EKS-TAG-00190

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAG-00190

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/RSKb	461.4	6.7E-139	434	691	258

Status

Unreviewed

Ensembl Protein

ENSTGUP00000001046

UniProt Accession

H0YRY6;

Protein Name

Ribosomal protein S6 kinase

Protein Synonyms/Alias

Gene Name

RPS6KA1

Gene Synonyms/Alias

RPS6KA1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTGUG00000001002	ENSTGUP00000001046	ENSTGUT00000001058

Organism

Taeniopygia guttata

Functional Description

Protein Length

751

Protein Sequence
(FASTA)

MPLAQLAEPW PDMELVHLDT ENGQPAPEEG GNPPSKAKSD ITWIEKDLVD TADKGEGVVQ 60

EINITHHVKE GSEKADPSQF ELLKVLGQGS FGKVFLVRKI TPPDSNHLYA MKVLKKATLK 120

VRDRLRTKIE RDILADVNHP FVVKLHYAFQ TEGKLYLILD FLRGGDLFTR LSKEVMFTED 180

DVKFYLAELA LGLDHLHSLG IIYRDLKPEN ILDEEGHIKL TDFGLSKEAI DHEKKAYSFC 240

GTVEYMAPEV VNRQGHSHSA DWWSYGVLMF EMLTGALPFQ GKDRKETMTL ILKAKLGMPQ 300

FLSTEAQSLL RALFKRNPAN RLGSGPDGAE EIKRHPFYST IDWNKLYRRE IKPPFKPAVA 360

QPDDTFYFDT EFTSRTPKDS PGVPPSAGAH QLFRGFSFVA TGLMEDGKVK PAQPPLHSVV 420

QQLHGKNVQF SDGYVVKEAI GVGSYSVCKR CIHKATNMEY AVKVIDKSKR DPSEEIEILL 480

RYGQHPNIIT LKDVYDDGKY VYLVTELMRG GELLDKILRQ KFFSEREASS VLHMICKTVE 540

YLHSQGVVHR DLKPSNILYV DKSGNPESIR ICDFGFAKQL RAENGLLMTP CYTANFVAPE 600

VLKRQGYNEG CDIWSLGGFS LSSLPSCTPF ANGPSDTPEE ILTRIGGGKF SISGGNWDTI 660

SDMAKDLVSK MLHVDPHQRL TAKQVLQHPW ITQKDSLPQS QLNHQDIQLV KGAMAATYSA 720

LNSSKPSPQL KPIESSILAQ RRVKKLPSTT L 751

Nucleotide Sequence
(FASTA)

