EKS-TAG-00289

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAG-00289

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	458.2	9.2E-138	179	466	288

Status

Unreviewed

Ensembl Protein

ENSTGUP00000003361

UniProt Accession

H0YYI3;

Protein Name

Protein Synonyms/Alias

Gene Name

ACVR1B

Gene Synonyms/Alias

ACVR1B;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTGUG00000003248	ENSTGUP00000003361	ENSTGUT00000003395

Organism

Taeniopygia guttata

Functional Description

Protein Length

477

Protein Sequence
(FASTA)

ISALTCLCSD CKQANSTCET DGACMVSVFN LDGVKHHVRT CIPEAKLIPA GKPFYCLSSE 60

DLRNTHCCYS DFCNKIDLMV PSGHLKDNEP PSSWGPVELV AVIAGPVFLV FVVMIIVVFV 120

FHHHQRVYHN RQRLDMEDPS CEMCLSKDKT LQDLVYDLST SGSGSGLPLF VQRTVARTIV 180

LQEIIGKGRF GEVWRGRWRG GDVAVKIFSS REERSWFREA EIYQTVMLRH ENILGFIAAD 240

NKDNGTWTQL WLVSDYHEHG SLFDYLNRYT VTIEGMIKLA LSAASGLAHL HMEIVGTQGK 300

PGIAHRDLKS KNILVKKNGT CAIADLGLAV RHDSVTDTID IAPNQRVGTK RYMAPEVLDE 360

TINMKHFDSF KCADIYALGL VYWEIARRCN AGGIHEEYQL PYYDLVPSDP SIEEMRKVVC 420

DQKLRPNIPN WWQSYEALRV MGKMMRECWY ANGAARLTAL RIKKTLSQLS VQEDVKI 477

Nucleotide Sequence
(FASTA)

