EKS-TAG-00314
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-TAG-00314
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/EGFR498.63.1E-150686943258
StatusUnreviewed
Ensembl ProteinENSTGUP00000001863
UniProt AccessionH0YU95;
Protein Name
Protein Synonyms/Alias
Gene NameEGFR
Gene Synonyms/Alias EGFR;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSTGUG00000001806ENSTGUP00000001863ENSTGUT00000001881
OrganismTaeniopygia guttata
Functional Description
Protein Length1185
Protein Sequence
(FASTA)
VCQGTNNKLT QLGHVEDHFT SLQRMYNNCE VVLSNLEITY VEHNRDLSFL KTIQEVAGYV 60
LIALNMVDVI PLENLQIIRG NVLYDNSYAL AVLSNYHMNK TQGLRQLPMK RLSEILNGGV 120
KISNNPKLCN MDTVLWNDII DTSKKPPTVL EFASNLSSCP KCHQNCTEDH CWGPGEKNCQ 180
TLTKVICAQQ CSGRCRGKVP SDCCHNQCAA GCTGPRESDC LACRKFRDDA TCKDTCPPLV 240
LYNPTTYQMD VNPEGKYSFG ATCVKECPHN YVVTDHGSCV RSCNADTYEV EENGVRKCKK 300
CDGLCSKVCN GIGIGELKGI LSINATNIDS FKNCTKINGD VSILPVAFLG DAFTKTLPLD 360
PKKLDVFKTV KEISGFLLIQ AWPENATDLY AFENLEIIRG RTKQHGQYSL AVVNLKIQSL 420
GLRSLKEISD GDVAIMRNKN LCYADTMDWH SLFATESQKT KILQNRDKNE CAAAKHVCDP 480
LCSDVGCWGP GPFHCFSCRF FDRQKECVKQ CNILQGEPRE FEKDSKCLPC HPECLVQNST 540
MYNATCTGPG PDNCMKCAHF IDGPHCVKSC PAGVLGENDT LVWKYADGNN VCQLCHPNCT 600
RGCKGPGLEG CPNGSKIPSI AAGVVGGLLC LVVVGLGIGL YLRRRHIVRK RTLRRLLQER 660
ELVEPLTPSG EAPNQAHLRI LKETEFKKVK VLGSGAFGTV YKGLWIPEGE KVKIPVAIKE 720
LREATSPKAN KEILDEAYVM ASVDNPHVCR LLGICLTSTV QLITQLMPFG CLLDYIREHK 780
DNIGSQYLLN WCVQIAKGMN YLEERRLVHR DLAARNVLVK TPQHVKITDF GLAKLLGADE 840
KEYHAEGGKV PIKWMALESI LHRIYTHQSD VWSYGVTVWE LMTFGSKPYE GIPASEISSV 900
LEKGERLPQP PICTIDVYMI MVKCWMIDAD SRPKFRELIA EFSKMARDPP RYLVIQGDDR 960
MHLPSPTDSK FYRTLMEEED MEDIVDADEY LVPHQGFFNS PSTSRTPLLS SLSATSNNSA 1020
TTCIDRNGQG HPVREDSFVQ RYSSDPTGAF LEDSLDDSFL PAPEYVNQLV PNKTSASAVQ 1080
NPIYNFSHTA NSKASTDSSY QNSHSTAVDN PEYLNTNQSP LAKTVFESSP YWIQAGNHQI 1140
NLDNPDYQQD FLPKETKSNG LLKVPAAENP EYLRVAAPKS EYIEA 1185
Nucleotide Sequence
(FASTA)
GTTTGTCAAG GAACAAATAA CAAGCTGACC CAACTGGGAC ATGTGGAAGA CCATTTCACC 60
AGCCTGCAGA GGATGTACAA CAATTGCGAG GTGGTACTCA GCAACCTGGA GATTACATAT 120
GTGGAGCACA ATCGTGACCT CTCTTTCCTG AAGACAATAC AGGAGGTTGC AGGCTACGTG 180
CTCATCGCCC TTAACATGGT GGATGTCATT CCCCTTGAAA ACCTCCAGAT CATCCGAGGC 240
