EKS-TAG-00151

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAG-00151

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/LRRK	350.5	4.9E-105	1863	2110	248

Status

Unreviewed

Ensembl Protein

ENSTGUP00000003512

UniProt Accession

H0YYY0;

Protein Name

Protein Synonyms/Alias

Gene Name

LRRK2

Gene Synonyms/Alias

LRRK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTGUG00000003353	ENSTGUP00000003512	ENSTGUT00000003548

Organism

Taeniopygia guttata

Functional Description

Protein Length

2507

Protein Sequence
(FASTA)

EEQALRKLVV RLNVQERKRL ETLVQTLSDL ELAARQSAPR LFSGKNVHVP LLLVVDLYPG 60

AAGVQQMGWS LLCKLIEICP STLQNIAPKD VGKDWEVLGV HQQILKMLTV HKGNINLSVI 120

GLKALNLLLM SDIIAFLLLE EEVDVFSLVF NAMHTFPKNE EIQQHGCKAL HKLFEKVPEE 180

QLTEFVESKD HMIILKVFKE FPEKEEVILP ALYSLHSLAG PPSNVEVLMS GNVRCYNVIV 240

EIMKSFPSSE TVQEVSCCLL HKLTLGNFFN ILVLHKVPEV IVKAVTTYPE NAKLQAAALS 300

CLALLTETIF LNRDLEERKE EEEEEKLCWL EACYRALELH RKNTDVLEAA CWALKNLFLY 360

QRNLHEKIGD GDNQFPIDRE VMLSMLMHSS SKVFQAAAST LAILSQQNVN IRKTLLAKGI 420

HMNVLDIMRK HPHSPEVIES ACRILNHVFE GSFPHLDVMT VAVSEVVKAM RKHEKSLSVQ 480

LEALRVLLHF MMPISAMQSS ENAAFALTGK VIKSQCLLEG THSLVLNALN RFIGNPSIQK 540

CGLKLLGSVA ECTGALEILT QQGATDTVLH TLQMYPDEQD IQCLGLSLLR SLITRKSLCI 600

ATMHVLSAVL VSTLRRFKEV TEIQMHGFHA ILAILGLSPC FAKLLVNESF DTVIFYQMSM 660

CFTDQRDQQF QSLCCRCFAK IAENDELKNT MLEKACMEYN SIMAECLLLL GADINKKTKT 720

NSLIYQVCEK GSNPKLVELL LANGAREQDV RSALTISIKR GDSQIISLLL RKLSLDVTNS 780

SICLGGFGFG RLEPSWLIPL FPDKLTQTRK QSAGSALARM VLKFQMKNIS EDRSRASSDP 840

NLSEDGVDRN YDWNFIPDPL VDSIFPLSDD IDSEGSEGPL FTKKKSNSIA VADLYCREMA 900

CQRGSPTLPR HSYSVGPGSD YEPLMKQRRK FLLSDESPRV SKLSSNIRPS DSLSSLISEK 960

EYIKSLDLSS NELENIDAIS QNSCLSSHLE HLEKLELHQN ALTNIPEQLC ENLKCLTYLD 1020

