EKS-TAG-00206

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAG-00206

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/SRPK	816.7	6.7E-246	56	622	567

Status

Unreviewed

Ensembl Protein

ENSTGUP00000001709

UniProt Accession

H0YTU3;

Protein Name

Protein Synonyms/Alias

Gene Name

SRPK1

Gene Synonyms/Alias

SRPK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTGUG00000001648	ENSTGUP00000001709	ENSTGUT00000001725

Organism

Taeniopygia guttata

Functional Description

Protein Length

624

Protein Sequence
(FASTA)

RPDTQHRGLA ANSENELPEP EEEILGSDDD EQEDPNDYCK GGYHLVKIGD LFNGRYHVIR 60

KLGWGHFSTV WLAWDIQGRR FVAMKVVKSA EHYTETALDE IKLLKSVRNS DPDDPSKERV 120

VQLLDDFKIS GVNGSHICMV FEVLGHHLLK WIIKSNYQGL PLPCVKKIIQ QVLQGLDYLH 180

TKCRIIHTDI KPENILLCVN DQYIRRLAAE ATEWQRSGAP PPSGSAVSTA PQPKPADKMS 240

KNKKKKLKKK QKRQAELLEK RMQEIEEMEK EANPEQTQPE EEEEEAQTPL EMLIKVSPSE 300

EMLSEGYEEA QALGQEGSNL VEKHAREINC NGVIPITDLT DSGNEGSVQL EDDLHNANDC 360

ENHHHTQKTE NLHSCNYSQH NKAMLDLFVP LVPEDSMVCQ PIPNQKQAFS EQINNFQESI 420

RTEIPSEDEN ENNSPTDNKG KSAAGNFLLN PLEPKNADKL KVKIADLGNA CWVHKHFTED 480

IQTRQYRSLE VLIGSGYNTP ADIWSTACMA FELATGDYLF EPHSGEDYSR DEDHIALIIE 540

LLGKIPRKLI LAGKYSKEFF TKKGDLKHIT KLKPWGLFEV LVEKYEWSQD EAAAFTDFLL 600

PMLELIPEKR ATAAECLRHP WLNS 624

Nucleotide Sequence
(FASTA)