ATTTCAGCTT TGACATGCCT GTGCTCTGAC TGCAAACAAG CCAACTCCAC GTGTGAGACG 60

GACGGTGCCT GCATGGTCTC AGTATTCAAC CTGGATGGTG TCAAACACCA CGTTCGGACC 120

TGCATTCCTG AGGCAAAATT GATTCCTGCT GGGAAACCCT TCTATTGTCT GAGTTCAGAG 180

GATCTGCGTA ATACTCACTG CTGCTACTCC GATTTTTGCA ACAAAATTGA TTTAATGGTT 240

CCCAGTGGCC ACCTGAAAGA CAACGAGCCC CCGTCAAGCT GGGGTCCCGT GGAGCTGGTG 300

GCGGTGATTG CCGGGCCCGT GTTCCTCGTG TTTGTTGTCA TGATCATCGT GGTCTTCGTG 360

TTCCATCACC ACCAACGGGT CTATCACAAC CGCCAGCGGC TGGACATGGA AGATCCTTCT 420

TGTGAAATGT GCCTTTCCAA GGACAAGACC TTGCAGGATC TGGTCTATGA TCTCTCCACC 480

TCCGGCTCTG GCTCAGGCTT GCCTCTGTTT GTCCAGCGGA CCGTGGCTCG GACAATTGTC 540

CTTCAGGAGA TCATCGGCAA AGGCCGCTTC GGGGAGGTGT GGCGGGGCAG GTGGCGTGGA 600

GGTGACGTGG CTGTGAAGAT CTTCTCGTCT CGTGAGGAGC GTTCCTGGTT CAGGGAGGCA 660

GAGATCTACC AAACCGTGAT GCTGCGGCAC GAGAACATCC TGGGATTCAT TGCTGCAGAT 720

AACAAAGATA ATGGGACATG GACTCAGCTG TGGCTCGTCT CTGACTACCA CGAGCACGGG 780

TCTCTCTTTG ACTACCTGAA TCGCTACACG GTGACTATCG AGGGCATGAT CAAGCTCGCC 840

CTGTCTGCTG CCAGCGGGCT GGCCCACCTG CATATGGAGA TCGTGGGCAC TCAGGGAAAA 900

CCTGGGATCG CTCACAGAGA CCTGAAATCC AAGAATATTT TGGTGAAGAA GAACGGCACG 960

TGTGCCATCG CTGACCTCGG CCTGGCCGTC CGGCACGACT CCGTCACAGA CACGATCGAC 1020

ATCGCACCGA ACCAAAGGGT TGGAACCAAA CGATACATGG CCCCAGAAGT CTTGGATGAA 1080

ACCATCAACA TGAAGCATTT TGATTCGTTT AAATGTGCTG ATATCTACGC CCTGGGCTTG 1140

GTCTACTGGG AGATTGCCCG AAGGTGCAAC GCAGGAGGTA TCCATGAGGA GTATCAGCTT 1200

CCCTACTATG ACCTTGTACC CTCTGATCCT TCAATTGAGG AGATGCGGAA GGTTGTGTGT 1260

GACCAGAAAT TACGGCCAAA CATCCCAAAC TGGTGGCAGA GCTACGAGGC ACTACGGGTG 1320

ATGGGCAAGA TGATGCGAGA GTGCTGGTAC GCCAACGGAG CAGCTCGGCT CACTGCCCTC 1380

CGCATTAAGA AAACCCTCTC CCAGCTCAGC GTCCAGGAAG ATGTGAAAAT TTAG 1434

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         + l+e+igkGr+geVw++++rg +vAvKifs+++e+sw+rE+eiyqtv+lrhenil+fia

Q: 179   IVLQEIIGKGRFGEVWRGRWRGGDVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIA  238

         5789********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         ad+k+++++t+l+lv++yhe+gsL+dyL+r+t+++e +++lals+asGlahLH+eivgt+

Q: 239   ADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTIEGMIKLALSAASGLAHLHMEIVGTQ  298

         ************************************************************

S: 121   gkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaPE  180

         g  Kp iaHRDlkskNilvkk++tc+iaDlGLa+++++ ++++d+a n++vGtkRYmaPE

Q: 299   G--KPGIAHRDLKSKNILVKKNGTCAIADLGLAVRHDSVTDTIDIAPNQRVGTKRYMAPE  356

         *..*********************************************************

S: 181   vleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPsleem  240

         vl+e++n+k+f++fk+aD+Y+lgLv+WE+a+Rc++ ++++eey+lp+++ v+sdPs+eem

Q: 357   VLDETINMKHFDSFKCADIYALGLVYWEIARRCNA-GGIHEEYQLPYYDLVPSDPSIEEM  415

         ***********************************.************************

S: 241   kevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         ++vv+++klrP+ip+ w++ eal+++ k+++ecW+a+++aRltalr+kk+l

Q: 416   RKVVCDQKLRPNIPNWWQSYEALRVMGKMMRECWYANGAARLTALRIKKTL  466

         *************************************************97

Domain Sequence
(FASTA)

IVLQEIIGKG RFGEVWRGRW RGGDVAVKIF SSREERSWFR EAEIYQTVML RHENILGFIA 60

ADNKDNGTWT QLWLVSDYHE HGSLFDYLNR YTVTIEGMIK LALSAASGLA HLHMEIVGTQ 120

GKPGIAHRDL KSKNILVKKN GTCAIADLGL AVRHDSVTDT IDIAPNQRVG TKRYMAPEVL 180

DETINMKHFD SFKCADIYAL GLVYWEIARR CNAGGIHEEY QLPYYDLVPS DPSIEEMRKV 240

VCDQKLRPNI PNWWQSYEAL RVMGKMMREC WYANGAARLT ALRIKKTL 288

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0009986	; C:cell surface
GO:0005887	; C:integral to plasma membrane
GO:0017002	; F:activin-activated receptor activity
GO:0005524	; F:ATP binding
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0000082	; P:G1/S transition of mitotic cell cycle
GO:0006917	; P:induction of apoptosis
GO:0030308	; P:negative regulation of cell growth
GO:0038092	; P:nodal signaling pathway
GO:0018107	; P:peptidyl-threonine phosphorylation
GO:0032927	; P:positive regulation of activin receptor signaling pathway
GO:0045648	; P:positive regulation of erythrocyte differentiation
GO:0046777	; P:protein autophosphorylation
GO:0006355	; P:regulation of transcription, DNA-dependent

KEGG

InterPros

IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013