LHSNRFTYFP AYLLKMNCIA NLDISRNDIG PSLALDPCLR CPTLKQLNLS YNQLVCTPEF 1080

LTSVAENLEQ LLLEGNKISC LCSPLCLKDL KILNISKNSI SSLSEDVFMG CTKLEQFNAR 1140

MNILEKIPDL SSSITSLKLS QNCFTNVPEA ILLLPHLRSV DLSQNKITSL PGPMHWKSLN 1200

LRELLFNHNQ IDVLDLSEKA CAWSRLEKLH LSHNKLKEIP PQIGFLENLT SLDVSHNPDL 1260

RFFPDEMGRL SKVWDLPLEG LHLNLDFKHV GCKARDIIRF LQQRLKKAVP YNRMKLMIVG 1320

NTGSGKTTLL QQLMRSKRTE LGSPKATVGI DVKDWIIQGK GKIKKELILN VWDFGGQEEF 1380

YSTHPHFMTQ RALYLAVYDL SKGQAEVDAM KPWLFNIKAR ASTSPVILVG THLDISDEMQ 1440

RKACMSKITR ELLNKRGFPA IQDYHFVNAT EESDSIIRLR KIIIKESLHF KIRDQPVVGQ 1500

LIPDSYLGLE KRILLERKNV PVEFPVIDQK RLLELVQEGQ LQLDENELPH AIHFLNESGV 1560

LLHFQDPALQ LRDLYFVDPK WLCKIMAQIL MVKVEGSSKY PKGIVKRSDV EKFLLKKSKF 1620

PKIYMSQYFK LLEKFQIALP LGEDQLLIPS SLSDHRPVIE LPHCENSEII IRLYEMPYFP 1680

MGFWSRLINR LLEISPYMLS GRERALRPNR MYWRQGIYLN WSPEAYCLVE SAVFDNNPDS 1740

FLKITAPSCR KGCILLGQVV DHIDSLMEEW FPGLLEIDVC GEGETLLKKW ALYSFQDGEE 1800

HQKILLDDLL RKAEEGDLLV NPDQPRQTIP IAQIAPDLIL ADLPRNIMLN NDDLEFDEAP 1860

EFLLGDGGFG SVYRASYCGE EVAVKIFNKH TSLRLLRQEL AVLCHLHHPS LVSLLAAAVR 1920

PRMLVMELAL KGSLDRLLQQ DNASLTRTLQ HRIALHVADG LRYLHSAMII YRDLKPHNVL 1980

LFTLYPNSAV IAKIADYGIA QYCCRMGIKT SEGTPGFRAP EVAKGNVIYN QQADVYSFGL 2040

LLYDILTGGG RIMEGLKFPN EFDELAIQGK LPDPVKEYGC SPWPEVENLI KKCLKENPQE 2100

RPTSCQVYEI LNSAELICLM RYVSIPSTST AECMVAANQS CKKAGVWIGN GNTEKAQLSF 2160

VNLNTDGHTC EDIADSKIIS LALVTLPTEK ENWIVAGTQS GSLWAFNTED ETRRHRLQKM 2220

SDSITCLYCN SLSKQSKQKN FFLVGTADGR LAVFEDRAVK CKGATPLKIL TIGNVSTPLM 2280

CLNESSCLSE KNVIWGGCGT KIIALTSDFS VQKLIETKTS QLFCHNAYSD ANIISIAIDK 2340

SIYLAKKNSH FVEIWDKKTE KLSELIDCAH FLKNKVEKLN KESKHKLAYS GRVKTICLQK 2400

NTALWIGTGG GHILLLDLST RRPVRVIDKF CDSVRVMITA QLGNLKNVVL VLGYCYKSDT 2460

EDSKYHKELQ SCVSVWDINL PHEVQNLKKH IEMRQELAEK MKTFSLD 2507

Nucleotide Sequence
(FASTA)

