and ERK2 cascade
GO:0071902; P:positive regulation of protein serine/threonine kinase activity
GO:0061098; P:positive regulation of protein tyrosine kinase activity
GO:0042517; P:positive regulation of tyrosine phosphorylation of Stat3 protein
GO:2000249; P:regulation of actin cytoskeleton reorganization
GO:0031529; P:ruffle organization
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR003599; Ig_sub.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR001824; Tyr_kinase_rcpt_3_CS.
Pfam
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 1.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00240; RECEPTOR_TYR_KIN_III; 1.
Prints
Created Date20-Feb-2013