EKS-TAG-00281

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAG-00281

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/DYRK	462.0	9.7E-139	133	446	314

Status

Unreviewed

Ensembl Protein

ENSTGUP00000001119

UniProt Accession

H0YS59;

Protein Name

Protein Synonyms/Alias

Gene Name

DYRK3

Gene Synonyms/Alias

DYRK3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTGUG00000001091	ENSTGUP00000001119	ENSTGUT00000001131

Organism

Taeniopygia guttata

Functional Description

Protein Length

511

Protein Sequence
(FASTA)

HPLAGNQVKV EQLFEDSGNR RSSTLQSAGL TPERSLPSLT KEKTLESLGA RGSGSSLKSH 60

KAISQAPEEA VKQFKHLLSA YEQQEIFSFS EIYFVGPSAK KRQGVVGGPN NSGYDDDQGS 120

YIHVPHDHLA YRYEVLKIIG KGSFGQVAKV YDHKLHQHLA LKMVRNEKRF HRQAAEEIRI 180

LEHLKKQDKT DSMNVIHMLE SFTFRNHICM TFELLSMNLY ELIKRNKFQG FSLQLVRKFA 240

HSILQCLDAL YRNKIIHCDL KPENILLKQQ GRSGIKVIDF GSSCFEHQRV YTYIQSRFYR 300

APEVILGGRY GMPIDMWSFG CILVELLTGY PLFPGEDEAD QLACIMELLG MPPQKLLEQS 360

KRAKNFISSK GHPRYCTVVT QPDGKVTLSG SRSRRGKLRG APGNKDWVTA LKGCDDPLFT 420

GFLKNCLSWD PSTRMIPSQA LRHPWICKRV SKAAGLEKSS GRRISSYSGS FQGIANKLPP 480

VAAVPNKLRA SLATEPSGSI PLCTVLPKLV S 511

Nucleotide Sequence
(FASTA)