GAGGAACAAG CCCTGAGGAA GCTGGTCGTC CGGCTCAACG TCCAGGAGAG GAAGCGGCTG 60

GAGACGCTGG TGCAGACCCT GAGCGACCTG GAGCTGGCGG CCCGGCAGAG CGCTCCCCGG 120

CTCTTCAGCG GCAAAAACGT CCACGTGCCC CTGCTGCTGG TGGTGGATCT GTACCCGGGA 180

GCGGCGGGCG TGCAGCAGAT GGGCTGGTCA CTTCTTTGTA AATTGATAGA AATTTGTCCA 240

AGTACTCTGC AAAACATAGC TCCTAAGGAT GTTGGGAAGG ACTGGGAAGT CCTGGGTGTT 300

CACCAGCAGA TTCTTAAAAT GCTTACAGTC CACAAAGGAA ATATAAATCT TTCAGTAATA 360

GGACTAAAAG CATTAAATCT TCTCCTCATG TCAGACATAA TTGCTTTTCT GCTCTTGGAA 420

GAAGAGGTGG ATGTCTTTTC CTTGGTATTT AATGCCATGC ACACCTTCCC TAAAAATGAA 480

GAGATCCAGC AGCATGGATG TAAAGCGTTA CACAAACTTT TTGAGAAAGT TCCAGAAGAG 540

CAGCTGACTG AATTTGTTGA AAGCAAAGAT CATATGATCA TACTGAAAGT ATTTAAAGAG 600

TTTCCAGAGA AAGAAGAGGT GATTCTTCCT GCACTTTATT CATTACATTC CTTAGCTGGT 660

CCACCCAGCA ATGTTGAAGT GCTCATGTCG GGAAATGTTC GCTGCTACAA TGTTATAGTG 720

GAAATTATGA AGAGTTTCCC CAGTAGTGAA ACAGTTCAGG AAGTGAGTTG CTGTTTGTTG 780

CACAAGCTTA CATTGGGAAA TTTTTTCAAT ATCCTTGTAT TACATAAGGT TCCAGAAGTC 840

ATTGTGAAGG CTGTTACAAC ATATCCCGAA AATGCAAAGT TACAAGCTGC AGCTCTCAGT 900

TGTTTGGCTC TTCTAACTGA AACAATATTC TTAAACCGGG ACTTAGAGGA AAGAAAAGAA 960

GAGGAGGAGG AAGAAAAGTT ATGCTGGTTG GAAGCGTGTT ACAGAGCATT AGAGCTGCAC 1020

CGAAAAAATA CAGATGTGCT GGAGGCTGCG TGCTGGGCTT TGAAAAATCT GTTTCTGTAT 1080

CAACGCAACC TTCATGAGAA GATTGGAGAT GGAGATAATC AGTTCCCAAT AGACAGAGAA 1140

GTGATGCTGT CCATGCTGAT GCACTCCTCT TCAAAAGTGT TTCAGGCAGC TGCTAGTACC 1200

TTGGCAATTT TGTCACAACA AAATGTAAAT ATTAGGAAGA CACTACTGGC TAAAGGCATA 1260

CATATGAATG TTTTGGATAT AATGAGGAAA CATCCACATT CTCCTGAAGT GATTGAAAGT 1320

GCCTGCAGGA TTCTGAATCA TGTTTTTGAA GGAAGTTTCC CTCATCTGGA TGTAATGACA 1380

GTAGCAGTAT CTGAAGTTGT AAAAGCCATG AGGAAACATG AAAAATCACT CTCTGTACAA 1440

CTGGAAGCAC TTCGAGTCCT TTTACACTTC ATGATGCCCA TCTCTGCAAT GCAGTCTTCT 1500

GAAAATGCTG CTTTTGCACT TACAGGAAAA GTCATTAAAA GCCAGTGTCT GTTGGAGGGA 1560

ACTCACTCAT TGGTGCTTAA TGCTTTAAAC AGGTTTATTG GAAATCCTAG CATTCAGAAG 1620

TGTGGATTAA AGCTGCTTGG TTCTGTAGCT GAATGCACTG GTGCGCTGGA AATTTTAACC 1680