AGACCCGACA CCCAGCACCG GGGCCTTGCT GCTAATTCCG AGAATGAACT TCCAGAGCCA 60

GAGGAGGAAA TCCTGGGATC AGATGATGAT GAGCAAGAGG ATCCAAATGA TTACTGTAAA 120

GGGGGTTACC ACCTTGTGAA AATAGGAGAT CTCTTCAATG GGCGTTACCA CGTCATTCGG 180

AAGCTTGGAT GGGGTCATTT CTCCACCGTG TGGCTGGCTT GGGACATTCA AGGGAGGAGA 240

TTTGTGGCAA TGAAGGTGGT GAAGAGTGCA GAGCACTACA CAGAAACAGC ATTGGATGAA 300

ATCAAATTGC TGAAATCGGT CCGCAACAGT GATCCAGATG ATCCAAGCAA AGAGAGAGTT 360

GTTCAGTTAT TAGATGACTT CAAGATTTCA GGAGTGAATG GTTCCCATAT CTGTATGGTG 420

TTTGAAGTTC TAGGGCATCA TCTCCTGAAG TGGATCATCA AGTCAAATTA TCAGGGTCTT 480

CCGCTCCCTT GTGTCAAAAA AATCATCCAA CAGGTTCTTC AGGGTCTGGA TTACTTGCAT 540

ACAAAATGTA GAATCATCCA CACAGATATA AAGCCTGAGA ACATCCTGCT CTGTGTGAAT 600

GACCAGTACA TTCGCAGGCT GGCTGCAGAG GCAACAGAGT GGCAGAGATC TGGGGCTCCC 660

CCACCATCTG GCTCTGCAGT GAGCACTGCA CCACAGCCAA AACCAGCTGA CAAAATGTCA 720

AAGAATAAGA AAAAGAAGTT GAAAAAGAAG CAGAAAAGAC AGGCTGAGTT GTTGGAGAAG 780

CGAATGCAAG AGATAGAGGA AATGGAGAAG GAAGCAAACC CTGAGCAGAC ACAGCCTGAG 840

GAGGAGGAGG AAGAAGCTCA GACCCCTCTG GAAATGCTCA TAAAAGTCAG TCCATCAGAG 900

GAAATGTTGT CTGAGGGGTA TGAGGAGGCA CAAGCCCTTG GACAGGAGGG ATCTAATCTC 960

GTGGAAAAAC ATGCAAGAGA AATCAACTGC AACGGAGTGA TCCCGATAAC AGACTTGACA 1020

GACTCTGGGA ACGAGGGGTC TGTGCAGCTC GAGGACGACC TCCACAACGC CAATGACTGT 1080

GAAAACCACC ATCACACACA GAAGACTGAG AACTTGCACA GCTGTAATTA CAGTCAGCAC 1140

AACAAAGCAA TGTTGGACTT GTTTGTGCCC TTGGTCCCAG AGGATTCCAT GGTGTGCCAG 1200

CCCATACCCA ACCAAAAGCA GGCGTTCAGC GAGCAGATCA ACAATTTCCA GGAAAGCATC 1260

AGGACAGAGA TCCCTTCAGA GGATGAGAAT GAGAATAACA GCCCCACAGA CAACAAAGGA 1320

AAATCAGCTG CTGGGAATTT CCTTCTTAAT CCTCTTGAGC CCAAGAATGC AGATAAGCTC 1380

AAAGTGAAGA TAGCTGACCT AGGAAACGCC TGCTGGGTGC ACAAGCATTT CACTGAAGAC 1440

ATCCAGACGA GGCAGTACCG CTCCCTGGAG GTGTTGATAG GGTCAGGGTA CAACACCCCT 1500

GCAGACATCT GGAGCACAGC CTGCATGGCC TTTGAGTTGG CAACAGGGGA CTACCTGTTT 1560

GAGCCTCACT CTGGGGAAGA CTACTCACGA GATGAAGATC ATATTGCATT GATCATAGAA 1620

CTTCTGGGGA AAATACCTCG CAAGCTCATT TTGGCAGGAA AATATTCCAA GGAGTTTTTC 1680

ACCAAAAAAG GTGATCTGAA GCACATCACC AAACTGAAGC CCTGGGGCCT TTTTGAAGTG 1740

TTGGTGGAAA AATATGAGTG GTCCCAAGAT GAGGCAGCTG CATTCACAGA CTTCTTACTC 1800

CCCATGCTGG AGCTGATCCC AGAGAAACGA GCTACAGCAG CAGAATGTCT CAGGCACCCC 1860

TGGCTTAACT CCTAG 1875

Domain Profile

S: 1     yhvirkLGWGhfstvWLawdlqekrfvalkvvksaehytetaldeikllksvresdpsdp  60

         yhvirkLGWGhfstvWLawd+q++rfva+kvvksaehytetaldeikllksvr+sdp+dp

Q: 56    YHVIRKLGWGHFSTVWLAWDIQGRRFVAMKVVKSAEHYTETALDEIKLLKSVRNSDPDDP  115

         9***********************************************************

S: 61    krekvvqllddfkisGvnGvhvclvfevLGenLlkliiksnyrGlpleqvkkiirqvLeg  120

         ++e+vvqllddfkisGvnG h+c+vfevLG++Llk+iiksny+Glpl++vkkii+qvL+g

Q: 116   SKERVVQLLDDFKISGVNGSHICMVFEVLGHHLLKWIIKSNYQGLPLPCVKKIIQQVLQG  175

         ************************************************************

S: 121   LdylhekCkiihtdikPenvLlavddeyirrlaaeatewqkagakppsgsavstapqkka  180

         Ldylh+kC+iihtdikPen+Ll+v+d+yirrlaaeatewq++ga+ppsgsavstapq+k+

Q: 176   LDYLHTKCRIIHTDIKPENILLCVNDQYIRRLAAEATEWQRSGAPPPSGSAVSTAPQPKP  235