AATGTGCTAT ATGACAACTC TTACGCCCTG GCTGTTTTAT CCAACTACCA CATGAATAAA 300
ACCCAGGGAC TCCGACAGCT TCCAATGAAG CGGCTTTCAG AAATTCTTAA TGGAGGTGTT 360
AAAATCAGCA ACAACCCCAA ACTATGCAAC ATGGACACTG TTCTTTGGAA TGACATCATT 420
GACACAAGCA AGAAGCCTCC CACAGTGCTT GAATTTGCGA GCAACCTGTC TTCTTGTCCC 480
AAATGCCATC AGAACTGCAC AGAAGACCAC TGCTGGGGCC CTGGTGAAAA AAACTGCCAG 540
ACATTAACAA AAGTCATCTG TGCTCAGCAG TGCTCTGGTC GGTGCAGGGG AAAGGTGCCC 600
AGCGACTGCT GCCACAACCA GTGTGCCGCG GGGTGCACCG GGCCTCGGGA GAGTGACTGC 660
CTGGCATGCC GTAAGTTTCG GGACGATGCT ACGTGCAAGG ATACATGTCC CCCATTGGTC 720
CTGTATAACC CCACCACTTA CCAGATGGAT GTGAACCCTG AAGGAAAATA CAGCTTCGGA 780
GCCACTTGTG TGAAGGAATG TCCACACAAC TATGTGGTGA CAGACCATGG CTCCTGCGTT 840
CGCTCGTGCA ATGCTGATAC TTATGAAGTG GAAGAAAATG GTGTTCGGAA GTGTAAAAAG 900
TGTGATGGGC TATGCAGCAA AGTGTGCAAT GGCATCGGAA TAGGCGAACT TAAAGGGATC 960
CTCTCCATAA ATGCCACAAA TATTGACTCC TTCAAAAACT GTACCAAGAT CAATGGGGAT 1020
GTCAGCATTC TCCCAGTTGC GTTTCTAGGT GATGCCTTCA CAAAGACCCT GCCTTTGGAT 1080
CCCAAGAAAT TGGATGTCTT CAAAACAGTC AAAGAAATAT CAGGATTTTT GTTGATTCAA 1140
GCCTGGCCTG AGAATGCTAC TGATCTCTAT GCTTTTGAAA ATCTGGAGAT TATACGAGGC 1200
AGAACAAAGC AACATGGCCA GTATTCCCTA GCCGTTGTTA ACTTGAAAAT ACAGTCCTTA 1260
GGGCTGCGCT CCCTCAAGGA AATAAGTGAT GGAGATGTTG CCATTATGAG GAACAAGAAC 1320
CTCTGCTATG CTGACACCAT GGACTGGCAC AGCCTGTTTG CAACTGAGAG CCAGAAAACA 1380
AAGATTTTAC AGAATAGAGA TAAAAATGAG TGTGCTGCTG CCAAGCATGT TTGTGACCCC 1440
CTGTGCTCAG ACGTAGGCTG CTGGGGCCCA GGACCCTTCC ACTGCTTCTC CTGCAGGTTT 1500
TTTGATCGTC AGAAGGAATG TGTGAAACAG TGCAACATCC TGCAAGGGGA GCCAAGAGAG 1560
TTTGAAAAGG ACTCCAAGTG CCTCCCCTGC CACCCTGAGT GCCTGGTGCA GAACTCCACC 1620
ATGTACAATG CAACCTGCAC TGGACCTGGC CCTGACAATT GCATGAAGTG TGCCCATTTT 1680
ATAGATGGCC CCCACTGTGT GAAATCCTGC CCAGCAGGGG TTCTGGGTGA GAATGACACC 1740
CTCGTCTGGA AATATGCTGA TGGGAATAAT GTTTGCCAGC TCTGCCATCC AAACTGCACC 1800
CGGGGGTGCA AAGGGCCAGG TCTTGAAGGC TGTCCAAATG GCTCCAAGAT CCCCTCTATC 1860
GCAGCCGGTG TTGTCGGAGG GCTCCTGTGC CTGGTGGTGG TGGGGCTGGG CATCGGCCTG 1920
TACCTGCGGC GACGCCACAT CGTCAGGAAG CGCACCCTGC GCCGGCTGCT GCAGGAGAGG 1980
GAGCTTGTTG AACCACTGAC ACCCAGTGGG GAGGCACCAA ACCAGGCTCA TCTGAGAATT 2040
TTAAAGGAAA CAGAATTTAA GAAGGTCAAA GTTTTAGGCT CTGGAGCTTT TGGCACTGTT 2100
TATAAGGGAC TTTGGATCCC AGAAGGAGAG AAGGTTAAAA TTCCTGTTGC TATTAAAGAG 2160