CAGCAAGGAG CTACTGACAC TGTGCTTCAC ACCCTACAGA TGTACCCAGA TGAACAAGAT 1740

ATACAGTGTT TGGGTTTGAG TCTTCTACGC TCTTTGATTA CACGGAAGAG TTTGTGTATT 1800

GCAACCATGC ATGTCCTGTC AGCAGTTCTG GTTTCTACTC TGCGACGATT TAAAGAAGTC 1860

ACTGAAATCC AAATGCATGG ATTTCACGCA ATCTTGGCAA TTCTTGGTTT GTCACCTTGT 1920

TTTGCAAAGC TGCTGGTAAA TGAATCATTT GACACAGTAA TTTTCTACCA GATGTCTATG 1980

TGTTTCACTG ACCAGCGAGA TCAACAGTTT CAAAGCCTGT GTTGTAGATG TTTTGCTAAA 2040

ATAGCTGAAA ATGATGAGTT AAAAAATACA ATGCTGGAAA AAGCATGTAT GGAGTACAAT 2100

AGTATTATGG CTGAATGTTT ACTTTTACTG GGAGCTGATA TTAATAAGAA GACAAAGACA 2160

AACTCTTTAA TCTATCAGGT TTGTGAGAAA GGAAGTAATC CTAAATTGGT GGAATTGTTA 2220

TTAGCCAATG GTGCTCGAGA GCAGGATGTT CGGAGTGCTT TGACCATCAG TATAAAGAGA 2280

GGAGATAGCC AAATCATCAG CTTGCTCTTA AGGAAGCTTA GCCTTGATGT CACCAACAGC 2340

AGCATTTGTC TTGGAGGATT TGGTTTTGGC AGATTAGAGC CTTCCTGGCT CATTCCTTTG 2400

TTCCCAGATA AACTTACTCA AACAAGAAAA CAGAGTGCAG GTTCTGCACT GGCAAGGATG 2460

GTGCTCAAAT TCCAGATGAA GAACATTTCA GAGGATAGAT CAAGAGCCTC CTCCGATCCA 2520

AACTTGTCTG AAGATGGAGT GGACAGAAAC TATGACTGGA ATTTCATACC TGACCCATTA 2580

GTGGACAGTA TTTTTCCTTT GAGTGATGAT ATTGATAGTG AAGGGAGTGA AGGTCCACTT 2640

TTTACAAAAA AGAAGTCCAA TTCCATTGCA GTTGCTGATT TATATTGTAG GGAAATGGCA 2700

TGTCAGAGAG GTTCTCCTAC TTTGCCACGA CATTCCTACT CTGTGGGACC TGGCTCAGAT 2760

TATGAACCAT TAATGAAACA AAGACGAAAA TTCTTGCTCT CAGATGAATC CCCTAGAGTC 2820

TCAAAATTGT CATCAAATAT AAGACCATCA GACAGCCTTT CTTCATTGAT CTCAGAGAAA 2880

GAATATATTA AATCACTAGA TCTTTCATCA AATGAGCTGG AGAATATTGA TGCCATCAGC 2940

CAGAACAGCT GCTTATCTAG TCATCTAGAA CACCTTGAGA AACTGGAGCT CCACCAAAAT 3000

GCTCTTACAA ACATTCCAGA ACAGCTGTGT GAAAACTTGA AATGCTTGAC TTACCTGGAT 3060

TTGCACAGTA ACCGATTTAC TTATTTCCCG GCTTACTTAC TGAAAATGAA TTGTATTGCA 3120

AATCTCGACA TCTCGCGAAA TGACATTGGA CCTTCCTTGG CTTTGGATCC GTGCCTCAGA 3180

TGTCCAACTC TGAAACAACT TAACCTTTCA TACAATCAGC TGGTGTGCAC TCCTGAATTT 3240

CTTACAAGTG TTGCTGAAAA TCTGGAACAG CTCTTGCTGG AAGGAAACAA AATTTCATGC 3300