         ************************************************************

S: 181   ieklsknkkkklkkkqkrqaellekrlqeleele..........................  214

         ++k+sknkkkklkkkqkrqaellekr+qe+ee+e

Q: 236   ADKMSKNKKKKLKKKQKRQAELLEKRMQEIEEMEkeanpeqtqpeeeeeeaqtplemlik  295

         **********************************99999999999999999999999999

S: 215   ...............................aaeanseaedqelkedaekgeleei.ead  242

                                         +++n+    ++l+++ ++g+++ + + +

Q: 296   vspseemlsegyeeaqalgqegsnlvekharEINCNGVIPITDLTDSGNEGSVQLEdDLH  355

         999998887777777777777777766666644444444444444444444443220222

S: 243   veeevanedeaseeee........................essltsssdaesksgelsea  278

         + ++  n++++++ e+

Q: 356   NANDCENHHHTQKTENlhscnysqhnkamldlfvplvpedS-------------------  396

         22333333333333322222222223333333333333330...................

S: 279   stellsesleqlacgsvls.........................................  297

                    ++c+ + +

Q: 397   -----------MVCQPIPNqkqafseqinnfqesirteipsedenennsptdnkgksaag  445

         ...........3333322244444555555555555566666666666667777778888

S: 298   ...vnplepknadkikvkiadLGnaCwvhkhftediqtrqyrslevliGagygtpadiWs  354

            +nplepknadk+kvkiadLGnaCwvhkhftediqtrqyrslevliG+gy+tpadiWs

Q: 446   nflLNPLEPKNADKLKVKIADLGNACWVHKHFTEDIQTRQYRSLEVLIGSGYNTPADIWS  505

         888*********************************************************

S: 355   taClafeLatGdyLfephsgedysrdedhiakiiellGkiPrklilkGkysreffnkkge  414

         taC+afeLatGdyLfephsgedysrdedhia iiellGkiPrklil+Gkys+eff+kkg+

Q: 506   TACMAFELATGDYLFEPHSGEDYSRDEDHIALIIELLGKIPRKLILAGKYSKEFFTKKGD  565

         ************************************************************

S: 415   LrhitkLkpwsLlevLvekyewskeeaaefsdfLlPmleldpekrasaaeclkhpwL  471

         L+hitkLkpw+L+evLvekyews++eaa f+dfLlPmlel+pekra+aaecl+hpwL

Q: 566   LKHITKLKPWGLFEVLVEKYEWSQDEAAAFTDFLLPMLELIPEKRATAAECLRHPWL  622

         ********************************************************8

Domain Sequence
(FASTA)

YHVIRKLGWG HFSTVWLAWD IQGRRFVAMK VVKSAEHYTE TALDEIKLLK SVRNSDPDDP 60

SKERVVQLLD DFKISGVNGS HICMVFEVLG HHLLKWIIKS NYQGLPLPCV KKIIQQVLQG 120

LDYLHTKCRI IHTDIKPENI LLCVNDQYIR RLAAEATEWQ RSGAPPPSGS AVSTAPQPKP 180

ADKMSKNKKK KLKKKQKRQA ELLEKRMQEI EEMEKEANPE QTQPEEEEEE AQTPLEMLIK 240

VSPSEEMLSE GYEEAQALGQ EGSNLVEKHA REINCNGVIP ITDLTDSGNE GSVQLEDDLH 300

NANDCENHHH TQKTENLHSC NYSQHNKAML DLFVPLVPED SMVCQPIPNQ KQAFSEQINN 360

FQESIRTEIP SEDENENNSP TDNKGKSAAG NFLLNPLEPK NADKLKVKIA DLGNACWVHK 420

HFTEDIQTRQ YRSLEVLIGS GYNTPADIWS TACMAFELAT GDYLFEPHSG EDYSRDEDHI 480

ALIIELLGKI PRKLILAGKY SKEFFTKKGD LKHITKLKPW GLFEVLVEKY EWSQDEAAAF 540

TDFLLPMLEL IPEKRATAAE CLRHPWL 567

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007059	; P:chromosome segregation
GO:0045071	; P:negative regulation of viral genome replication
GO:0045070	; P:positive regulation of viral genome replication

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 2.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013