EKS-TAG-00114
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-TAG-00114
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Musk571.04.1E-172656934279
StatusUnreviewed
Ensembl ProteinENSTGUP00000001342
UniProt AccessionH0YST1;
Protein Name
Protein Synonyms/Alias
Gene NameMUSK
Gene Synonyms/Alias MUSK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSTGUG00000001301ENSTGUP00000001342ENSTGUT00000001355
OrganismTaeniopygia guttata
Functional Description
Protein Length948
Protein Sequence
(FASTA)
MNDLLKVPLL HVLTLAALSL AETLLKAPLI STPLETVDAL VEDIAKFVCV VESYPEPEIT 60
WTRNSIPIRL FDTRYSIQRN GQLLTILSVE DTDDGVYCCT ADNGVGAAAQ SCGALQVKMR 120
PKITRPPVNV EIIEGLKAVL PCTTMGSPKP SVSWVKGETV VKETARIAVL DSGNLRIHNV 180
QREDAGQYRC VAKNSLGTAY SKPATVVVEV FARILKAPES QNITFGSVVT LRCTATGLPV 240
PTVTWLENGK AVSVGSIAES VKDRVVDSRL QVYVTRPGLF TCLASNKHSK TFGAAKAAAT 300
ISISAYSVKL YKGDAGYCST YRGEVCSAIL AKNALVFFNS SYADPEETQE LLVHAAWTEL 360
KMVSSFCQPA AESLLCNYIF QECNPSGAGP APKPVCRENC LAVKDLYCFK EWLSMEENSQ 420
KGIYKPGLML LTLPECNRLP SLHQNPSSCT HIPFFDFKKE NITRTCYSGN GQFYQGTANV 480
TASGIPCQKW SDQAPHLHRR TPQVFPELFD AENYCRNPGG ENERPWCYTK DPAVTWEYCS 540
VSPCGDALLS LGTRKPNGEP LNLPPPPPFS PTYSMTVIIS IISSFALVVI FAIITLVCCR 600
SRKQWKNKKR ESETPTLTTL PSELLLDRLH PNPMYQRMPL LLNPKLLSLE YPRNNIEYVR 660
DIGEGAFGRV FQARAPGLLP YEPFTMVAVK MLKEEASADM QADFQREAAL MAEFDNPHIV 720
KLLGVCAVGK PMCLLFEYMA YGDLNEYLRD RSPRNLCSLV QGSLDTRLRL PNPLALCCTS 780
QLCIAKQVAA GMAYLSERKF VHRDLATRNC LVGENMVVKI ADFGLSRNMY SADYYKANEN 840
DAIPIRWMPP ESIFYNRYTT ESDVWAYGVV LWEIFSYGMQ PYYGMAHEEV IYYVRDGNVL 900
SCPDNCPLEL YNLMRLCWSR LPADRPGFAS IHRILERMYK KAVANMSV 948
Nucleotide Sequence
(FASTA)
ATGAATGACC TGCTGAAGGT GCCCCTGCTG CATGTCCTCA CCCTGGCAGC CCTCAGCTTG 60
GCTGAGACAC TTCTGAAAGC TCCCTTGATC AGCACTCCTC TGGAAACAGT GGATGCCCTG 120
GTGGAAGACA TTGCCAAGTT TGTCTGTGTA GTAGAGTCAT ATCCTGAGCC GGAGATTACA 180
TGGACACGCA ACAGCATTCC CATCAGGCTA TTTGACACCC GGTACAGCAT CCAGAGGAAC 240
GGGCAGCTCC TGACCATTCT GAGTGTGGAG GACACGGATG ATGGAGTGTA CTGCTGCACA 300
GCAGATAATG GAGTTGGAGC AGCTGCGCAG AGCTGTGGGG CTCTCCAGGT GAAAATGCGA 360
CCCAAAATAA CCCGTCCACC TGTAAATGTG GAAATAATAG AAGGATTAAA GGCTGTTCTT 420
CCATGCACTA CAATGGGGAG TCCAAAACCT TCTGTTTCAT GGGTCAAAGG AGAAACAGTT 480
GTAAAGGAGA CTGCTCGCAT TGCCGTCCTC GATTCTGGAA ATTTAAGGAT ACACAATGTT 540
CAGAGAGAAG ATGCAGGACA GTATCGTTGT GTAGCCAAGA ACAGTCTGGG CACAGCCTAT 600
TCAAAACCTG CAACTGTGGT AGTGGAAGTG TTTGCCAGAA TCCTGAAGGC TCCTGAATCC 660
CAAAACATCA CCTTTGGGTC TGTGGTGACA TTGCGGTGCA CGGCAACCGG CCTTCCAGTC 720
CCTACTGTCA CCTGGCTGGA AAATGGGAAA GCTGTTTCTG TGGGGTCGAT AGCAGAAAGT 780
GTCAAGGACA GAGTGGTTGA CTCCAGACTG CAAGTGTATG TCACCCGACC TGGCCTGTTC 840
ACTTGTCTTG CTTCAAACAA GCACAGCAAA ACTTTTGGAG CCGCAAAAGC AGCAGCAACC 900
ATCAGCATTT CAGCTTACTC TGTCAAGCTG TACAAGGGTG ATGCAGGCTA CTGCAGCACA 960
TACAGAGGTG AGGTATGTAG TGCTATCTTG GCAAAGAATG CTCTTGTTTT CTTCAACTCC 1020