ATGCCGCTCG CCCAGCTGGC CGAGCCCTGG CCCGACATGG AGCTGGTGCA TCTGGACACG 60

GAGAACGGGC AGCCAGCTCC AGAAGAAGGT GGGAATCCTC CATCCAAGGC CAAGTCTGAC 120

ATCACTTGGA TAGAGAAAGA CCTCGTGGAC ACGGCAGACA AGGGGGAAGG TGTTGTGCAG 180

GAAATCAACA TCACACACCA TGTGAAGGAG GGCTCGGAGA AGGCTGATCC CTCACAGTTT 240

GAGCTCCTGA AGGTGCTGGG ACAGGGCTCT TTTGGCAAGG TTTTCTTGGT GAGAAAAATA 300

ACCCCCCCAG ACAGCAACCA CCTCTATGCC ATGAAAGTGC TCAAGAAGGC CACGCTGAAA 360

GTGCGGGACC GACTGAGGAC AAAGATAGAA AGGGACATCC TGGCTGATGT CAACCATCCC 420

TTTGTGGTGA AACTCCACTA TGCATTCCAG ACGGAGGGGA AGCTGTACCT CATCTTGGAT 480

TTCCTCAGAG GAGGTGACCT TTTCACTCGG CTTTCCAAAG AGGTCATGTT CACCGAAGAT 540

GATGTCAAGT TCTACCTGGC AGAGCTGGCA CTGGGACTCG ACCACTTGCA CAGCCTGGGG 600

ATCATCTACA GGGACCTCAA GCCAGAGAAC ATCCTCGATG AAGAGGGGCA CATCAAACTC 660

ACAGATTTTG GTTTGAGTAA GGAGGCCATA GACCACGAGA AGAAAGCCTA CTCCTTCTGT 720

GGGACTGTGG AGTACATGGC TCCGGAGGTG GTCAATCGCC AGGGCCACTC GCACAGTGCT 780

GACTGGTGGT CCTACGGGGT CCTCATGTTT GAAATGCTCA CGGGGGCACT GCCCTTCCAG 840

GGGAAGGACC GTAAGGAGAC GATGACCCTC ATCCTCAAAG CGAAACTGGG CATGCCACAG 900

TTCCTGAGCA CTGAGGCTCA GAGTCTCCTA CGAGCCCTTT TCAAAAGGAA TCCAGCCAAC 960

AGATTAGGGT CTGGGCCAGA TGGGGCAGAG GAGATTAAGC GCCACCCTTT CTACTCCACC 1020

ATCGACTGGA ATAAGCTGTA CCGCAGGGAA ATCAAACCCC CTTTCAAGCC TGCAGTGGCC 1080

CAGCCAGATG ACACCTTTTA TTTTGACACA GAGTTCACGT CACGGACACC AAAAGATTCC 1140

CCGGGTGTGC CCCCAAGTGC AGGGGCCCAT CAGCTCTTCC GAGGCTTCAG TTTTGTGGCA 1200

ACCGGGTTAA TGGAGGATGG CAAAGTGAAA CCTGCCCAGC CACCCCTGCA TTCAGTTGTG 1260

CAGCAACTGC ATGGCAAGAA CGTCCAGTTC AGCGATGGGT ACGTGGTGAA GGAGGCCATC 1320

GGCGTCGGCT CCTACTCCGT CTGCAAACGC TGCATCCACA AGGCCACCAA CATGGAGTAT 1380

GCAGTCAAGG TGATTGACAA GAGCAAGCGA GACCCTTCTG AGGAGATTGA GATCCTGCTG 1440

CGGTACGGGC AGCACCCAAA CATCATCACC CTGAAAGATG TGTACGATGA TGGGAAGTAT 1500

GTGTACCTGG TGACCGAGCT CATGAGGGGA GGGGAACTGC TGGATAAAAT CCTCAGACAG 1560

AAATTTTTCT CGGAGAGAGA AGCCAGTTCA GTCCTGCACA TGATCTGTAA AACAGTGGAG 1620

TATCTGCATT CCCAAGGGGT GGTTCACAGG GACCTGAAGC CCAGCAATAT CCTCTACGTG 1680

GATAAATCAG GGAACCCAGA GAGCATCCGA ATTTGTGACT TTGGCTTTGC CAAGCAGCTC 1740

AGGGCTGAGA ACGGGCTCCT CATGACCCCC TGTTACACAG CAAACTTCGT GGCACCCGAG 1800

GTCCTGAAAC GCCAAGGCTA CAACGAGGGC TGTGACATCT GGAGCCTGGG GGGCTTTTCT 1860

CTCTCCTCTC TCCCCAGCTG CACTCCCTTT GCAAATGGTC CCAGTGACAC TCCAGAAGAG 1920

ATCCTGACAC GGATAGGAGG GGGAAAATTC TCCATCAGTG GGGGCAATTG GGACACTATT 1980

TCTGACATGG CCAAGGATCT GGTATCAAAG ATGCTCCACG TAGATCCTCA CCAGCGTCTC 2040

ACAGCCAAGC AGGTCCTGCA GCATCCTTGG ATAACACAGA AGGACAGTTT ACCCCAGAGC 2100

CAGCTCAATC ACCAGGACAT TCAGCTTGTA AAGGGCGCCA TGGCTGCCAC ATACTCGGCA 2160

CTGAACAGCT CCAAGCCAAG CCCTCAGCTG AAGCCCATCG AATCCTCCAT CCTGGCACAG 2220

AGGCGGGTGA AGAAGCTCCC CTCCACAACC CTGTGA 2256

Domain Profile

S: 1     yevkedlGvGsysvckrcvhkatnqefavkiidkskrdtseeieillryeqhpnivtlkd  60

         y+vke +GvGsysvckrc+hkatn+e+avk+idkskrd+seeieillry+qhpni+tlkd

Q: 434   YVVKEAIGVGSYSVCKRCIHKATNMEYAVKVIDKSKRDPSEEIEILLRYGQHPNIITLKD  493

         689*********************************************************

S: 61    vyddgkyvylvlellkGGelldrikkkkffsereasailrtlvkaveylheqGvvhrdlk  120

         vyddgkyvylv+el++GGelld+i+++kffsereas++l+ ++k+veylh+qGvvhrdlk

Q: 494   VYDDGKYVYLVTELMRGGELLDKILRQKFFSEREASSVLHMICKTVEYLHSQGVVHRDLK  553

         ************************************************************

S: 121   penilyvdesdnaesikiidfGfaklkraengllktpcytlnfvapevlkrqGydeacdl  180

         p+nilyvd+s+n+esi+i+dfGfak++raengll+tpcyt+nfvapevlkrqGy+e+cd+

Q: 554   PSNILYVDKSGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYNEGCDI  613

         ************************************************************

S: 181   wslGvllytmlaGyvpfangpedtaeeilakikeGkfslsGeawdsvseeakdlvskllt  240

         wslG +    l   +pfangp+dt+eeil++i+ Gkfs+sG++wd++s+ akdlvsk+l+

Q: 614   WSLGGFSLSSLPSCTPFANGPSDTPEEILTRIGGGKFSISGGNWDTISDMAKDLVSKMLH  673

         ************************************************************

S: 241   vdpakrlkleqllkhswl  258

         vdp++rl+++q+l+h+w+

Q: 674   VDPHQRLTAKQVLQHPWI  691

         *****************8

Domain Sequence
(FASTA)

YVVKEAIGVG SYSVCKRCIH KATNMEYAVK VIDKSKRDPS EEIEILLRYG QHPNIITLKD 60

VYDDGKYVYL VTELMRGGEL LDKILRQKFF SEREASSVLH MICKTVEYLH SQGVVHRDLK 120

PSNILYVDKS GNPESIRICD FGFAKQLRAE NGLLMTPCYT ANFVAPEVLK RQGYNEGCDI 180

WSLGGFSLSS LPSCTPFANG PSDTPEEILT RIGGGKFSIS GGNWDTISDM AKDLVSKMLH 240

VDPHQRLTAK QVLQHPWI 258

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005819	; C:spindle
GO:0005524	; F:ATP binding
GO:0043027	; F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007243	; P:intracellular protein kinase cascade
GO:0043066	; P:negative regulation of apoptotic process
GO:2000491	; P:positive regulation of hepatic stellate cell activation
GO:0045944	; P:positive regulation of transcription from RNA polymerase II promoter

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR016239	; Ribosomal_S6_kinase_II.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 2.
PF00433	; Pkinase_C; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 2.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 2.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013