EKS-TAG-00278

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAG-00278

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/PLK	379.6	6.6E-114	12	265	254

Status

Unreviewed

Ensembl Protein

ENSTGUP00000002148

UniProt Accession

H0YV27;

Protein Name

Protein Synonyms/Alias

Gene Name

PLK4

Gene Synonyms/Alias

PLK4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTGUG00000002083	ENSTGUP00000002148	ENSTGUT00000002168

Organism

Taeniopygia guttata

Functional Description

Protein Length

976

Protein Sequence
(FASTA)

MATCIGERIE DFKVGNLLGK GSFAGVYRAV SLKTGLEVAI KMIDKKAMHK VGMVQRVQNE 60

VKIHCQLKHP SILELYNYFE DSNYVYLILE ICHNGEMSRY IKNRKKPFSE DEARHFLHQI 120

ITGMLYLHSH GILHRDLTLS NILLTSNMNV KIADFGLATQ LKMPHEKHYT MCGTPNYISP 180

EIATRSPHGL ESDVWSLGCM FYTLLIGKPP FDTDTVRNTL NKVVLADYEM PAFLSREAQD 240

LIHKLLRKNP ADRLSLSSVL DHPFMSRGSS ARSRDLGTSE DSMDSGNATI STTFTGSSSI 300

STSGSLKEKK KLLVGQPLPN KITFFPTNKN SSNNSLGEGS GSFQQWGIQG KEVGVNGRGR 360

TTQPAEERPH SRYLRRAHSS DRSGTSHSQT QGISNIMDRC HSLEVLSKPK IGPRDNTEYF 420

SPANSYTDIG EIFKEKTSST SGSFEEQISP PVKDQPHSNY LCPVKPQVGL LEQKSQAETM 480

QQWLGSMQTN DPLGPPADLT GKSNAQGGFR YHLDVQQDAP RNAWNTLKDI RNHSASGDCP 540

HSLNQRNPKQ CIPGVLCKNE KIQPGLWLNS RMPCDLWSTP EQSQTCGQEP SAHQKPTLRS 600

VVSPLTAHRL KPIRQKTKNA VVSILDTGEV CMEFLKEHRS QELVKEVLRI SCDGYVIAVY 660

HPNEGRGFLL DDRPPPPPEG ICTYNFDNLP EKYWKKYQYA AKFVQLVRTK TPKVTFYTRY 720

AKCMLMENSP PADVEICFYD GAKIHKTAGI IRVIEKSGKS FTLKGESKAG LKKEIQAYMD 780

HANEGHRICL ALECAVLEEE KRSGSAPFFP IIVGRKPGST ESPQDLAPPL LDKTNYSKEV 840

VALDRNQAAS STPVQTPNCA PVVPCEKPTF LTNTVEKTCS SVLQTECSPN SAQLVKSVFV 900

KNVGWASQLT SGAVWVQFND GSQLVAQAGV SSITYTSPDG HTTRYGEDDK LPEYIKEKLH 960

CLSSILVMFT NPAGPH 976

Nucleotide Sequence
(FASTA)

