EKS-TAG-00186

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAG-00186

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/TLK	623.8	2.8E-188	407	686	280

Status

Unreviewed

Ensembl Protein

ENSTGUP00000003201

UniProt Accession

H0YY24;

Protein Name

Protein Synonyms/Alias

Gene Name

TLK2

Gene Synonyms/Alias

TLK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTGUG00000003073	ENSTGUP00000003201	ENSTGUT00000003233

Organism

Taeniopygia guttata

Functional Description

Protein Length

696

Protein Sequence
(FASTA)

MEELHSLDPR RQELLEARFT GVGVAKVIST WIIFLCKQIL CHFESSNQSL CSVGSLSDKE 60

LETPEKKQND QRNRKRKAEA YETSQGKGTP RGHKISDYFE FAGGSGPGTS PGRSVPPVAR 120

SSPQHSLSNP LPVSAQQGSP SSTGSGNTEH SCTSQKQISF QHKQSQSDLT MEKISALENS 180

KNSDLEKKEG RIDDLLRANC DLRRQIDEQQ KMLEKYKERL NRCVTMSKKL LIEKSKQEKM 240

ACRDKSMQDR LRLGHFTTVR HGASFTEQWT DGYAFQNLIK QQERINSQRE EIERQRKMLA 300

KRKPPAMGQT PPASTEQKQR KNKTNGAENE TFKVFLSFSC RLTLAEYHEQ EEIFKLRLGH 360

LKKEEAEIQA ELERLERVRN LHIRELKRIH NEDNSQFKDH PTLNDRYLLL HLLGRGGFSE 420

VYKAFDLTEQ RYVAVKIHQL NKNWRDEKKE NYHKHACREY RIHKELDHPR IVKLYDYFSL 480

DTDSFCTVLE YCEGNDLDFY LKQHKLMSEK EARSIIMQIV NALKYLNEIK PPIIHYDLKP 540

GNILLVNGTA CGEIKITDFG LSKIMDDDSY NSVDGMELTS QGAGTYWYLP PECFVVGKEP 600

PKISNKVDVW SVGVIFYQCL YGRKPFGHNQ SQQDILQENT ILKATEVQFP PKPVVTPEAK 660

AFIRRCLAYR KEDRIDVQQL ACDPYLLPHI RKSVST 696

Nucleotide Sequence
(FASTA)