TTATGTTCAC CCCTATGCTT GAAAGACCTG AAAATTTTAA ACATTAGTAA GAACAGTATT 3360

TCATCCCTTT CTGAGGATGT CTTCATGGGC TGTACAAAAC TGGAGCAGTT CAATGCCAGG 3420

ATGAATATTC TTGAAAAGAT ACCTGACCTG TCATCCAGCA TAACAAGTTT AAAATTATCC 3480

CAGAATTGTT TTACTAATGT TCCAGAAGCA ATTCTTCTTC TACCACATTT GCGATCAGTA 3540

GATTTAAGCC AAAACAAGAT CACAAGCCTG CCTGGACCAA TGCACTGGAA ATCACTAAAT 3600

TTAAGGGAGC TGTTATTTAA TCATAATCAA ATAGATGTCT TGGACTTGAG TGAAAAAGCA 3660

TGTGCATGGT CTAGGCTAGA AAAGCTGCAC CTCTCCCACA ACAAGTTAAA GGAGATTCCT 3720

CCTCAGATTG GCTTCCTAGA GAACTTGACT TCTCTGGATG TAAGTCATAA TCCTGATTTG 3780

AGATTTTTTC CTGATGAAAT GGGAAGACTG TCCAAAGTCT GGGACCTTCC TTTGGAAGGA 3840

CTCCATCTTA ATTTAGACTT CAAGCATGTG GGATGCAAAG CCAGAGACAT TATCAGATTT 3900

CTTCAACAGC GACTGAAGAA GGCTGTGCCT TATAACAGAA TGAAGCTGAT GATTGTTGGA 3960

AACACTGGCA GTGGGAAAAC TACCCTGCTG CAACAACTCA TGAGAAGCAA ACGAACAGAA 4020

CTGGGCTCTC CAAAAGCCAC AGTAGGCATT GATGTAAAAG ACTGGATCAT TCAAGGGAAA 4080

GGCAAAATTA AGAAGGAACT TATATTAAAT GTGTGGGACT TTGGAGGACA AGAAGAGTTC 4140

TACAGTACCC ATCCTCATTT CATGACCCAG AGAGCTTTAT ATCTTGCTGT TTATGATCTC 4200

AGCAAAGGAC AAGCAGAGGT GGATGCTATG AAGCCATGGC TTTTTAACAT CAAGGCTCGA 4260

GCATCAACAT CCCCTGTCAT TCTTGTTGGC ACTCATTTGG ATATTTCTGA TGAAATGCAA 4320

CGTAAGGCCT GCATGAGTAA AATTACAAGA GAGCTGTTGA ACAAGCGAGG CTTCCCAGCA 4380

ATCCAAGATT ACCACTTTGT CAACGCTACA GAAGAATCTG ATTCCATTAT CAGGCTTCGG 4440

AAAATCATCA TAAAGGAGAG TCTTCACTTC AAGATCAGAG ATCAGCCAGT GGTTGGTCAG 4500

CTAATTCCTG ACAGCTACCT GGGGCTGGAA AAGAGAATTT TGCTGGAACG TAAAAATGTC 4560

CCAGTGGAAT TTCCTGTAAT TGATCAGAAA CGCTTGCTGG AACTGGTACA AGAAGGCCAG 4620

TTACAACTGG ATGAAAATGA ACTCCCTCAT GCAATTCACT TTCTGAATGA ATCAGGTGTT 4680

CTCCTTCATT TCCAAGATCC AGCACTACAG CTAAGAGATC TGTATTTCGT AGATCCGAAG 4740

TGGCTGTGTA AAATCATGGC ACAGATTCTG ATGGTGAAAG TAGAAGGCTC TTCTAAATAC 4800

CCTAAGGGAA TTGTAAAGCG TTCAGATGTG GAAAAATTCC TTTTGAAGAA GAGCAAGTTC 4860

CCTAAAATCT ATATGTCACA ATACTTTAAG CTTCTGGAAA AGTTTCAGAT TGCTTTGCCA 4920