ATGGCGACCT GCATCGGCGA GAGGATAGAG GATTTCAAGG TGGGGAACCT CCTAGGGAAG 60

GGCTCCTTCG CAGGAGTTTA CAGAGCAGTA TCCCTGAAAA CCGGCCTGGA AGTGGCCATC 120

AAAATGATAG ACAAAAAAGC CATGCACAAA GTTGGAATGG TACAGAGGGT TCAGAATGAG 180

GTGAAAATAC ATTGTCAGCT AAAGCATCCA TCTATACTTG AGCTTTATAA CTATTTTGAA 240

GATAGCAACT ACGTGTACTT GATACTTGAG ATATGTCACA ATGGCGAAAT GAGCAGATAC 300

ATAAAGAACC GAAAGAAACC CTTTTCAGAA GATGAAGCAC GACACTTCTT GCACCAGATT 360

ATCACGGGTA TGCTGTACCT CCATTCCCAC GGAATATTGC ACCGGGACCT CACCCTCTCC 420

AACATCTTAC TCACCAGTAA CATGAATGTC AAGATTGCTG ATTTTGGGTT GGCGACTCAG 480

CTGAAGATGC CTCATGAGAA GCATTACACC ATGTGTGGGA CTCCGAATTA CATTTCTCCG 540

GAGATAGCCA CGAGGAGCCC GCACGGGCTG GAGTCCGACG TGTGGTCTCT GGGCTGCATG 600

TTTTACACTC TTCTCATCGG CAAGCCGCCT TTTGACACGG ACACGGTCAG GAACACGCTG 660

AATAAAGTGG TGCTGGCAGA CTATGAAATG CCAGCCTTCT TGTCGAGAGA GGCGCAGGAC 720

CTCATTCACA AGCTACTGCG CAAAAACCCC GCAGATCGCT TGAGTCTTTC CTCAGTCTTG 780

GATCATCCTT TTATGTCCAG GGGTAGCTCT GCACGGAGCA GAGATCTGGG AACCTCAGAA 840

GATTCCATGG ACAGTGGAAA TGCCACCATC TCTACAACCT TCACAGGCTC TTCCAGCATC 900

AGTACCAGTG GTAGCTTGAA GGAAAAGAAG AAGCTGTTAG TTGGACAGCC ACTCCCAAAT 960

AAAATTACTT TTTTTCCTAC AAACAAGAAT TCCAGTAATA ATTCTCTGGG AGAGGGAAGT 1020

GGTTCTTTCC AACAGTGGGG AATTCAGGGA AAGGAAGTTG GAGTAAATGG CAGGGGAAGA 1080

ACCACGCAGC CTGCTGAGGA GAGGCCACAT TCCCGCTACC TCCGAAGAGC CCACTCCTCA 1140

GACAGGTCTG GCACATCCCA CAGCCAGACT CAAGGCATAT CCAACATCAT GGATCGATGT 1200

CACTCTTTAG AGGTGCTCTC CAAGCCTAAA ATAGGACCAA GGGACAACAC AGAATACTTT 1260

TCACCTGCCA ACAGCTATAC TGATATAGGA GAAATATTTA AGGAGAAGAC TTCTAGTACT 1320

TCTGGTTCTT TTGAAGAGCA GATATCGCCA CCTGTAAAAG ACCAACCACA TTCAAATTAT 1380

CTGTGCCCAG TGAAGCCCCA GGTTGGTTTG TTAGAGCAGA AGTCCCAGGC TGAGACAATG 1440

CAGCAGTGGC TTGGAAGTAT GCAGACGAAT GATCCTCTGG GACCACCTGC AGACCTGACT 1500

GGCAAGAGTA ATGCACAGGG AGGTTTTCGG TACCATCTGG ATGTGCAGCA GGATGCACCA 1560

AGGAATGCAT GGAACACCTT AAAGGATATA AGGAATCACA GTGCATCTGG TGACTGTCCA 1620

CATTCTTTAA ACCAGAGAAA CCCAAAGCAA TGCATCCCTG GAGTTCTCTG CAAAAACGAG 1680

AAAATTCAGC CTGGCCTCTG GCTGAACTCC AGAATGCCAT GTGACCTTTG GTCAACTCCA 1740

GAGCAAAGCC AAACTTGTGG CCAAGAACCA TCAGCACACC AGAAACCTAC ACTGCGAAGT 1800

GTTGTGTCAC CTCTCACTGC TCACAGGCTG AAACCCATCA GGCAAAAAAC CAAAAATGCA 1860

GTGGTGAGCA TTTTAGATAC CGGGGAAGTG TGTATGGAGT TTCTGAAAGA ACACCGCTCA 1920

CAGGAACTTG TGAAAGAAGT TCTCAGAATA TCTTGTGATG GATATGTGAT TGCAGTTTAT 1980

CATCCAAATG AAGGAAGAGG TTTCCTTCTT GATGACAGAC CTCCTCCTCC TCCTGAAGGC 2040

ATCTGCACGT ATAATTTTGA CAACTTGCCA GAAAAGTACT GGAAAAAATA CCAGTATGCA 2100

GCTAAGTTTG TGCAGTTGGT GAGAACAAAA ACCCCCAAAG TGACCTTTTA TACAAGATAT 2160

GCCAAGTGCA TGTTGATGGA AAATTCACCC CCTGCAGATG TTGAAATTTG TTTCTATGAT 2220

GGAGCAAAGA TCCATAAGAC AGCTGGTATA ATTCGTGTGA TTGAAAAGTC AGGGAAATCC 2280

TTCACTTTGA AAGGAGAAAG CAAAGCAGGG TTAAAGAAGG AAATCCAGGC TTATATGGAT 2340

CATGCAAATG AGGGACATCG TATATGCCTT GCGCTGGAAT GTGCTGTTTT GGAAGAAGAG 2400

AAAAGGAGTG GAAGTGCTCC ATTTTTTCCA ATAATTGTTG GAAGAAAACC TGGTAGTACT 2460