TTGAGAGAGG CTACATCACC AAAAGCCAAC AAGGAAATAC TTGATGAAGC TTATGTGATG 2220
GCTAGTGTTG ACAATCCTCA TGTGTGTCGC TTGTTGGGAA TCTGCCTCAC TTCAACTGTT 2280
CAGCTCATCA CACAGCTGAT GCCTTTTGGC TGCCTCCTGG ATTACATCCG AGAGCACAAG 2340
GACAACATCG GCTCTCAGTA CCTCCTCAAC TGGTGTGTGC AGATTGCAAA GGGAATGAAC 2400
TATCTGGAGG AACGGCGCCT GGTGCACCGT GACCTTGCTG CCAGGAATGT CCTTGTTAAG 2460
ACTCCTCAAC ATGTGAAAAT CACGGACTTC GGGCTGGCAA AGCTGCTTGG TGCAGACGAG 2520
AAGGAATATC ATGCTGAGGG AGGCAAGGTT CCTATTAAAT GGATGGCGTT GGAGTCAATT 2580
TTACATCGGA TTTACACTCA TCAAAGTGAT GTCTGGAGTT ATGGTGTGAC AGTTTGGGAG 2640
CTGATGACAT TTGGCTCCAA GCCGTATGAA GGGATTCCTG CCAGTGAGAT CTCCTCTGTC 2700
CTGGAGAAGG GCGAGCGTTT GCCGCAGCCC CCCATCTGTA CCATCGACGT GTACATGATC 2760
ATGGTCAAAT GCTGGATGAT CGATGCAGAC AGCCGTCCCA AGTTTCGTGA GCTGATAGCT 2820
GAATTCTCAA AAATGGCCCG TGACCCTCCA CGCTATCTTG TTATACAGGG AGATGATAGG 2880
ATGCACCTGC CCAGCCCTAC GGACTCCAAG TTTTATCGCA CTCTGATGGA GGAGGAGGAC 2940
ATGGAGGATA TAGTGGATGC AGATGAGTAC CTTGTGCCAC ACCAGGGCTT TTTCAACAGC 3000
CCTTCAACGT CTCGCACTCC TCTCTTGAGT TCATTGAGTG CTACCAGCAA CAACTCTGCT 3060
ACAACCTGCA TTGACAGGAA CGGGCAGGGG CACCCTGTGC GGGAAGACAG CTTTGTCCAG 3120
AGGTATAGCT CGGACCCAAC AGGCGCTTTC TTGGAGGACA GCTTAGATGA CAGCTTCCTA 3180
CCAGCCCCAG AGTATGTAAA CCAATTGGTG CCCAACAAAA CATCTGCCTC AGCAGTCCAG 3240
AATCCAATCT ACAACTTCTC TCACACAGCA AACTCAAAGG CCTCCACAGA TTCCAGCTAC 3300
CAGAATTCAC ACAGCACAGC TGTGGACAAC CCTGAGTATC TCAACACCAA CCAGTCTCCT 3360
CTGGCCAAGA CAGTCTTTGA GAGTTCTCCC TACTGGATCC AGGCAGGAAA CCACCAAATA 3420
AACCTGGACA ATCCTGACTA CCAGCAGGAC TTCTTACCGA AGGAAACCAA ATCTAATGGT 3480
CTCTTGAAAG TTCCCGCAGC AGAAAACCCA GAGTACTTGA GGGTAGCAGC ACCAAAAAGT 3540
GAATACATTG AAGCC 3555
Domain Profile
S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60
         +kk+kvlGsGafGtvykG+wipege+vkipvaik+l+e+t++kanke+ldea+v+as+d+
Q: 686   FKKVKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDN  745
         59**********************************************************
S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyleek  120
         ++++rllg+cl+st+ql+tql+p+Gclldy+rehkd++Gsq+llnwcvqiakGm+ylee+
Q: 746   PHVCRLLGICLTSTVQLITQLMPFGCLLDYIREHKDNIGSQYLLNWCVQIAKGMNYLEER  805
         ************************************************************
