EKS-TAG-00276

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAG-00276

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/PLK	429.0	5.7E-129	13	265	253

Status

Unreviewed

Ensembl Protein

ENSTGUP00000002695

UniProt Accession

H0YWM2;

Protein Name

Protein Synonyms/Alias

Gene Name

PLK2

Gene Synonyms/Alias

PLK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTGUG00000002609	ENSTGUP00000002695	ENSTGUT00000002723

Organism

Taeniopygia guttata

Functional Description

Protein Length

614

Protein Sequence
(FASTA)

SRIITDPTTG KRYCRGKVLG KGGFAKCYEM TDLTTNKVYA AKIIPHSRVA KPHQREKIDK 60

EIELHRMLNH RHVVQFYHYF EDRENIYILL EYCSRRSMAH ILKARKVLTE PEVRYYLRQI 120

VSGLKYLHEQ EILHRDLKLG NFFINENMEL KLGDFGLAAR LEPLEHRRRT ICGTPNYLSP 180

EVLNKQGHGC ESDIWALGCV MYTMLLGRPP FETTNLKETY RCIREARYSL PSSLLAPAKH 240

LIASMLSKNP EDRPSLDEII QHEFFLQGFT PDRLSASCCH TVPDFHLSSP AKNFFKKAAA 300

ALFGGKKDKA RYLDTHNRLA KEDEEIYKLR HDLKKTSITQ QAPKHKTDEE IQPLITTVVK 360

PGALPEAKQI GDSIRMIVRG TLGSCSSSSE CLEDSTMGSV ADTVARVLRG CLENMPEADS 420

NPKEQLTASF QWVTKWVDYS NKYGFGYQLS DHTVGVLFNN GAHMSLLPDK KTVHYYAELG 480

QCSVFSATEA PEQFINQVTV LKYFSHYMEE NLMDGGDLPS LTDVRRPRLY LLQWLKSDKA 540

LMMLFNDGTF QVNFYHDHTK VIICNQSEEY LLTYINEDRI STTFRLTTLL VSGCSLELKY 600

RMEYALNMLL QRCN 614

Nucleotide Sequence
(FASTA)