GAATCACCAC AGGATTTAGC ACCTCCACTG TTGGACAAGA CAAACTATTC AAAAGAAGTC 2520

GTGGCATTGG ATAGAAATCA AGCTGCCAGT TCTACTCCAG TTCAGACTCC AAACTGTGCT 2580

CCTGTGGTGC CCTGTGAAAA GCCTACGTTT CTGACTAACA CTGTTGAAAA GACCTGCTCC 2640

TCTGTTCTTC AAACAGAATG CAGTCCAAAT TCAGCCCAAC TTGTCAAATC TGTTTTTGTG 2700

AAAAATGTTG GTTGGGCTTC TCAGCTGACC AGTGGAGCAG TATGGGTTCA GTTCAATGAT 2760

GGATCCCAGC TGGTAGCCCA GGCAGGTGTC TCTTCCATCA CTTACACTTC TCCAGATGGC 2820

CACACAACCA GGTATGGAGA AGATGATAAG TTGCCAGAAT ACATCAAAGA GAAGCTGCAC 2880

TGTCTGTCTT CTATTCTCGT AATGTTTACC AATCCAGCTG GTCCTCAC 2928

Domain Profile

S: 1     yergkllGkGgfakcyelkdletkevfavkvvpksllakekqrekvekeieihrslkhkn  60

         +++g+llGkG+fa +y++ +l+t+ ++a+k+++k++++k  + ++v++e++ih++lkh++

Q: 12    FKVGNLLGKGSFAGVYRAVSLKTGLEVAIKMIDKKAMHKVGMVQRVQNEVKIHCQLKHPS  71

         6899********************************************************

S: 61    ivklyeffedkenvylvlelcsrrslaellkrr.kaltepevryylrqivsglkylhekr  119

         i++ly++fed+++vyl+le+c+++++ +++k+r k+++e e+r++l+qi++g++ylh++

Q: 72    ILELYNYFEDSNYVYLILEICHNGEMSRYIKNRkKPFSEDEARHFLHQIITGMLYLHSHG  131

         *******************************99899************************

S: 120   ilhrdlklgnlflneelevkigdfGlatrlekeeerkktlcGtPnyiaPevlskkghsle  179

         ilhrdl+l+n++l+++++vki+dfGlat+l++++e+++t+cGtPnyi+Pe+++++ h+le

Q: 132   ILHRDLTLSNILLTSNMNVKIADFGLATQLKMPHEKHYTMCGTPNYISPEIATRSPHGLE  191

         ************************************************************

S: 180   vdiWslGcilytllvGkPPfetkelketyekikkaeyslPsslskeaksliakllkkePe  239

         +d+WslGc++ytll+GkPPf+t+++++t++k++ a+y++P+ ls+ea++li+kll+k+P+

Q: 192   SDVWSLGCMFYTLLIGKPPFDTDTVRNTLNKVVLADYEMPAFLSREAQDLIHKLLRKNPA  251

         ************************************************************

S: 240   erpsleevlkdefl  253

         +r+sl++vl+++f+

Q: 252   DRLSLSSVLDHPFM  265

         ************98

Domain Sequence
(FASTA)

FKVGNLLGKG SFAGVYRAVS LKTGLEVAIK MIDKKAMHKV GMVQRVQNEV KIHCQLKHPS 60

ILELYNYFED SNYVYLILEI CHNGEMSRYI KNRKKPFSED EARHFLHQII TGMLYLHSHG 120

ILHRDLTLSN ILLTSNMNVK IADFGLATQL KMPHEKHYTM CGTPNYISPE IATRSPHGLE 180

SDVWSLGCMF YTLLIGKPPF DTDTVRNTLN KVVLADYEMP AFLSREAQDL IHKLLRKNPA 240

DRLSLSSVLD HPFM 254

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005814	; C:centriole
GO:0005730	; C:nucleolus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0004713	; F:protein tyrosine kinase activity
GO:0007099	; P:centriole replication
GO:0046601	; P:positive regulation of centriole replication

KEGG

tgu:100231569

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000959	; POLO_box_duplicated_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008266	; Tyr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00659	; POLO_box; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50078	; POLO_BOX; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

Created Date

20-Feb-2013