ATGGAAGAAT TGCATAGCCT GGACCCACGC AGGCAGGAGC TCCTGGAGGC CAGGTTCACT 60

GGGGTTGGGG TTGCCAAGGT GATTTCTACA TGGATAATTT TTCTTTGCAA ACAAATTCTG 120

TGTCACTTTG AGTCTTCCAA CCAGAGCTTG TGCAGCGTGG GCTCTCTGAG TGATAAAGAA 180

TTGGAGACTC CTGAGAAAAA GCAGAATGAC CAGCGGAATA GGAAGAGAAA AGCAGAAGCC 240

TACGAGACCA GTCAAGGGAA AGGCACTCCT AGAGGGCATA AAATTAGTGA TTATTTTGAG 300

TTTGCTGGGG GCAGTGGCCC AGGAACCAGT CCCGGTAGAA GCGTGCCACC CGTCGCCAGA 360

TCCTCTCCGC AGCATTCCCT GTCCAACCCC TTGCCGGTGA GTGCCCAGCA AGGCAGCCCA 420

TCTTCTACCG GATCAGGGAA CACTGAGCAT TCCTGCACCT CCCAAAAACA GATTTCCTTC 480

CAGCACAAAC AGTCACAGTC TGACCTCACA ATGGAAAAAA TATCTGCACT AGAAAACAGT 540

AAGAACTCTG ACTTGGAGAA GAAGGAGGGG AGGATAGATG ACTTATTAAG AGCCAACTGT 600

GATTTGAGAC GGCAGATAGA CGAGCAGCAA AAGATGCTGG AGAAGTACAA GGAGCGGTTG 660

AATCGATGTG TAACGATGAG CAAGAAGCTT CTTATAGAAA AGTCAAAGCA GGAGAAGATG 720

GCATGCCGAG ATAAGAGCAT GCAGGATCGC TTGAGGCTGG GGCACTTCAC CACGGTGCGG 780

CACGGCGCAT CCTTCACCGA GCAGTGGACA GATGGTTATG CCTTCCAGAA CCTCATCAAG 840

CAACAGGAAA GGATAAATTC CCAGCGGGAA GAAATAGAAA GACAACGAAA AATGTTAGCA 900

AAGCGGAAGC CACCCGCAAT GGGCCAGACC CCTCCAGCAA GCACAGAGCA GAAACAACGC 960

AAGAACAAGA CCAATGGAGC AGAAAATGAA ACGTTTAAGG TTTTTCTTTC TTTTTCATGC 1020

AGGTTAACAT TAGCAGAATA CCATGAACAG GAGGAAATCT TCAAACTCCG ACTAGGTCAT 1080

CTTAAAAAGG AAGAAGCTGA GATCCAGGCA GAGCTGGAAC GGCTAGAGAG GGTTAGAAAT 1140

CTGCACATCA GGGAATTGAA AAGGATACAC AATGAAGATA ATTCACAATT TAAAGACCAT 1200

CCAACGCTAA ATGATAGATA TTTGTTGCTA CATCTTCTGG GTAGAGGTGG CTTCAGTGAA 1260

GTATATAAGG CATTTGATTT AACAGAACAG AGATATGTAG CTGTGAAAAT ACACCAGTTA 1320

AATAAAAACT GGAGGGATGA GAAGAAAGAA AACTATCACA AACATGCATG TAGAGAGTAC 1380

AGAATTCACA AAGAACTGGA TCACCCTCGA ATAGTTAAAC TATACGATTA CTTCTCACTG 1440

GATACTGACT CGTTTTGTAC AGTGTTAGAA TACTGTGAGG GGAATGATCT GGACTTCTAC 1500

CTGAAACAGC ACAAGCTAAT GTCAGAGAAA GAGGCACGAT CCATTATCAT GCAAATTGTG 1560

AATGCTTTAA AATACTTAAA TGAAATCAAA CCTCCCATCA TACACTATGA CCTTAAACCA 1620

GGTAACATTC TTCTAGTCAA TGGTACTGCA TGTGGAGAGA TAAAAATCAC AGATTTTGGA 1680

CTTTCCAAAA TTATGGATGA TGATAGCTAC AACTCAGTTG ATGGCATGGA GCTGACATCG 1740

CAGGGGGCTG GTACTTACTG GTATTTGCCA CCAGAATGTT TTGTGGTTGG GAAAGAACCT 1800

CCAAAGATTT CAAATAAAGT TGATGTCTGG TCAGTGGGAG TCATCTTCTA TCAGTGTCTG 1860

TATGGCAGAA AGCCCTTCGG CCACAACCAG TCACAACAGG ATATTTTGCA GGAGAACACA 1920

ATTCTGAAAG CTACTGAGGT GCAGTTCCCT CCAAAGCCAG TAGTCACACC AGAAGCAAAG 1980

GCGTTCATCA GGCGGTGTCT GGCCTATCGA AAGGAGGACC GGATAGATGT CCAGCAGCTG 2040

GCCTGTGACC CCTACTTGCT GCCTCACATC CGCAAATCTG TATCCACA 2088

Domain Profile

S: 1     ylllkllgkggfsevykafdlkeqryvavkihqlnkdwkdekkenyvkhalreyrihkel  60

         ylll+llg+ggfsevykafdl+eqryvavkihqlnk+w+dekkeny+kha+reyrihkel

Q: 407   YLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKEL  466

         9***********************************************************

S: 61    dhprivklydllsldtdsfctvleyvegndldfylkqhkllsekearsiimqivsalkyl  120

         dhprivklyd++sldtdsfctvley+egndldfylkqhkl+sekearsiimqiv+alkyl

Q: 467   DHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYL  526

         ************************************************************

S: 121   neikppiihydlkpgnillvegtacgeikitdfglskimdddsydsddgleltsqgagty  180

         neikppiihydlkpgnillv+gtacgeikitdfglskimdddsy+s+dg+eltsqgagty

Q: 527   NEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTY  586

         ************************************************************

S: 181   wylppecfvvgkeppkisnkvdvwsvgvifyqclygkkpfghnqsqqdileentilkate  240

         wylppecfvvgkeppkisnkvdvwsvgvifyqclyg+kpfghnqsqqdil+entilkate

Q: 587   WYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATE  646

         ************************************************************

S: 241   vqfpskpvvsseakafirrclayrkedridvqqlakdeyl  280

         vqfp+kpvv++eakafirrclayrkedridvqqla+d+yl

Q: 647   VQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYL  686

         **************************************97

Domain Sequence
(FASTA)

YLLLHLLGRG GFSEVYKAFD LTEQRYVAVK IHQLNKNWRD EKKENYHKHA CREYRIHKEL 60

DHPRIVKLYD YFSLDTDSFC TVLEYCEGND LDFYLKQHKL MSEKEARSII MQIVNALKYL 120

NEIKPPIIHY DLKPGNILLV NGTACGEIKI TDFGLSKIMD DDSYNSVDGM ELTSQGAGTY 180

WYLPPECFVV GKEPPKISNK VDVWSVGVIF YQCLYGRKPF GHNQSQQDIL QENTILKATE 240

VQFPPKPVVT PEAKAFIRRC LAYRKEDRID VQQLACDPYL 280

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005882	; C:intermediate filament
GO:0005634	; C:nucleus
GO:0048471	; C:perinuclear region of cytoplasm
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0035556	; P:intracellular signal transduction
GO:0001672	; P:regulation of chromatin assembly or disassembly

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013