S: 121   rlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkrky  180
         rlvhrdlaarnvlvk+p+hvkitdfGlakll adeke++aeggkvpikw+alesil+r+y
Q: 806   RLVHRDLAARNVLVKTPQHVKITDFGLAKLLGADEKEYHAEGGKVPIKWMALESILHRIY  865
         ************************************************************
S: 181   thqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlvkcw  240
         thqsdvwsyGvtvwel+tfG+kpy+gipa+ei+++lekGerl+qppictidvym++vkcw
Q: 866   THQSDVWSYGVTVWELMTFGSKPYEGIPASEISSVLEKGERLPQPPICTIDVYMIMVKCW  925
         ************************************************************
S: 241   midaesrpkfkelaeefs  258
         mida+srpkf+el++efs
Q: 926   MIDADSRPKFRELIAEFS  943
         ****************96
Domain Sequence
(FASTA)
FKKVKVLGSG AFGTVYKGLW IPEGEKVKIP VAIKELREAT SPKANKEILD EAYVMASVDN 60
PHVCRLLGIC LTSTVQLITQ LMPFGCLLDY IREHKDNIGS QYLLNWCVQI AKGMNYLEER 120
RLVHRDLAAR NVLVKTPQHV KITDFGLAKL LGADEKEYHA EGGKVPIKWM ALESILHRIY 180
THQSDVWSYG VTVWELMTFG SKPYEGIPAS EISSVLEKGE RLPQPPICTI DVYMIMVKCW 240
MIDADSRPKF RELIAEFS 258
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00280
EKS-ANC-00290
EKS-BOT-00297
EKS-CAJ-00304
EKS-CAF-00304
EKS-CAP-00333
EKS-CII-00175
EKS-CIS-00072
EKS-DAR-00652
EKS-EQC-00289
EKS-FEC-00283
EKS-GAG-00251
EKS-GAA-00368
EKS-GOG-00295
EKS-HOS-00304
EKS-ICT-00280
EKS-LAC-00310
EKS-LOA-00308
EKS-MAM-00301
EKS-MEG-00239
EKS-MOD-00292
EKS-MUM-00329
EKS-MUP-00295
EKS-MYL-00300
EKS-NOL-00274
EKS-ORN-00388
EKS-ORA-00262
EKS-ORC-00280
EKS-ORL-00359
EKS-OTG-00304
EKS-PAT-00283
EKS-PES-00265
EKS-POA-00289
EKS-RAN-00314
EKS-SAH-00279
EKS-SUS-00262
EKS-TAR-00390
EKS-TEN-00385
EKS-XET-00371
EKS-XIM-00378
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0004716; F:receptor signaling protein tyrosine kinase activity
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0023014; P:signal transduction by phosphorylation
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR000494; EGF_rcpt_L.
IPR006211; Furin-like_Cys-rich_dom.
IPR006212; Furin_repeat.
IPR009030; Growth_fac_rcpt.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016245; Tyr_kinase_EGF/ERB/XmrK_rcpt.
Pfam
PF00757; Furin-like; 1.
PF07714; Pkinase_Tyr; 1.
PF01030; Recep_L_domain; 2.
SMARTs
SM00261; FU; 5.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013