EKS-TAG-00525

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAG-00525

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	416.5	4.4E-125	26	321	296

Status

Unreviewed

Ensembl Protein

ENSTGUP00000002837

UniProt Accession

H0YX11;

Protein Name

Protein Synonyms/Alias

Gene Name

MAPK10

Gene Synonyms/Alias

MAPK10;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTGUG00000002750	ENSTGUP00000002837	ENSTGUT00000002866

Organism

Taeniopygia guttata

Functional Description

Protein Length

426

Protein Sequence
(FASTA)

MSKSKVDNQF YSVEVGDSTF TVLKRYQNLK PIGSGAQGIV CAAYDAVLDR NVAIKKLSRP 60

FQNQTHAKRA YRELVLMKCV NHKNIISLLN VFTPQKSLEE FQDVYLVMEL MDANLCQVIQ 120

MELDHERMSY LLYQMLCGIK HLHSAGIIHR DLKPSNIVVK SDCTLKILDF GLARTAGTSF 180

MMTPYVVTRY YRAPEVILGM GYKENVDMWS VGCIMGEMIK GAVLFPGTDH IDQWNKVIEQ 240

LGTPCPEFMK KLQPTVRNYV ENRPKYAGLT FPKLFPDSLF PADSEHNKLK ASQARDLLSK 300

MLVIDPAKRI SVDEALQHPY INVWYDPAEV EAPPPQIYDK QLDEREHTIE EWKELIYKEV 360

MNSEEKTKNG VVKGQPSPSG AAVNSSESLP PSSSVNDISS MSTDQTLASD TDSSLEASAG 420

PLGCCR 426

Nucleotide Sequence
(FASTA)