TTAGGAGAGG ACCAACTACT AATCCCAAGC AGCTTGTCTG ATCACAGGCC TGTTATAGAA 4980

CTTCCCCACT GTGAAAATTC AGAAATTATC ATCAGGCTTT ATGAGATGCC ATACTTCCCT 5040

ATGGGATTTT GGTCCAGGCT CATCAACAGG TTGCTCGAGA TATCACCTTA CATGCTATCA 5100

GGAAGAGAGC GAGCTCTTCG TCCTAACAGA ATGTACTGGA GACAAGGCAT CTATTTGAAC 5160

TGGTCTCCTG AAGCTTATTG TCTAGTGGAA TCAGCAGTAT TTGACAACAA CCCAGACAGT 5220

TTTTTGAAAA TTACAGCACC TTCTTGCAGA AAAGGGTGCA TTCTTTTGGG GCAAGTTGTG 5280

GATCACATAG ATTCTCTTAT GGAAGAATGG TTTCCAGGTT TGTTGGAAAT AGATGTTTGT 5340

GGTGAAGGGG AAACACTGTT GAAGAAATGG GCTCTGTACA GCTTTCAAGA TGGCGAAGAA 5400

CACCAAAAAA TACTACTTGA TGACTTGCTT AGGAAGGCTG AAGAAGGTGA CCTTTTAGTA 5460

AATCCAGATC AACCAAGACA GACCATTCCA ATTGCTCAGA TTGCTCCTGA TCTGATACTG 5520

GCTGATTTGC CTAGAAATAT TATGTTGAAC AATGATGATC TGGAATTTGA TGAAGCTCCT 5580

GAATTTCTCT TGGGTGATGG TGGGTTTGGA TCTGTGTACC GTGCATCCTA TTGTGGTGAA 5640

GAGGTTGCTG TGAAGATTTT CAATAAACAT ACTTCTCTCA GGCTCCTAAG ACAAGAGCTT 5700

GCAGTGCTTT GTCACCTCCA CCATCCCAGC TTGGTGTCTT TGCTGGCTGC TGCAGTCCGT 5760

CCCCGGATGC TGGTGATGGA ATTGGCCCTC AAAGGATCTC TTGATCGTTT GCTTCAACAG 5820

GACAATGCAA GTTTAACTAG AACACTTCAG CACAGGATAG CTCTCCATGT AGCAGATGGC 5880

TTAAGGTACC TGCATTCAGC AATGATCATC TACCGCGATT TAAAGCCTCA CAACGTGTTG 5940

CTCTTTACCT TATATCCCAA TTCAGCTGTT ATTGCAAAAA TAGCTGACTA TGGCATTGCC 6000

CAGTATTGTT GCCGAATGGG AATAAAAACC TCAGAAGGCA CACCAGGATT TCGAGCGCCA 6060

GAGGTTGCCA AAGGAAATGT TATTTACAAT CAGCAAGCTG ATGTTTATTC ATTTGGCCTG 6120

CTGCTTTATG ACATTTTAAC AGGAGGAGGT AGAATAATGG AAGGCTTGAA GTTTCCAAAT 6180

GAATTTGATG AATTAGCAAT ACAAGGAAAA TTACCAGATC CTGTCAAAGA ATATGGGTGT 6240

TCCCCCTGGC CTGAAGTTGA AAATTTAATT AAAAAGTGTT TGAAGGAAAA CCCTCAGGAA 6300

CGACCAACAT CTTGCCAGGT TTATGAGATC CTGAATTCTG CAGAGCTTAT CTGTTTGATG 6360

AGGTATGTCT CCATACCCAG CACATCTACA GCAGAATGCA TGGTGGCTGC CAATCAAAGC 6420

TGCAAGAAGG CAGGAGTCTG GATAGGCAAT GGGAATACAG AAAAGGCACA ACTTTCATTT 6480

GTTAACCTAA ACACAGATGG ACATACTTGT GAGGATATTG CAGACAGTAA AATTATAAGT 6540

TTGGCCTTAG TGACTCTTCC TACTGAGAAG GAAAACTGGA TTGTAGCAGG AACCCAGTCT 6600