TCCCGGATTA TTACCGACCC CACGACGGGG AAGCGTTACT GCCGCGGCAA GGTGCTCGGA 60

AAGGGTGGAT TTGCCAAGTG TTATGAGATG ACAGACTTGA CAACAAATAA AGTTTATGCT 120

GCGAAAATCA TTCCTCACAG CAGAGTAGCA AAACCTCATC AAAGGGAGAA GATTGATAAA 180

GAGATTGAGC TGCACAGAAT GCTTAATCAT AGACATGTTG TGCAGTTTTA CCACTACTTT 240

GAAGATAGAG AGAATATTTA CATTCTTCTG GAATACTGCA GCAGAAGGTC AATGGCTCAC 300

ATCTTAAAAG CGAGGAAGGT ATTAACAGAA CCAGAAGTAC GATACTACCT CAGGCAAATT 360

GTGTCAGGGC TAAAGTATCT TCATGAACAG GAAATCTTAC ACAGGGATCT TAAACTAGGT 420

AACTTTTTTA TCAATGAGAA CATGGAACTG AAGCTTGGTG ACTTTGGCTT GGCAGCTAGG 480

CTGGAACCAC TGGAACACAG AAGGAGAACA ATATGTGGCA CACCAAATTA CCTCTCTCCA 540

GAAGTCCTCA ACAAACAAGG GCATGGCTGT GAATCTGATA TATGGGCCTT AGGCTGTGTA 600

ATGTATACAA TGCTGTTGGG AAGACCCCCG TTTGAGACTA CAAATCTTAA AGAAACATAC 660

AGATGTATAA GGGAAGCAAG ATACAGTCTG CCTTCATCTC TCTTGGCACC TGCAAAACAC 720

TTAATAGCTA GCATGTTGTC AAAAAACCCT GAGGATCGAC CCAGTTTAGA TGAAATAATT 780

CAACATGAAT TCTTCTTACA GGGTTTTACA CCTGATAGAC TGTCTGCAAG CTGTTGTCAC 840

ACTGTCCCTG ATTTCCATTT GTCAAGTCCT GCTAAAAATT TCTTCAAAAA AGCAGCTGCT 900

GCTCTCTTTG GGGGAAAAAA GGATAAGGCC AGATACTTGG ACACACATAA CAGGCTAGCT 960

AAAGAAGATG AAGAAATCTA CAAGCTCAGA CATGATTTGA AGAAGACATC GATAACCCAG 1020

CAGGCCCCCA AACACAAGAC AGATGAGGAG ATTCAGCCTC TTATCACAAC AGTGGTGAAG 1080

CCTGGAGCAT TGCCAGAAGC TAAGCAGATT GGAGACTCCA TTCGGATGAT AGTCAGAGGA 1140

ACTTTGGGAA GCTGTAGCAG TAGCAGTGAA TGTTTGGAAG ACAGTACTAT GGGAAGCGTT 1200

GCCGATACAG TTGCAAGAGT CTTGAGGGGA TGTCTGGAGA ACATGCCAGA AGCAGACAGC 1260

AATCCCAAAG AACAGCTGAC AGCATCCTTC CAGTGGGTTA CAAAATGGGT GGACTACTCC 1320

AACAAGTATG GCTTTGGGTA CCAGCTGTCA GATCACACTG TTGGTGTCCT CTTCAACAAT 1380

GGGGCACATA TGAGCCTTCT GCCAGACAAA AAGACAGTGC ATTACTATGC TGAGCTAGGC 1440

CAGTGCTCTG TCTTCTCAGC CACAGAGGCC CCTGAACAGT TCATTAACCA AGTAACTGTG 1500

CTGAAGTATT TCTCTCACTA TATGGAGGAG AACCTTATGG ATGGAGGAGA CTTGCCCAGC 1560

CTAACAGATG TACGCAGGCC CAGGCTTTAC CTCTTACAGT GGCTCAAATC TGATAAAGCA 1620

TTAATGATGC TCTTCAATGA TGGCACTTTT CAAGTGAACT TCTACCATGA TCACACAAAA 1680

GTCATAATTT GCAATCAGAG TGAGGAATAT CTCCTTACCT ACATAAATGA AGACAGGATA 1740

TCCACAACGT TTCGTCTGAC AACTCTTCTG GTTTCGGGAT GTTCATTGGA ACTAAAATAC 1800

AGAATGGAAT ATGCTCTGAA CATGCTGCTG CAGCGATGTA ACTGA 1845

Domain Profile

S: 1     yergkllGkGgfakcyelkdletkevfavkvvpksllakekqrekvekeieihrslkhkn  60

         y+rgk+lGkGgfakcye++dl+t++v+a+k++p+s++ak++qrek++keie+hr l+h++

Q: 13    YCRGKVLGKGGFAKCYEMTDLTTNKVYAAKIIPHSRVAKPHQREKIDKEIELHRMLNHRH  72

         99**********************************************************

S: 61    ivklyeffedkenvylvlelcsrrslaellkrrkaltepevryylrqivsglkylhekri  120

         +v++y++fed+en+y++le+csrrs+a++lk+rk+ltepevryylrqivsglkylhe++i

Q: 73    VVQFYHYFEDRENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQEI  132

         ************************************************************

S: 121   lhrdlklgnlflneelevkigdfGlatrlekeeerkktlcGtPnyiaPevlskkghslev  180

         lhrdlklgn+f+ne++e+k+gdfGla+rle+ e+r++t+cGtPny++Pevl+k+gh++e+

Q: 133   LHRDLKLGNFFINENMELKLGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNKQGHGCES  192

         ************************************************************

S: 181   diWslGcilytllvGkPPfetkelketyekikkaeyslPsslskeaksliakllkkePee  240

         diW+lGc++yt+l+G+PPfet++lkety++i++a+yslPssl ++ak+lia++l+k+Pe+

Q: 193   DIWALGCVMYTMLLGRPPFETTNLKETYRCIREARYSLPSSLLAPAKHLIASMLSKNPED  252

         ************************************************************

S: 241   rpsleevlkdefl  253

         rpsl+e++++ef+

Q: 253   RPSLDEIIQHEFF  265

         ************8

Domain Sequence
(FASTA)

YCRGKVLGKG GFAKCYEMTD LTTNKVYAAK IIPHSRVAKP HQREKIDKEI ELHRMLNHRH 60

VVQFYHYFED RENIYILLEY CSRRSMAHIL KARKVLTEPE VRYYLRQIVS GLKYLHEQEI 120

LHRDLKLGNF FINENMELKL GDFGLAARLE PLEHRRRTIC GTPNYLSPEV LNKQGHGCES 180

DIWALGCVMY TMLLGRPPFE TTNLKETYRC IREARYSLPS SLLAPAKHLI ASMLSKNPED 240

RPSLDEIIQH EFF 253

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005814	; C:centriole
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0004871	; F:signal transducer activity
GO:0000082	; P:G1/S transition of mitotic cell cycle
GO:0007093	; P:mitotic cell cycle checkpoint
GO:0007052	; P:mitotic spindle organization
GO:0043066	; P:negative regulation of apoptotic process
GO:0043123	; P:positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0046599	; P:regulation of centriole replication
GO:0048167	; P:regulation of synaptic plasticity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000959	; POLO_box_duplicated_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00659	; POLO_box; 2.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50078	; POLO_BOX; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013