ATGAGCAAAA GCAAAGTCGA CAACCAGTTC TACAGTGTGG AAGTAGGTGA CTCGACCTTC 60

ACAGTCCTCA AACGCTACCA GAACTTGAAA CCTATTGGCT CTGGGGCTCA GGGAATAGTT 120

TGTGCTGCAT ATGATGCCGT CCTTGACAGA AATGTGGCCA TTAAGAAGCT CAGCAGACCA 180

TTTCAGAACC AAACTCACGC CAAGAGAGCT TACAGGGAGC TGGTCCTCAT GAAGTGTGTG 240

AATCATAAAA ATATTATAAG TTTATTAAAT GTCTTCACAC CACAGAAATC TCTGGAGGAG 300

TTCCAGGATG TCTACCTAGT AATGGAATTA ATGGATGCCA ACCTGTGCCA GGTCATTCAG 360

ATGGAGCTGG ACCATGAGCG AATGTCTTAC CTTCTGTACC AAATGCTCTG TGGAATCAAG 420

CATCTTCACT CTGCAGGGAT TATTCACAGG GATTTAAAAC CAAGTAACAT TGTAGTAAAA 480

TCTGACTGCA CGTTGAAGAT TCTGGATTTT GGACTGGCCA GGACTGCAGG CACTAGCTTC 540

ATGATGACCC CCTATGTGGT GACACGCTAC TACAGAGCAC CAGAGGTCAT CCTGGGAATG 600

GGTTACAAGG AGAACGTTGA CATGTGGTCA GTAGGGTGCA TCATGGGAGA AATGATTAAA 660

GGTGCTGTGT TGTTTCCTGG CACTGATCAT ATTGATCAGT GGAATAAAGT TATTGAGCAG 720

CTGGGAACAC CCTGTCCAGA ATTCATGAAG AAGCTGCAGC CAACAGTACG GAACTATGTT 780

GAGAACAGAC CCAAGTATGC TGGCCTCACT TTCCCCAAAC TTTTTCCAGA CTCTCTCTTC 840

CCAGCAGACT CGGAACACAA CAAACTCAAA GCCAGCCAAG CCAGGGACCT CTTATCAAAG 900

ATGCTGGTCA TTGATCCGGC CAAGAGGATA TCAGTAGATG AAGCCTTACA GCATCCATAC 960

ATTAATGTCT GGTACGACCC AGCAGAGGTG GAGGCGCCTC CTCCTCAGAT ATATGATAAA 1020

CAGCTGGATG AAAGGGAACA TACAATTGAG GAATGGAAAG AACTCATCTA CAAAGAAGTA 1080

ATGAATTCTG AAGAAAAGAC TAAAAATGGA GTAGTAAAAG GACAGCCTTC TCCTTCAGGT 1140

GCAGCAGTGA ACAGCAGTGA GAGCCTCCCT CCATCCTCAT CTGTCAACGA CATCTCATCC 1200

ATGTCCACGG ATCAAACCCT GGCGTCTGAC ACGGACAGCA GCCTGGAAGC TTCTGCGGGA 1260

CCCCTCGGTT GTTGCAGG 1278

Domain Profile

S: 1     yeslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNi  60

         y++lkp+g+Ga+g+v++a+d+  +++vaikklsrpfq++t+akr++REl l+k+++h+Ni

Q: 26    YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNI  85

         899*********************************************************

S: 61    iklldvftpeeeleelkdvYlvtelmetdLkkviksqklsdehiklllyqilrglkylHs  120

         i+ll+vftp+++lee++dvYlv+elm+++L++vi+++ l++e++++llyq+l+g+k+lHs

Q: 86    ISLLNVFTPQKSLEEFQDVYLVMELMDANLCQVIQME-LDHERMSYLLYQMLCGIKHLHS  144

         ************************************9.**********************

S: 121   anviHrDlKPsNllvnedcelkildFGlarsadkekekklteyvatrwYraPeillslke  180

         a++iHrDlKPsN++v++dc+lkildFGlar+a ++ +  +t+yv+tr+YraPe++l  +

Q: 145   AGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFM--MTPYVVTRYYRAPEVILG-MG  201

         **********************************976..*****************9.99

S: 181   ytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkieseearnyi  240

         y+++vD+WsvGCI++E+++g +lfpg+d+idq++k++e+lgtp  ef+kk++  ++rny+

Q: 202   YKENVDMWSVGCIMGEMIKGAVLFPGTDHIDQWNKVIEQLGTPCPEFMKKLQP-TVRNYV  260

         *****************************************************.5*****

S: 241   kslpkkkkkdfeelfpk............aseealdLleklLvldpdkRisveeaLehpY  288

         +++pk++  +f +lfp+            + ++a+dLl+k+Lv+dp kRisv+eaL+hpY

Q: 261   ENRPKYAGLTFPKLFPDslfpadsehnklKASQARDLLSKMLVIDPAKRISVDEALQHPY  320

         *****************************99*****************************

S: 289   l  289

Q: 321   I  321

Domain Sequence
(FASTA)

YQNLKPIGSG AQGIVCAAYD AVLDRNVAIK KLSRPFQNQT HAKRAYRELV LMKCVNHKNI 60

ISLLNVFTPQ KSLEEFQDVY LVMELMDANL CQVIQMELDH ERMSYLLYQM LCGIKHLHSA 120

GIIHRDLKPS NIVVKSDCTL KILDFGLART AGTSFMMTPY VVTRYYRAPE VILGMGYKEN 180

VDMWSVGCIM GEMIKGAVLF PGTDHIDQWN KVIEQLGTPC PEFMKKLQPT VRNYVENRPK 240

YAGLTFPKLF PDSLFPADSE HNKLKASQAR DLLSKMLVID PAKRISVDEA LQHPYI 296

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005739	; C:mitochondrion
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity
GO:0000165	; P:MAPK cascade

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR003527	; MAP_kinase_CS.
IPR008351	; MAPK_JNK.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS01351	; MAPK; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR01772

; JNKMAPKINASE.

Created Date

20-Feb-2013