GGTTCTCTGT GGGCATTTAA TACAGAAGAT GAAACTAGAA GGCATCGTCT GCAGAAAATG 6660

TCAGATTCTA TCACTTGTTT ATACTGTAAT TCTCTTTCGA AGCAAAGCAA ACAGAAGAAT 6720

TTCTTCTTGG TAGGCACAGC TGATGGCAGA CTGGCAGTTT TTGAAGACAG AGCAGTAAAG 6780

TGTAAGGGTG CTACACCTTT GAAGATACTG ACTATAGGAA ATGTTAGCAC ACCCCTGATG 6840

TGCTTAAACG AATCCTCATG CTTATCTGAA AAAAATGTAA TCTGGGGAGG CTGTGGAACA 6900

AAAATCATTG CCTTAACCAG TGACTTCTCC GTTCAAAAGC TCATTGAAAC AAAGACAAGT 6960

CAACTGTTCT GTCATAATGC TTACAGTGAT GCAAACATTA TTTCAATAGC AATAGACAAA 7020

TCCATCTACT TGGCAAAGAA AAACAGCCAT TTTGTGGAAA TCTGGGACAA GAAGACAGAA 7080

AAGCTTTCTG AATTAATTGA CTGTGCACAT TTTCTTAAGA ACAAAGTGGA AAAATTAAAT 7140

AAGGAATCAA AACATAAATT GGCTTATTCT GGAAGAGTGA AGACCATTTG TCTGCAGAAA 7200

AATACTGCAC TGTGGATAGG GACAGGAGGA GGACATATCT TGCTGCTTGA TTTGTCAACG 7260

CGTCGTCCTG TACGAGTTAT AGACAAGTTC TGTGATTCTG TTCGAGTCAT GATAACAGCT 7320

CAGCTGGGTA ATCTCAAGAA TGTGGTCCTT GTTTTGGGAT ATTGCTATAA GAGTGACACC 7380

GAAGACAGCA AATATCACAA AGAGTTACAA TCCTGCGTGT CAGTGTGGGA CATTAACCTA 7440

CCCCATGAAG TGCAAAACCT GAAAAAACAC ATAGAAATGA GACAGGAATT AGCAGAAAAA 7500

ATGAAGACTT TTTCTTTGGA CTGA 7524

Domain Profile

S: 6     llGrGafGsvyraavkGeevavkafkiaadklkrdslelalkayselrqelsvLlalkhP  65

         llG+G+fGsvyra++ Geevavk+f+      k++sl+l       lrqel+vL++l+hP

Q: 1863  LLGDGGFGSVYRASYCGEEVAVKIFN------KHTSLRL-------LRQELAVLCHLHHP  1909

         79************************......*******.......**************

S: 66    sivsLvgisikPlalvleLaplgsLdrlLsedkksssklgrtltkkialqvargleyLhk  125

         s+vsL++++++P++lv+eLa +gsLdrlL++d++s   l+rtl+++ial+va+gl+yLh+

Q: 1910  SLVSLLAAAVRPRMLVMELALKGSLDRLLQQDNAS---LTRTLQHRIALHVADGLRYLHS  1966

         ********************************999...**********************

S: 126   kkiiyrdLksenvLvwslspkeailikladyGisrqslrsGakgveGteGfraPeivrge  185

         ++iiyrdLk++nvL+++l+p++a+++k+adyGi+++++r+G+k++eGt+GfraPe+++g+

Q: 1967  AMIIYRDLKPHNVLLFTLYPNSAVIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVAKGN  2026