TCGTATGCTG ACCCAGAGGA GACCCAAGAG CTGCTTGTGC ACGCTGCCTG GACTGAACTG 1080
AAAATGGTGA GTTCATTCTG CCAACCGGCT GCTGAGTCTC TGCTGTGTAA CTACATCTTC 1140
CAGGAGTGCA ATCCCTCGGG AGCTGGGCCA GCTCCAAAAC CAGTGTGCAG AGAGAATTGC 1200
CTTGCTGTAA AGGATCTCTA CTGCTTTAAG GAATGGCTGT CAATGGAGGA GAACTCTCAG 1260
AAGGGGATTT ACAAGCCAGG GCTGATGCTG CTCACTCTTC CTGAATGCAA CAGATTGCCC 1320
AGCCTGCACC AGAATCCCAG TTCCTGTACC CACATCCCTT TTTTTGATTT TAAGAAGGAG 1380
AACATAACCA GGACTTGCTA CAGTGGCAAT GGCCAGTTTT ACCAGGGCAC AGCCAATGTC 1440
ACAGCATCTG GCATTCCCTG CCAGAAGTGG AGTGATCAGG CTCCCCATTT GCACAGGAGG 1500
ACTCCTCAGG TTTTCCCTGA GCTGTTTGAT GCTGAGAATT ACTGCAGAAA TCCAGGAGGT 1560
GAGAATGAGC GTCCCTGGTG CTACACAAAG GATCCAGCTG TGACCTGGGA ATACTGCAGT 1620
GTGTCTCCAT GTGGAGATGC ATTGTTGTCC CTGGGAACAA GAAAACCAAA TGGAGAGCCT 1680
CTAAATCTTC CCCCTCCTCC TCCATTCTCC CCTACATACT CCATGACTGT TATCATCTCG 1740
ATCATCTCTA GCTTTGCTCT GGTTGTGATC TTTGCCATTA TCACCCTGGT TTGCTGCCGT 1800
AGCCGAAAAC AGTGGAAAAA CAAAAAAAGA GAGTCGGAGA CACCAACTCT CACCACTCTG 1860
CCCTCCGAAC TGCTCCTGGA CCGGCTGCAC CCCAACCCAA TGTATCAGCG CATGCCTCTT 1920
CTCCTCAATC CAAAATTGCT TAGTCTGGAG TATCCCAGGA ACAATATTGA ATATGTGAGG 1980
GATATTGGGG AGGGAGCATT TGGGAGAGTC TTCCAAGCCA GGGCCCCAGG GCTGCTGCCA 2040
TATGAACCTT TCACCATGGT AGCAGTGAAA ATGCTGAAGG AGGAAGCATC TGCAGACATG 2100
CAGGCTGACT TTCAGAGGGA AGCAGCTCTC ATGGCAGAGT TCGACAATCC TCATATTGTC 2160
AAGCTTTTAG GCGTGTGTGC AGTTGGGAAG CCGATGTGCC TGCTGTTCGA GTACATGGCC 2220
TACGGGGATC TGAACGAGTA CCTGCGTGAC CGCTCACCCC GCAACCTCTG CAGCCTGGTG 2280
CAGGGCAGCC TGGACACGAG GCTGCGCCTC CCGAACCCCC TGGCGCTGTG CTGCACCAGC 2340
CAGCTCTGCA TTGCCAAACA GGTTGCCGCT GGCATGGCGT ACCTCTCTGA GCGCAAGTTT 2400
GTCCACCGGG ATTTGGCCAC CAGGAACTGC CTCGTAGGGG AGAATATGGT GGTGAAAATT 2460
GCAGATTTTG GTCTCTCAAG GAACATGTAT TCAGCTGACT ATTACAAAGC AAATGAGAAC 2520
GATGCCATTC CCATCCGCTG GATGCCCCCT GAGTCCATTT TCTACAACCG CTACACCACA 2580
GAGTCTGATG TGTGGGCCTA TGGGGTGGTG CTGTGGGAGA TTTTCTCCTA CGGCATGCAG 2640
CCTTACTATG GGATGGCTCA CGAAGAGGTC ATCTACTATG TGAGGGATGG GAATGTCCTC 2700
TCCTGCCCAG ACAATTGTCC TCTGGAGCTC TACAACCTGA TGCGCCTCTG CTGGAGCAGG 2760
TTGCCTGCCG ATCGGCCAGG CTTTGCCAGC ATCCACCGCA TCTTGGAGCG CATGTACAAG 2820
AAGGCCGTGG CCAACATGTC TGTCTGA 2847
Domain Profile
S: 1     ieyvrdlgegafgrvfqarapgllpyeefllvavkmlkeeasadmqadfereaallaefd  60
         ieyvrd+gegafgrvfqarapgllpye+f++vavkmlkeeasadmqadf+reaal+aefd
Q: 656   IEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAALMAEFD  715
         89**********************************************************
S: 61    npnivkllgvcavgkpmcllfeymaygdlneflrslspytvcslshsdlslraqvsspdr  120
         np ivkllgvcavgkpmcllfeymaygdlne+lr  sp   csl +  l +r +   p++
Q: 716   NPHIVKLLGVCAVGKPMCLLFEYMAYGDLNEYLRDRSPRNLCSLVQGSLDTRLRL--PNP  773
         ***********************************************99999887..578
S: 121   lplseaellciarqvaagmaylserkfvhrdlatrnclvgetmvvkiadfglsrkiysad  180