CACCCTCTGG CTGGAAATCA GGTCAAAGTG GAGCAGTTAT TTGAGGATTC TGGCAACAGA 60

AGGAGCAGCA CTCTTCAGTC TGCAGGCCTT ACTCCAGAAA GATCTCTCCC TTCCCTGACA 120

AAAGAGAAAA CCCTAGAGAG CCTGGGTGCT AGAGGCAGTG GAAGCTCCTT GAAATCACAT 180

AAAGCCATCT CCCAAGCTCC AGAGGAAGCT GTCAAACAGT TCAAACATCT GCTGTCAGCT 240

TACGAGCAGC AGGAGATCTT TAGTTTCTCT GAGATTTACT TCGTGGGGCC ATCTGCCAAA 300

AAGAGGCAGG GGGTGGTCGG CGGCCCCAAC AACAGCGGCT ACGACGACGA CCAAGGCAGC 360

TACATCCATG TGCCCCACGA CCACCTGGCT TACAGGTATG AGGTGCTCAA AATCATTGGC 420

AAGGGCAGTT TTGGACAAGT TGCTAAAGTC TATGATCACA AACTCCACCA GCACCTGGCC 480

TTAAAGATGG TTCGCAATGA GAAGAGGTTC CATCGGCAAG CTGCCGAGGA GATCAGGATC 540

CTGGAGCACC TGAAGAAGCA GGATAAAACA GACAGCATGA ACGTGATCCA CATGCTGGAA 600

AGCTTCACCT TTCGCAACCA CATCTGCATG ACCTTTGAAC TCTTGAGTAT GAACCTGTAC 660

GAGCTGATTA AAAGGAATAA GTTCCAGGGC TTCAGCCTCC AGCTGGTTCG GAAGTTCGCT 720

CACTCCATCC TGCAATGTTT GGATGCCCTT TATAGAAACA AAATCATCCA CTGTGACTTG 780

AAGCCAGAAA ATATCCTCCT AAAACAGCAA GGGAGGAGTG GAATCAAGGT TATAGATTTT 840

GGGTCCAGCT GTTTTGAGCA CCAAAGGGTC TACACCTACA TCCAGTCCCG TTTTTATCGG 900

GCGCCAGAGG TGATCCTGGG CGGCCGCTAT GGGATGCCCA TAGACATGTG GAGTTTTGGC 960

TGTATTCTGG TGGAGCTTTT GACTGGCTAC CCTCTTTTTC CTGGAGAGGA CGAGGCAGAC 1020

CAACTGGCCT GTATCATGGA ACTTCTTGGA ATGCCACCTC AGAAGCTTTT GGAGCAATCC 1080

AAGCGAGCCA AGAACTTCAT CAGCTCCAAG GGCCACCCGC GTTACTGCAC GGTGGTGACG 1140

CAGCCGGACG GGAAGGTGAC GCTGAGCGGG AGCCGCTCGC GCCGGGGCAA GCTCCGGGGT 1200

GCCCCGGGGA ACAAGGACTG GGTGACAGCT CTGAAGGGCT GTGACGACCC CTTGTTCACT 1260

GGTTTCCTGA AGAACTGCCT CAGCTGGGAT CCTTCCACGC GAATGATTCC CAGCCAGGCC 1320

CTGCGGCACC CCTGGATCTG CAAACGGGTG TCCAAAGCGG CTGGCTTGGA GAAAAGCTCC 1380

GGCAGGAGGA TTTCCAGCTA TTCAGGTTCC TTCCAAGGAA TTGCTAACAA GTTGCCTCCC 1440

GTGGCTGCAG TTCCCAACAA GCTGAGGGCC AGTCTGGCCA CTGAGCCCAG TGGCAGCATC 1500

CCTCTGTGTA CTGTGCTGCC CAAACTGGTC AGCTAG 1536

Domain Profile

S: 1     yevlevigkGsfgqVvkaldkktkeivaikiiknkkrfarqaqeEveiLeklnkkdkeek  60

         yevl++igkGsfgqV+k++d+k ++++a+k+++n+krf+rqa+eE++iLe+l+k+dk+++

Q: 133   YEVLKIIGKGSFGQVAKVYDHKLHQHLALKMVRNEKRFHRQAAEEIRILEHLKKQDKTDS  192

         9***********************************************************

S: 61    ynvvrllelfvfrnhlclvfellsqnLyellkknkfsglslklvrklaqqilkaLklLke  120

         +nv+++le+f+frnh+c++fells+nLyel+k+nkf+g+sl+lvrk+a++il++L++L++

Q: 193   MNVIHMLESFTFRNHICMTFELLSMNLYELIKRNKFQGFSLQLVRKFAHSILQCLDALYR  252

         ************************************************************

S: 121   lkiiHaDlKPeNillvekkrsevkviDFGsssavsqkeiytyiqsrfYraPEiilglkyd  180

         +kiiH+DlKPeNill++++rs +kviDFGss++++q+ +ytyiqsrfYraPE+ilg +y

Q: 253   NKIIHCDLKPENILLKQQGRSGIKVIDFGSSCFEHQR-VYTYIQSRFYRAPEVILGGRYG  311

         *************************************.**********************

S: 181   eaiDmWSlGcvlaElftGkpLfpGenevdqlalivevlglppekllekakkakkfftkke  240

         + iDmWS+Gc+l+El+tG+pLfpGe+e dqla+i+e+lg+pp+klle++k+ak+f+++k+

Q: 312   MPIDMWSFGCILVELLTGYPLFPGEDEADQLACIMELLGMPPQKLLEQSKRAKNFISSKG  371

         ************************************************************

S: 241   apkyilktkksdrkkklvlnvkkaakkrkaplskelgealkekedklfkdllkrmleldp  300

         +p+y+++ ++ d k++l+ ++++++k r ap++k++++alk ++d lf+ +lk++l++dp

Q: 372   HPRYCTVVTQPDGKVTLSGSRSRRGKLRGAPGNKDWVTALKGCDDPLFTGFLKNCLSWDP  431

         ************************************************************

S: 301   akRitpkealkhpfv  315

         ++R+ p++al+hp++

Q: 432   STRMIPSQALRHPWI  446

         **************7

Domain Sequence
(FASTA)

YEVLKIIGKG SFGQVAKVYD HKLHQHLALK MVRNEKRFHR QAAEEIRILE HLKKQDKTDS 60

MNVIHMLESF TFRNHICMTF ELLSMNLYEL IKRNKFQGFS LQLVRKFAHS ILQCLDALYR 120

NKIIHCDLKP ENILLKQQGR SGIKVIDFGS SCFEHQRVYT YIQSRFYRAP EVILGGRYGM 180

PIDMWSFGCI LVELLTGYPL FPGEDEADQL ACIMELLGMP PQKLLEQSKR AKNFISSKGH 240

PRYCTVVTQP DGKVTLSGSR SRRGKLRGAP GNKDWVTALK GCDDPLFTGF LKNCLSWDPS 300

TRMIPSQALR HPWI 314

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013