         ************************************************************

S: 186   vvydekvdvfsfGlllyell.sgkrpvegeeqlkivekl.lkGkrPvlvkeeevlptpll  243

         v+y++++dv+sfGllly++l  g r++eg ++++++++l ++Gk+P++vke+++ p+p +

Q: 2027  VIYNQQADVYSFGLLLYDILtGGGRIMEGLKFPNEFDELaIQGKLPDPVKEYGCSPWPEV  2086

         ********************4468**********************************99

S: 244   d.LlveCwkekPekrPtasqvvsi  266

         + L+++C+ke+P++rPt+ qv +i

Q: 2087  EnLIKKCLKENPQERPTSCQVYEI  2110

         88*******************875

Domain Sequence
(FASTA)

LLGDGGFGSV YRASYCGEEV AVKIFNKHTS LRLLRQELAV LCHLHHPSLV SLLAAAVRPR 60

MLVMELALKG SLDRLLQQDN ASLTRTLQHR IALHVADGLR YLHSAMIIYR DLKPHNVLLF 120

TLYPNSAVIA KIADYGIAQY CCRMGIKTSE GTPGFRAPEV AKGNVIYNQQ ADVYSFGLLL 180

YDILTGGGRI MEGLKFPNEF DELAIQGKLP DPVKEYGCSP WPEVENLIKK CLKENPQERP 240

TSCQVYEI 248

Keyword

ATP-binding; Complete proteome; GTP-binding; Leucine-rich repeat; Nucleotide-binding; Reference proteome; Repeat.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0032839	; C:dendrite cytoplasm
GO:0032473	; C:external side of mitochondrial outer membrane
GO:0045121	; C:membrane raft
GO:0043025	; C:neuronal cell body
GO:0005886	; C:plasma membrane
GO:0008021	; C:synaptic vesicle
GO:0005802	; C:trans-Golgi network
GO:0005524	; F:ATP binding
GO:0005525	; F:GTP binding
GO:0034211	; F:GTP-dependent protein kinase activity
GO:0005096	; F:GTPase activator activity
GO:0003924	; F:GTPase activity
GO:0004708	; F:MAP kinase kinase activity
GO:0000186	; P:activation of MAPKK activity
GO:0048312	; P:intracellular distribution of mitochondria
GO:2000173	; P:negative regulation of branching morphogenesis of a nerve
GO:0034260	; P:negative regulation of GTPase activity
GO:0070997	; P:neuron death
GO:0018105	; P:peptidyl-serine phosphorylation
GO:0018107	; P:peptidyl-threonine phosphorylation
GO:0010508	; P:positive regulation of autophagy
GO:0060161	; P:positive regulation of dopamine receptor signaling pathway
GO:0043068	; P:positive regulation of programmed cell death
GO:0032436	; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0031398	; P:positive regulation of protein ubiquitination
GO:0046777	; P:protein autophosphorylation
GO:0040012	; P:regulation of locomotion
GO:0042391	; P:regulation of membrane potential
GO:0006979	; P:response to oxidative stress
GO:0007264	; P:small GTPase mediated signal transduction

KEGG

InterPros

IPR002110	; Ankyrin_rpt.
IPR020683	; Ankyrin_rpt-contain_dom.
IPR011989	; ARM-like.
IPR016024	; ARM-type_fold.
IPR011009	; Kinase-like_dom.
IPR001611	; Leu-rich_rpt.
IPR025875	; Leu-rich_rpt_4.
IPR003591	; Leu-rich_rpt_typical-subtyp.
IPR013684	; MIRO-like.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR020859	; ROC_GTPase.
IPR008271	; Ser/Thr_kinase_AS.
IPR005225	; Small_GTP-bd_dom.
IPR001806	; Small_GTPase.
IPR015943	; WD40/YVTN_repeat-like_dom.
IPR017986	; WD40_repeat_dom.

Pfam

PF12799	; LRR_4; 1.
PF08477	; Miro; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00248	; ANK; 2.
SM00369	; LRR_TYP; 1.

Prosites

PS50297	; ANK_REP_REGION; 1.
PS51450	; LRR; 12.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS51424	; ROC; 1.

Prints

PR00449

; RASTRNSFRMNG.

Created Date

20-Feb-2013