         l l ++ +lcia+qvaagmaylserkfvhrdlatrnclvge+mvvkiadfglsr++ysad
Q: 774   LALCCTSQLCIAKQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNMYSAD  833
         9***********************************************************
S: 181   yykadendaipirwmplesilynrytlesdvwaygvvlweifsyalqpyyglaheeviky  240
         yyka+endaipirwmp+esi+ynryt+esdvwaygvvlweifsy++qpyyg+aheevi+y
Q: 834   YYKANENDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGMQPYYGMAHEEVIYY  893
         ************************************************************
S: 241   vrdgnilacpentplelyalmrlcwsklpadrpsfasihri  281
         vrdgn+l+cp+n+plely+lmrlcws+lpadrp+fasihri
Q: 894   VRDGNVLSCPDNCPLELYNLMRLCWSRLPADRPGFASIHRI  934
         ***************************************98
Domain Sequence
(FASTA)
IEYVRDIGEG AFGRVFQARA PGLLPYEPFT MVAVKMLKEE ASADMQADFQ REAALMAEFD 60
NPHIVKLLGV CAVGKPMCLL FEYMAYGDLN EYLRDRSPRN LCSLVQGSLD TRLRLPNPLA 120
LCCTSQLCIA KQVAAGMAYL SERKFVHRDL ATRNCLVGEN MVVKIADFGL SRNMYSADYY 180
KANENDAIPI RWMPPESIFY NRYTTESDVW AYGVVLWEIF SYGMQPYYGM AHEEVIYYVR 240
DGNVLSCPDN CPLELYNLMR LCWSRLPADR PGFASIHRI 279
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Kringle; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00073
EKS-ANC-00070
EKS-BOT-00079
EKS-CAJ-00080
EKS-CAP-00079
EKS-DAR-00333
EKS-DRM-00037
EKS-EQC-00077
EKS-FEC-00076
EKS-GAG-00063
EKS-GAA-00097
EKS-GOG-00078
EKS-HOS-00081
EKS-ICT-00074
EKS-LAC-00084
EKS-LOA-00078
EKS-MAM-00078
EKS-MEG-00059
EKS-MOD-00079
EKS-MUM-00082
EKS-MUP-00082
EKS-MYL-00087
EKS-NOL-00075
EKS-ORN-00106
EKS-ORA-00065
EKS-ORC-00074
EKS-ORL-00098
EKS-OTG-00083
EKS-PAT-00071
EKS-PES-00069
EKS-PEM-00043
EKS-POA-00076
EKS-RAN-00075
EKS-SAH-00075
EKS-TAR-00112
EKS-TEN-00104
EKS-XET-00074
EKS-XIM-00101
Gene Ontology
GO:0016021; C:integral to membrane
GO:0031594; C:neuromuscular junction
GO:0005886; C:plasma membrane
GO:0045211; C:postsynaptic membrane
GO:0005524; F:ATP binding
GO:0004713; F:protein tyrosine kinase activity
GO:0043525; P:positive regulation of neuron apoptotic process
GO:2000541; P:positive regulation of protein geranylgeranylation
GO:0001934; P:positive regulation of protein phosphorylation
GO:0043113; P:receptor clustering
GO:0006355; P:regulation of transcription, DNA-dependent
KEGG
InterPros
IPR020067; Frizzled_dom.
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003598; Ig_sub2.
IPR011009; Kinase-like_dom.
IPR000001; Kringle.
IPR013806; Kringle-like.
IPR018056; Kringle_CS.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF01392; Fz; 1.
PF07679; I-set; 3.
PF00051; Kringle; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00408; IGc2; 3.
SM00130; KR; 1.
SM00219; TyrKc; 1.
Prosites
PS50038; FZ; 1.
PS50835; IG_LIKE; 3.
PS00021; KRINGLE_1; 1.
PS50070; KRINGLE_2; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013